Ginsenoside Rg1 attenuates β-amyloid-induced apoptosis in mutant PS1 M146L cells

Neuroscience Letters

Volumn 443, Issue 3, 2008, Pages 145-149

  Wei, Cuibai ^a   Jia, Jianping ^a   Liang, Ping ^b   Guan, Yunqian ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Alzheimer's disease; Apoptosis; Beta amyloid; Caspase 3; Ginsenoside Rg1

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN 751; CASPASE 3; GINSENOSIDE RG 1; LIPOCORTIN 5; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOFLUORESCENCE; NEUROPROTECTION; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMYLOID BETA-PROTEIN; ANIMALS; ANNEXIN A5; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GINSENOSIDES; IN SITU NICK-END LABELING; LEUCINE; METHIONINE; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION;

EID: 50249165853     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.07.089     Document Type: Article

References (29)

1. Anandatheerthavarada H.K., and Devi L. Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease. Neuroscientist 13 (2007) 626-638
2. Awasthi A., Matsunaga Y., and Yamada T. Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides. Exp. Neurol. 196 (2005) 282-289
3. Bobich J.A., Zheng Q., and Campbell A. Incubation of nerve endings with a physiological concentration of Abeta1-42 activates CaV2.2(N-Type)-voltage operated calcium channels and acutely increases glutamate and noradrenaline release. J. Alzheimers Dis. 6 (2004) 243-255
4. Borghi R., Pellegrini L., Lacaná E., Diaspro A., Pronzato M.A., Vitali A., Roncarati R., Strocchi P., Zaccheo D., D'Adamio L., and Tabaton M. Neuronal apoptosis is accompanied by amyloid beta-protein accumulation in the endoplasmic reticulum. J. Alzheimers Dis. 4 (2002) 39-40
5. Chen X.C., Zhu Y.G., Zhu L.A., Huang C., Chen Y., Chen L.M., Fang F., Zhou Y.C., and Zhao C.H. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur. J. Pharmacol. 473 (2003) 1-7
6. +-induced apoptosis in SHSY5Y cells. J. Neural. Trans. 110 (2003) 835-845
7. Clementi M.E., Pezzotti M., Orsini F., Sampaolese B., Mezzogori D., Grassi C., Giardina B., and Misiti F. Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35. Biochem. Biophys. Res. Commun. 342 (2006) 206-213
8. Cohen G.M. Caspases: the executioners of apoptosis. Biochem. J. 326 (1997) 1-16
9. Harkany T., Abrahám I., Kónya C., Nyakas C., Zarándi M., Penke B., and Luiten P.G. Mechanisms of beta-amyloid neurotoxicity: perspectives of pharmacotherapy. Rev. Neurosci. 11 (2000) 329-382
10. Kienlen-Campard P., Miolet S., Tasiaux B., and Octave J.N. Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J. Biol. Chem. 277 (2002) 15666-15670
11. Kim C.S., Park J.B., Kim K.J., Chang S.J., Ryoo S.W., and Jeon B.H. Effect of Korea red ginseng on cerebral blood flow and superoxide production. Acta Pharmacol. Sin. 23 (2002) 1152-1156
12. LaFerla F.M., Green K.N., and Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci. 8 (2007) 499-509
13. Lecanu L., Yao W., Piechot A., Greeson J., Tzalis D., and Papadopoulos V. Identification, design, synthesis, and pharmacological activity of (4-ethyl-piperazin-1-yl)-phenylmethanone derivatives with neuroprotective properties against beta-amyloid-induced toxicity. Neuropharmacology 49 (2005) 86-96
14. Lee S.Y., Ha T.Y., Son D.J., Kim S.R., and Hong J.T. Effect of sesaminol glucosides on beta-amyloid-induced PC12 cell death through antioxidant mechanisms. Neurosci. Res. 52 (2005) 330-341
15. + channels in Ginsenoside-induced aortic relaxation in rats. J. Cardiovasc. Pharmacol. 37 (2001) 41-47
16. Liao B., Newmark H., and Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp. Neurol. 173 (2002) 224-234
17. Massieu L., Morán J., and Christen Y. Effect of Ginkgo biloba (EGb 761) on staurosporine-induced neuronal death and caspase activity in cortical cultured neurons. Brain Res. 1002 (2004) 76-85
18. Morais Cardoso S., Swerdlow R.H., and Oliveira C.R. Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. Brain Res. 931 (2002) 117-125
19. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
20. Murayama K.S., Kametani F., Tabira T., and Araki W. A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein. J. Neurosci. Methods 161 (2007) 244-249
21. Nilsen J., Chen S., Irwin R.W., Iwamoto S., and Brinton R.D. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. BMC Neurosci. 7 (2006) 74
22. Park E.K., Choo M.K., Oh J.K., Ryu J.H., and Kim D.H. Ginsenoside Rh2 reduces ischemic brain injury in rats. Biol. Pharm. Bull. 27 (2004) 433-436
23. Park H.Y., Park J.I., Baek D.W., Lee S.Y., Lee M.J., Jin J.O., Kim J.W., Hong Y.S., Lee Y.H., and Kwak J.Y. Modulation of neutrophil apoptosis by beta-amyloid proteins. Int. Immunopharmacol. 6 (2006) 1061-1069
24. Pereira C., Agostinho P., Moreira P.I., Cardoso S.M., and Oliveira C.R. Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies. Curr. Drug Targets CNS Neurol. Disord. 4 (2005) 383-403
25. Shen L., and Zhang J. NMDA receptor and iNOS are involved in the effects of ginsenoside Rg1 on hippocampal neurogenesis in ischemic gerbils. Neurol. Res. 29 (2007) 270-273
26. Takeda K., Araki W., Akiyama H., and Tabira T. Amino-truncated amyloid beta peptide (A beta 5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. FASEB J. 18 (2004) 1755-1757
27. Takuma H., Tomiyama T., Kuida K., and Mori H. Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo. J. Neuropathol. Exp. Neurol. 63 (2004) 255-261
28. Vassar R. beta-Secretase, APP and Abeta in Alzheimer's disease. Subcell Biochem. 38 (2005) 79-103
29. Zou H., Li Y., Liu X., and Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274 (1999) 11549-11556