Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6939-6942

  Alqasoumi, Saleh I ^a   Al Taweel, Areej M ^a   Alafeefy, Ahmed M ^a   Hamed, Mostafa M ^b   Noaman, Eman ^c   Ghorab, Mostafa M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b German University in Cairo   (Egypt)

^c NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Anticancer; Hexahydroquinoline; Trimethoxyphenyl; Tubulin

Indexed keywords

2 AMINO 7,7 DIMETHYL 4 5 OXO 1 (3,4,5 TRIMETHOXY) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE DERIVATIVE; 3 (3,4,5 TRIMETHOXYANILINO) 5,5 DIMETHYL CYCLOHEX 2 ENONE; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DOXORUBICIN; QUINOLINE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HODGKIN DISEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; POLYMERIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; NITRILES; QUINOLINES; TUBULIN MODULATORS;

EID: 71849083070     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.065     Document Type: Article

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