The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway

Toxicology in Vitro

Volumn 22, Issue 7, 2008, Pages 1671-1680

  Ayed Boussema, Imen ^a   Bouaziz, Chayma ^a   Rjiba, Karima ^a   Valenti, Kita ^b   Laporte, François ^b   Bacha, Hassen ^a   Hassen, Wafa ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Apoptosis; Gene expression; Mitochondrial pathway; Mycotoxin; Zearalenone

Indexed keywords

ATM PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA; DOUBLE STRANDED DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; IODINE DERIVATIVE; MYCOTOXIN; PROTEIN BAX; PROTEIN P53; ZEARALENONE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LIVER CELL; LIVER CELL CARCINOMA; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MULTIGENE FAMILY; NITROBLUE TETRAZOLIUM TEST; PROTEIN SECRETION; PROTEIN STABILITY; STRESS; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DNA BREAKS, DOUBLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; ZEARALENONE;

EID: 51949119422     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.06.016     Document Type: Article

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