Development of a microencapsulated form of cefuroxime axetil using pH-sensitive acrylic polymers

Journal of Microencapsulation

Volumn 14, Issue 5, 1997, Pages 607-616

  Lorenzo Lamosa, M L ^a   Cuna M ^a   Vila Jato, J L ^a   Torres, D ^a   Alonso, M J ^a  

^a Faculty of Pharmacy Universidade de   (Spain)

Author keywords

Cefuroxime axetil; Eudragit; Microspheres; pH sensitive polymers; Stability; Taste masking

Indexed keywords

CEFUROXIME AXETIL; CEPHALOSPORIN DERIVATIVE; EUDRAGIT; POLYACRYLIC ACID;

ARTICLE; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; MICROENCAPSULATION;

EID: 0030768652     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652049709006813     Document Type: Article

References (18)

1. BIANCHINI, R., BRUNI, G., GAZZANIGA, A., and VECCHIO, C., 1993, d-Indobufen extended-release pellets prepared by coating with aqueous polymer dispersions. Drug Development and Industrial Pharmacy, 19, 2021-2041.
2. BODMEIER, R., CHEN, H., TYLE, R., and JAROSZ, P., 1991, Pseudoephedrine HCl microspheres formulated into an oral suspension dosage form. Journal of Controlled Release, 15, 65-77.
3. BOGATAJ, M., MRHAR, A., KRISTL, A., and KOZJEK, F., 1989, Preparation and evaluation of Eudragit E microspheres containing Bacampicillin. Drug Development and Industrial Pharmacy, 15, 2295-2313.
4. BOGATAJ, M., MRHAR, A., KRISTL, A., and KOZJEK, F., 1991, Eudragit E microspheres containing bacampicillin: preparation by solvent removal methods. Journal of Microencapsulation, 8, 401-406.
5. British Pharmacopeia, 1993, addendum 1994.
6. FABRE, H., IBORK, H., and LERNER, D. A., 1994, Photoisomerization kinetics of cefuroxime axetil and related compounds. Journal of Pharmaceutical Sciences, 83, 553-558.
7. FRIEND, D. R., 1992, Polyacrylate resin microcapsules for taste masking of antibiotics. Journal of Microencapsulation, 9, 469-480.
8. FUKUMORI, Y., YAMAOKA, Y., and ICHIKAWA, H., 1988, Coating of Pharmaceutical powders by fluidized bed process. IV. Softening temperature of acrylic copolymers and its relation to film formation in aqueous coating. Chemical Pharmaceutical Bulletin, 36, 4927-4932.
9. KAURA, S., BANAKAR, U. V., and GALINSKY, A. M., 1988, A study of the effect of sucrose concentration, lacquer concentration and coating time on the formulation of stable and effective Carbenicillin Indanyl Sodium microcapsules. Drug Development and Industrial Pharmacy, 14, 925-937.
10. KAWASHIMA, Y., IWAMOTO, T., NIWA, T., TAKEUCHI, H., and ITOH, Y., 1991, Preparation and characterization of a new controlled release ibuprofen suspension for improving suspendability. International Journal of Pharmaceutics, 75, 25-36.
11. KISLALIOGLU, M. S., KHAN, M. A., BLOUNT, C., GOETTSCH, R. W., and BOLTON, S., 1991, Physical characterization and dissolution properties of ibuprofen/Eudragit coprecipitates. Journal of Pharmaceutical Sciences, 80, 799-804.
12. LEE, H.-K., HADJU, J., and MCGOFF, P., 1991, Propanolol/methacrylic acid copolymer binding interaction. Journal of Pharmaceutical Sciences, 80, 178-180.
13. LEHMANN, K., 1994, Coating of multiparticulates using polymeric solutions: formulation and process considerations. In Multiparticulate Oral Drug Delivery, edited by I. Ghebre-Sellassie (New York: Marcel Dekker), pp. 51-78.
14. LIN, S.-Y., Lee, C.-J., and LIN, Y.-Y., 1995, Drug-polymer interaction affecting the mechanical properties, adhesion strength and release kinetics of piroxicam-loaded Eudragit E films plasticized with different plasticizers. Journal of Controlled Release, 33, 375-381.
15. LIN, S. Y., and PERNG, R. I., 1993, Solid-state interaction studies of drugs/polymers. I. Indomethacin/Eudragit E, RL or S resins. S.T.P. Pharma Sciences, 3, 465-471.
16. NGUYEN, N.-A. T., 1991, The relationship of diastereomer hydrolysis kinetics to shelf-life predictions for cefuroxime axetil. Pharmaceutical Research, 8, 893-898.
17. PONGPAIBUL, Y., PRICE, J. C., and WHITWORTH, C. W., 1984, Preparation and evaluation of controlled release indomethacin microspheres. Drug Development and Industrial Pharmacy, 10, 1597-1616.
18. SPROCKEL, O. L., and PRAPAITRAKUL, W., 1990, A comparison of microencapsulation by various emulsion techniques. International Journal of Pharmaceutics, 58, 123-127.