Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocytes primary culture

Journal of Ethnopharmacology

Volumn 112, Issue 2, 2007, Pages 262-270

  Naval, M V ^a   Gomez Serranillos M P ^a   Carretero, M E ^a   Villar, A M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antioxidants; Astrocytes; Ginseng; Ginsenosides; Hydrogen peroxide; Primary culture

Indexed keywords

CATALASE; GINSENG EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GINSENG; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATION REDUCTION REACTION; PLANT ROOT; RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; ASCORBIC ACID; ASTROCYTES; BIOLOGICAL TRANSPORT, ACTIVE; CELL SURVIVAL; CELLS, CULTURED; GLUCOSE; GLUTATHIONE; HYDROGEN PEROXIDE; LACTIC ACID; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; OXIDANTS; OXIDATIVE STRESS; PANAX; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

PANAX GINSENG; RATTUS;

EID: 34248578982     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.03.010     Document Type: Article

References (46)

1. Aebi H. Catalase in vivo. Methods in Enzymology 121 (1984) 121-126
2. Attele A.S., Wu J.A., and Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology 58 (1999) 1685-1693
3. Barja G., Pérez-Campo R., and López-Torres M. Antioxidant defenses and peroxidation in liver and brain of aged rats. Biochemical Journal 272 (1990) 247-250
4. Bastianetto S., and Quirion R. Natural extracts as possible protective agents of brain aging. Neurobiology of Aging 23 (2002) 891-897
5. Braughler J.M., Chase R.L., Neff G.L., Yonkers P.A., Day J.S., and Hall E.D. A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells. Journal of Pharmacology and Experimental Therapeutics 244 (1988) 423-427
6. Carter W.O., Narayanan P.K., and Robinson J.P. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. Journal of Leukocyte Biology 55 (1994) 253-258
7. Chang M.S., Lee S.G., and Rho H.M. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytotherapy Research 13 (1999) 641-644
8. Chen X.C., Chen Y., Zhu Y.G., Fang F., and Chen L.M. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacologica Sinica 23 (2002) 829-834
9. Chen C.X., Gui Z.Y., An Z.L., Chen H., Ying C., and Min C.L. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. European Journal of Pharmacology 473 (2003) 1-7
10. Chen X., Li Y.J., Deng H.W., Yang B.C., Li D.Y., and Shen N. Protective effects of ginsenosides on anoxia/reoxygenation of cultured rat myocytes and on reperfusion injuries against lipid peroxidation. Biomedica Biochimica Acta 46 (1987) S646-S649
11. Ehrhart J., and Zeevalk G.D. Hydrogen peroxide removal and glutathione mixed disulfide formation during metabolic inhibition in mesencephalic cultures. Journal of Neurochemistry 77 (2001) 1496-1507
12. Facino R.M., Carini M., Aldini G., Berti F., and Rossoni G. Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence for an antioxidant intervention. Planta Medica 65 (1999) 614-619
13. Ferger B., Rose S., Jenner A., Halliwell B., and Jenner P. 6-Hydroxydopamine increases hydroxyl free radical production and DNA damage in rat striatum. NeuroReport 12 (2001) 1155-1159
14. Fridovich I. Biological effects of the superoxide radical. Archives of Biochemistry and Biophysics 247 (1986) 1-11
15. Furuta A., Price D.L., Pardo C.A., Troncoso J.C., Xu Z.S., Taniguchi N., and Martin L.J. Localization of superoxide dismutases in Alxheimer's disease and Down's syndrome neocortex and hippocampus. American Journal of Pathology 146 (1995) 357-367
16. Gong Y.S., and Zhang J.T. Effect of 17-beta-estradiol and ginsenoside Rg1 on reactive microglia induced by beta-amyloid peptides. Journal of Asian Natural Products Research 1 (1999) 153-161
17. Himi T., Saito H., and Nishiyama N. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chemical and Pharmaceutical Bulletin 37 (1989) 481-484
18. Hissin P.J., and Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Analytical Biochemistry 74 (1976) 214-226
19. Huong N., Matsumoto K., Kasai R., Yamasaki K., and Watanabe H. In vitro antioxidant activity of Vietnamese ginseng saponin and its components. Biological and Pharmaceutical Bulletin 21 (1998) 978-981
20. Kim E.H., Jang M.H., Shin M.C., Shin M.S., and Kim C.J. Protective effect of aqueous extract of Ginseng radix against 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 cells. Biological and Pharmaceutical Bulletin 26 (2003) 1668-1673
21. Kim H.S., Zhang Y.H., Fang L.H., and Lee M.K. Effects of ginsenosides on bovine adrenal tyrosine hydroxylase. Journal of Ethnopharmacology 66 (1999) 107-111
22. Kim Y.K., Guo Q., and Packer L. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology 172 (2002) 149-156
23. Kitts D.D., Wijewickreme A.N., and Hu C. Antioxidant properties of a North American ginseng extract. Molecular and Cellular Biochemistry 203 (2000) 1-10
24. Lee J.Y., Kim J.W., Cho S.D., Kim Y.H., Choi K.J., Joo W.H., Cho Y.K., and Moon J.Y. Protective effect of ginseng extract against apoptotic cell death induced by 2,2′,5,5′-tetrachlorobiphenyl in neuronal SK-N-MC cells. Life Sciences 75 (2004) 1621-1634
25. Li J., Huang M., Teoh H., and Man R.Y. Panax quinquefolium saponins protects low density lipoproteins from oxidation. Life Science 64 (1999) 53-62
26. Lian X.Y., Zhang Z., and Stringer J.L. Protective effects of ginseng components in a rodent model of neurodegeneration. Annals of Neurology 57 (2005) 642-648
27. Liao B., Newmark H., and Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Experimental Neurology 173 (2002) 224-234
28. Liu X.-H., Kato H., Nakata N., Kogure K., and Kato K. An immunohistochemical study of copper/zinc superoxide dismutase and manganese superoxide dismutase in rat hippocampus after transient cerebral ischemia. Brain Research 625 (1993) 29-37
29. Marklund S.L., and Marklund G. Involvement of the superoxide anion radical in the autoxidation of pirogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry 47 (1974) 469-474
30. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65 (1983) 55-63
31. Nassi-Calo L., Mello-Filho C., and Meneghini R. o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation. Carcinogenesis 10 (1989) 1055-1057
32. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of Laboratory and Clinical Medicine 70 (1967) 158-169
33. Pantopoulos K., Mueller S., Atzberger A., Ansorge W., Stremmel W., and Hentze M.W. Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress. Journal of Biological Chemistry 272 (1997) 9802-9808
34. Radad K., Gille G., Liu L., and Rausch W.D. Use of ginseng in medicine with emphasis on neurodegenerative disorders. Journal of Pharmacological Sciences 100 (2006) 175-186
35. a edición, 2005. Agencia Española del Medicamento, Ministerio de Sanidad y Consumo, Madrid, España, pp. 1512-1513.
36. 1. Planta Medica 67 (2001) 533-537
37. Sagara J., Makino N., and Bannai S. Glutatione efflux from cultured astrocytes. Journal of Neurochemistry 66 (1996) 1876-1881
38. Seong Y.H., Shin C.S., Kim H.S., and Baba A. Inhibitory effects of ginseng total saponins on glutamate-induced swelling of cultured astrocytes. Biological and Pharmaceutical Bulletin 18 (1995) 1776-1778
39. Shah Z.A., Gilani R.A., Sharma P., and Vohora S.B. Cerebroprotective effect of Korean ginseng tea against global and focal models of ischemia in rats. Journal of Ethnopharmacology 101 (2005) 299-307
40. Shao Z.H., Xie J.T., Vanden Hoek T.L., Mehendale S., Aung H., Li C.-Q., Qin Y., Shumacker P.T., Becker L.B., and Yuan C.-S. Antioxidant effects of American ginseng berry in cardiomyocites exposed to acute oxidant stress. Biochimica et Biophysica Acta 1670 (2004) 165-171
41. Shin H.R., Kim J.Y., Yun T.K., Morgan G., and Vainio H. The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 11 (2000) 565-576
42. Tang W., and Eisenbrand G. Chinese Drugs of Plant Origin (1992), Springer-Verlag, Berlin pp. 711-737
43. Voces J., Álvarez A.I., Vila L., Ferrando A., Cabral de Oliveira C., and Prieto J.G. Effects of administration of the standarized Panax ginseng extract G115 on hepatic antioxidant function after exhaustive exercise. Comparative Biochemistry and Physiology Part C 123 (1999) 175-184
44. Wang H., and Joseph J. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radical Biology and Medicine 27 (1999) 612-616
45. Wang L.C.H., Wang B., Ng S.-Y., and Lee T.-F. Effects of ginseng saponins on beta-amyloid-induced amnesia in rats. Journal of Ethnopharmacology 103 (2006) 103-108
46. Wilson J.X. Antioxidant defense of the brain: a role for astrocytes. Canadian Journal of Physiology and Pharmacology 75 (1997) 1149-1163