Metabolic activation of vinyl chloride by rat liver microsomes: Low- dose kinetics and involvement of cytochrome P450 2E1

Biochemical Pharmacology

Volumn 55, Issue 9, 1998, Pages 1445-1452

  El Ghissassi, Fatiha ^a   Barbin, Alain ^a   Bartsch, Helmut ^b  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

CYP 2E1; Enzyme kinetics; Etheno cAMP; Metabolism; Rat liver microsomes; Vinyl chloride

Indexed keywords

CYCLIC AMP DERIVATIVE; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; VINYL CHLORIDE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; ASSAY; DRUG ACTIVATION; DRUG UPTAKE; EPOXIDATION; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; ANTIBODIES; BIOTRANSFORMATION; CYCLIC AMP; CYTOCHROME P-450 CYP2E1; KINETICS; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; VINYL CHLORIDE;

EID: 0032499405     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00645-X     Document Type: Article

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