Inhibiting the gastric burst release of drugs from enteric microparticles: The influence of drug molecular mass and solubility

Journal of Pharmaceutical Sciences

Volumn 99, Issue 11, 2010, Pages 4576-4583

  Alhnan, Mohamed A ^a   Cosi, Daniele ^a   Murdan, Sudaxshina ^a   Basit, Abdul W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Colonic delivery; Delayed release; Enteric polymers; Gastric resistance; Methacrylic polymers; Microspheres

Indexed keywords

AMPRENAVIR; BENDROFLUMETHIAZIDE; BUDESONIDE; CINNARIZINE; DIPYRIDAMOLE; EUDRAGIT; KETOPROFEN; PARACETAMOL; PREDNISOLONE; SALICYLIC ACID;

ARTICLE; DELAYED DRUG RELEASE; DRUG SOLUBILITY; EMULSION; ENCAPSULATION; EVAPORATION; HUMAN; MOLECULAR WEIGHT; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY;

EID: 78149356749     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22174     Document Type: Article

References (21)

1. Kawashima Y, Niwa T, Handa T, Takeuchi H, Iwamoto T, Itoh Y. 1989. Preparation of prolonged-release spherical micro-matrix of ibuprofen with acrylic polymer by the emulsion-solvent diffusion method for improving bioavailability. Chem Pharm Bull (Tokyo) 37: 425-429.
2. Huang HP, Ghebre-Sellassie I. 1989. Preparation of microspheres of water-soluble pharmaceuticals. J Microencapsul 6: 219-225.
3. Watts PJ, Davies MC, Melia CD. 1990. Microencapsulation using emulsification/solvent evaporation: An overview of techniques and applications. Crit Rev Ther Drug Carrier Syst 7: 235-259.
4. Kilicarslan M, Baykara T. 2004. Effects of the permeability characteristics of different polymethacrylates on the pharmaceutical characteristics of verapamil hyhdrochloride-loaded microspheres. J Microencapsul 21: 175-189.
5. Obeidat WM, Price JC. 2005. Preparation and in vitro evaluation of propylthiouracil microspheres made of Eudragit RL 100 and cellulose acetate butyrate polymers using the emulsion-solvent evaporation method. J Microencapsul 22: 281-289.
6. Obeidat WM, Price JC. 2006. Preparation and evaluation of Eudragit S 100 microspheres as pH-sensitive release preparations for piroxicam and theophylline using the emulsion-solvent evaporation method. J Microencapsul 23: 195-202.
7. Silva JP, Ferreira JP. 1999. Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method. J Microencapsul 16: 95-103.
8. Esposito E, Cervellati F, Menegatti E, Nastruzzi C, Cortesi R. 2002. Spray dried Eudragit microparticles as encapsulation devices for vitamin C. Int J Pharm 242: 329-334.
9. Raffin RP, Colome LM, Pohlmann AR, Guterres SS. 2006. Preparation, characterization, and in vivo anti-ulcer evaluation of pantoprazole-loaded microparticles. Eur J Pharm Biopharm 63: 198-204.
10. Raffin RP, Jornada DS, Re MI, Pohlmann AR, Guterres SS. 2006. Sodium pantoprazole-loaded enteric microparticles prepared by spray drying: Effect of the scale of production and process validation. Int J Pharm 324: 10-18.
11. Obeidat WM, Price JC. 2006. Preparation and evaluation of Eudragit S 100 microspheres as pH-sensitive release preparations for piroxicam and theophylline using the emulsion-solvent evaporation method. J Microencapsul 23: 195-202.
12. Song M, Li N, Sun S, Tiedt LR, Liebenberg W, de Villiers MM. 2005. Effect of viscosity and concentration of wall former, emulsifier and pore-inducer on the properties of amoxicillin microcapsules prepared by emulsion solvent evaporation. Farmaco 60: 261-267.
13. Nilkumhang S, Basit AW. 2009. The robustness and flexibility of an emulsion solvent evaporation method to prepare pH-responsive microparticles. Int J Pharm 377: 135-141.
14. Nilkumhang S, Alhnan MA, McConnell E, Basit AW. 2009. Drug distribution in enteric microparticles. Int J Pharm 379: 1-8.
15. Song M, Li N, Sun S, Tiedt LR, Liebenberg W, de Villiers MM. 2005. Effect of viscosity and concentration of wall former, emulsifier and pore-inducer on the properties of amoxicillin microcapsules prepared by emulsion solvent evaporation. Farmaco 60: 261-267.
16. Kendall R, Alhnan MA, Nilkumhang S, Murdan S, Basit AW. 2009. Fabrication and in vivo evaluation of highly pH-responsive acrylic microparticles for targeted gastrointestinal delivery. Eur J Pharm Sci 37: 284-290.
17. Lehmann K, Petereit H, Dreher D. 1993. Fast disintegrating controlled-release tablets from coated particles. Pharm Ind 55: 940-947.
18. Hsiue GH, Liao CM, Lin SY. 1998. Effect of drug-polymer interaction on the release characteristics of methacrylic acid copolymer microcapsules containing theophylline. Artif Organs 22: 651-656.
19. Jenquin MR, Liebowitz SM, Sarabia RE, McGinity JW. 1990. Physical and chemical factors influencing the release of drugs from acrylic resin films. J Pharm Sci 79: 811-816.
20. Karavas E, Ktistis G, Xenakis A, Georgarakis E. 2006. Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone. Eur J Pharm Biopharm 63: 103-114.
21. Mortada LM, Bostanian LA, Salib NN. 1990. Interactions of oxyphenbutazone with polyvinylpyrrolidone. Pharmazie 45.