Analysis of biological samples by capillary electrophoresis with laser induced fluorescence detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 5, 2010, Pages 1180-1192

  Szöko, Éva ^a   Tábi, Tamás ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Capillary electrophoresis; Fluorescent derivatization; Immunoassay; Laser induced fluorescence detection

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE;

ANTIBODY AFFINITY; ARGON LASER; ARTICLE; CAPILLARY ELECTROPHORESIS; DIODE LASER; DNA BINDING; ELECTROPHORESIS; ENZYME ASSAY; GEL ELECTROPHORESIS; GEL MOBILITY SHIFT ASSAY; HELIUM CADMIUM LASER; IMMUNOASSAY; INFRARED RADIATION; NEAR INFRARED SPECTROSCOPY; PHOSPHORYLATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ANIMALS; BIOLOGICAL PRODUCTS; CHEMISTRY TECHNIQUES, ANALYTICAL; ELECTROPHORESIS, CAPILLARY; HUMANS; LASERS; SPECTROMETRY, FLUORESCENCE;

EID: 77955926669     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.07.045     Document Type: Article

References (200)

1. Johnson M.E., Landers J.P. Fundamentals and practice for ultrasensitive laser-induced fluorescence detection in microanalytical systems. Electrophoresis 2004, 25:3513-3527.
2. Lacroix M., Poinsot V., Fournier C., Couderc F. Laser-induced fluorescence detection schemes for the analysis of proteins and peptides using capillary electrophoresis. Electrophoresis 2005, 26:2608-2621.
3. Chiu T.C., Lin Y.W., Huang Y.F., Chang H.T. Analysis of biologically active amines by CE. Electrophoresis 2006, 27:4792-4807.
4. Garcia-Campana A.M., Taverna M., Fabre H. LIF detection of peptides and proteins in CE. Electrophoresis 2007, 28:208-232.
5. Poinsot V., Gavard P., Feurer B., Couderc F. Recent advances in amino acid analysis by CE. Electrophoresis 2010, 31:105-121.
6. Hsieh M.M., Hsu C.E., Tseng W.L., Chang H.T. Amplification of small analytes in polymer solution by capillary electrophoresis. Electrophoresis 2002, 23:1633-1641.
7. Chang H.T., Yeung E.S. Determination of catecholamines in single adrenal medullary cells by capillary electrophoresis and laser-induced native fluorescence. Anal. Chem. 1995, 67:1079-1083.
8. Hsieh M.M., Chang H.T. Discontinuous electrolyte systems for improved detection of biologically active amines and acids by capillary electrophoresis with laser-induced native fluorescence detection. Electrophoresis 2005, 26:187-195.
9. Li M.D., Tseng W.L., Cheng T.L. Ultrasensitive detection of indoleamines by combination of nanoparticle-based extraction with capillary electrophoresis/laser-induced native fluorescence. J. Chromatogr. A 2009, 1216:6451-6458.
10. Schappler J., Staub A., Veuthey J.L., Rudaz S. Highly sensitive detection of pharmaceutical compounds in biological fluids using capillary electrophoresis coupled with laser-induced native fluorescence. J. Chromatogr. A 2008, 1204:183-190.
11. Caslavska J., Thormann W. Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp-based and laser-induced fluorescence detection. Electrophoresis 2004, 25:1623-1631.
12. Gibbons S.E., Stayton I., Ma Y. Optimization of urinary pteridine analysis conditions by CE-LIF for clinical use in early cancer detection. Electrophoresis 2009, 30:3591-3597.
13. Moller J.G., Stass H., Heinig R., Blaschke G. Capillary electrophoresis with laser-induced fluorescence: a routine method to determine moxifloxacin in human body fluids in very small sample volumes. J. Chromatogr. B Biomed. Sci. Appl. 1998, 716:325-334.
14. Cheng C.L., Fu C.H., Chou C.H. Determination of norfloxacin in rat liver perfusate using capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 856:381-385.
15. Horstkotter C., Kober S., Spahn-Langguth H., Mutschler E., Blaschke G. Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 769:107-117.
16. Chankvetadze B., Burjanadze N., Blaschke G. Enantioseparation of the anticoagulant drug phenprocoumon in capillary electrophoresis with UV and laser-induced fluorescence detection and application of the method to urine samples. Electrophoresis 2001, 22:3281-3285.
17. Soetebeer U.B., Schierenberg M.O., Schulz H., Grunefeld G., Andresen P., Blaschke G. Assay of tramadol in urine by capillary electrophoresis using laser-induced native fluorescence detection. J. Chromatogr. B Biomed. Sci. Appl. 2000, 745:271-278.
18. Behn F., Michels S., Laer S., Blaschke G. Separation of carvedilol enantiomers in very small volumes of human plasma by capillary electrophoresis with laser-induced fluorescence. J. Chromatogr. B Biomed. Sci. Appl. 2001, 755:111-117.
19. Horstkotter C., Schepmann D., Blaschke G. Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser-induced fluorescence detection and liquid chromatography-mass spectrometry. J. Chromatogr. A 2003, 1014:71-81.
20. Hempel G., Blaschke G. Enantioselective determination of zopiclone and its metabolites in urine by capillary electrophoresis. J. Chromatogr. B Biomed. Appl. 1996, 675:139-146.
21. Zaugg S., Zhang X., Sweedler J., Thormann W. Determination of salicylate, gentisic acid and salicyluric acid in human urine by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B Biomed. Sci. Appl. 2001, 752:17-31.
22. Hustad S., Ueland P.M., Schneede J. Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma by capillary electrophoresis and laser-induced fluorescence detection. Clin. Chem. 1999, 45:862-868.
23. Perez-Ruiz T., Martinez-Lozano C., Sanz A., Bravo E. Determination of riboflavin, flavin mononucletide and flavin adenine dinucleotide in biological tissues by capillary zone electrophoresis and laser-induced fluorescence detection. Electrophoresis 2001, 22:1170-1174.
24. Britz-McKibbin P., Otsuka K., Terabe S. On-line focusing of flavin derivatives using Dynamic pH junction-sweeping capillary electrophoresis with laser-induced fluorescence detection. Anal. Chem. 2002, 74:3736-3743.
25. Britz-McKibbin P., Markuszewski M.J., Iyanagi T., Matsuda K., Nishioka T., Terabe S. Picomolar analysis of flavins in biological samples by dynamic pH junction-sweeping capillary electrophoresis with laser-induced fluorescence detection. Anal. Biochem. 2003, 313:89-96.
26. Perez-Ruiz T., Martinez-Lozano C., Sanz A., Bravo E. Simultaneous determination of doxorubicin, daunorubicin, and idarubicin by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2001, 22:134-138.
27. Kim H.S., Wainer I.W. Simultaneous analysis of liposomal doxorubicin and doxorubicin using capillary electrophoresis and laser induced fluorescence. J. Pharm. Biomed. Anal. 2010, 52:372-376.
28. Yang X., Wang X., Zhang X. Indirect laser-induced fluorescence detection of diuretics separated by capillary electrophoresis. J. Sep. Sci. 2006, 29:677-683.
29. Wang W., Tang J., Wang S., Zhou L., Hu Z. Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. J. Chromatogr. A 2007, 1148:108-114.
30. Colyer C. Noncovalent labeling of proteins in capillary electrophoresis with laser-induced fluorescence detection. Cell. Biochem. Biophys. 2000, 33:323-337.
31. Liu M.S., Zang J., Evangelista R.A., Rampal S., Chen F.T., Double-stranded DNA analysis by capillary electrophoresis with laser-induced fluorescence using ethidium bromide as an intercalator. Biotechniques 1995, 18. pp. 316-317, 320, 313-322.
32. Zabzdyr J.L., Lillard S.J. UV- and visible-excited fluorescence of nucleic acids separated by capillary electrophoresis. J. Chromatogr. A 2001, 911:269-276.
33. Garcia-Canas V., Gonzalez R., Cifuentes A. Ultrasensitive detection of genetically modified maize DNA by capillary gel electrophoresis with laser-induced fluorescence using different fluorescent intercalating dyes. J. Agric. Food Chem. 2002, 50:4497-4502.
34. Sang F., Ren J. Capillary electrophoresis of double-stranded DNA fragments using a new fluorescence intercalating dye EvaGreen. J. Sep. Sci. 2006, 29:1275-1280.
35. Amundsen L.K., Siren H. Immunoaffinity CE in clinical analysis of body fluids and tissues. Electrophoresis 2007, 28:99-113.
36. Yang W.C., Yeung E.S., Schmerr M.J. Detection of prion protein using a capillary electrophoresis-based competitive immunoassay with laser-induced fluorescence detection and cyclodextrin-aided separation. Electrophoresis 2005, 26:1751-1759.
37. Ban E., Nam H.S., Yoo Y.S. Competitive immunoassay for recombinant hirudin using capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A 2001, 924:337-344.
38. Han K.Y., Ban E., Yoo Y.S. Analysis of vasopressin using capillary electrophoresis with laser-induced fluorescence detector based on competitive immunoassay. J. Chromatogr. A 2003, 1013:215-220.
39. Babu C.V.S., Chung B.C., Lho D.S., Yoo Y.S. Capillary electrophoretic competitive immunoassay with laser-induced fluorescence detection for methionine-enkephalin. J. Chromatogr. 2006, 1111:133-138.
40. Schultz N.M., Huang L., Kennedy R.T. Capillary electrophoresis-based immunoassay to determine insulin content and insulin secretion from single islets of Langerhans. Anal. Chem. 1995, 67:924-929.
41. Tao L., Kennedy R.T. On-line competitive immunoassay for insulin based on capillary electrophoresis with laser-induced fluorescence detection. Anal. Chem. 1996, 68:3899-3906.
42. German I., Kennedy R.T. Rapid simultaneous determination of glucagon and insulin by capillary electrophoresis immunoassays. J. Chromatogr. B Biomed. Sci. Appl. 2000, 742:353-362.
43. Dishinger J.F., Kennedy R.T. Serial immunoassays in parallel on a microfluidic chip for monitoring hormone secretion from living cells. Anal. Chem. 2007, 79:947-954.
44. Chen F.T., Evangelista R.A. Feasibility studies for simultaneous immunochemical multianalyte drug assay by capillary electrophoresis with laser-induced fluorescence. Clin. Chem. 1994, 40:1819-1822.
45. Thormann W., Lanz M., Caslavska J., Siegenthaler P., Portmann R. Screening for urinary methadone by capillary electrophoretic immunoassays and confirmation by capillary electrophoresis-mass spectrometry. Electrophoresis 1998, 19:57-65.
46. Caslavska J., Allemann D., Thormann W. Analysis of urinary drugs of abuse by a multianalyte capillary electrophoretic immunoassay. J. Chromatogr. A 1999, 838:197-211.
47. Wey A.B., Caslavska J., Thormann W. Analysis of codeine, dihydrocodeine and their glucuronides in human urine by electrokinetic capillary immunoassays and capillary electrophoresis-ion trap mass spectrometry. J. Chromatogr. A 2000, 895:133-146.
48. Choi J., Kim C., Choi M.J. Immunological analysis of methamphetamine antibody and its use for the detection of methamphetamine by capillary electrophoresis with laser-induced fluorescence. J. Chromatogr. B Biomed. Sci. Appl. 1998, 705:277-282.
49. Zhou J., Xu X., Wang Y. Competitive immunoassay for clenbuterol using capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 848:226-231.
50. Chen H.X., Zhang X.X. Antibody development to testosterone and its application in capillary electrophoresis-based immunoassay. Electrophoresis 2008, 29:3406-3413.
51. Chen F.T., Pentoney S.L. Characterization of digoxigenin-labeled B-phycoerythrin by capillary electrophoresis with laser-induced fluorescence. Application to homogeneous digoxin immunoassay. J. Chromatogr. A 1994, 680:425-430.
52. Steinmann L., Caslavska J., Thormann W. Feasibility study of a drug immunoassay based on micellar electrokinetic capillary chromatography with laser induced fluorescence detection: determination of theophylline in serum. Electrophoresis 1995, 16:1912-1916.
53. Steinmann L., Thormann W. Characterization of competitive binding, fluorescent drug immunoassays based on micellar electrokinetic capillary chromatography. Electrophoresis 1996, 17:1348-1356.
54. Schmalzing D., Nashabeh W., Yao X.W., Mhatre R., Regnier F.E., Afeyan N.B., Fuchs M. Capillary electrophoresis-based immunoassay for cortisol in serum. Anal. Chem. 1995, 67:606-612.
55. Schmalzing D., Koutny L.B., Taylor T.A., Nashabeh W., Fuchs M. Immunoassay for thyroxine (T4) in serum using capillary electrophoresis and micromachined devices. J. Chromatogr. B Biomed. Sci. Appl. 1997, 697:175-180.
56. Su P., Zhang X.X., Chang W.B. Direct immunoassay of estrone by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2003, 24:3197-3201.
57. Su P., Zhang X.-X., Wang Y.-C., Chang W.-B. Direct immunoassay of estriol in pregnancy serum by capillary electrophoresis with laser-induced fluorescence detector. Talanta 2003, 60:969-975.
58. Chen H.X., Huang T., Zhang X.X. Immunoaffinity extraction of testosterone by antibody immobilized monolithic capillary with on-line laser-induced fluorescence detection. Talanta 2009, 78:259-264.
59. LeBlanc A., Shen S., Lew K., Weinfeld M., Le X.C. Detection of benzo(a)pyrene diol epoxide-DNA adducts in mononuclear white blood cells by CE immunoassay and its application to studying the effect of glutathione depletion. Electrophoresis 2009, 30:1558-1563.
60. Ye F., Shi M., Huang Y., Zhao S. Noncompetitive immunoassay for carcinoembryonic antigen in human serum by microchip electrophoresis for cancer diagnosis. Clin. Chim. Acta 2010.
61. Reichmuth D.S., Wang S.K., Barrett L.M., Throckmorton D.J., Einfeld W., Singh A.K. Rapid microchip-based electrophoretic immunoassays for the detection of swine influenza virus. Lab. Chip 2008, 8:1319-1324.
62. Giovannoli C., Anfossi L., Baggiani C., Giraudi G. A novel approach for a non competitive capillary electrophoresis immunoassay with laser-induced fluorescence detection for the determination of human serum albumin. J. Chromatogr. A 2007, 1155:187-192.
63. Xian J., Harrington M.G., Davidson E.H. DNA-protein binding assays from a single sea urchin egg: a high-sensitivity capillary electrophoresis method. Proc. Natl. Acad. Sci. USA 1996, 93:86-90.
64. Foulds G.J., Etzkorn F.A. A capillary electrophoresis mobility shift assay for protein-DNA binding affinities free in solution. Nucleic Acids Res. 1998, 26:4304-4305.
65. Fraga M.F., Ballestar E., Esteller M. Capillary electrophoresis-based method to quantitate DNA-protein interactions. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003, 789:431-435.
66. Rónai Z., Wang Y., Khandurina J., Budworth P., Sasvári-Székely M., Wang X., Guttman A. Transcription factor binding study by capillary zone electrophoretic mobility shift assay. Electrophoresis 2003, 24:96-100.
67. Rónai Z., Guttman A., Keszler G., Sasvári-Székely M. Capillary electrophoresis study on DNA-protein complex formation in the polymorphic 5' upstream region of the dopamine D4 receptor (DRD4) gene. Curr. Med. Chem. 2004, 11:1023-1029.
68. Hu S., Zhang L., Dovichi N.J. Characterization of the interaction between phospholipid and protein by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A 2001, 924:369-375.
69. Starkey D.E., Abdelaziez Y., Ahn C.H., Tu J., Anderson L., Wehmeyer K.R., Izzo N.J., Carr A.N., Peters K.G., Bao J.J., Halsall H.B., Heineman W.R. Determination of endogenous extracellular signal-regulated protein kinase by microchip capillary electrophoresis. Anal. Biochem. 2003, 316:181-191.
70. Tu J., Anderson L.N., Dai J., Peters K., Carr A., Loos P., Buchanan D., Bao J.J., Liu C., Wehmeyer K.R. Application of multiplexed capillary electrophoresis with laser-induced fluorescence (MCE-LIF) detection for the rapid measurement of endogenous extracellular signal-regulated protein kinase (ERK) levels in cell extracts. J. Chromatogr. B 2003, 789:323-335.
71. Enayetul Babar S.M., Song E.J., Yoo Y.S. Analysis of calcineurin activity by capillary electrophoresis with laser-induced fluorescence detection using peptide substrate. J. Sep. Sci. 2008, 31:579-587.
72. Lee K.J., Mwongela S.M., Kottegoda S., Borland L., Nelson A.R., Sims C.E., Allbritton N.L. Determination of sphingosine kinase activity for cellular signaling studies. Anal. Chem. 2008, 80:1620-1627.
73. Cunliffe J.M., Sunahara R.K., Kennedy R.T. Detection of g protein coupled receptor mediated adenylyl cyclase activity by capillary electrophoresis using fluorescently labeled ATP. Anal. Chem. 2007, 79:7534-7539.
74. Stege P.W., Messina G.A., Bianchi G., Olsina R.A. Determination of the beta-glucosidase activity in different soils by pre capillary enzyme assay using capillary electrophoresis with laser-induced fluorescence detection. J. Fluoresc. 2010, 20:517-523.
75. Sano M., Nishino I., Ueno K., Kamimori H. Assay of collagenase activity for native triple-helical collagen using capillary gel electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B 2004, 809:251-256.
76. Chichester K.D., Sebastian M., Ammerman J.W., Colyer C.L. Enzymatic assay of marine bacterial phosphatases by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2008, 29:3810-3816.
77. Arkhipov S.N., Berezovski M., Jitkova J., Krylov S.N. Chemical cytometry for monitoring metabolism of a Ras-mimicking substrate in single cells. Cytometry A 2005, 63:41-47.
78. Shoemaker G.K., Lorieau J., Lau L.H., Gillmor C.S., Palcic M.M. Multiple sampling in single-cell enzyme assays using CE-laser-induced fluorescence to monitor reaction progress. Anal. Chem. 2005, 77:3132-3137.
79. Kaneta T., Maeda H., Miyazaki M., Miyake R., Izaki H., Sakoda Y., Kinoshita S., Imasaka T. Determination of amino acids in urine by cyclodextrin-modified capillary electrophoresis-laser-induced fluorescence detection. J. Chromatogr. Sci. 2008, 46:712-716.
80. Lin Y.F., Wang Y.C., Chang S.Y. Capillary electrophoresis of aminoglycosides with argon-ion laser-induced fluorescence detection. J. Chromatogr. A 2008, 1188:331-333.
81. Gu Y.S., Whang C.W. Capillary electrophoresis of baclofen with argon-ion laser-induced fluorescence detection. J. Chromatogr. A 2002, 972:289-293.
82. Chang S.Y., Wang F.Y. Determination of gabapentin in human plasma by capillary electrophoresis with laser-induced fluorescence detection and acetonitrile stacking technique. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004, 799:265-270.
83. Musenga A., Amore M., Mandrioli R., Kenndler E., de Martino L., Raggi M.A. Determination of duloxetine in human plasma by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009, 877:1126-1132.
84. Liu X., Yang L.X., Lu Y.T. Determination of biogenic amines by 3-(2-furoyl)quinoline-2-carboxaldehyde and capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A 2003, 998:213-219.
85. Musenga A., Kenndler E., Mercolini L., Amore M., Fanali S., Raggi M.A. Determination of sertraline and N-desmethylsertraline in human plasma by CE with LIF detection. Electrophoresis 2007, 28:1823-1831.
86. Fu N.N., Zhang H.S., Ma M., Wang H. Quantification of polyamines in human erythrocytes using a new near-infrared cyanine 1-(epsilon-succinimidyl-hexanoate)-1'-methyl-3,3,3',3'-tetramethyl-indocarbocyani ne-5,5'-disulfonate potassium with CE-LIF detection. Electrophoresis 2007, 28:822-829.
87. Zhu X., Shaw P.N., Pritchard J., Newbury J., Hunt E.J., Barrett D.A. Amino acid analysis by micellar electrokinetic chromatography with laser-induced fluorescence detection: application to nanolitre-volume biological samples from Arabidopsis thaliana and Myzus persicae. Electrophoresis 2005, 26:911-919.
88. Benturquia N., Parrot S., Sauvinet V., Renaud B., Denoroy L. Simultaneous determination of vigabatrin and amino acid neurotransmitters in brain microdialysates by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004, 806:237-244.
89. Hu S., Li P.C. Micellar electrokinetic capillary chromatographic separation and fluorescent detection of amino acids derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole. J. Chromatogr. A 2000, 876:183-191.
90. Ramseier A., von Heeren F., Thormann W. Analysis of fluorescein isothiocyanate derivatized amphetamine and analogs in human urine by capillary electrophoresis in chip-based and fused-silica capillary instrumentation. Electrophoresis 1998, 19:2967-2975.
91. Musenga A., Kenndler E., Morganti E., Rasi F., Raggi M.A. Analysis of the anti-Parkinson drug pramipexole in human urine by capillary electrophoresis with laser-induced fluorescence detection. Anal. Chim. Acta 2008, 626:89-96.
92. Zhang L., Wang R., Yu Y., Zhang Y. Capillary electrophoresis with laser-induced fluorescence and pre-column derivatization for the analysis of illicit drugs. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 857:130-135.
93. Lalljie S.P.D., Sandra P. Practical and quantitative aspects in the analysis of FITC and DTAF amino-acid cerivatives by capillary electrophoresis and LIF detection. Chromatographia 1995, 40:519-526.
94. Cheng Y.F., Dovichi N.J. Subattomole amino acid analysis by capillary zone electrophoresis and laser-induced fluorescence. Science 1988, 242:562-564.
95. Wu S., Dovichi N.J. Capillary zone electrophoresis separation and laser-induced fluorescence detection of zeptomole quantities of fluorescein thiohydantoin derivatives of amino acids. Talanta 1992, 39:173-178.
96. Siri N., Riolet P., Bayle C., Couderc F. Automated large-volume sample stacking procedure to detect labeled peptides at picomolar concentration using capillary electrophoresis and laser-induced fluorescence detection. J. Chromatogr. B 2003, 793:151-157.
97. Roman D.A., Carretero A.S., Blanco C.C., Gutierrez A.F. Subminute and sensitive determination of the neurotransmitter serotonin in urine by capillary electrophoresis with laser-induced fluorescence detection. Biomed. Chromatogr. 2004, 18:422-426.
98. Church W.H., Lee C.S., Dranchak K.M. Capillary electrophoresis of glutamate and aspartate in rat brain dialysate. Improvements in detection and analysis time using cyclodextrins. J. Chromatogr. B Biomed. Sci. Appl. 1997, 700:67-75.
99. Kei Lau S., Zaccardo F., Little M., Banks P. Nanomolar derivatizations with 5-carboxyfluorescein succinimidyl ester for fluorescence detection in capillary electrophoresis. J. Chromatogr. 1998, 809:203-210.
100. Dong Y., Chen Y., Chen X., Hu Z. Method for derivatization of ephedrine and pseudoephedrine in nonaqueous media and determination by nonaqueous capillary electrophoresis with laser induced fluorescence detection. Biomed. Chromatogr. 2006, 20:1150-1156.
101. Tábi T., Lohinai Z., Pálfi M., Levine M., Szöko{double acute} E. CE-LIF determination of salivary cadaverine and lysine concentration ratio as an indicator of lysine decarboxylase enzyme activity. Anal. Bioanal. Chem. 2008.
102. Zhao J.Y., Waldron K.C., Miller J., Zhang J.Z., Harke H., Dovichi N.J. Attachment of a single fluorescent label to peptides for determination by capillary zone electrophoresis. J. Chromatogr. 1992, 608:239-242.
103. Cao L., Wang H., Ma M., Zhang H. Determination of biogenic amines in HeLa cell lysate by 6-oxy-(N-succinimidyl acetate)-9-(2'-methoxycarbonyl) fluorescein and micellar electrokinetic capillary chromatography with laser-induced fluorescence detection. Electrophoresis 2006, 27:827-836.
104. Stoyanov A.V., Ahmadzadeh H., Krylov S.N. Heterogeneity of protein labeling with a fluorogenic reagent, 3-(2-furoyl)quinoline-2-carboxaldehyde. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 780:283-287.
105. Li H., Wang H., Chen J.H., Wang L.H., Zhang H.S., Fan Y. Determination of amino acid neurotransmitters in cerebral cortex of rats administered with baicalin prior to cerebral ischemia by capillary electrophoresis-laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003, 788:93-101.
106. Li Y.M., Qu Y., Vandenbussche E., Arckens L., Vandesande F. Analysis of extracellular gamma-aminobutyric acid, glutamate and aspartate in cat visual cortex by in vivo microdialysis and capillary electrophoresis-laser induced fluorescence detection. J. Neurosci. Methods 2001, 105:211-215.
107. Annovazzi L., Viglio S., Perani E., Luisetti M., Baraniuk J., Casado B., Cetta G., Iadarola P. Capillary electrophoresis with laser-induced fluorescence detection as a novel sensitive approach for the analysis of desmosines in real samples. Electrophoresis 2004, 25:683-691.
108. Zinellu A., Sotgia S., Scanu B., Chessa R., Gaspa L., Franconi F., Deiana L., Carru C. Taurine determination by capillary electrophoresis with laser-induced fluorescence detection: from clinical field to quality food applications. Amino Acids 2009, 36:35-41.
109. Chen Y., Xu L., Lin J., Chen G. Assay of bradykinin-related peptides in human body fluids using capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2008, 29:1302-1307.
110. Chen Y., Xu L., Zhang L., Chen G. Separation and determination of peptide hormones by capillary electrophoresis with laser-induced fluorescence coupled with transient pseudo-isotachophoresis preconcentration. Anal. Biochem. 2008, 380:297-302.
111. Musenga A., Mandrioli R., Comin I., Kenndler E., Raggi M.A. Determination of vigabatrin in human plasma by means of CE with LIF detection. Electrophoresis 2007, 28:3535-3541.
112. Chen H.L., Zhang X.J., Qi S.D., Xu H.X., Sung J.J., Bian Z.X. Simultaneous determination of glutamate and aspartate in rat periaqueductal gray matter microdialysates by capillary electrophoresis with laser-induced fluorescence. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009, 877:3248-3252.
113. Deng Y.H., Wang H., Zhong L., Zhang H.S. Trace determination of short-chain aliphatic amines in biological samples by micellar electrokinetic capillary chromatography with laser-induced fluorescence detection. Talanta 2009, 77:1337-1342.
114. Molina M., Silva M. Analytical potential of fluorescein analogues for ultrasensitive determinations of phosphorus-containing amino acid herbicides by micellar electrokinetic chromatography with laser-induced fluorescence detection. Electrophoresis 2002, 23:1096-1103.
115. Chen Y., Zhang L., Xu L., Lin J.M., Chen G. Assay of bradykinin metabolites in human body fluids by CE-LIF coupled with transient ITP preconcentration. Electrophoresis 2009, 30:2300-2306.
116. Molina M., Silva M. In-capillary derivatization and analysis of amino acids, amino phosphonic acid-herbicides and biogenic amines by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2002, 23:2333-2340.
117. Causse E., Malatray P., Calaf R., Charpiot P., Candito M., Bayle C., Valdiguie P., Salvayre R., Couderc F. Plasma total homocysteine and other thiols analyzed by capillary electrophoresis/laser-induced fluorescence detection: comparison with two other methods. Electrophoresis 2000, 21:2074-2079.
118. Zinellu A., Carru C., Galistu F., Usai M.F., Pes G.M., Baggio G., Federici G., Deiana L. N-methyl-D-glucamine improves the laser-induced fluorescence capillary electrophoresis performance in the total plasma thiols measurement. Electrophoresis 2003, 24:2796-2804.
119. Zinellu A., Carru C., Sotgia S., Deiana L. Plasma D-penicillamine redox state evaluation by capillary electrophoresis with laser-induced fluorescence. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004, 803:299-304.
120. Zinellu A., Sotgia S., Posadino A.M., Pasciu V., Perino M.G., Tadolini B., Deiana L., Carru C. Highly sensitive simultaneous detection of cultured cellular thiols by laser induced fluorescence-capillary electrophoresis. Electrophoresis 2005, 26:1063-1070.
121. Musenga A., Mandrioli R., Bonifazi P., Kenndler E., Pompei A., Raggi M.A. Sensitive and selective determination of glutathione in probiotic bacteria by capillary electrophoresis-laser induced fluorescence. Anal. Bioanal. Chem. 2007, 387:917-924.
122. Wang Y., Xie Y., Bernier M., Wainer I.W. Determination of free and protein-bound glutathione in HepG2 cells using capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A 2009, 1216:3533-3537.
123. Perez-Ruiz T., Martinez-Lozano C., Sanz A., Galera R. An ultrasensitive method for the determination of thiouracil and phenylthiouracil using capillary zone electrophoresis and laser-induced fluorescence detection. Electrophoresis 2005, 26:2384-2390.
124. Perez-Ruiz T., Martinez-Lozano C., Galera R. Development and validation of a capillary electrophoresis method with laser-induced fluorescence detection for the determination of captopril in human urine and pharmaceutical preparations. Electrophoresis 2006, 27:2310-2316.
125. Watanabe Y., Imai K. Precolumn labeling for high-performance liquid-chromatography of amino-acids with 7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole and its application to protein hydrolysates. J. Chromatogr. 1982, 239:723-732.
126. Al-Dirbashi O., Kuroda N., Nakashima K. Characterization of the fluorescence properties of 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole derivatives of some primary and secondary sympathomimetic amines. Anal. Chim. Acta 1998, 365:169-176.
127. Zhang L.Y., Tang X.C., Sun M.X. Simultaneous determination of histamine and polyamines by capillary zone electrophoresis with 4-fluor-7-nitro-2,1,3-benzoxadiazole derivatization and fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 820:211-219.
128. Beijersten I., Westerlund D. Derivatization of dipeptides with 4-fluoro-7-nitro-2,1,3-benzoxadiazole for laser-induced fluorescence and separation by micellar electrokinetic chromatography. J. Chromatogr. A 1995, 716:389-399.
129. Trapp G., Sydow K., Dulay M.T., Chou T., Cooke J.P., Zare R.N. Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma. J. Sep. Sci. 2004, 27:1483-1490.
130. Zhao S., Yuan H., Xiao D. Detection of d-Serine in rat brain by capillary electrophoresis with laser induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 822:334-338.
131. Tseng H.M., Li Y., Barrett D.A. Profiling of amine metabolites in human biofluids by micellar electrokinetic chromatography with laser-induced fluorescence detection. Anal. Bioanal. Chem. 2007, 388:433-439.
132. Zhang J., Hu Z., Chen X. Quantification of glutathione and glutathione disulfide in human plasma and tobacco leaves by capillary electrophoresis with laser-induced fluorescence detection. Talanta 2005, 65:986-990.
133. Klinker C.C., Bowser M.T. 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorogenic labeling reagent for the in vivo analysis of amino acid neurotransmitters using online microdialysis-capillary electrophoresis. Anal. Chem. 2007, 79:8747-8754.
134. Zhang H., Le Potier I., Smadja C., Zhang J., Taverna M. Fluorescent detection of peptides and amino acids for capillary electrophoresis via on-line derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole. Anal. Bioanal. Chem. 2006, 386:1387-1394.
135. Wu J., Chen Z., Dovichi N.J. Reaction rate, activation energy, and detection limit for the reaction of 5-furoylquinoline-3-carboxaldehyde with neurotransmitters in artificial cerebrospinal fluid. J. Chromatogr. B Biomed. Sci. Appl. 2000, 741:85-88.
136. Hu S., Zhang Z., Cook L.M., Carpenter E.J., Dovichi N.J. Separation of proteins by sodium dodecylsulfate capillary electrophoresis in hydroxypropylcellulose sieving matrix with laser-induced fluorescence detection. J. Chromatogr. A 2000, 894:291-296.
137. Zhang Z., Krylov S., Arriaga E.A., Polakowski R., Dovichi N.J. One-dimensional protein analysis of an HT29 human colon adenocarcinoma cell. Anal. Chem. 2000, 72:318-322.
138. Hu S., Zhang L., Cook L.M., Dovichi N.J. Capillary sodium dodecyl sulfate-DALT electrophoresis of proteins in a single human cancer cell. Electrophoresis 2001, 22:3677-3682.
139. Veledo M.T., Pelaez-Lorenzo C., Gonzalez R., de Frutos M., Diez-Masa J.C. Protein fingerprinting of Staphylococcus species by capillary electrophoresis with on-capillary derivatization and laser-induced fluorescence detection. Anal. Chim. Acta 2010, 658:81-86.
140. Zhang L., Hu S., Cook L., Dovichi N.J. Analysis of aminophospholipid molecular species by methyl-beta-cyclodextrin modified micellar electrokinetic capillary chromatography with laser-induced fluorescence detection. Electrophoresis 2002, 23:3071-3077.
141. Liu X., Li D.F., Wang Y., Lu Y.T. Determination of 1-aminocyclopropane-1-carboxylic acid in apple extracts by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A 2004, 1061:99-104.
142. Ehlen J.C., Albers H.E., Breyer E.D. MEKC-LIF of gamma-amino butyric acid in microdialysate: systematic optimization of the separation conditions by factorial analysis. J. Neurosci. Methods 2005, 147:36-47.
143. Veledo M.T., de Frutos M., Diez-Masa J.C. Amino acids determination using capillary electrophoresis with on-capillary derivatization and laser-induced fluorescence detection. J. Chromatogr. A 2005, 1079:335-343.
144. Veledo M.T., de Frutos M., Diez-Masa J.C. On-capillary derivatization and analysis of amino acids in human plasma by capillary electrophoresis with laser-induced fluorescence detection: application to diagnosis of aminoacidopathies. Electrophoresis 2006, 27:3101-3107.
145. Liu J.P., Hsieh Y.Z., Wiesler D., Novotny M. Design of 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde as a reagent for ultrasensitive determination of primary amines by capillary electrophoresis using laser fluorescence detection. Anal. Chem. 1991, 63:408-412.
146. Bergquist J., Gilman S.D., Ewing A.G., Ekman R. Analysis of human cerebrospinal fluid by capillary electrophoresis with laser-induced fluorescence detection. Anal. Chem. 1994, 66:3512-3518.
147. Bergquist J., Vona M.J., Stiller C.O., O'Connor W.T., Falkenberg T., Ekman R. Capillary electrophoresis with laser-induced fluorescence detection: a sensitive method for monitoring extracellular concentrations of amino acids in the periaqueductal grey matter. J. Neurosci. Methods 1996, 65:33-42.
148. Thongkhao-On K., Kottegoda S., Pulido J.S., Shippy S.A. Determination of amino acids in rat vitreous perfusates by capillary electrophoresis. Electrophoresis 2004, 25:2978-2984.
149. Boulat O., McLaren D.G., Arriaga E.A., Chen D.D. Separation of free amino acids in human plasma by capillary electrophoresis with laser induced fluorescence: potential for emergency diagnosis of inborn errors of metabolism. J. Chromatogr. B Biomed. Sci. Appl. 2001, 754:217-228.
150. Huang Y., Duan J., Chen H., Chen M., Chen G. Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2005, 26:593-599.
151. Laing T.D., Marenco A.J., Moore D.M., Moore G.J., Mah D.C., Lee W.E. Capillary electrophoresis laser-induced fluorescence for screening combinatorial peptide libraries in assays of botulinum neurotoxin A. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006, 843:240-246.
152. Demontigny P., Stobaugh J.F., Givens R.S., Carlson R.G., Srinivasachar K., Sternson L.A., Higuchi T. Naphthalene-2,3-dicarboxaldehyde cyanide ion-a rationally designed fluorogenic reagent for primary amines. Anal. Chem. 1987, 59:1096-1101.
153. Hernandez L., Joshi N., Murzi E., Verdeguer P., Mifsud J.C., Guzman N. Colinear laser-induced fluorescence detector for capillary electrophoresis. Analysis of glutamic acid in brain dialysates. J. Chromatogr. A 1993, 652:399-405.
154. Robert F., Bert L., Denoroy L., Renaud B. Capillary zone electrophoresis with laser-induced fluorescence detection for the determination of nanomolar concentrations of noradrenaline and dopamine: application to brain microdialysate analysis. Anal. Chem. 1995, 67:1838-1844.
155. Bert L., Robert F., Denoroy L., Stoppini L., Renaud B. Enhanced temporal resolution for the microdialysis monitoring of catecholamines and excitatory amino acids using capillary electrophoresis with laser-induced fluorescence detection. Analytical developments and in vitro validations. J. Chromatogr. A 1996, 755:99-111.
156. Robert F., Bert L., Lambas-Senas L., Denoroy L., Renaud B. In vivo monitoring of extracellular noradrenaline and glutamate from rat brain cortex with 2-min microdialysis sampling using capillary electrophoresis with laser-induced fluorescence detection. J. Neurosci. Methods 1996, 70:153-162.
157. Sauvinet V., Parrot S., Benturquia N., Bravo-Moraton E., Renaud B., Denoroy L. In vivo simultaneous monitoring of gamma-aminobutyric acid, glutamate, and L-aspartate using brain microdialysis and capillary electrophoresis with laser-induced fluorescence detection: analytical developments and in vitro/in vivo validations. Electrophoresis 2003, 24:3187-3196.
158. Parrot S., Sauvinet V., Riban V., Depaulis A., Renaud B., Denoroy L. High temporal resolution for in vivo monitoring of neurotransmitters in awake epileptic rats using brain microdialysis and capillary electrophoresis with laser-induced fluorescence detection. J. Neurosci. Methods 2004, 140:29-38.
159. Denoroy L., Parrot S., Renaud L., Renaud B., Zimmer L. In-capillary derivatization and capillary electrophoresis separation of amino acid neurotransmitters from brain microdialysis samples. J. Chromatogr. A 2008, 1205:144-149.
160. Zhou S.Y., Zuo H., Stobaugh J.F., Lunte C.E., Lunte S.M. Continuous in vivo monitoring of amino acid neurotransmitters by microdialysis sampling with on-line derivatization and capillary electrophoresis separation. Anal. Chem. 1995, 67:594-599.
161. Shou M., Smith A.D., Shackman J.G., Peris J., Kennedy R.T. In vivo monitoring of amino acids by microdialysis sampling with on-line derivatization by naphthalene-2,3-dicarboxyaldehyde and rapid micellar electrokinetic capillary chromatography. J. Neurosci. Methods 2004, 138:189-197.
162. Gilman S.D., Ewing A.G. Analysis of single cells by capillary electrophoresis with on-column derivatization and laser-induced fluorescence detection. Anal. Chem. 1995, 67:58-64.
163. Zhao S., LifuYm Quantification of amino acid enantiomers in single cells by capillary electrophoresis. Cell. Mol. Biol. 2001, 47:1217-1222.
164. Chiu D.T., Lillard S.J., Scheller R.H., Zare R.N., Rodriguez-Cruz S.E., Williams E.R., Orwar O., Sandberg M., Lundqvist J.A. Probing single secretory vesicles with capillary electrophoresis. Science 1998, 279:1190-1193.
165. Miao H., Rubakhin S.S., Sweedler J.V. Subcellular analysis of D-aspartate. Anal. Chem. 2005, 77:7190-7194.
166. Zhang L.Y., Sun M.X. Capillary electrophoresis of phosphorylated amino acids with fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 859:30-36.
167. Zhao S., Prasad C., Robertson H.J., Liu Y.M. Determination of enterostatin in human cerebrospinal fluid by capillary electrophoresis with laser induced fluorescence detection. Fresenius J. Anal. Chem. 2001, 369:220-224.
168. Freed A.L., Cooper J.D., Davies M.I., Lunte S.M. Investigation of the metabolism of substance P in rat striatum by microdialysis sampling and capillary electrophoresis with laser-induced fluorescence detection. J. Neurosci. Methods 2001, 109:23-29.
169. Zhao S., Liu Y.M. Electrophoretic separation of tryptophan enantiomers in biological samples. Electrophoresis 2001, 22:2769-2774.
170. Quan Z., Liu Y.M. Capillary electrophoretic separation of glutamate enantiomers in neural samples. Electrophoresis 2003, 24:1092-1096.
171. Chiang M.T., Chang S.Y., Whang C.W. Chiral analysis of baclofen by alpha-cyclodextrin-modified capillary electrophoresis and laser-induced fluorescence detection. Electrophoresis 2001, 22:123-127.
172. Kavran-Belin G., Rudaz S., Veuthey J.L. Enantioseparation of baclofen with highly sulfated beta-cyclodextrin by capillary electrophoresis with laser-induced fluorescence detection. J. Sep. Sci. 2005, 28:2187-2192.
173. Parmentier C., Wellman M., Nicolas A., Siest G., Leroy P. Simultaneous measurement of reactive oxygen species and reduced glutathione using capillary electrophoresis and laser-induced fluorescence detection in cultured cell lines. Electrophoresis 1999, 20:2938-2944.
174. Kostel K.L., Lunte S.M. Evaluation of capillary electrophoresis with post-column derivatization and laser-induced fluorescence detection for the determination of substance P and its metabolites. J. Chromatogr. B Biomed. Sci. Appl. 1997, 695:27-38.
175. Ye M., Hu S., Quigley W.W., Dovichi N.J. Post-column fluorescence derivatization of proteins and peptides in capillary electrophoresis with a sheath flow reactor and 488nm argon ion laser excitation. J. Chromatogr. A 2004, 1022:201-206.
176. Yu C.Z., He Y.Z., Fu G.N., Xie H.Y., Gan W.E. Determination of kanamycin A, amikacin and tobramycin residues in milk by capillary zone electrophoresis with post-column derivatization and laser-induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009, 877:333-338.
177. Li M.W., Martin R.S. Microchip-based integration of cell immobilization, electrophoresis, post-column derivatization, and fluorescence detection for monitoring the release of dopamine from PC 12 cells. Analyst 2008, 133:1358-1366.
178. Tsai C.H., Huang H.M., Lin C.H. Violet light emitting diode-induced fluorescence detection combined with on-line sample concentration techniques for use in capillary electrophoresis. Electrophoresis 2003, 24:3083-3088.
179. Siri N., Lacroix M., Garrigues J.C., Poinsot V., Couderc F. HPLC-fluorescence detection and MEKC-LIF detection for the study of amino acids and catecholamines labelled with naphthalene-2,3-dicarboxyaldehyde. Electrophoresis 2006, 27:4446-4455.
180. Wang C., Zhao S., Yuan H., Xiao D. Determination of excitatory amino acids in biological fluids by capillary electrophoresis with optical fiber light-emitting diode induced fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006, 833:129-134.
181. Lu M.-J., Chiu T.-C., Chang P.-L., Ho H.-T., Chang H.-T. Determination of glycine, glutamine, glutamate, and [gamma]-aminobutyric acid in cerebrospinal fluids by capillary electrophoresis with light-emitting diode-induced fluorescence detection. Anal. Chim. Acta 2005, 538:143-150.
182. Chang P.L., Chiu T.C., Chang H.T. Stacking, derivatization, and separation by capillary electrophoresis of amino acids from cerebrospinal fluids. Electrophoresis 2006, 27:1922-1931.
183. Chiu T.C., Tu W.C., Chang H.T. Stacking and separation of protein derivatives of naphthalene-2,3-dicarboxaldehyde by CE with light-emitting diode induced fluorescence detection. Electrophoresis 2008, 29:433-440.
184. Yu Q., Zhao S., Ye F., Li S. Determination of octopamine in human plasma by capillary electrophoresis with optical fiber light-emitting diode-induced fluorescence detection. Anal. Biochem. 2007, 369:187-191.
185. Chen F.T., Tusak A., Pentoney S., Konrad K., Lew C., Koh E., Sternberg J. Semiconductor laser-induced fluorescence detection in capillary electrophoresis using a cyanine dye. J. Chromatogr. A 1993, 652:355-360.
186. Nagaraj S., Rahavendran S.V., Karnes H.T. Visible diode laser induced fluorescence detection for capillary electrophoretic analysis of amantadine in human plasma following precolumn derivatization with Cy5.29.OSu. J. Pharm. Biomed. Anal. 1998, 18:411-420.
187. Serrano J.M., Silva M. Trace analysis of aminoglycoside antibiotics in bovine milk by MEKC with LIF detection. Electrophoresis 2006, 27:4703-4710.
188. Orejuela E., Silva M. Rapid and sensitive determination of phosphorus-containing amino acid herbicides in soil samples by capillary zone electrophoresis with diode laser-induced fluorescence detection. Electrophoresis 2005, 26:4478-4485.
189. Yoon S., Ban E., Yoo Y.S. Direct monitoring of the expression of the green fluorescent protein-extracellular signal-regulated kinase 2 fusion protein in transfected cells using capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A 2002, 976:87-93.
190. Yoon S., Han K.Y., Nam H.S., Nga le V., Yoo Y.S. Determination of protein phosphorylation and the translocation of green fluorescence protein-extracellular signal-regulated kinase 2 by capillary electrophoresis using laser induced fluorescence detection. J. Chromatogr. A 2004, 1056:237-242.
191. Phillips T.M., Kennedy L.M., De Fabo E.C. Microdialysis-immunoaffinity capillary electrophoresis studies on neuropeptide-induced lymphocyte secretion. J. Chromatogr. B Biomed. Sci. Appl. 1997, 697:101-109.
192. Kalish H., Phillips T.M. Application of immunoaffinity capillary electrophoresis to the measurements of secreted cytokines by cultured astrocytes. J. Sep. Sci. 2009, 32:1605-1612.
193. Phillips T.M. Analysis of single-cell cultures by immunoaffinity capillary electrophoresis with laser-induced fluorescence detection. Luminescence 2001, 16:145-152.
194. Phillips T.M., Dickens B.F. Analysis of recombinant cytokines in human body fluids by immunoaffinity capillary electrophoresis. Electrophoresis 1998, 19:2991-2996.
195. Phillips T.M. Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis 2004, 25:1652-1659.
196. Phillips T.M., Wellner E.F. Analysis of inflammatory biomarkers from tissue biopsies by chip-based immunoaffinity CE. Electrophoresis 2007, 28:3041-3048.
197. Phillips T.M., Smith P. Analysis of intracellular regulatory proteins by immunoaffinity capillary electrophoresis coupled with laser-induced fluorescence detection. Biomed. Chromatogr. 2003, 17:182-187.
198. Phillips T.M., Wellner E.F. Chip-based immunoaffinity CE: application to the measurement of brain-derived neurotrophic factor in skin biopsies. Electrophoresis 2009, 30:2307-2312.
199. Wellner E.F., Kalish H. A chip-based immunoaffinity capillary electrophoresis assay for assessing hormones in human biological fluids. Electrophoresis 2008, 29:3477-3483.
200. Yang W., Sun X., Wang H.Y., Woolley A.T. Integrated microfluidic device for serum biomarker quantitation using either standard addition or a calibration curve. Anal. Chem. 2009, 81:8230-8235.