Free cholesterol deposition in the cornea of human apolipoprotein A-II transgenic mice with functional lecithin: Cholesterol acyltransferase deficiency

Metabolism: Clinical and Experimental

Volumn 48, Issue 4, 1999, Pages 415-421

  Julve Gil, Josep ^b   Ruiz Pérez, Elena ^b   Casaroli Marano, Ricardo P ^b   Marzal Casacuberta, Àfrica ^b   Escolà Gil, Joan Carles ^b   González Sastre, Francesc ^b   Blanco Vaca, Francisco ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ULTRASTRUCTURE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CORNEA OPACITY; ENZYME ACTIVITY; ESTERIFICATION; FIBROBLAST; HYPOLIPOPROTEINEMIA; IMMUNOREACTIVITY; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0032915196     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90097-5     Document Type: Article

References (25)

1. Gaynor PM, Zhang W-Y, Salehizadeh B, et al: Cholesterol accumulation in human cornea: Evidence that extracellular cholesterylester rich lipid particles deposit independently of foam cells. J Lipid Res 37:1849-1861, 1996
2. Glomset JA, Assmann G, Gjone E, et al: Lecithin:cholesterol acyltransferase deficiency and fish eye disease, in Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic and Molecular Basis of Inherited Disease, vol 2. New York, NY, McGraw-Hill, 1995, pp 1933-1951
3. Qu S-J, Fan H-Z, Blanco-Vaca F, et al: In vitro expression of natural mutants of human lecithin:cholesterol acyltransferase. J Lipid Res 36:967-974, 1995
4. Klein H-G, Duverger N, Albers JJ, et al: In vitro expression of structural defects in the lecithin;cholesterol acyltransferase gene. J Biol Chem 270:9443-9447, 1995
5. Marzal-Casacuberta À, Blanco-Vaca F, Ishida BY, et al: Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. J Biol Chem 271:6720-6728, 1996
6. Escolà-Gil JC, Marzal-Casacuberta À, Julve-Gil J, et al: Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: Evidence of a potentially relevant species-specific interaction with diet. J Lipid Res 39:457-462, 1998
7. Ishida BY, Paigen B: Silver-enhanced radial immunodiffusion assay of plasma apolipoproteins. J Lipid Res 33:1073-1078, 1992
8. Hara A, Radin NS: Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 90:420-426, 1978
9. Contreras JA, Castro M, Bocos C, et al: Combination of an enzymatic method and HPLC for the quantitation of cholesterol in cultured cells. J Lipid Res 33:931-936, 1992
10. Gaynor PM, Zhang W-Y, Weiss JS, et al: Accumulation of HDL apolipoproteins accompanies abnormal cholesterol accumulation in Schnyder's dystrophy. Arterioscler Thromb Vasc Biol 16:992-999, 1996
11. Wessel D, Flügge UI: A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138:141-143, 1984
12. Blanco-Vaca F, Via DP, Yang C-Y, et al: Characterization of disulfide-linked heterodimers containing apolipoprotein D in human plasma lipoproteins. J Lipid Res 33:1785-1796, 1992
13. Seligman AM, Wasserkrung HL, Hanker JS: A new staining method (OTO) for enhancing contrast of lipid-containing membranes and droplets in osmium tetroxide-fixed tissue with osmophilic thiocarbohydrazide (TCH). J Cell Biol 30:424-432, 1966
14. de la Liera Moya M, Atger V, Paul JL, et al: A cell culture for screening human serum for ability to promote cellular cholesterol efflux: Relationships between serum components and efflux, esterification and transfer. Arterioscler Thromb 14:1056-1065, 1994
15. Blanco-Vaca F, Qu S-J, Fiol C, et al: Molecular basis of fish-eye disease in a patient from Spain: Characterization of a novel mutation in the LCAT gene and lipid analysis of the cornea. Arterioscler Thromb Vasc Biol 17:1382-1391, 1997
16. Barchiesi BJ, Eckel RH, Ellis PP: The cornea and disorders of lipid metabolism. Surv Ophthalmol 36:1-22, 1991
17. Czarnecka H, Yokoyama S: Regulation of cellular cholesterol efflux by lecithin:cholesterol acyltransferase reaction through nonspecific lipid exchange. J Biol Chem 271:2023-2028, 1996
18. Castro G, Nihoul LP, Dengremont C, et al: Cholesterol efflux, lecithin:cholesterol acyltransferase activity, and pre-β particle formation by serum from human apolipoprotein A-I and apolipoprotein A-I/A-II transgenic mice are consistent with the latter being less effective for reverse cholesterol transport. Biochemistry 36:2243-2249, 1997
19. Davidson WS, Rodrigueza WV, Lund-Katz S, et al: Effects of acceptor particle size on the efflux of cellular free cholesterol. J Biol Chem 270:17106-17113, 1995
20. Fournier N, Paul J-L, Atger V, et al: HDL phospholipid content and composition as the major factor determining cholesterol efflux capacity from Fu5AH cells to human serum. Arterioscler Thromb Vasc Biol 17:2685-2691, 1997
21. Jian B, de la Llera-Moya M, Royer L, et al: Modification of the cholesterol efflux properties of human serum by enrichment with phospholipid. J Lipid Res 38:734-744, 1997
22. Marzal-Casacuberta À: Ratolins transgènics per l'apolipoproteïna A-II humana: obtenció i caracterització, perfil lipoproteic i susceptibilitat a l'arteriosclerosi. Doctoral thesis, Universitat Autònoma de Barcelona, Barcelona, Spain, 1995
23. Parks JS, Li H, Gebre AK, et al: Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma. J Lipid Res 36:349-355, 1995
24. Sakai N, Vaisman BL, Koch CA, et al: Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. J Biol Chem 272:7506-7510, 1997
25. Ng DS, Francone OL, Forte TM, et al: Disruption of the murine lecithin;cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I. J Biol Chem 272:15777-15781, 1997