Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS)

Sleep and Breathing

Volumn 14, Issue 3, 2010, Pages 261-269

  Quercioli, Alessandra ^a   Mach, François ^a   Montecucco, Fabrizio ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Atherosclerosis; Inflammation; Obstructive sleep apnea syndrome; Oxidative stress

Indexed keywords

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; HUMAN; INFLAMMATION; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SLEEP APNEA SYNDROME;

ANOXIA; ATHEROSCLEROSIS; CYTOKINES; DISEASE PROGRESSION; HUMANS; INFLAMMATION; LEPTIN; OXIDATIVE STRESS; PLATELET AGGREGATION; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE;

EID: 78650188288     PISSN: 15209512     EISSN: 15221709     Source Type: Journal    
DOI: 10.1007/s11325-010-0338-3     Document Type: Article

References (163)

1. Shamsuzzaman AS, Gersh BJ, Somers VK (2003) Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA 290:1906-1914
2. Phillipson EA (1993) Sleep apnea-a major public health problem. N Engl J Med 328:1271-1273
3. Yamauchi M, Kimura H (2008) Oxidative stress in obstructive sleep apnea: putative pathways to the cardiovascular complications. Antioxid Redox Signal 10:755-768
4. Ryan S, McNicholas WT (2008) Intermittent hypoxia and activation of inflammatory molecular pathways in OSAS. Arch Physiol Biochem 114:261-266
5. McNicholas WT (2009) Obstructive sleep apnea and inflammation. Prog Cardiovasc Dis 51:392-399
6. Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline S, Resnick HE, Robbins JA, Shahar E, Unruh ML, Samet JM (2009) Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med 6: e1000132
7. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering TG (2000) Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283:1829-1836
8. Logan AG, Perlikowski SM, Mente A, Tisler A, Tkacova R, Niroumand M, Leung RS, Bradley TD (2001) High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens 19:2271-2277
9. Munoz R, Duran-Cantolla J, Martinez-Vila E, Gallego J, Rubio R, Aizpuru F, De La Torre G (2006) Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke 37:2317-2321
10. Yaggi H, Mohsenin V (2004) Obstructive sleep apnoea and stroke. Lancet Neurol 3:333-342
11. Portela PC, Fumado JC, Garcia HQ, Borrego FR (2009) Sleepdisordered breathing and acute stroke. Cerebrovasc Dis 27 (Suppl 1):104-110
12. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V (2005) Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353:2034-2041
13. Peker Y, Hedner J, Kraiczi H, Loth S (2000) Respiratory disturbance index: an independent predictor of mortality in coronary artery disease. Am J Respir Crit Care Med 162:81-86
14. Hung J, Whitford EG, Parsons RW, Hillman DR (1990) Association of sleep apnoea with myocardial infarction in men. Lancet 336:261-264
15. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, O'Connor GT, Boland LL, Schwartz JE, Samet JM (2001) Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the sleep heart health study. Am J Respir Crit Care Med 163:19-25
16. Marin JM, Carrizo SJ, Vicente E, Agusti AG (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365:1046-1053
17. Sajkov D, Cowie RJ, Thornton AT, Espinoza HA, McEvoy RD (1994) Pulmonary hypertension and hypoxemia in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 149:416-422
18. Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, Stubbs R, Hla KM (2008) Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 31:1071-1078
19. Dyken ME, Somers VK, Yamada T, Ren ZY, Zimmerman MB (1996) Investigating the relationship between stroke and obstructive sleep apnea. Stroke 27:401-407
20. Peppard PE, Young T, Palta M, Skatrud J (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378-1384
21. Lorenzi-Filho G, Drager LF (2007) Obstructive sleep apnea and atherosclerosis: a new paradigm. Am J Respir Crit Care Med 175:1219-1221
22. Kyzer S, Charuzi I (1998) Obstructive sleep apnea in the obese. World J Surg 22:998-1001
23. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230-1235
24. Flemons WW (2002) Clinical practice. Obstructive sleep apnea. N Engl J Med 347:498-504
25. Wysocka E, Cofta S, Cymerys M, Gozdzik J, Torlinski L, Batura-Gabryel H (2008) The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients. J Physiol Pharmacol 59 (Suppl 6):761-769
26. Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165:1217-1239
27. He J, Kryger MH, Zorick FJ, Conway W, Roth T (1988) Mortality and apnea index in obstructive sleep apnea. Experience in 385 male patients. Chest 94:9-14
28. Partinen M, Jamieson A, Guilleminault C (1998) Long-term outcome for obstructive sleep apnea syndrome patients. Mortality Chest 94:1200-1204
29. Marshall NS, Wong KK, Liu PY, Cullen SR, Knuiman MW, Grunstein RR (2008) Sleep apnea as an independent risk factor for all-cause mortality: the Busselton health study. Sleep 31:1079-1085
30. Doherty LS, Kiely JL, Swan V, McNicholas WT (2005) Longterm effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome. Chest 127:2076-2084
31. Peker Y, Kraiczi H, Hedner J, Loth S, Johansson A, Bende M (1999) An independent association between obstructive sleep apnoea and coronary artery disease. Eur Respir J 14:179-184
32. Mooe T, Franklin KA, Holmstrom K, Rabben T, Wiklund U (2001) Sleep-disordered breathing and coronary artery disease: long-term prognosis. Am J Respir Crit Care Med 164:1910-1913
33. Yumino D, Tsurumi Y, Takagi A, Suzuki K, Kasanuki H (2007) Impact of obstructive sleep apnea on clinical and angiographic outcomes following percutaneous coronary intervention in patients with acute coronary syndrome. Am J Cardiol 99:26-30
34. Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G (2005) Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 172:613-618
35. Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Tanaka A, Oda N, Okada S, Ohta S, Naito H, Adachi M (2005) Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea. Am J Respir Crit Care Med 172:625-630
36. Baguet JP, Hammer L, Levy P, Pierre H, Launois S, Mallion JM, Pepin JL (2005) The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest 128:3407-3412
37. Drager LF, Bortolotto LA, Figueiredo AC, Silva BC, Krieger EM, Lorenzi-Filho G (2007) Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling. Chest 131:1379-1386
38. Guilleminault C, Simmons FB, Motta J, Cummiskey J, Rosekind M, Schroeder JS, Dement WC (1981) Obstructive sleep apnea syndrome and tracheostomy. Long-term follow-up experience. Arch Intern Med 141:985-988
39. Kales A, Bixler EO, Cadieux RJ, Schneck DW, Shaw LC 3rd, Locke TW, Vela-Bueno A, Soldatos CR (1984) Sleep apnoea in a hypertensive population. Lancet 2:1005-1008
40. Fletcher EC, DeBehnke RD, Lovoi MS, Gorin AB (1985) Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med 103:190-195
41. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Leiby BE, Vela-Bueno A, Kales A (2000) Association of hypertension and sleepdisordered breathing. Arch Intern Med 160:2289-2295
42. Parish JM, Somers VK (2004) Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc 79:1036-1046
43. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N, Mullins R, Jenkinson C, Stradling JR, Davies RJ (2002) Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet 359:204-210
44. Faccenda JF, Mackay TW, Boon NA, Douglas NJ (2001) Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. Am J Respir Crit Care Med 163:344-348
45. Becker HF, Jerrentrup A, Ploch T, Grote L, Penzel T, Sullivan CE, Peter JH (2003) Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 107:68-73
46. Campos-Rodriguez F, Grilo-Reina A, Perez-Ronchel J, Merino-Sanchez M, Gonzalez-Benitez MA, Beltran-Robles M, Almeida-Gonzalez C (2006) Effect of continuous positive airway pressure on ambulatory BP in patients with sleep apnea and hypertension: a placebo-controlled trial. Chest 129:1459-1467
47. Good DC, Henkle JQ, Gelber D, Welsh J, Verhulst S (1996) Sleep-disordered breathing and poor functional outcome after stroke. Stroke 27:252-259
48. Guilleminault C, Connolly SJ, Winkle RA (1983) Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 52:490-494
49. Shepard JW Jr, Garrison MW, Grither DA, Dolan GF (1985) Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. Chest 88:335-340
50. Weitzenblum E, Krieger J, Apprill M, Vallee E, Ehrhart M, Ratomaharo J, Oswald M, Kurtz D (1988) Daytime pulmonary hypertension in patients with obstructive sleep apnea syndrome. Am Rev Respir Dis 138:345-349
51. Sanner BM, Doberauer C, Konermann M, Sturm A, Zidek W (1997) Pulmonary hypertension in patients with obstructive sleep apnea syndrome. Arch Intern Med 157:2483-2487
52. Alchanatis M, Tourkohoriti G, Kakouros S, Kosmas E, Podaras S, Jordanoglou JB (2001) Daytime pulmonary hypertension in patients with obstructive sleep apnea: the effect of continuous positive airway pressure on pulmonary hemodynamics. Respiration 68:566-572
53. Malone S, Liu PP, Holloway R, Rutherford R, Xie A, Bradley TD (1991) Obstructive sleep apnoea in patients with dilated cardiomyopathy: effects of continuous positive airway pressure. Lancet 338:1480-1484
54. Naughton MT (1998) Impact of treatment of sleep apnoea on left ventricular function in congestive heart failure. Thorax 53 (Suppl 3): S37-S40
55. Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, Somers VK (2002) Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 105:2462-2464
56. Minoguchi K, Tazaki T, Yokoe T, Minoguchi H, Watanabe Y, Yamamoto M, Adachi M (2004) Elevated production of tumor necrosis factor-alpha by monocytes in patients with obstructive sleep apnea syndrome. Chest 126:1473-1479
57. Ryan S, Taylor CT, McNicholas WT (2006) Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 174:824-830
58. Yokoe T, Minoguchi K, Matsuo H, Oda N, Minoguchi H, Yoshino G, Hirano T, Adachi M (2003) Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation 107:1129-1134
59. Dean RT, Wilcox I (1993) Possible atherogenic effects of hypoxia during obstructive sleep apnea. Sleep 16: S15: S1515-S21
60. Hatipoglu U, Rubinstein I (2003) Inflammation and obstructive sleep apnea syndrome pathogenesis: a working hypothesis. Respiration 70:665-671
61. Lattimore JD, Celermajer DS, Wilcox I (2003) Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol 41:1429-1437
62. Lavie L (2003) Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med Rev 7:35-51
63. Asehnoune K, Strassheim D, Mitra S, Kim JY, Abraham E (2004) Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol 172:2522-2529
64. Christou K, Markoulis N, Moulas AN, Pastaka C, Gourgoulianis KI (2003) Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients. Sleep Breath 7:105-110
65. Suzuki YJ, Jain V, Park AM, Day RM (2006) Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med 40:1683-1692
66. Barcelo A, Miralles C, Barbe F, Vila M, Pons S, Agusti AG (2000) Abnormal lipid peroxidation in patients with sleep apnoea. Eur Respir J 16:644-647
67. Lavie L, Vishnevsky A, Lavie P (2004) Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 27:123-128
68. Carpagnano GE, Kharitonov SA, Resta O, Foschino-Barbaro MP, Gramiccioni E, Barnes PJ (2003) 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. Chest 124:1386-1392
69. Minoguchi K, Yokoe T, Tanaka A, Ohta S, Hirano T, Yoshino G, O'Donnell CP, Adachi M (2006) Association between lipid peroxidation and inflammation in obstructive sleep apnoea. Eur Respir J 28:378-385
70. Schulz R, Mahmoudi S, Hattar K, Sibelius U, Olschewski H, Mayer K, Seeger W, Grimminger F (2000) Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy. Am J Respir Crit Care Med 162:566-570
71. Yamamoto H, Teramoto S, Yamaguchi Y, Ouchi Y (2007) Effect of nasal continuous positive airway pressure treatment on plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome: roles of nocturnal hypoxia and oxidant stress. Hypertens Res 30:1065-1076
72. Ryan S, Taylor CT, McNicholas WT (2005) Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112:2660-2667
73. Greenberg H, Ye X, Wilson D, Htoo AK, Hendersen T, Liu SF (2006) Chronic intermittent hypoxia activates nuclear factorkappaB in cardiovascular tissues in vivo. Biochem Biophys Res Commun 343:591-596
74. Ayas NT, Mancini GB, Fleetham J (2006) Does CPAP delay the development of cardiovascular disease in patients with obstructive sleep apnoea hypopnoea? Thorax 61:459-460
75. Htoo AK, Greenberg H, Tongia S, Chen G, Henderson T, Wilson D, Liu SF (2006) Activation of nuclear factor kappaB in obstructive sleep apnea: a pathway leading to systemic inflammation. Sleep Breath 10:43-50
76. Alzoghaibi MA, Bahammam AS (2005) Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: a pilot study. Sleep Breath 9:119-126
77. Yamauchi M, Tamaki S, Tomoda K, Yoshikawa M, Fukuoka A, Makinodan K, Koyama N, Suzuki T, Kimura H (2006) Evidence for activation of nuclear factor kappaB in obstructive sleep apnea. Sleep Breath 10:189-193
78. Feng J, Chen BY, Cui LY, Wang BL, Liu CX, Chen PF, Guo MN, Dong LX, Li S (2009) Inflammation status of rabbit carotid artery model endothelium during intermittent hypoxia exposure and its relationship with leptin. Sleep Breath 13:277-283
79. Schofield CJ, Ratcliffe PJ (2004) Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5:343-354
80. Schulz R, Hummel C, Heinemann S, Seeger W, Grimminger F (2002) Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia. Am J Respir Crit Care Med 165:67-70
81. Phillips BG, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME, Somers VK (1999) Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 17:61-66
82. Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL (2005) Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105:659-669
83. Semenza G (2000) Oxygen-regulated transcription factors and their role in pulmonary disease. Respir Res 1:159-162
84. Gjorup PH, Sadauskiene L, Wessels J, Nyvad O, Strunge B, Pedersen EB (2007) Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Am J Hypertens 20:44-52
85. Saarelainen S, Seppala E, Laasonen K, Hasan J (1997) Circulating endothelin-1 in obstructive sleep apnea. Endothelium 5:115-118
86. Imagawa S, Yamaguchi Y, Higuchi M, Neichi T, Hasegawa Y, Mukai HY, Suzuki N, Yamamoto M, Nagasawa T (2001) Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome. Blood 98:1255-1257
87. Lavie L, Kraiczi H, Hefetz A, Ghandour H, Perelman A, Hedner J, Lavie P (2002) Plasma vascular endothelial growth factor in sleep apnea syndrome: effects of nasal continuous positive air pressure treatment. Am J Respir Crit Care Med 165:1624-1628
88. Moldofsky H, Lue FA, Eisen J, Keystone E, Gorczynski RM (1986) The relationship of interleukin-1 and immune functions to sleep in humans. Psychosom Med 48:309-318
89. Krueger JM, Obal F Jr (1994) In: Saunders NA, Sullivan CE (eds) Sleep factors. Sleep and breathing. Marcel Dekker, New York, pp 79-112
90. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP (1997) Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab 82:1313-1316
91. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, Kales A, Chrousos GP (2000) Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 85:1151-1158
92. Steiropoulos P, Kotsianidis I, Nena E, Tsara V, Gounari E, Hatzizisi O, Kyriazis G, Christaki P, Froudarakis M, Bouros D (2009) Long-term effect of continuous positive airway pressure therapy on inflammation markers of patients with obstructive sleep apnea syndrome. Sleep 32:537-543
93. Entzian P, Linnemann K, Schlaak M, Zabel P (1996) Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 153:1080-1086
94. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82:4196-4200
95. Heinrich PC, Castell JV, Andus T (1990) Interleukin-6 and the acute phase response. Biochem J 265:621-636
96. Kobayashi K, Nishimura Y, Shimada T, Yoshimura S, Funada Y, Satouchi M, Yokoyama M (2006) Effect of continuous positive airway pressure on soluble CD40 ligand in patients with obstructive sleep apnea syndrome. Chest 129:632-637
97. Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G, Chrousos GP (2004) Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist. J Clin Endocrinol Metab 89:4409-4413
98. Ueda K, Takahashi M, Ozawa K, Kinoshita M (1999) Decreased soluble interleukin-6 receptor in patients with acute myocardial infarction. Am Heart J 138:908-915
99. Al Lawati N, Mulgrew A, Cheema R, Vaneeden S, Butt A, Fleetham J, Ryan F, Ayas N (2009) Pro-atherogenic cytokine profile of patients with suspected obstructive sleep apnea. Sleep Breath 13:391-395
100. Zhang X, Liu RY, Lei Z, Zhu Y, Huang JA, Jiang X, Liu Z, Liu X, Peng X, Hu H, Zhang HT (2009) Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome. Int J Mol Med 23:485-493
101. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131-2135
102. Can M, Acikgoz S, Mungan G, Bayraktaroglu T, Kocak E, Guven B, Demirtas S (2006) Serum cardiovascular risk factors in obstructive sleep apnea. Chest 129:233-237
103. Hayashi M, Fujimoto K, Urushibata K, Takamizawa A, Kinoshita O, Kubo K (2006) Hypoxia-sensitive molecules may modulate the development of atherosclerosis in sleep apnoea syndrome. Respirology 11:24-31
104. Larkin EK, Rosen CL, Kirchner HL, Storfer-Isser A, Emancipator JL, Johnson NL, Zambito AM, Tracy RP, Jenny NS, Redline S (2005) Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration. Circulation 111:1978-1984
105. Tauman R, Ivanenko A, O'Brien LM, Gozal D (2004) Plasma C-reactive protein levels among children with sleep-disordered breathing. Pediatrics 113: e564-e569
106. Yao M, Tachibana N, Okura M, Ikeda A, Tanigawa T, Yamagishi K, Sato S, Shimamoto T, Iso H (2006) The relationship between sleep-disordered breathing and high-sensitivity C-reactive protein in Japanese men. Sleep 29:661-665
107. Zouaoui Boudjeltia K, Van Meerhaeghe A, Doumit S, Guillaume M, Cauchie P, Brohee D, Vanhaeverbeek M, Kerkhofs M (2006) Sleep apnoea-hypopnoea index is an independent predictor of highsensitivity C-reactive protein elevation. Respiration 73:243-246
108. Kokturk O, Ciftci TU, Mollarecep E, Ciftci B (2005) Elevated C-reactive protein levels and increased cardiovascular risk in patients with obstructive sleep apnea syndrome. Int Heart J 46:801-809
109. Punjabi NM, Beamer BA (2007) C-reactive protein is associated with sleep disordered breathing independent of adiposity. Sleep 30:29-34
110. Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K (2008) Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea. Lung 186:209-217
111. Chung S, Yoon IY, Lee CH, Kim JW (2010) The effects of nasal continuous positive airway pressure on vascular functions and serum cardiovascular risk factors in obstructive sleep apnea syndrome. Sleep Breath. doi:10.1007/s11325- 009-0323-x
112. Ryan S, Nolan GM, Hannigan E, Cunningham S, Taylor C, McNicholas WT (2007) Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity. Thorax 62:509-514
113. Guilleminault C, Kirisoglu C, Ohayon MM (2004) C-reactive protein and sleep-disordered breathing. Sleep 27:1507-1511
114. Kaditis AG, Alexopoulos EI, Kalampouka E, Kostadima E, Germenis A, Zintzaras E, Gourgoulianis K (2005) Morning levels of C-reactive protein in children with obstructive sleepdisordered breathing. Am J Respir Crit Care Med 171:282-286
115. Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E (2007) Correlates of serum C-reactive protein (CRP)-no association with sleep duration or sleep disordered breathing. Sleep 30:991-996
116. Kohler M, Ayers L, Pepperell JC, Packwood KL, Ferry B, Crosthwaite N, Craig S, Siccoli MM, Davies RJ, Stradling JR (2009) Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial. Thorax 64:67-73
117. Ohga E, Tomita T, Wada H, Yamamoto H, Nagase T, Ouchi Y (2003) Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol 94:179-184
118. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Luscinskas FW, Rosenzweig A (1999) MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398:718-723
119. Aukrust P, Yndestad A, Smith C, Ueland T, Gullestad L, Damås JK (2007) Chemokines in cardiovascular risk prediction. Thromb Haemost 97:748-754
120. Tazaki T, Minoguchi K, Yokoe T, Samson KT, Minoguchi H, Tanaka A, Watanabe Y, Adachi M (2004) Increased levels and activity of matrix metalloproteinase-9 in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 170:1354-1359
121. Kuramoto E, Kinami S, Ishida Y, Shiotani H, Nishimura Y (2009) Continuous positive nasal airway pressure decreases levels of serum amyloid A and improves autonomic function in obstructive sleep apnea syndrome. Int J Cardiol 135:338-345
122. Klein S, Coppack SW, Mohamed-Ali V, Landt M (1996) Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45:984-987
123. Schwartz MW, Seeley RJ (1997) Seminars in medicine of the Beth Israel Deaconess Medical Center. Neuroendocrine responses to starvation and weight loss. N Engl J Med 336:1802-1811
124. Münzberg H, Björnholm M, Bates SH, Myers MG Jr (2005) Leptin receptor action and mechanisms of leptin resistance. Cell Mol Life Sci 62:642-652
125. Cinaz P, Bideci A, Camurdan MO, Güven A, Gönen S (2005) Leptin and soluble leptin receptor levels in obese children in fasting and satiety states. J Pediatr Endocrinol Metab 18:303-307
126. Grosfeld A, Andre J, Hauguel-De Mouzon S, Berra E, Pouyssegur J, Guerre-Millo M (2002) Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem 277:42953-42957
127. Meissner U, Hänisch C, Ostreicher I, Knerr I, Hofbauer KH, Blum WF, Allabauer I, Rascher W, Dötsch J (2005) Differential regulation of leptin synthesis in rats during short-term hypoxia and short-term carbon monoxide inhalation. Endocrinology 146:215-220
128. Finck BN, Johnson RW (2000) Tumor necrosis factor-alpha regulates secretion of the adipocyte-derived cytokine, leptin. Microsc Res Tech 50:209-215
129. Phillips BG, Kato M, Narkiewicz K, Choe I, Somers VK (2000) Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea. Am J Physiol Heart Circ Physiol 279: H234-H237
130. Chin K, Shimizu K, Nakamura T, Narai N, Masuzaki H, Ogawa Y, Mishima M, Nakamura T, Nakao K, Ohi M (1999) Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 100:706-712
131. Ozturk L, Unal M, Tamer L, Celikoglu F (2003) The association of the severity of obstructive sleep apnea with plasma leptin levels. Arch Otolaryngol Head Neck Surg 129:538-540
132. Tokuda F, Sando Y, Matsui H, Koike H, Yokoyama T (2008) Serum levels of adipocytokines, adiponectin and leptin, in patients with obstructive sleep apnea syndrome. Intern Med 47:1843-1849
133. Ip MS, Lam KS, Ho C, Tsang KW, Lam W (2000) Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 118:580-586
134. Schafer H, Pauleit D, Sudhop T, Gouni-Berthold I, Ewig S, Berthold HK (2002) Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea. Chest 122:829-839
135. Sanner BM, Kollhosser P, Buechner N, Zidek W, Tepel M (2004) Influence of treatment on leptin levels in patients with obstructive sleep apnoea. Eur Respir J 23:601-604
136. Barcelo A, Barbe F, Llompart E, de la Pena M, Duran-Cantolla J, Ladaria A, Bosch M, Guerra L, Agusti AG (2005) Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity. Am J Respir Crit Care Med 171:183-187
137. Harsch IA, Konturek PC, Koebnick C, Kuehnlein PP, Fuchs FS, Pour Schahin S, Wiest GH, Hahn EG, Lohmann T, Ficker JH (2003) Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. Eur Respir J 22:251-257
138. Townend J, O'Sullivan J, Wilde JT (1998) Hyperhomocysteinaemia and vascular disease. Blood Rev 12:23-34
139. Dudman NP, Hicks C, Lynch JF, Wilcken DE, Wang J (1991) Homocysteine thiolactone disposal by human arterial endothelial cells and serum in vitro. Arterioscler Thromb 11:663-670
140. Wall RT, Harlan JM, Harker LA, Striker GE (1980) Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res 18:113-121
141. Jamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, Loscalzo J (1993) Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 91:308-318
142. Kokturk O, Ciftci TU, Mollarecep E, Ciftci B (2006) Serum homocysteine levels and cardiovascular morbidity in obstructive sleep apnea syndrome. Respir Med 100:536-541
143. Jordan W, Berger C, Cohrs S, Rodenbeck A, Mayer G, Niedmann PD, von Ahsen N, Ruther E, Kornhuber J, Bleich S (2004) CPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome. J Neural Transm 111:683-689
144. Svatikova A, Wolk R, Magera MJ, Shamsuzzaman AS, Phillips BG, Somers VK (2004) Plasma homocysteine in obstructive sleep apnoea. Eur Heart J 25:1325-1329
145. Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165:670-676
146. Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, Smith PL (2002) Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 165:677-682
147. Makino S, Handa H, Suzukawa K, Fujiwara M, Nakamura M, Muraoka S, Takasago I, Tanaka Y, Hashimoto K, Sugimoto T (2006) Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance. Clin Endocrinol (Oxf) 64:12-19
148. Harsch IA, Wallaschofski H, Koebnick C, Pour Schahin S, Hahn EG, Ficker JH, Lohmann T (2004) Adiponectin in patients with obstructive sleep apnea syndrome: course and physiological relevance. Respiration 71:580-586
149. Masserini B, Morpurgo PS, Donadio F, Baldessari C, Bossi R, Beck-Peccoz P, Orsi E (2006) Reduced levels of adiponectin in sleep apnea syndrome. J Endocrinol Invest 29:700-705
150. Kanbay A, Kokturk O, Ciftci TU, Tavil Y, Bukan N (2008) Comparison of serum adiponectin and tumor necrosis factoralpha levels between patients with and without obstructive sleep apnea syndrome. Respiration 76:324-330
151. Aird WC (2007) Phenotypic heterogeneity of the endothelium: II. Representative vascular beds. Circ Res 100:174-190
152. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, Somers VK (2000) Impairment of endotheliumdependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 102:2607-2610
153. Carlson JT, Rangemark C, Hedner JA (1996) Attenuated endothelium- dependent vascular relaxation in patients with sleep apnoea. J Hypertens 14:577-584
154. Nieto FJ, Herrington DM, Redline S, Benjamin EJ, Robbins JA (2004) Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Med 169:354-360
155. Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC, Lam WK (2000) Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 162:2166-2171
156. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lucke C, Mayer K, Olschewski H, Seeger W, Grimminger F (2000) Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 55:1046-1051
157. Ohike Y, Kozaki K, Iijima K, Eto M, Kojima T, Ohga E, Santa T, Imai K, Hashimoto M, Yoshizumi M, Ouchi Y (2005) Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure-possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circ J 69:221-226
158. Atkeson A, Yeh SY, Malhotra A, Jelic S (2009) Endothelial function in obstructive sleep apnea. Prog Cardiovasc Dis 51:351-362
159. Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A (2004) Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol 27:223-227
160. Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM (2004) Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 43:678-683
161. Mausbach BT, Ancoli-Israel S, von Känel R, Patterson TL, Aschbacher K, Mills PJ, Ziegler MG, Dimsdale JE, Calleran S, Grant I (2006) Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease. Sleep 29:1347-1352
162. von Känel R, Loredo JS, Ancoli-Israel S, Mills PJ, Natarajan L, Dimsdale JE (2007) Association between polysomnographic measures of disrupted sleep and prothrombotic factors. Chest 131:733-739
163. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK (2004) Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 169:348-353