Modulation of very low density lipoprotein production and clearance contributes to age- and gender-dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice

Journal of Clinical Investigation

Volumn 97, Issue 5, 1996, Pages 1184-1192

  Van Vlijmen, Bart J M ^a   Van 'T Hof, H Belinda ^a   Mol, Marc J T M ^b   Van Der Boom, Hans ^a   Van Der Zee, André ^c   Frants, Rune R ^c   Hofker, Marten H ^c   Havekes, Louis M ^a  

^a TNO   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

age; familial dysbetalipoproteinemia; gender; sex hormones; transgenic mice

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; CHYLOMICRON; ESTROGEN; LOW DENSITY LIPOPROTEIN; SEX HORMONE; TESTOSTERONE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENDER; GENE EXPRESSION; HYPERLIPOPROTEINEMIA TYPE 3; LIPID DIET; LIPOPROTEIN METABOLISM; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 13344269692     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118532     Document Type: Article

References (41)

1. Mahley, R.W., and S.C. Rall. 1989. Type III hyperlipoproteinemia (dysbetalipoproteinemia). the role of apolipoprotein E in normal and abnormal metabolism In The Metabolic Basis of Inherited Disease. C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, editors. McGraw Hill Inc. New York. 1195-1213.
2. Mahley, R.W., T.L. Innerarity, S.C. Rall, Jr., K.H. Weisgraber, and J.M. Taylor. 1990. Apolipoprotein E: genetic variants provide insight into its structure and function. Curr. Opin. Lipid 1 87-95.
3. Havel, R.J., Y.-S. Chao, E. Windler, L. Kotite, and L.S.S. Guo. 1980 Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia. Proc. Natl. Acad. Sci. USA. 77:4349-4353.
4. Sherill, B.C., T.L. Innerarity, and R.W. Mahley. 1980. Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. J. Biol Chem. 255:1804-1807.
5. Mahley, R.W. 1988 Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science (Wash. DC). 240:622-630.
6. de Knijff, P , A.M.J.M. van den Maagdenberg, A.F.H. Stalenhoef, J.A. Gevers Leuven, P.N.M. Demacker, L.P. Kuyt, R.R. Frants, and L.M. Havekes. 1991. Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree. J. Clin. Invest. 88.643-655.
7. Nishina, P.M., J Verstuyft, and B. Paigen. 1990. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J. Lipid Res. 31:859-869.
8. van den Maagdenberg, A.M.J.M , M.H. Hofker, P.J.A. Krimpenfort, I H. de Bruijn, B.J.M. van Vhijmen, H. van der Boom, L.M. Havekes, and R.R. Frants. 1993. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia. J. Biol Chem 268:10540-10545.
9. van Vlijmen, B.J.M, A.M.J.M. van den Maagdenberg, M.J. Gijbels, H. van der Boom, H. HogenEsch, R.R. Frants, M.H. Hofker, and L.M. Havekes. 1994. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J. Clin. Invest 93:1403-1410.
10. Zannis, V.I., J. McPherson, G. Goldberger, S.K. Krathanasis, and J.L. Breslow. 1984. Synthesis, intracellular processing, and signal peptide of human apolipoprotein E J. Biol Chem. 259:5495-5499.
11. Hoffer, M.J.V., M.M. van Eck, F. Pretrij, A. van der Zee, E. de Wit, D. Meijer, G. Grosveld, L.M. Havekes, M.H. Hofker, and R.R. Frants. 1993. The mouse low density receptor gene: cDNA sequence and exon-intron structure. Biochem. Biophys Res. Commun. 191:880-886.
12. Otway, S., and D.S. Robinson. 1967. The use of a non-ionic detergent (Triton WR1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions J Biol. Chem. 244:4406-4412.
13. Bernstein, S.E. 1975. Physiological characteristics. In Biology of the Laboratory Mouse. 2nd ed. E.L. Green, editor Dover Publications, Inc., New York. 337-350
14. Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall. 1951 Protein measurement with the Folin phenol reagent. J. Biol. Chem. 249:5133-5162.
15. Bilheimer, D.W , S. Eisenberg, and R.I. Levy. 1972 The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations. Biochim. Biophys. Acta. 260:212-221.
16. Kita, T., M.S. Brown, D.W. Bilheimer, and J.L. Goldstein 1982. The metabolism of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits. Proc. Natl. Acad. Sci. USA. 79:5693-5697.
17. Holmquist, L., K. Carlson, and L.A. Carlson. 1978. Comparison between the use of isopropanol and tetramethylurea for the solubilization and quantitation of human serum very low density apolipoproteins. Anal. Biochem. 88:457-460.
18. Kovanen, P.T., M.S. Brown, and J.L Goldstein. 1979. Increased binding of low density lipoprotein to liver membranes from rats treated with 17α-ethinyl estradiol J. Biol. Chem. 254.11367-11373.
19. Chao, Y.-S., E.E. Windler, G C. Chen, and R.J. Havel. 1979. Hepatic catabolism of rat and human lipoproteins in rats treated with 17α-ethinyl estradiol. J. Biol. Chem. 254.11360-11366
20. Windler, E.E.T., P.T. Kovanen, Y.-S. Chao, M.S. Brown, R.J. Havel, and J.L. Goldstein. 1980. The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that mediates the uptake of rat lipoproteins containing apolipoproteins B and E. J. Biol. Chem. 255:10464-10471.
21. Angelin, B., H Olivecrona, E. Reihner, M. Rudling, D. Stahlberg, M. Eriksson, S. Ewerth, P. Hendrikson, and K Einarsson. 1992 Hepatic cholesterol metabolism in estrogen-treated men. Gastroenterology. 103:1657-1663.
22. Elam, M B., C P, Simkevich, S.S. Solomon, H G. Wilcox, and M. Heimberg. 1988. Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo. Endocrinology. 122:1397-1402.
23. Elam, M B., H.G. Wilcox, S.S. Solomon, and M. Heimberg. 1992. In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver. Endocrinology. 131:2717-2722.
24. Knijff, P., A.M.J.M van den Maagdenberg, D.I. Boomsma, A.F.H. Stalenhoef, A.H M. Smelt, J.J.P. Kastelein, A.D. Marais, R.R. Frants, and L.M. Havekes. 1994. Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2(Lys146→Gln) allele carriers. J Clin. Invest. 94:1252-1262.
25. Walsh, B.W , I. Schiff, B. Rosner, L. Greenberg, V. Ravnikar, and F M. Sacks. 1991. Effects of postmenopausal estrogen replacement on concentrations and metabolism of plasma lipoproteins. N. Engl. J. Med. 325:1196-1204.
26. Weinstein, I, F.C. Turner, C. Soler-Argilaga, and M Heimberg. 1978. Effects of ethynyl estradiol on serum lipoprotein lipids in male and female rats. Biochim. Biophys. Acta 530:394-401.
27. Stuyt, P.M.J., P.N.M. Demacker, and A. van 't Laar. 1986. A study of the hypolipidemic effect of estrogen in Type III hyperlipoproteinemia. Horm Metab. Res. 18:607-610.
28. Srivastava, R.A.K.. D. Baumann, and G. Schonfeld 1993. In vivo regulation of low density receptors by estrogen differs at the post-transcnptional level in rat and mouse. Eur. J. Biochem. 216:527-538.
29. Himber, J., B. Missano, and H. Kuhl. 1994. Lack of effect on the low density lipoprotein receptor in hamsters treated with 17α-ethinyl estradiol. Biochim. Biophys. Acta. 1211:359-363.
30. Tang, J., R.A.K. Srivastava, E.S. Krul, D. Baumann, B.A. Pfleger, R.T. Kitchens, and G. Schonfeld. 1991 In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs by different mechanisms in inbred strains of mice. J. Lipid Res 32.1571-1585.
31. Dueland, S., J. Drisko, L. Graf, D. Machleder, A.J. Lusis, and R.A Davis. 1993 Effect of dietary cholesterol on 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice. J Lipid Res. 34:923-931.
32. Rudling, M. 1992. Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo. J. Lipid Res. 33:493-501.
33. Fazio, S., Y.L. Lee, Z S. Ji, and S.C. Rall, Jr. 1993. Type III Hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E. J Clin Invest. 92:1497-1503.
34. Fazio, S., D.A. Sanan, Y.-L Lee, Z.-S. Ji, R.W. Mahley, and S C Rall, Jr. 1994. Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142). Arterioscler. Thromb. 14:1873-1879.
35. van Ree, J.H., J.A A. van den Broek, V.E.H. Dahlmans, P.H.E Groot, M. Vidgeon-Hart, R.R. Frants, B. Wierenga, L M. Havekes, and M.H. Hofker. 1994. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 111:25-37.
36. Zhang, S.H , R.L Reddick, J A. Piedrahita, and N. Maeda. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (Wash. DC). 258:468-471
37. Plump, A S., J.D. Smith, T. Hayek, K. Aalto Setalä, A. Walsh, J.G. Verstuyft, E.M. Rubin, and J.L. Breslow. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71.343-353.
38. Reddick, R.L., S.H. Zhang, and N. Maeda. 1993. Atherosclerosis in mice lacking apo E Evaluation of lesional development and progression. Arterioscler. Thromb. 14:141-147.
39. Nakashima, Y., A.S. Plump, E.W. Raines, J.L. Breslow, and R. Ross. 1994. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14.133-140.
40. Grundy, S.M , and M.A. Denke 1990. Dietary influences on serum lipids and lipoproteins. J. Lipid Res. 31:1149-1172.
41. Witztum, J.L , and G. Schonfeld 1978 Carbohydrate diet induced changes in very low density lipoprotein composition and structure. Diabetes. 27: 1215-1229.