Discovering some novel tetrahydroquinoline derivatives bearing the biologically active sulfonamide moiety as a new class of antitumor agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1849-1853

  Alqasoumi, Saleh I ^a   Al Taweel, Areej M ^a   Alafeefy, Ahmed M ^a   Ghorab, Mostafa M ^a   Noaman, Eman ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Antitumor activity; Sulfonamide; Synthesis; Tetrahydroquinoline

Indexed keywords

4 (3 OXO CYCLOHEX 1 ENYLAMINO)BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 FURYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 HYDROXY 1 NAPHTHYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 METHOXY 1 NAPHTHYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 METHOXYPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2 THIENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2,4 DICHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (2,4,5 TRIMETHOXYPHENYL) 5 OXO 5,6,7,8-TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (3 ETHOXY 4 METHOXYPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (3 NITROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 HYDROXY 3 METHOXYPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 METHOXY 1 NAPHTHYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 METHOXYPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (4 NITROPHENYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 (5 METHYL 2 FURYL) 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 PARA HYDROXYPHENYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 PARA TOLYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H)YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 PHENYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 3 CYANO 4 STYRYL 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; 4 [2 AMINO 4 (BENZO[D][1,3]DIOXOL 5 YL) 3 CYANO 5 OXO 5,6,7,8 TETRAHYDROQUINOLIN 1 (4H) YL]BENZENESULFONAMIDE; ANTINEOPLASTIC AGENT; DOXORUBICIN; QUINOLINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR CELL; FEMALE; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; MICE; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; QUINOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77949489197     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.022     Document Type: Article

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