In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3677-3684

  Ghorab, Mostafa M ^a   Ragab, Fatma A ^b   Heiba, Helmy I ^c   Arafa, Reem K ^b   El Hossary, Ebaa M ^c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Radiation; Anticancer; Carbonic anhydrase II; Pyrimido 4,5 b quinoline; Quinoline; Sulfonamide

Indexed keywords

2 AMINO 4 (4 CHLOROPHENYL) 7,7 DIMETHYL 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXAMIDE; 2 CHLORO N (4 (4 CHLOROPHENYL) 3 CYANO 7,7 DIMETHYL 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YL)ACETAMIDE; 4 (2 (CHLOROMETHYL) 5 (4 CHLOROPHENYL) 8,8 DIMETHYL 4,6 DIOXO 3,4,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (2 AMINO 4 (4 CHLOROPHENYL) 3 (4,5 DIHYDRO 1H IMIDAZOL 2-YL) 7,7DIMETHYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL)BENZENESULFONAMIDE; 4 (4 (4 CHLOROPHENYL) 3 CYANO 2 (2,5 DIOXOPYRROLIDIN 1 YL) 7,7 DIMETHYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL)BENZENESULFONAMIDE; 4 (4 (4 CHLOROPHENYL) 3 CYANO 2 (3 ETHYLTHIOUREIDO) 7,7 METHYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL)BENZENESULFONAMIDE; 4 (4 AMINO 5 (4 CHLOROPHENYL) 8,8 DIMETHYL 6 OXO 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (4 CHLORO 5 (4 CHLOROPHENYL) 8,8 DIMETHYL 6 OXO 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (5 (4 CHLOROPHENYL) 2 (CYANOMETHYL) 8,8 DIMETHYL 4,6 DIOXO 3,4,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H YL)BENZENESULFONAMIDE; 4 (5 (4 CHLOROPHENYL) 2,8,8 TRIMETHYL 4,6 DIOXO 3,4,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (5 (4 CHLOROPHENYL) 4 HYDRAZINYL 8,8 DIMETHYL 6 OXO 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (5 (4 CHLOROPHENYL) 4 ISOTHIOCYANATO 8,8 DIMETHYL 6 OXO 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H)YL)BENZENESULFONAMIDE; 4 (5 (4 CHLOROPHENYL) 8,8 DIMETHYL 4,6 DIOXO 3,4,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (5 (4 CHLOROPHENYL) 8,8 DIMETHYL 6 OXO 4 THIOXO 3,4,6,7,8,9 HEXAHYDROPYRIMIDO[4,5 B]QUINOLIN 10(5H) YL)BENZENESULFONAMIDE; 4 (5,5 DIMETHYL 3 OXOCYCLOHEX 1 ENYLAMINO)BENZENESULFONAMIDE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETHYL 2 (5 (4 CHLOROPHENYL) 8,8 DIMETHYL 4,6 DIOXO 10 (4 SULFAMOYLPHENYL) 6,7,8,9 TETRAHYDROPYRIMIDO[4,5 B]QUINOLIN 3 (4H,5H,10H) YL)ACETATE; ETHYL N 4 (4 CHLOROPHENYL) 3 CYANO 7,7 DIMETHYL 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YLFORMIMIDATE; N (4 (4 CHLOROPHENYL) 3 CYANO 7,7 DIMETHYL 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YL) 3 OXOBUTANAMIDE; N ACETYL N (4 (4 CHLOROPHENYL) 3 CYANO 7,7 DIMETHYL 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YL) ACETAMODE; N(4 (4 CHLOROPHENYL) 3 CYANO 7,7 DIMETHYL 5 OXO 1 (4 SULFAMOYLPHENYL) 1,4,5,6,7,8 HEXAHYDROQUINOLIN 2 YL)ACETAMIDE; QUINOLINE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL KILLING; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG SCREENING; GAMMA RADIATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GAMMA RAYS; HUMANS; INHIBITORY CONCENTRATION 50; QUINOLINES; RADIATION-SENSITIZING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77955550512     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.014     Document Type: Article

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