Role of xenobiotic metabolic enzymes in cancer epidemiology

Methods in Molecular Biology

Volumn 472, Issue , 2009, Pages 243-264

  Singh, Madhu S ^a   Michael, Michael ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Alcohol dehydrogenase; Aldehyde dehydroge nase; Cancer epidemiology; Cancer risk; Glutathione S transferase; P450; Sulphatase; Xenobiotic

Indexed keywords

XENOBIOTIC AGENT;

ENZYMOLOGY; EPIDEMIOLOGY; HUMAN; METABOLISM; NEOPLASM; REVIEW;

EPIDEMIOLOGIC METHODS; HUMANS; NEOPLASMS; XENOBIOTICS;

EID: 58149465746     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-492-0_10     Document Type: Review

References (79)

1. Mathers CD. Projection of Global Mortality and Burden of Disease from 2002 to 2030. WHO 2006.
2. Key TJ, Verkasalo PK, Banks E. Epidemiology of breast cancer. Lancet Oncology 2001; 2:133.
3. Boulton SJ. Cellular functions of the BRCA tumour-suppressor proteins. Biochem Soc Trans. 2006; 34(Pt 5):633-645.
4. www.who.int/mediacentre/factsheets/fs297/ en/index.html .
5. Gonzalez FJ, Gelboin HV. Role of human cytochromes 450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab Rev 1994; 26:165-183.
6. www.drnelson.utmem.edu.
7. Capdevila Harris RC, Falck JR: Microsomal P450 function and Eicosanoid metabolism: Cell Mol Life Science 2002; 59(5):780-789.
8. Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286:487-491.
9. Nebert DW, Dalton TD. The role of cytochrome P450 enzymes in endogenous signaling pathways and environmental carcinogenesis. Nat Rev Cancer 2006; 6:947-960.
10. Rendic S, DiCarlo FJ. Human cytochrome P 450 enzymes: Status report summarizing their reactions, substrates, inducers and inhibitors. Drug Metab Rev 1997; 29:413-580.
11. Windmill KF, McKinnon RA, Zhu X, Gaedigk A, Grant DM, McManus ME. The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. Mutat Res 1997 May 12; 376(1-2):153-160.
12. Hecht SS . Biochemistry, biology and carcinogenicities of Tobacco Specific N-Nitrosamines Chem Res Toxicology 1998; June, Vol 11 No. 6, 560-603.
13. Caporaso N, Hayes RB, Dosemeci M, Hoover R, Ayesh R, Hetzel M, Idle J. Lung cancer risk, occupational exposure, and the Debrisoquine metabolic phenotype. Cancer Res 1989; 49:3675-3679.
14. Jiao L, Bondy ML, Hassan MM, Chang DZ, Abbruzzese JL, Evans DB, Smolensky MH, Li D: Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer. Cancer 2007; 109(5):840-848.
15. Rodriguez-Antona C, Ingelman-Sundberg M. Cytochrome P450 pharmacogenetics and cancer. Oncogene 2006; 25:1679-1691.
16. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 2004; 279(23):23847-23850.
17. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, Tohyama C, Krust A, Mimura J, Chambon P, Yanagisawa J, Fujii-Kuriyama Y, Kato S. Modulation of oestrogen receptor signaling by association with the activated dioxin receptor. Nature 2003; 423:545-550.
18. Puga A Barnes SJ, Dalton TP, Chang C, Knudsen ES, Maier MA. Aromatic hydrocarbon receptor interaction with retinoblastoma protein potentiates repression of E2F dependent transcription and cell cycle arrest. J Biol Chem 2000; 275:2943-2950.
19. Currier N, Solomon SE, Demicco EG, Chang DL, Farago M, Ying H, Dominguez I, Sonenshein GE, Cardiff RD, Xiao ZX, Sherr DH, Seldin DC. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol 2005; 33:726-737.
20. Momand J Wu HH, Dasgupta G. MDM2-master regulator of the p53 tumor suppressor protein. Gene 2000; 242 (1-2): 15-29.
21. Liehr JG. Dual role of oestrogens as hormones and pro-carcinogens: tumour initiation by metabolic activation of oestrogens. Eur J Cancer Prev 1997; 6:3-10.
22. Zumoff B. Does postmenopausal estrogen administration increase the risk of breast cancer? Contributions of animal, biochemical, and clinical investigative studies to a resolution of the controversy. Proc Soc Exp Biol Med 1998; 217:30-7.
23. Russo J, Hasan Lareef M, Balogh G, Guo S, Russo IH. Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol 2003; 87:1-25.
24. Basseres D, Baldwin Jr AS. Nuclear factor- B and inhibitor of B kinase pathways in oncogenic initiation and progression. Oncogene 2006; 25:6817-6830.
25. Aklillu E, Oscarson M, Hidestrand M, Leidvik B, Otter C, Ingelman-Sundberg M, et al. Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population. Mol Pharmacol 2002; 61(3):586-594.
26. Yang CX, Matsuo K, Wang ZM, Tajima K, et al. Phase I/II enzyme gene polymorphisms and esophageal cancer: a meta-analysis of the literature. World J Gastroenterol 2005; 11:2531-2538.
27. Slattery ML, Samowtiz W, Ma K, Murtaugh M, Sweeney C, Levin TR, Neuhausen S. CYP1A1, cigarette smoking, and colon and rectal cancer. Am J Epidemiol 2004; 160;842-852.
28. Landi S, Gemignani F, Moreno V, Gioia-Patricola L, Chabrier A, Guino E, Navarro M, de Oca J, Capellà G, Canzian F; Bellvitge Colorectal Cancer Study Group. Comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. Pharmacogenet Genomics 2005; 15(8):535-546.
29. Rasmussen BB, Brix TH, Kyvik KO, Brøsen K. The Interindividual differences in the 3-demethylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. Pharmacogenetics. 2002; 12(6):473-478.
30. Van Ashwegen CH, Purdy RH, Wittliff JL. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem 1989; 32(4):485-492.
31. Zhu BT, Conney AH. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Res 1998; 58(11):2269-2277.
32. Hanna IH, Dawling S, Roodi N, Guengerich FP, Parl FF. Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphism with functional differences in estrogen hydroxylation activity. Cancer Res 2000; 60:3440-3444.
33. Chang BL, Zheng SL, Isaacs SD, Turner A, Hawkins GA, Wiley KE, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J. Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer. Br J Cancer 2003; 89(8):1524-1529.
34. Goodman MT, McDuffie K, Kolonel LN, Terada K, Donlon TA, Wilkens LR, Guo C, Le Marchand L. Case-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism. Cancer Epidemiol Biomarkers Prev 2001; 10(3):209-216.
35. Sasaki M, Tanaka Y, Okino ST, Nomoto M, Yonezawa S, Nakagawa M, Fujimoto S, Sakuragi N, Dahiya R. et al. Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer. Clin Cancer Res 2004; 10(6):2015-2019.
36. Sasaki M, Tanaka Y, Kaneuchi M, Sakuragi N, Dahiya R. CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor and estrogen receptor β expressions. Cancer Res 2003; 63(14):3913-3918.
37. Watanabe J, Shimada T, Gillam EM, Ikuta T, Suemasu K, Higashi Y, Gotoh O, Kawajiri K, et al. Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics 2000; 10(1):25-33.
38. Ariyoshi N, Miyamoto M, Umetsu Y, Kunitoh H, Dosaka-Akita H, Sawamura Y, Yokota J, Nemoto N, Sato K, Kamataki T, et al. Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers. Cancer Epidemiol Biomarkers Prev 2002; 11(9):890-894.
39. Nakajima M, Yamamoto T, Nunoya K, Yokoi T, Nagashima K, Inoue K, Funae Y, Shimada N, Kamataki T, Kuroiwa Y. Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos 1996; 24(11):1212-1217.
40. Benowitz NL, Pérez-Stable EJ, Herrera B, Jacob P 3rd. Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans J Natl Cancer Inst 2002; 94(2):108-115.
41. Kumagai J, Fujimura T, Takahashi S, Urano T, Ogushi T, Horie-Inoue K, Ouchi Y, Kitamura T, Muramatsu M, Blumberg B, Inoue S. Cytochrome P450 2B6 is a growth-inhibitory and prognostic factor for prostate cancer. Prostate 2007; 67(10):1029-1037.
42. Waxman DJ, Attisano C, Guengerich FP, Lapenson DP. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 betahydroxylase cytochrome P-450 enzyme. Arch Biochem Biophys 1988; 263(2):424-436.
43. Bergheim I, Wolfgarten E, Bollschweiler E, Hölscher AH, Bode C, Parlesak A. Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma. World J Gastroenterol 2007; 13(7):997-1002.
44. Knupfer H, Schmidt R, Stanitz D, et al. CYP2C and IL-6 expression in breast cancer. Breast 2004; 343(44):28-34.
45. Caporaso NE, Tucker MA, Hoover RN, Hayes RB, Pickle LW, Issaq HJ, Muschik GM, Green-Gallo L, Buivys D, Aisner S, et al. Lung cancer and the debrisoquine metabolic phenotype: J Natl Cancer Inst 1990; 82(15):1264-1272.
46. Shaw GL, Falk RT, Frame JN, Weiffenbach B, Nesbitt JC, Pass HI, Caporaso NE, Moir DT, Tucker MA. Genetic polymorphism of CYP2D6 and lung cancer risk. Cancer Epidemiol Biomarkers Prev 1998; 7(3):215-219.
47. Laforest. L, Wikman H, Benhamou S, Saarikoski ST, Bouchardy C, Hirvonen A, Dayer P, Husgafvel-Pursiainen K. CYP2D6 gene polymorphism in Caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships. Eur J Cancer 2000; 36(14):1825-1832.
48. Aydin-Sayitoglu M, Hatirnaz O, Erensoy N, Ozbek U, et al. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias. Am J Hematol 2006; 81(3):162-170.
49. Gonzalez A, Ramírez V, Cuenca P, Sierra R. Polymorphisms in detoxification genes CYP1A1, CYP2E1, GSTT1 and GSTM1 in gastric cancer susceptibility Rev Biol Trop 2004; 52(3):591-600.
50. Choi JY, Abel J, Neuhaus T, Ko Y, Harth V, Hamajima N, Tajima K, Yoo KY, Park SK, Noh DY, Han W, Choe KJ, Ahn SH, Kim SU, Hirvonen A, Kang D. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. Pharmacogenetics 2003; 13(2): 67-72.
51. Petridou E, Syrigou E, Toupadaki N, Zavitsanos X, Willett W, Trichopoulos D. Determinants of age at menarche as early life predictors of breast cancer risk. Int J Cancer 1996; 68:193-198.
52. Waxman DJ, Attisano C, Guengerich FP, Lapenson DP. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 betahydroxylase cytochrome P-450 enzyme. Arch Biochem Biophys 1988; 263(2):424-436.
53. Kadlubar FF, Berkowitz GS, Delongchamp RR, Wang C, Green BL, Tang G, Lamba J, Schuetz E, Wolff MS, et al. The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiol Biomarkers Prev 2003; 12(4):327-331.
54. Keshava C, McCanlies EC, Weston A, et al. CYP3A4 polymorphisms-potential risk factors for breast and prostate cancer: a HuGE review. Am J Epidemiol 2004; 160(9):825-841.
55. Zeigler-Johnson C, Friebel T, Walker AH, Wang Y, Spangler E, Panossian S, Patacsil M, Aplenc R, Wein AJ, Malkowicz SB, Rebbeck TR. CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. Cancer Res 2004; 64(22):8461-8467.
56. Michael M, Doherty MM. Tumoral drug metabolism: overview and its implications for cancer therapy. J Clin Oncol 2005; 23:205-229.
57. Lamba JK, Lin YS, Schuetz EG, Thummel KE. Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev 2002; 54:1271-1294.
58. Dandara C, Ballo R, Parker MI, et al. CYP3A5 genotypes and risk of oesophageal cancer in two South African populations. Cancer Lett. 2005; 225(2):275-282.
59. Zhenhua L, Tsuchiya N, Narita S, Inoue T, Horikawa Y, Kakinuma H, Kato T, Ogawa O, Habuchi T. CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population. Cancer Letters 2005; 225(2):237-243.
60. McIlwain CC, Townsend DM, Tew KD, et al. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene 2006; 25:1639-1648.
61. Ates NA, Tamer L, Ates C, Ercan B, Elipek T, cal K, Camdeviren H, et al. Glutathione S-transferase M1, T1, P1 genotypes and risk for development of colorectal cancer. Biochem Genet 2005; 43(3-4): 149-163.
62. Martinez C, Martín F, Fernández JM, García- Martín E, Sastre J, Díaz-Rubio M, Agúndez JA, Ladero JM, et al. Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. Pharmacogenomics 2006; 7(5):711-718.
63. Pandey SN, Jain M, Nigam P, Choudhuri G, Mittal B, et al. Genetic polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3 and the susceptibility to gallbladder cancer in North India. Biomarkers 2006; 11(3):250-261.
64. Schneider J, Bernges U, Philipp M, Woitowitz HJ. GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking. Cancer Lett 2004; 208(1):65-74.
65. Seitz HK, Pöschl G, Simanowski UA. Alcohol and cancer. Recent Dev Alcohol 1998; 14:67-95.
66. Stickel F, Schuppan D, Hahn EG, Seitz HK. Cocarcinogenic effects of alcohol in hepatocarcinogenesis. Gut 2002; 51(1):132-139.
67. Obe G, Ristow H. Mutagenic, cancerogenic and teratogenic effects of alcohol. Mutat Res 1979; 65(4):229-259.
68. Dellarco VL, et al. A mutagenicity assessment of acetaldehyde. Mutat Res 1988; 195:1-20.
69. Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Bencko V, Moullan N, Chabrier A, Hung R, Hall J, Canzian F, Brennan P. Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev 2006; 15(4).
70. Minegishi Y, Tsukino H, Muto M, Goto K, Gemma A, Tsugane S, Kudoh S, Nishiwaki Y, Esumi H, et al. Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population. Cancer 2007; 110(2):353-362.
71. Harty LC, Caporaso NE, Hayes RB, Winn DM, Bravo-Otero E, Blot WJ, Kleinman DV, Brown LM, Armenian HK, Fraumeni JF Jr, Shields PG, et al. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 1997; 89:1698-1705.
72. Chen YJ, Chen C, Wu DC, Lee CH, Wu CI, Lee JM, Goan YG, Huang SP, Lin CC, Li TC, Chou YP, Wu MT. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. Int J Cancer 2006; 119(12):2827-2831.
73. Hori H, Kawano T, Endo M, Yuasa Y. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. J Clin Gastroenterol 1997; 25(4):568-575.
74. Stanway SJ, Delavault P, Purohit A, Woo LW, Thurieau C, Potter BV, Reed MJ, et al. Steroid sulfatase: a new target for the endocrine therapy of breast cancer. Oncologist 2007; 12:370-374.
75. Chacko P, Rajan B, Mathew BS, Joseph T, Pillai MR. CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer. Breast Cancer 2004; 11(4):380-388.
76. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Breast Cancer Res 2005; 7(6):R909-921.
77. Rebbeck TR, Troxel AB, Wang Y, Walker AH, Panossian S, Gallagher S, Shatalova EG, Blanchard R, Bunin G, DeMichele A, Rubin SC, Baumgarten M, Berlin M, Schinnar R, Berlin JA, Strom BL, et al. Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk. J Natl Cancer Inst 2006; 98(18):1311-1320.
78. Wang Y Y, Spitz MR, Tsou AM, Zhang K, Makan N, Wu X. Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis. Lung Cancer 2002; 35(2):137-142.
79. Wu MT, Wang YT, Ho CK, Wu DC, Lee YC, Hsu HK, Kao EL, Lee JM. SULT1A1 polymorphism and esophageal cancer in males. Int J Cancer 2003; 103(1):101-104.