Differential effects of gemfibrozil and fenofibrate on reverse cholesterol transport from macrophages to feces in vivo

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1811, Issue 2, 2011, Pages 104-110

  Rotllan, Noemí ^a,b   Llaverías, Gemma ^a,b   Julve, Josep ^a,b   Jauhiainen, Matti ^c   Calpe Berdiel, Laura ^a   Hernández, Cristina ^b,d   Simó, Rafael ^b,d   Blanco Vaca, Francisco ^a,b,e   Escolà Gil, Joan Carles ^a,b  

^a BIOMEDICAL RESEARCH INSTITUTE SANT PAU IIB SANT PAU   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

apoA I; Atherosclerosis; Cardiovascular disease; Fibrate; HDL; PPAR alpha

Indexed keywords

APOLIPOPROTEIN A1; CHOLESTEROL ESTER; FENOFIBRATE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; PHOSPHOLIPID TRANSFER PROTEIN; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; FECES ANALYSIS; FEMALE; GENE EXPRESSION; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; APOLIPOPROTEIN A-I; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; FECES; FEMALE; FENOFIBRATE; GEMFIBROZIL; HUMANS; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RANDOM ALLOCATION; RNA, MESSENGER;

MUS;

EID: 78650546846     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.11.006     Document Type: Article

References (42)

1. D.J. Rader Molecular regulation of HDL metabolism and function: implications for novel therapies J. Clin. Invest. 116 2006 3090 3100
2. J.C. Escola-Gil, N. Rotllan, J. Julve, and F. Blanco-Vaca In vivo macrophage-specific RCT and antioxidant and antiinflammatory HDL activity measurements: new tools for predicting HDL atheroprotection Atherosclerosis 206 2009 321 327
3. D.J. Rader, E.T. Alexander, G.L. Weibel, J. Billheimer, and G.H. Rothblat The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis J. Lipid Res. 50 2009 S189 194 Suppl
4. J.C. Fruchart, P. Duriez, and B. Staels Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis Curr. Opin. Lipidol. 10 1999 245 257
5. B. Staels, M. Maes, and A. Zambon Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease Nat. Clin. Pract. Cardiovasc. Med. 5 2008 542 553
6. C. Fievet, and B. Staels Combination therapy of statins and fibrates in the management of cardiovascular risk Curr. Opin. Lipidol. 20 2009 505 511
7. S.M. Grundy, B. Hansen, S.C. Smith Jr., J.I. Cleeman, and R.A. Kahn Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management Circulation 109 2004 551 556
8. L. Berthou, N. Duverger, F. Emmanuel, S. Langouet, J. Auwerx, A. Guillouzo, J.C. Fruchart, E. Rubin, P. Denefle, B. Staels, and D. Branellec Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice J. Clin. Invest. 97 1996 2408 2416
9. H. Duez, B. Lefebvre, P. Poulain, I.P. Torra, F. Percevault, G. Luc, J.M. Peters, F.J. Gonzalez, R. Gineste, S. Helleboid, V. Dzavik, J.C. Fruchart, C. Fievet, P. Lefebvre, and B. Staels Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation Arterioscler. Thromb. Vasc. Biol. 25 2005 585 591
10. G.F. Watts, P.H. Barrett, and D.C. Chan HDL metabolism in context: looking on the bright side Curr. Opin. Lipidol. 19 2008 395 404
11. M. Bouly, D. Masson, B. Gross, X.C. Jiang, C. Fievet, G. Castro, A.R. Tall, J.C. Fruchart, B. Staels, L. Lagrost, and G. Luc Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate J. Biol. Chem. 276 2001 25841 25847
12. J. Lie, I.M. Lankhuizen, B. Gross, T. van Gent, R. van Haperen, L. Scheek, B. Staels, R. de Crom, and A. van Tol Fenofibrate reverses the decline in HDL cholesterol in mice overexpressing human phospholipid transfer protein Biochim. Biophys. Acta 1738 2005 48 53
13. A.Y. Tu, and J.J. Albers DNA sequences responsible for reduced promoter activity of human phospholipid transfer protein by fibrate Biochem. Biophys. Res. Commun. 264 1999 802 807
14. J. Kahri, T. Sane, A. van Tol, and M.R. Taskinen Effect of gemfibrozil on the regulation of HDL subfractions in hypertriglyceridaemic patients J. Intern. Med. 238 1995 429 436
15. I.J. Jonkers, A.H. Smelt, H. Hattori, L.M. Scheek, T. van Gent, F.H. de Man, A. van der Laarse, and A. van Tol Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG: effects of bezafibrate therapy J. Lipid Res. 44 2003 1462 1469
16. G.F. Watts, J. Ji, D.C. Chan, E.M. Ooi, A.G. Johnson, K.A. Rye, and P.H. Barrett Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome Clin. Sci. (Lond) 111 2006 193 199
17. G. Chinetti, S. Lestavel, V. Bocher, A.T. Remaley, B. Neve, I.P. Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger, H.B. Brewer, J.C. Fruchart, V. Clavey, and B. Staels PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway Nat. Med. 7 2001 53 58
18. A.C. Li, C.J. Binder, A. Gutierrez, K.K. Brown, C.R. Plotkin, J.W. Pattison, A.F. Valledor, R.A. Davis, T.M. Willson, J.L. Witztum, W. Palinski, and C.K. Glass Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma J. Clin. Invest. 114 2004 1564 1576
19. R. Arakawa, N. Tamehiro, T. Nishimaki-Mogami, K. Ueda, and S. Yokoyama Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner Arterioscler. Thromb. Vasc. Biol. 25 2005 1193 1197
20. N. Rotllan, V. Ribas, L. Calpe-Berdiel, J.M. Martin-Campos, F. Blanco-Vaca, and J.C. Escola-Gil Overexpression of human apolipoprotein A-II in transgenic mice does not impair macrophage-specific reverse cholesterol transport in vivo Arterioscler. Thromb. Vasc. Biol. 25 2005 e128 132
21. L. Calpe-Berdiel, N. Rotllan, C. Fievet, R. Roig, F. Blanco-Vaca, and J.C. Escola-Gil Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8 J. Lipid Res. 49 2008 1904 1911
22. J. Julve, J.C. Escola-Gil, N. Rotllan, C. Fievet, E. Vallez, C. de la Torre, V. Ribas, J.H. Sloan, and F. Blanco-Vaca Human apolipoprotein A-II determines plasma triglycerides by regulating lipoprotein lipase activity and high-density lipoprotein proteome Arterioscler. Thromb. Vasc. Biol. 30 2010 232 238
23. R. van Haperen, A. van Tol, P. Vermeulen, M. Jauhiainen, T. van Gent, P. van den Berg, S. Ehnholm, F. Grosveld, A. van der Kamp, and R. de Crom Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice Arterioscler. Thromb. Vasc. Biol. 20 2000 1082 1088
24. A. Marzal-Casacuberta, F. Blanco-Vaca, B.Y. Ishida, J. Julve-Gil, J. Shen, S. Calvet-Marquez, F. Gonzalez-Sastre, and L. Chan Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II J. Biol. Chem. 271 1996 6720 6728
25. M. Jauhiainen, J. Metso, R. Pahlman, S. Blomqvist, A. van Tol, and C. Ehnholm Human plasma phospholipid transfer protein causes high density lipoprotein conversion J. Biol. Chem. 268 1993 4032 4036
26. J. Julve-Gil, E. Ruiz-Perez, R.P. Casaroli-Marano, A. Marzal-Casacuberta, J.C. Escola-Gil, F. Gonzalez-Sastre, and F. Blanco-Vaca Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin: cholesterol acyltransferase deficiency Metabolism 48 1999 415 421
27. J. Julve, J.C. Escola-Gil, V. Ribas, F. Gonzalez-Sastre, J. Ordonez-Llanos, J.L. Sanchez-Quesada, and F. Blanco-Vaca Mechanisms of HDL deficiency in mice overexpressing human apoA-II J. Lipid Res. 43 2002 1734 1742
28. H. Samyn, M. Moerland, T. van Gent, R. van Haperen, F. Grosveld, A. van Tol, and R. de Crom Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice Atherosclerosis 204 2009 429 434
29. X. Jiang, O.L. Francone, C. Bruce, R. Milne, J. Mar, A. Walsh, J.L. Breslow, and A.R. Tall Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes J. Clin. Invest. 98 1996 2373 2380
30. R. Vikstedt, J. Metso, J. Hakala, V.M. Olkkonen, C. Ehnholm, and M. Jauhiainen Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles Biochemistry 46 2007 11979 11986
31. Y. Zhang, J.R. Da Silva, M. Reilly, J.T. Billheimer, G.H. Rothblat, and D.J. Rader Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo J. Clin. Invest. 115 2005 2870 2874
32. E. Sehayek, and S.L. Hazen Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages Arterioscler. Thromb. Vasc. Biol. 28 2008 1296 1297
33. M.A. Valasek, S.L. Clarke, and J.J. Repa Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse J. Lipid Res. 48 2007 2725 2735
34. N. Vu-Dac, S. Chopin-Delannoy, P. Gervois, E. Bonnelye, G. Martin, J.C. Fruchart, V. Laudet, and B. Staels The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates J. Biol. Chem. 273 1998 25713 25720
35. S. Braschi, N. Couture, A. Gambarotta, B.R. Gauthier, C.R. Coffill, D.L. Sparks, N. Maeda, and J.R. Schultz Hepatic lipase affects both HDL and ApoB-containing lipoprotein levels in the mouse Biochim. Biophys. Acta 1392 1998 276 290
36. T.J. Nieland, J.T. Shaw, F.A. Jaipuri, Z. Maliga, J.L. Duffner, A.N. Koehler, and M. Krieger Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI J. Lipid Res. 48 2007 1832 1845
37. M.A. Hossain, M. Tsujita, F.J. Gonzalez, and S. Yokoyama Effects of fibrate drugs on expression of ABCA1 and HDL biogenesis in hepatocytes J. Cardiovasc. Pharmacol. 51 2008 258 266
38. M. Bunger, H.M. van den Bosch, J. van der Meijde, S. Kersten, G.J. Hooiveld, and M. Muller Genome-wide analysis of PPARalpha activation in murine small intestine Physiol. Genomics 30 2007 192 204
39. X. Zhou, W. He, Z. Huang, A.M. Gotto Jr., D.P. Hajjar, and J. Han Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism J. Biol. Chem. 283 2008 2129 2138
40. B.J. van Vlijmen, H.B. van't Hof, M.J. Mol, H. van der Boom, A. van der Zee, R.R. Frants, M.H. Hofker, and L.M. Havekes Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice J. Clin. Invest. 97 1996 1184 1192
41. N. Guillen, S. Acin, M.A. Navarro, J.S. Perona, J.M. Arbones-Mainar, C. Arnal, A.J. Sarria, J.C. Surra, R. Carnicer, I. Orman, J.C. Segovia, V. Ruiz-Gutierrez, and J. Osada Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE-knockout male mice Atherosclerosis 197 2008 72 83
42. B. Staels, A. van Tol, T. Andreu, and J. Auwerx Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat Arterioscler. Thromb. 12 1992 286 294