Suppression of nitric oxide implicated in the protective effect of echinacoside on H2O2-induced PC12 cell injury

Natural Product Communications

Volumn 5, Issue 4, 2010, Pages 571-574

  Kuang, Rong ^a,b   Sun, Yiguo ^a   Zheng, Xiaoxiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Zhejiang Institute for Food and Drug Control   (China)

Author keywords

Apoptosis; ECH; Echinacoside; iNOS; NF B; NO

Indexed keywords

ECHINACOSIDE; HYDROGEN PEROXIDE; NITRIC OXIDE; SYNAPTOTAGMIN I; GLYCOSIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG STRUCTURE; NONHUMAN; PHEOCHROMOCYTOMA CELL; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CELL STRAIN; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

RATTUS;

ANIMALS; APOPTOSIS; GLYCOSIDES; HYDROGEN PEROXIDE; MICROSCOPY, CONFOCAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PC12 CELLS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; UP-REGULATION;

EID: 77952983713     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1000500416     Document Type: Article

References (16)

1. Butterfield DA, Howard B, Yatin S, Koppal T, Drake J, Hensley K, Aksenov M, Aksenova M, Subramaniam R, Varadarajan S, Harris-White ME, Pedigo NW Jr, Carney JM.(1999) Elevated oxidative stress in models of normal brain aging and Alzheimer's disease. Life Sciences, 65, 1883-1892. (Pubitemid 29506923)
2. Greene LA, Tischler AS. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proceedings of National Academy of Sciences U S A, 73, 2424-2428.
3. Li RC, Morris MW, Lee SK, Pouranfar F, Wang Y, Gozal D. (2008) Neuroglobin protects PC12 cells against oxidative stress. Brain Research, 23, 159-166.
4. 2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. Biochemical Pharmacology, 76, 1577-1589.
5. Xu HB, Li L, Liu GQ. (2008) Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by guggulsterone. Yao Xue Xue Bao, 43, 1190-1197.
6. Carbone DL, Moreno JA, Tjalkens RB. (2008) Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP. Brain Research, 27, 1-9.
7. Liu FX, Wang XW, Luo L, Xin H, Wang XF. (2006) The effects of glycosides of Cistanche on learning and memory in β-amyloid peptide induced Alzheimer's disease in mice and its possible mechanism. Chinese Pharmacological Bulletin, 22, 595-599. (Pubitemid 44229544)
8. Mourboul A, Mao XM , Rena K, Ma SY, Leininger M, Gérard S. (2008) Antioxidant property of general cistanosides in human HL-60 cell line. Chinese Pharmacological Bulletin, 24, 362-364.
9. Deng M, Zhao JY, Tu PF, Jiang Y, Li ZB, Wang YH. (2004) Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis. European Journal of Pharmacology, 505, 11-18. (Pubitemid 39535671)
10. Geng X, Tian X, Tu P, Pu X. (2007) Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease. European Journal of Pharmacology, 564, 66-74.
11. Jhaveri KA, Toth LA, Sekino Y, Ramkumar V. (2006) Nitric oxide serves as an endogenous regulator of neuronal adenosine A1 receptor expression. Journal of Neurochemistry, 99, 42-53.
12. Koh PO. (2008) Melatonin regulates nitric oxide synthase expression in ischemic brain injury. Journal of Veterinary Medical Science, 70, 747-750.
13. Wang YH, Wang WY, Chang CC, Liou KT, Sung YJ, Liao JF, Chen CF, Chang S, Hou YC, Chou YC, Shen YC. (2006) Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. Journal of Biomedical Science, 13, 127-141.
14. Hong H, Liu GQ. (2004) Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life Sciences, 74, 2959-2973. (Pubitemid 38402293)
15. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.
16. Zeng XH, Zhang SM, Zhang L, Zhang KP, Zheng XX. (2006) A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Medica, 72, 1359-1365. (Pubitemid 46102388)