-
1
-
-
0034769960
-
Viruses and interferons
-
Sen, G.C. Viruses and interferons. Annu. Rev. Microbiol. 55, 255-281 (2001).
-
(2001)
Annu. Rev. Microbiol.
, vol.55
, pp. 255-281
-
-
Sen, G.C.1
-
2
-
-
33748475531
-
Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors
-
DOI 10.1016/j.immuni.2006.08.009, PII S1074761306003943
-
Honda, K., Takaoka, A. & Taniguchi, T. Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 25, 349-360 (2006). (Pubitemid 44354220)
-
(2006)
Immunity
, vol.25
, Issue.3
, pp. 349-360
-
-
Honda, K.1
Takaoka, A.2
Taniguchi, T.3
-
3
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type i interferons through the RIG-I pathway
-
Chiu, Y.H., Macmillan, J.B. & Chen, Z.J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576-591 (2009).
-
(2009)
Cell
, vol.138
, pp. 576-591
-
-
Chiu, Y.H.1
MacMillan, J.B.2
Chen, Z.J.3
-
4
-
-
70349459734
-
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
-
Ablasser, A. et al. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10, 1065-1072 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1065-1072
-
-
Ablasser, A.1
-
5
-
-
33646555810
-
Type 1 interferons and the virus-host relationship: A lesson in détente
-
DOI 10.1126/science.1125676
-
García-Sastre, A. & Biron, C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 312, 879-882 (2006). (Pubitemid 43727313)
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 879-882
-
-
Garcia-Sastre, A.1
Biron, C.A.2
-
6
-
-
0036668242
-
Links between innate and adaptive immunity via type I interferon
-
DOI 10.1016/S0952-7915(02)00354-0
-
Le Bon, A. & Tough, D.F. Links between innate and adaptive immunity via type I interferon. Curr. Opin. Immunol. 14, 432-436 (2002). (Pubitemid 34671244)
-
(2002)
Current Opinion in Immunology
, vol.14
, Issue.4
, pp. 432-436
-
-
Le Bon, A.1
Tough, D.F.2
-
7
-
-
33748447541
-
Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases
-
DOI 10.1016/j.immuni.2006.08.010, PII S1074761306003955
-
Banchereau, J. & Pascual, V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25, 383-392 (2006). (Pubitemid 44354221)
-
(2006)
Immunity
, vol.25
, Issue.3
, pp. 383-392
-
-
Banchereau, J.1
Pascual, V.2
-
8
-
-
75149189005
-
Type I interferons: Crucial participants in disease amplification in autoimmunity
-
Hall, J.C. & Rosen, A. Type I interferons: crucial participants in disease amplification in autoimmunity. Nat. Rev. Rheumatol. 6, 40-49 (2010).
-
(2010)
Nat. Rev. Rheumatol.
, vol.6
, pp. 40-49
-
-
Hall, J.C.1
Rosen, A.2
-
9
-
-
53549103852
-
Divergent TLR7 and TLR9 signaling and type i interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
-
Mandl, J.N. et al. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat. Med. 14, 1077-1087 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 1077-1087
-
-
Mandl, J.N.1
-
10
-
-
0025212710
-
Postinduction turnoff of beta-interferon gene expression
-
Whittemore, L.A. & Maniatis, T. Postinduction turnoff of beta-interferon gene expression. Mol. Cell. Biol. 10, 1329-1337 (1990). (Pubitemid 20105001)
-
(1990)
Molecular and Cellular Biology
, vol.10
, Issue.4
, pp. 1329-1337
-
-
Whittemore, L.-A.1
Maniatis, T.2
-
11
-
-
72849136282
-
Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type i IFN response
-
Jacquelin, B. et al. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J. Clin. Invest. 119, 3544-3555 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3544-3555
-
-
Jacquelin, B.1
-
12
-
-
0032458247
-
Structure and function of the interferon-beta enhanceosome
-
Maniatis, T. et al. Structure and function of the interferon-beta enhanceosome. Cold Spring Harb. Symp. Quant. Biol. 63, 609-620 (1998).
-
(1998)
Cold Spring Harb. Symp. Quant. Biol.
, vol.63
, pp. 609-620
-
-
Maniatis, T.1
-
13
-
-
75749090852
-
SnapShot: Pathways of antiviral innate immunity
-
Sun, L., Liu, S. & Chen, Z.J. SnapShot: pathways of antiviral innate immunity. Cell 140, 436-436.e2 (2010).
-
(2010)
Cell
, vol.140
-
-
Sun, L.1
Liu, S.2
Chen, Z.J.3
-
14
-
-
77749242510
-
The transcriptional code of human IFN-beta gene expression
-
Ford, E. & Thanos, D. The transcriptional code of human IFN-beta gene expression. Biochim. Biophys. Acta 1799, 328-336 (2010).
-
(2010)
Biochim. Biophys. Acta
, vol.1799
, pp. 328-336
-
-
Ford, E.1
Thanos, D.2
-
15
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
DOI 10.1038/nature04734, PII N04734
-
Kato, H. et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105 (2006). (Pubitemid 43827959)
-
(2006)
Nature
, vol.441
, Issue.1
, pp. 101-105
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
Yoneyama, M.4
Yamamoto, M.5
Matsui, K.6
Uematsu, S.7
Jung, A.8
Kawai, T.9
Ishii, K.J.10
Yamaguchi, O.11
Otsu, K.12
Tsujimura, T.13
Koh, C.-S.14
Reis E Sousa, C.15
Matsuura, Y.16
Fujita, T.17
Akira, S.18
-
16
-
-
38649089789
-
The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I
-
DOI 10.1016/j.molcel.2007.10.032, PII S1097276507008222
-
Cui, S. et al. The C-terminal regulatory domain is the RNA 5?-triphosphate sensor of RIG-I. Mol. Cell 29, 169-179 (2008). (Pubitemid 351172822)
-
(2008)
Molecular Cell
, vol.29
, Issue.2
, pp. 169-179
-
-
Cui, S.1
Eisenacher, K.2
Kirchhofer, A.3
Brzozka, K.4
Lammens, A.5
Lammens, K.6
Fujita, T.7
Conzelmann, K.-K.8
Krug, A.9
Hopfner, K.-P.10
-
17
-
-
39649092731
-
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses
-
Takahasi, K. et al. Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol. Cell 29, 428-440 (2008).
-
(2008)
Mol. Cell
, vol.29
, pp. 428-440
-
-
Takahasi, K.1
-
18
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3
-
DOI 10.1016/j.cell.2005.08.012, PII S0092867405008160
-
Seth, R.B., Sun, L., Ea, C.K. & Chen, Z.J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-682 (2005). (Pubitemid 41242633)
-
(2005)
Cell
, vol.122
, Issue.5
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.-K.3
Chen, Z.J.4
-
19
-
-
64049090624
-
MAVS self-association mediates antiviral innate immune signaling
-
Tang, E.D. & Wang, C.Y. MAVS self-association mediates antiviral innate immune signaling. J. Virol. 83, 3420-3428 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 3420-3428
-
-
Tang, E.D.1
Wang, C.Y.2
-
20
-
-
68249146531
-
A nonself RNA pattern: Tri-p to panhandle
-
Fujita, T. A nonself RNA pattern: tri-p to panhandle. Immunity 31, 4-5 (2009).
-
(2009)
Immunity
, vol.31
, pp. 4-5
-
-
Fujita, T.1
-
21
-
-
60749124538
-
Cytosolic viral sensor RIG-I is a 5?-triphosphate-dependent translocase on double-stranded RNA
-
Myong, S. et al. Cytosolic viral sensor RIG-I is a 5?-triphosphate- dependent translocase on double-stranded RNA. Science 323, 1070-1074 (2009).
-
(2009)
Science
, vol.323
, pp. 1070-1074
-
-
Myong, S.1
-
22
-
-
34247341367
-
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
-
Gack, M.U. et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920 (2007).
-
(2007)
Nature
, vol.446
, pp. 916-920
-
-
Gack, M.U.1
-
23
-
-
77949422543
-
Phosphorylation-mediated negative regulation of RIG-I antiviral activity
-
Gack, M.U., Nistal-Villan, E., Inn, K.S., Garcia-Sastre, A. & Jung, J.U. Phosphorylation-mediated negative regulation of RIG-I antiviral activity. J. Virol. 84, 3220-3229 (2010).
-
(2010)
J. Virol.
, vol.84
, pp. 3220-3229
-
-
Gack, M.U.1
Nistal-Villan, E.2
Inn, K.S.3
Garcia-Sastre, A.4
Jung, J.U.5
-
24
-
-
33746479050
-
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
-
Saha, S.K. et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25, 3257-3263 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 3257-3263
-
-
Saha, S.K.1
-
25
-
-
34249058290
-
Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
-
DOI 10.1074/jbc.M700017200
-
Guo, B. & Cheng, G. Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J. Biol. Chem. 282, 11817-11826 (2007). (Pubitemid 47100710)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.16
, pp. 11817-11826
-
-
Guo, B.1
Cheng, G.2
-
26
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
DOI 10.1038/ni1243, PII N1243
-
Kawai, T. et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6, 981-988 (2005). (Pubitemid 41486182)
-
(2005)
Nature Immunology
, vol.6
, Issue.10
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
Kato, H.6
Ishii, K.J.7
Takeuchi, O.8
Akira, S.9
-
27
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa, H. & Barber, G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455, 674-678 (2008).
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
28
-
-
53349168904
-
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
-
Zhong, B. et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538-550 (2008).
-
(2008)
Immunity
, vol.29
, pp. 538-550
-
-
Zhong, B.1
-
29
-
-
49149113373
-
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
-
Schröder, M., Baran, M. & Bowie, A.G. Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. EMBO J. 27, 2147-2157 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 2147-2157
-
-
Schröder, M.1
Baran, M.2
Bowie, A.G.3
-
30
-
-
55349103358
-
Novel therapeutic applications of cardiac glycosides
-
Prassas, I. & Diamandis, E.P. Novel therapeutic applications of cardiac glycosides. Nat. Rev. Drug Discov. 7, 926-935 (2008).
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 926-935
-
-
Prassas, I.1
Diamandis, E.P.2
-
31
-
-
4344566281
-
The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
-
DOI 10.1084/jem.20040520
-
Hemmi, H. et al. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650 (2004). (Pubitemid 38821997)
-
(2004)
Journal of Experimental Medicine
, vol.199
, Issue.12
, pp. 1641-1650
-
-
Hemmi, H.1
Takeuchi, O.2
Sato, S.3
Yamamoto, M.4
Kaisho, T.5
Sanjo, H.6
Kawai, T.7
Hoshino, K.8
Takeda, K.9
Akira, S.10
-
32
-
-
0038393016
-
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
-
Fitzgerald, K.A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
-
33
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
DOI 10.1038/ni1087
-
Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737 (2004). (Pubitemid 39023305)
-
(2004)
Nature Immunology
, vol.5
, Issue.7
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
Shinobu, N.4
Imaizumi, T.5
Miyagishi, M.6
Taira, K.7
Akira, S.8
Fujita, T.9
-
34
-
-
33846307026
-
Regulation of innate antiviral defenses through a shared repressor domain in RIG-1 and LGP2
-
DOI 10.1073/pnas.0606699104
-
Saito, T. et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. USA 104, 582-587 (2007). (Pubitemid 46123068)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.2
, pp. 582-587
-
-
Saito, T.1
Hirai, R.2
Loo, Y.-M.3
Owen, D.4
Johnson, C.L.5
Sinha, S.C.6
Akira, S.7
Fujita, T.8
Gale Jr., M.9
-
35
-
-
0017424583
-
Ionic basis of myocardial contractility
-
Langer, G.A. Ionic basis of myocardial contractility. Annu. Rev. Med. 28, 13-20 (1977).
-
(1977)
Annu. Rev. Med.
, vol.28
, pp. 13-20
-
-
Langer, G.A.1
-
36
-
-
77951883450
-
The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase
-
Lingrel, J.B. The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase. Annu. Rev. Physiol. 72, 395-412 (2010).
-
(2010)
Annu. Rev. Physiol.
, vol.72
, pp. 395-412
-
-
Lingrel, J.B.1
-
37
-
-
0025058006
-
+-ATPase
-
DOI 10.1016/0005-2736(90)90028-M
-
Ohtsubo, M., Noguchi, S., Takeda, K., Morohashi, M. & Kawamura, M. Site-directed mutagenesis of Asp-376, the catalytic phosphorylation site, and Lys-507, the putative ATP-binding site, of the alpha-subunit of Torpedo californica Na+/K(+)-ATPase. Biochim. Biophys. Acta 1021, 157-160 (1990). (Pubitemid 20037564)
-
(1990)
Biochimica et Biophysica Acta - Biomembranes
, vol.1021
, Issue.2
, pp. 157-160
-
-
Ohtsubo, M.1
Noguchi, S.2
Takeda, K.3
Morohashi, M.4
Kawamura, M.5
-
38
-
-
66149142810
-
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation
-
Simpson, C.D. et al. Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Res. 69, 2739-2747 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 2739-2747
-
-
Simpson, C.D.1
-
39
-
-
0025297358
-
Nimodipine and the recovery of memory
-
DOI 10.1016/0165-6147(90)90229-2
-
Izquierdo, I. Nimodipine and the recovery of memory. Trends Pharmacol. Sci. 11, 309-310 (1990). (Pubitemid 20240656)
-
(1990)
Trends in Pharmacological Sciences
, vol.11
, Issue.8
, pp. 309-310
-
-
Izquierdo, I.1
-
40
-
-
0023009379
-
+ channel in mouse pancreatic β-cells
-
DOI 10.1007/BF00657506
-
Trube, G., Rorsman, P. & Ohno-Shosaku, T. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 407, 493-499 (1986). (Pubitemid 17175041)
-
(1986)
Pflugers Archiv European Journal of Physiology
, vol.407
, Issue.5
, pp. 493-499
-
-
Trube, G.1
Rorsman, P.2
Ohno-Shosaku, T.3
-
41
-
-
0021971015
-
Phenamil: An irreversible inhibitor of sodium channels in the toad urinary bladder
-
DOI 10.1007/BF01870698
-
Garvin, J.L., Simon, S.A., Cragoe, E.J. Jr. & Mandel, L.J. Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder. J. Membr. Biol. 87, 45-54 (1985). (Pubitemid 15236751)
-
(1985)
Journal of Membrane Biology
, vol.87
, Issue.1
, pp. 45-54
-
-
Garvin, J.L.1
Simon, S.A.2
Cragoe Jr., E.J.3
Mandel, L.J.4
-
42
-
-
2342487353
-
Na+-K+-ATPase-mediated signal transduction: From protein interaction to cellular function
-
Xie, Z. & Cai, T. Na+-K+-ATPase-mediated signal transduction: from protein interaction to cellular function. Mol. Interv. 3, 157-168 (2003).
-
(2003)
Mol. Interv.
, vol.3
, pp. 157-168
-
-
Xie, Z.1
Cai, T.2
-
43
-
-
44049095441
-
Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity
-
Gee, P. et al. Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity. J. Biol. Chem. 283, 9488-9496 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 9488-9496
-
-
Gee, P.1
-
44
-
-
0035877590
-
Regulation of Nuclear Localization during Signaling
-
DOI 10.1074/jbc.R100012200
-
Cyert, M.S. Regulation of nuclear localization during signaling. J. Biol. Chem. 276, 20805-20808 (2001). (Pubitemid 37413055)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.24
, pp. 20805-20808
-
-
Cyert, M.S.1
-
45
-
-
22144480948
-
Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
-
DOI 10.1073/pnas.0504097102
-
Yang, Q. et al. Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc. Natl. Acad. Sci. USA 102, 9631-9636 (2005). (Pubitemid 40981732)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.27
, pp. 9631-9636
-
-
Yang, Q.1
Huang, W.2
Jozwik, C.3
Lin, Y.4
Glasman, M.5
Caohuy, H.6
Srivastava, M.7
Esposito, D.8
Gillette, W.9
Hartley, J.10
Pollard, H.B.11
-
46
-
-
77953555514
-
Cytokines as therapeutic targets in SLE
-
Ronnblom, L. & Elkon, K.B. Cytokines as therapeutic targets in SLE. Nat. Rev. Rheumatol. 6, 339-347 (2010).
-
(2010)
Nat. Rev. Rheumatol.
, vol.6
, pp. 339-347
-
-
Ronnblom, L.1
Elkon, K.B.2
-
47
-
-
70449376872
-
Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer
-
Meng, Z. et al. Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer. Cancer 115, 5309-5318 (2009).
-
(2009)
Cancer
, vol.115
, pp. 5309-5318
-
-
Meng, Z.1
-
48
-
-
62649138086
-
A small molecule that directs differentiation of human ESCs into the pancreatic lineage
-
Chen, S. et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat. Chem. Biol. 5, 258-265 (2009)
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 258-265
-
-
Chen, S.1
|