Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 137-141

  Al Said, Mansour S ^a   Bashandy, Mahmoud S ^b   Al Qasoumi, Saleh I ^a   Ghorab, Mostafa M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Al Azhar University   (Egypt)

Author keywords

1,2 Dihydropyridines; Anticancer activity; Sulfones; Thiazole; Thiophenes

Indexed keywords

1,2 DIHYDROPYRIDINE; 2 AMINO 4 (4 CHLOROPHENYL) 5 CYANO 6 OXO 1 {1 [4 (PIPERIDINE 1 SULF ONYL)PHENYL]ETHYLIDENEAMINO} 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 5 CYANO 4 (4 DIMETHYLAMINOPHENYL) 6 OXO 1 {1 [4 (PIPERIDINE 1 SULFONYL)PHENYL]ETHYLIDENEAMINO} 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 5 CYANO 4 (4 HYDROXY 3 METHOXYPHENYL) 6 OXO 1 {1 [4 (PIPERIDINE 1 SULFONYL)PHENYL]ETHYLIDENEAMINO} 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 5 CYANO 4 (4 HYDROXYPHENYL) 6 OXO 1 {1 [4 (PIPERIDINE 1 SULF ONYL)PHENYL]ETHYLIDENEAMINO} 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 5 CYANO 4 (4 METHOXYPHENYL) 6 OXO 1 {1 [4 (PIPERIDINE 1 SULF ONYL)PHENYL]ETHYLIDENEAMINO} 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 5 CYANO 6 [OXO 1 {1 [4 (PIPERIDINE 1 SULFONYL)PHENYL]ETHYLIDENE AMINO} 4 P TOLYL 1,6 DIHYDROPYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 2 CYANO N' (1 (4 (PIPERIDIN 1 YLSULFONYL) PHENYL) ETHYLIDENE)ACETOHYDR AZIDE; 3 AMINO N' [1 (4 (PIPERIDIN 1 YLSULFONYL)PHENYL)ETHYLIDENE] 5,6 DIHY DRO 4H CYCLOPENTA[B]THIOPHENE 2 CARBOHYDRAZIDE; 3,5 DIAMINO 4 CYANO N`(1 (4 (PIPERIDIN 1 YLSULFONYL)PHENYL)ETHYLIDENE] THIOPHENE 2 CARBOHYDRAZIDE; 4,6 DIAMINO 2 OXO 1 [1 (1 (4 (PIPERIDIN 1 YLSULFONYL)PHENYL)ETHYLIDENE AMINO] 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 6 AMINO 2 OXO 1 (1 (4 (PIPERIDIN 1 YLSULFONLY) PHENYLETHYLIDENE AMINO) 4 SUBSTITUTED 1,2 DIHYDROPYRIDINE; AND 4 AMINO 6 HYDROXY 2 OXO 1 [1 (4 (PIPERIDIN 1 YLSULFONYL)PHENYL)ETHYLIDENEAMINO) 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; ANTINEOPLASTIC AGENT; ETHYL 2,4 DIAMINO 5 [2 (1 (4 PIPERIDIN 1 YLSULFONYL)PHENYL)ETHYLIDENE)HYDRAZINECARBONYL]THIOPHENE 3 CARBOXYLATE; THIAZOLE DERIVATIVE; THIOPHENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DIHYDROPYRIDINES; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES;

EID: 78650512770     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.10.024     Document Type: Article

References (27)

1. G. Malicorne, J. Bompart, L. Giral, and E. Despaux Eur. J. Med. Chem. 26 1991 3 11
2. S.L. Hargreaves, B.L. Pilkington, S.E. Russell, and P.A. Worthington Tetrahedron Lett. 41 10 2000 1653 1656
3. E. Szoko, T. Tabi, and J. Pharm Biomed. Anal. 53 5 2010 1180 1192
4. H. Zhao, L. Shi, J.Q. Cao, W. Li, X. Wen, and Y.Q. Zhao Chin. Chem. Lett. 21 10 2010 1216 1218
5. B.K. Banik, and F.F. Becker Eur. J. Med. Chem. 45 2010 4687 4691
6. M.T. Rodrigues, J.C. Gomes, J. Smith, and F. Coelho Tetrahedron Lett. 51 38 2010 4988 4990
7. S. Bondock, W. Fadaly, and M.A. Metwally Eur. J. Med. Chem. 45 2010 3692 3701
8. F. Bellina, S. Cauteruccio, and R. Rossi Tetrahedron 63 22 2007 4571 4624
9. L.S. Konstantinova, O.I. Bol'shakov, N.V. Obruchnikova, H. Laborie, A. Tanga, V. Sopéna, I. Lanneluc, L. Picot, S. Sable, V. Thiery, and O.A. Rakitin Bioorg. Med. Chem. Lett. 19 1 2009 136 141
10. F. Bellina, and R. Rossi Tetrahedron 62 31 2006 7213 7256
11. A.L. Gottumukkala, F. Derridj, S. Djebbar, and H. Doucet Tetrahedron Lett. 49 18 2008 2926 2930
12. A.K. Gadad, M.B. Palkar, K. Anand, M.N. Noolvi, T.S. Boreddy, and J. Wagwade Bioorg. Med. Chem. 16 1 2008 276 283
13. M.S. Al-Said, M.M. Ghorab, S.I. Al-qasoumi, E.M. El-Hossary, and E. Noaman Eur. J. Med. Chem. 45 2010 3011 3018
14. M.M. Ghorab, Z.H. Ismail, and M. Abdalla Arzneimittelforschung 60 2 2010 87 95
15. S.I. Al-qasoumi, A.M. Al-Taweel, A.M. Alafeefy, E. Noaman, and M.M. Ghorab Eur. J. Med. Chem. 45 2010 738 744
16. S.I. Al-qasoumi, A.M. Al-Taweel, A.M. Alafeefy, M.M. Ghorab, and E. Noaman Eur. J. Med. Chem. 45 2010 1849 1853
17. M.M. Ghorab, F.A. Ragab, S.I. Al-qasoumi, A.M. Alafeefy, and S.A. Aboulmagd Eur. J. Med. Chem. 45 2010 171 178
18. S.I. Al-qasoumi, A.M. Al-Taweel, A.M. Alafeefy, M.M. Hamid, E. Noaman, and M.M. Ghorab Bioorg. Med. Chem. Lett. 19 2009 6939 6942
19. M.A. Shaaban, M.M. Ghorab, H.I. Heiba, M.M. Kamel, N.H. Zaher, and M.I. Mostafa Arch. Pharm. Chem. Life Sci. 343 2010 404 410
20. M.M. Ghorab, F.A. Ragab, H.I. Heiba, R.K. Arafa, and E.M. El-Hossary Eur. J. Med. Chem. 45 9 2010 3677 3684
21. S.M. Hassan, A.A. El-Maghraby, M.M. Abdel Aal, and M.S. Bashandy Phosphorus, Sulfur, Silicon Relat. Elem. 184 2009 291 308
22. S.M. Hassan, M.M. Abdel Aal, A.A. El-Maghraby, and M.S. Bashandy Phosphorus, Sulfur, Silicon Relat. Elem. 184 2009 427 452
23. H.S. El-Kashef, B.E. Bayoumy, and T.I. Aly J. Pharm. Sci. 27 27 1986
24. B.P. Mckibben, C.H. Cartwright, and L. Castelhano Tetrahedron Lett. 40 1999 5471 5474
25. R.M. Scrowston Recent advances in the chemistry of benzo[b]thiophene Adv. Heterocyclic Chem. 29 1981 171 249
26. J.V. Tormos, Y.U. Khodorkovsky, O.Y. Neilands, and S.V. Belyakov Tetrahedron 48 1992 6863 6874
27. P. Skehan, R. Storegng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1107 1112