Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways

Journal of Cellular Physiology

Volumn 226, Issue 3, 2011, Pages 720-728

  Huang, Tsung Teng ^a   Lin, Hung Chi ^b   Chen, Chang Chieh ^b   Lu, Chia Chen ^c   Wei, Chia Fong ^b   Wu, Ting Shu ^b,d   Liu, Fu Guo ^a   Lai, Hsin Chih ^b  

^a NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 4; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS LIGAND; GLUCOSE REGULATED PROTEIN 78; PROTEIN BAX; PROTEIN BCL 2; RESVERATROL;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRION; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; UPREGULATION;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; NASOPHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STILBENES; TRANSCRIPTION FACTOR CHOP;

EID: 78650630361     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22391     Document Type: Article

References (51)

1. Adams JM, Cory S. 2001. Life or death decisions by the Bcl-2 family. Trends Biochem Sci 26: 61-66.
2. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL. 2007. Resveratrol: A review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224: 274-283.
3. Aziz MH, Kumar R, Ahmad N. 2003. Cancer chemopreventation by resveratrol: In vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol 23: 17-28.
4. Baur JA, Sinclair DA. 2006. Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Discov 5: 493-506.
5. Bishayee A. 2009. Cancer prevention and treatment with resveratrol: From rodent studies to clinical trails. Cancer Prev Res 2: 409-418.
6. Boya P, Cohen I, Zamzami N, Vieira HL, Kroemer G. 2002. Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization. Cell Death Differ 9: 465-467.
7. Breitschopf K, Zeiher AM, Dimmeler S. 2000. Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. J Biol Chem 275: 21648-21652.
8. Clément MV, Hirpara JL, Chawdhury SH, Pervaiz S. 1998. Chemopreventive agent resveratrol, a natural product derived from grapes, triggering CD95 signaling-dependent apoptosis in human tumor cells. Blood 92: 996-1002.
9. Delmas D, Robe C, Lacour S, Filomenko R, Athias A, Gambert P, Cherkaoui-Malki M, Jannin B, Dubrez-Daloz L, Latruffe N, Solary E. 2003. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Biol Chem 278: 41482-41490.
10. Dörrie J, Gerauer H, Wachter Y, Zunino SJ. 2001. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic cells. Cancer Res 61: 4731-4739.
11. Erkal HS, Serin M, Cakmak A. 2001. Nasopharyngeal carcinomas: Analysis of patient, tumor and treatment characteristics determining outcome. Radiother Oncol 61: 247-256.
12. Ferri KF, Kroemer G. 2001. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3: E255-E263.
13. Fisher H, Koenig U, Eckhart L, Tschachler E. 2002. Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun 293: 722-726.
14. Fulda S, Debatin KM. 2004. Apoptosis signaling in tumor therapy. Ann NY Acad Sci 1028: 150-156.
15. Fulda S, Debatin KM. 2006. Resveratrol modulation of signal transduction in apoptosis and cell survival: A mini-review. Cancer Detect Prev 30: 217-223.
16. Green DR, Reed JC. 1998. Mitochondria and apoptosis. Science 281: 1309-1312.
17. Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M. 2004. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis in Abeta-induced cell death. J Cell Biol 165: 347-356.
18. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220.
19. Johnstone RW, Ruefli AA, Lowe SW. 2002. Apoptosis: A link between cancer genetics and chemotherapy. Cell 108: 153-164.
20. Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H. 1995. Metalloprotease-mediated release of human Fas ligand. J Exp Med 182: 1777-1783.
21. Kim SJ, Zhang Z, Hitomi E, Lee YC, Mukherjee AB. 2006. Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurogeneration in INCL. Hum Mol Genet 15: 1826-1835.
22. Konopleva M, Konoplev S, Hu W, Zaritskey AY, Afanasiev BV, Andreeff M. 2002. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia 16: 1713-1724.
23. Lee AS. 2001. The glucose-regulated proteins: Stress induction and clinical applications. Trends Biochem Sci 26: 504-510.
24. Lee AS. 2007. GRP78 induction in cancer: Therapeutic and prognostic implication. Cancer Res 67: 3496-3499.
25. Li J, Lee AS. 2006. Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 6: 45-54.
26. Li H, Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501.
27. Lictera L, Bernier J, Cvitkovic E, Grandi C, Spinazzé S, Bruzzi P, Gatta G, Molinari R. 2003. Cancer of the nasopharynx. Crit Rev Oncol Hematol 45: 199-214.
28. Lo KW, To KF, Huang DP. 2007. Focus on nasopharyngeal carcinoma. Cancer Cell 5: 423-428.
29. Lowe SW, Lin AW. 2000. Apoptosis in cancer. Carcinogenesis 21: 485-495.
30. 2+ and mCICR-mediated MPT activation in HepG2 cells. Mol Cell Biochem 302: 99-109.
31. Madan E, Prasad S, Roy P, George J, Shukla Y. 2008. Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells. Biochem Biophys Res Commun 377: 1232-1237.
32. Martin SJ, Green DR. 1995. Protease activation during apoptosis: Death by a thousand cuts? Cell 82: 349-352.
33. McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. 2001. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259.
34. Nagata S. 1997. Apoptosis by death receptor. Cell 88: 355-365.
35. O'Sullivan B. 2007. Nasopharynx cancer: Therapeutic value of chemoradiotherapy. Int J Radiat Oncol Biol Phys 69: S118-S121.
36. Panaretakis T, Pokrovskaja K, Shoshan MC, Grander D. 2002. Activation of Bak, Bax and BH3-only proteins in the apoptotic response to doxorubicin. J Biol Chem 277: 44317-44326.
37. Park JW, Woo KJ, Lee JT, Lim JH, Lee TJ, Kim SH, Choi YH, Kwon TK. 2007. Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncol Rep 18: 1269-1273.
38. Pervaiz S. 2004. Chemotherapeutic potential of the chemopreventive phytoalexin resveratrol. Drug Resist Updat 7: 333-344.
39. Pettersson F, Dalgleish AG, Bissonnette RP, Colston KW. 2002. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. Br J Cancer 87: 555-561.
40. Rao RV, Ellerby HM, Bredesen DE. 2004. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11: 372-380.
41. Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS. 2003. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: Role of ATP binding site in suppression of caspase-7 activation. J Biol Chem 278: 20915-20924.
42. Roy S, Nicholson DW. 2000. Cross-talk in cell death signaling. J Exp Med 192: 21-26.
43. Schneider P, Holler N, Bodmer JL, Hahne M, Frei K, Fontana A, Tschopp J. 1998. Conversion of membrane-bound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med 187: 1205-1213.
44. Surh YJ. 2003. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3: 768-780.
45. Tao Q, Chan AT. 2007. Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments. Expert Rev Mol Med 9: 1-24.
46. Tombal B, Weeraratna AT, Denmeade SR, Isaaces JT. 2000. Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells. Prostate 43: 303-317.
47. Ulrich S, Wolter F, Stein JM. 2005. Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis. Mol Nutr Food Res 49: 452-461.
48. Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, Ron D. 1996. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 16: 4273-4280.
49. Woo KJ, Lee TJ, Lee SH, Lee JM, Seo JH, Jeong YJ, Park JW, Kwon TK. 2007. Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. Biochem Pharmacol 73: 68-76.
50. Zhang Z, Lee YC, Kim SJ, Choi MS, Tsai PC, Xu Y, Xiao YJ, Zhang P, Heffer A, Mukherjee AB. 2006. Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL. Hum Mol Genet 15: 337-346.
51. Zhou HB, Yan Y, Sun YN, Zhu JR. 2003. Resveratrol induces apoptosis in human esopharyngeal carcinoma cells. World J Gastroenterol 9: 408-411.