Catalytic proficiency of ubiquitin conjugation enzymes: Balancing p k a suppression, entropy, and electrostatics

Journal of the American Chemical Society

Volumn 132, Issue 50, 2010, Pages 17775-17786

  Markin, Craig J ^a   Saltibus, Linda F ^a   Kean, Melissa J ^a   McKay, Ryan T ^a   Xiao, Wei ^b   Spyracopoulos, Leo ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; AMIDE BOND; BIOCHEMICAL ASSAY; BIOLOGICAL ORGANISMS; ELECTROSTATIC EFFECT; ENTROPIC EFFECTS; ENZYME ACTIVE SITES; EXTERNAL STIMULUS; FUNCTIONAL DIVERSITY; LYSINE AMINO GROUPS; MOLECULAR MECHANISM; POLYUBIQUITIN; POLYUBIQUITINATION; PROFICIENT ENZYMES; PROTEIN-PROTEIN INTERACTION NETWORKS; PROTEIN-PROTEIN INTERACTIONS; RATE ENHANCEMENT; SUBSTRATE AFFINITY; TARGET PROTEINS; TEMPORAL FLUCTUATION; THIOESTER GROUP; TRANSITION STATE; UBIQUITIN; UBIQUITINATION;

AMIDES; AMINO ACIDS; CATALYSIS; CATALYSTS; COORDINATION REACTIONS; ELECTROSTATICS; ENTROPY; REACTION RATES; SYNTHESIS (CHEMICAL);

ENZYMES;

HETERODIMER; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME 13; UBIQUITIN CONJUGATING ENZYME E2; WATER;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENTROPY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; PKA; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; UBIQUITINATION;

CATALYSIS; ENTROPY; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STATIC ELECTRICITY; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION; WATER;

EID: 78650260963     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja105267w     Document Type: Article

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