Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production

Neurochemistry International

Volumn 57, Issue 3, 2010, Pages 206-215

  Liu, Wen Bo ^a   Zhou, Jun ^a,b   Qu, Yan ^a   Li, Xia ^a   Lu, Cheng Tao ^a   Xie, Ke Liang ^c   Sun, Xiao Li ^a   Fei, Zhou ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Urumqi General Hospital   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; MPP+; Osthole; PC12 cells; ROS

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CASPASE 3; CYTOCHROME C; LACTATE DEHYDROGENASE; OSTHOLE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; CASPASE; COUMARIN DERIVATIVE; MESSENGER RNA; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG STRUCTURE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MITOCHONDRIAL MYOPATHY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CELL NUCLEUS; CELL SURVIVAL; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; MEMBRANE POTENTIAL; METABOLISM; MITOCHONDRION; MPTP POISONING; PATHOLOGY; PC12 CELL LINE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL NUCLEUS; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROMES C; DNA FRAGMENTATION; FLOW CYTOMETRY; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIALS; MITOCHONDRIA; MPTP POISONING; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

CNIDIUM MONNIERI; RATTUS;

EID: 77955092871     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.05.011     Document Type: Article

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