Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl] benzenesulfonamides

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 3011-3018

  Al Said, Mansour S ^a   Ghorab, Mostafa M ^a   Al Qasoumi, Saleh I ^a   El Hossary, Ebaa M ^b   Noaman, Eman ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Anticancer activity; Carbonic anhydrase II; quinoline; Sulfonamide; Synthesis

Indexed keywords

4 [2 AMINO 3 CYANO 4 (2 HYDROXYNAPHTHALEN 1 YL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 HYDROXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 METHOXYNAPHTHALEN 1 YL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2,4 DICHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2,4,5 TRIMETHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (3 ETHOXY 4 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (3 NITROPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (3,4 DICHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 HYDROXY 3 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 HYDROXYPHENYL) 5,6,7,8 TETRAHYDRO QUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 METHOXYNAPHTHALEN 1 YL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 NITROPHENYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 TOLYL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (5 METHYLFURAN 2 YL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (THIOPHEN 2 YL) 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 PHENYL 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 STYRYL 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 4 (2 CHLOROPHENYL) 3 CYANO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 4 (BENZO[D][1,3]DIOXOL 5 YL)DIOXOL 5 YL) 3 CYANO 5,6,7,8 TETRAHYDROQUINOLIN 1(4H) YL]BENZENESULFONAMIDE; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

EID: 77954349073     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.030     Document Type: Article

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