In Vitro cytochrome P450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities: Possible occurrence of this metabolite in Vivo

International Journal of Molecular Sciences

Volumn 10, Issue 4, 2009, Pages 1824-1837

  Bravin, Frederique ^a   Duca, Radu C ^a   Balaguer, Patrick ^b,c,d   Delaforge, Marcel ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^c UNIV MONTPELLIER   (France)

^d CENTRE VAL D AURELLE   (France)

Author keywords

Cytochrome P450; Estrogenic activities; Human; Hydroxy metabolites; Zearalenone

Indexed keywords

ALPHA ZEARALENOL; BETA ZEARALENOL; CYTOCHROME P450; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ZEARALENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLISM; MICROSOME; MOUSE; NONHUMAN; RAT; TOXICOKINETICS;

CYTOCHROME P450; ESTROGENIC ACTIVITIES; HUMAN; HYDROXY-METABOLITES; ZEARALENONE;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HELA CELLS; HUMANS; HYDROXYLATION; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, ANIMAL; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; ZEARALENONE;

ANIMALIA; RATTUS;

EID: 67149096039     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms10041824     Document Type: Article

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