Tumor necrosis factor-α regulates secretion of the adipocyte-derived cytokine, Leptin

Microscopy Research and Technique

Volumn 50, Issue 3, 2000, Pages 209-215

  Finck, Brian N ^a   Johnson, Rodney W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cachexia; Endocrine immune; Food intake; Immunomodulation; Obesity

Indexed keywords

GLYCOPROTEINS; HORMONES; MOLECULAR WEIGHT; TUMORS;

ADIPOCYTES; CACHEXIA; CYTOKINES; ENDOCRINE-IMMUNE; FOOD INTAKE; HORMONE LEPTIN; IMMUNO MODULATIONS; LEPTINS; OBESITY; TUMOR NECROSIS FACTORS;

MACROPHAGES;

CYTOKINE; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; CACHEXIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENERGY EXPENDITURE; FOOD INTAKE; IMMUNOMODULATION; INFLAMMATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ANIMALIA;

EID: 0034254289     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0029(20000801)50:3<209::AID-JEMT4>3.0.CO;2-T     Document Type: Article

References (86)

1. Adi S, Pollock AS, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C. 1992. Role of monokines in the metabolic effects of endotoxin. J Clin Invest 89:1603-1609.
2. Arnalich F, Lopez J, Codoceo R, Jimnez M, Madero R, Montiel C. 1999. Relationship of plasma leptin to plasma cytokines and human survival in sepsis and septic shock. J Infect Dis 180:908-911.
3. Banks WA, Kastin AJ, Huant W, Jaspan JB, Maness LM. 1996. Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311.
4. Baumann H, Morella KK, White DW, Dembski MD, Bailon PS, Kim H, Lai C, Tartaglia LA. 1996. The full-length leptin receptor has signaling capabilities of interleukin-6-type cytokine receptors. Proc Natl Acad Sci USA 93:8374-8378.
5. Benigni F, Faggioni R, Sironi M, Fantuzzi G, Vandenabeele P, Nozomi T, Sacco S, Fiers W, Buurman WA, Ghezzi P. 1996. TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF. J Immunol 157:5563-5568.
6. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W. 1996. A role for leptin and its cognate receptor in hematopoiesis. Current Biology 6:1170-1180.
7. Beutler B, Cerami A. 1986. Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 320:584-88.
8. Beutler B, Greenwald D, Hulmes JD, Chang M, Pan YC, Mathison J, Ulevitch R, Cerami A. 1985a. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316:552-554.
9. Beutler B, Mahoney J, Le Trang N, Pekala P, Cerami A. 1985b. Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J Exp Med 161: 984-995.
10. Boden G, Chen X, Mozzoli M, Ryan I. 1996. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81:3419-3423.
11. Bornstein SR, Licinio J, Tauchnitz R, Engelmann L, Negrao AB, Gold P, Chrousos GP. 1998. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab 83:280-283.
12. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549.
13. Chance WT, Sheriff S, Moore J, Peng F, Balasubramaniam A. 1998. Reciprocal changes in hypothalamic receptor binding and circulating leptin in anorectic tumor-bearing rats. Brain Res 803:27-33.
14. Chandra RK. 1980. Cell-mediated immunity in genetically obese C57BL/6J ob/ob mice. Am J Clin Nutr 33:13-16.
15. Chen G, Koyam K, Yuan X, Lee Y, Zhou YT, O'Doherty R, Newgard CB, Unger RH. 1996. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 93:14795-14799.
16. Cioffi JA, Shafer AW, Zupancic TJ, Smith GJ, Mikhail A, Platika D, Snodgrass HR. 1996. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med 2:585-589.
17. Darnay BG, Aggarwal BB. 1997. Early events in TNF signaling: a story of associations and dissociations. J Leuk Biol 61:559-566.
18. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB. 1997. Leptin activates neurons in the ventrobasal hypothalamus and brainstem. Endocrinology 138:839-842.
19. Espat NJ, Auffenberg T, Rosenberg JJ, Rogy M, Martin D, Fang CH, Hasselgren PO, Copeland EM, Moldawer LL. 1996. Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am J Physiol 271:R185-R190.
20. Fain JN, Bahouth SW. 1998. Effect of tri-iodothyronine on leptin release and leptin mRNA accumulation in rat adipose tissue. Biochem J 332:361-366.
21. Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold KR, Grunfeld C. 1998. IL-1b mediates leptin induction during inflammation. Am J Physiol 274:R204-R208.
22. Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C. 1999. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276:R136-142.
23. Fernandez-Real JM, Gutierrez C, Ricart W, Casamitjana R, Fernandez-Castener M, Vendrell J, Richart C, Soler J. 1997. The TNF-α gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels. Diabetes 46:1468-1472.
24. Finck BN, Johnson RW. 2000. Tumor necrosis factor (TNF)-α induces leptin production through the p55 TNF receptor. Am J Phys 278: R537-R543.
25. Finck BN, Dantzer R, Kelley KW, Johnson RW. 1998. In vitro and in vivo evidence for the involvement of tumor necrosis factor-α in the induction of leptin by lipopolysaccharide. Endocrinology 139:2278-2283.
26. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. 1995. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med 1:1311-1314.
27. Fried SK, Zechner R. 1989. Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity. J Lipid Res 30:1917-1993.
28. Gainsford T, Wilson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ. 1996. Leptin can induce proliferation, differentiation, and functional activation of hematopoetic cells. Proc Natl Acad Sci USA 93:14564-14568.
29. Gottschling-Zeller H, Birgel M, Scriba D, Blum WF, Hauner H. 1999. Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture: effect of tumor necrosis factor-α and transforming growth factor-β1. Eur J Endorinol 141:436-442.
30. Grunfeld C, Pang M, Shigenaga JK, Jensen P, Lallone R, Friedman J, Feingold KR. 1996a. Serum leptin levels in the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 81:4342-4346.
31. Grunfeld C, Zhao C, Fuller J, Pollock A, Moser A, Friedman J, Feingold K. 1996b. Endotoxin and cytokines induce expression of leptin, the ob gene product in hamsters: a role for leptin in the anorexia of infection. J Clin Invest 97:2152-2157.
32. Halaas JL, Gajinala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546.
33. Hardardottir I, Doerrler W, Feingold KR, Grunfeld C. 1992. Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism. Biochem Biophys Res Commun 186:237-243.
34. Havel PJ, Townsend R, Chaump L, Teff K. 1999. High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes 48:334-341.
35. Hotamisligil GS, Spiegelman BM. 1994. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 43:1271-1278.
36. Hotamisligil GS, Shargill NS, Spiegelman BM. 1993. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91.
37. Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. 1997. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46:451-455.
38. Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR. 1999. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104:1051-1059.
39. Jirillo E, Covelli V, Maffione A, Greco B, Pece S, Fumarola S, De Simoni C. 1994. Endotoxins, cytokines and neuroimmune networks with a special reference to HIV infection. Ann NY Acad Sci 741: 174-184.
40. Kaibara A, Moshyedi A, Auffenberg T, Abouhamze A, Copeland EM, Kalra S, Moldawer LL. 1998. Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting. Am J Physiol 274:R1518-R1525.
41. Kalb A, Bluethmann H, Moore MW, Lesslauer W. 1996. Tumor necrosis factor receptors (Tnfr) in mouse fibroblasts deficient in Tnfr1 or Tnfr2 are signaling competent and activate the mitogen-activated protein kinase pathway with differential kinetics. J Biol Chem 271:28097-28104.
42. Kern PA, Saghizadeh M, JM Ong, Bosch RJ, Deem R, Simsolo RB. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95:2111-2119.
43. Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. 1997. Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 100:2777-2782.
44. Kohno T, Brewer MT, Baker SL, Schwartz PE, King MW, Hale KK, Squires CH, Thompson RC, Vannice JL. 1990. A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. Proc Natl Acad Sci USA 87:8331-8335.
45. Kotler DP, Tierney AR, Francisco A, Wang J, Pierson RN. 1989. The magnitude of body cell mass depletion determines the timing of death from wasting in AIDS. Am J Clin Nutr 50:444-447.
46. Leroy P, Dessolin S, Villagesis P, Moon BC, Friedman JM, Ailaud G, Dani C. 1996. Expression of ob gene in adipose cells. J Biol Chem 271:2365-2368.
47. Llovera M, Garcia-Martinez C, Lopez-Soriano J, Carbo N, Agell N, Lopez-Soriano FJ, Argiles JM. 1998. Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice. Mol Cell Endocrinol 142:183-189.
48. Loetscher H, Pan YC, Lahm HW, Gentz R, Brockhaus M, Tabuchi H, Lesslauer W. 1990. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell 61:351-359.
49. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM. 1998. Leptin regulates proinflammatory immune responses. FASEB J 12:57-65.
50. López-Soriano J, Llovera M, Carbó N, Garcia-Martinez C, López-Soriano FJ, Argiles JM. 1997. Lipid metabolism in tumour-bearing mice: studies with knockout mice for tumour necrosis factor receptor 1 protein. Mol Cell Endocrinol 132:93-99.
51. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897-901.
52. Mackay AG, Oliver JD, Rogers MP. 1990. Regulation of lipoprotein lipase activity and mRNA content in rat epididymal adipose tissue in vitro by recombinant tumour necrosis factor. Biochem J 269:123-126.
53. Medina EA, Stanhope KL, Mizuno TM, Mobbs CV, Gregoire F, Hubbard NE, Erickson KL, Havel PJ. 1999. Effects of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes. Int J Obes Relat Metab Disord 23:896-903.
54. Mikhail AA, Beck EX, Shafer A, Barut B, Gbur JS, Zupancic TJ, Schweitzer AC, Cioffi JA, Lacaud G, Ouyang B, Keller G, Snodgrass HR. 1997. Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89:1507-1512.
55. Morin CL, Pagliassotti MJ, Windmiller D, Eckel RH. 1997. Adipose tissue-derived tumor necrosis factor-alpha activity is elevated in older rats. J Gerontol A Biol Sci Med Sci 52:B190-B195.
56. Morin CL, Gayles EC, Podolin DA, Wei Y, Xu M, Pagliassotti MJ. 1998. Adipose tissue-derived tumor necrosis factor activity correlates with fat cell size but not insulin action in aging rats. Endocrinology 139:4998-5005.
57. Murdoch DR, Rooney E, Dargie HJ, Shapiro D, Morton JJ, McMurray JJV. 1999. Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure. Heart 82:352-356.
58. Muzzin P, Eisensmith RC, Copeland KC, Woo SL. 1996. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci USA 93:14804-14808.
59. Oliff A, Defeo-Jones D, Boyer M, Martinez D, Kiefer D, Vuocolo G, Wolfe A, Socher SH. 1987. Tumor secreting human TNF/cachectin induces cachexia in mice. Cell 50:555-563.
60. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543.
61. Renno T, Krakowski M, Piccirillo C, Lin J, Owens T. 1995. TNF-α expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. J Immunol 154:944-953.
62. Roberts SB, Fuss P, Heyman MB, Evans WJ, Tsay R, Rasmussen H, Fiatarone M, Cortiella J, Dallal GE, Young VR. 1994. Control of food intake in older men. JAMA 272:1601-1606.
63. Rothe J, Wong SC, Henzel WJ, Goeddel DV. 1994. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681-686.
64. Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel MG, Boyadjian R, Jinagouda SD, Steil GM, Kamdar V. 1998. Physiological insulinemia acutely modulates plasma leptin. Diabetes 47:544-549.
65. Sarraf P, Frederich RA, Turner EM, Ma G, Jaskowiak NT, Rivet III DJ, Flier JS, Lowell BB, Fraker DL, Alexander HR. 1997. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 185:171-175.
66. Schreyer SA, Streamson CC, LeBoeuf RC. 1998. Obesity and diabetes in TNF-α receptor-deficient mice. J Clin Invest 102:402-411.
67. Schwartz MW, Dallman M, Woods S. 1995. Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol 269:R949-R957.
68. Sewter CP, Digby JE, Blows F, Prins J, O'Rahilly S. 1999. Regulation of tumor necrosis factor-alpha release from human adipose tissue in vitro. J Endocrinol 163:33-38.
69. Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW. 1996. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271:5301-5304.
70. Stephens JM, Pekala PH. 1991. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem 266:21839-21845.
71. Takahashi N, Waelput W, Guisez Y. 1999. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 189:207-212.
72. Tartaglia LA, Pennica D, Goeddel DV. 1993. Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem 268:18542-18548.
73. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, De vos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
74. Trayhurn P, Duncan JS, Rayner DV. 1995. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic nervous system. Biochem J 311:729-733.
75. Umemoto Y, Tsuji K, Yang FC, Ebihara Y, Kaneko A, Furukawa S, Nakahata T. 1997. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 90: 3438-3443.
76. Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF. 1992. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci USA 89:4845-4849.
77. Ventre J, Doebber T, Wu M, MacNaul K, Stevens K, Pasparakis M, Kollias G, Moller DE. 1997. Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes 46:1526-1531.
78. Wang J, Liu R, Hawkins M, Barzilai N, Rosseti L. 1998. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393:684-687.
79. Weiss T, Grell M, Hessabi B, Bourteele S, Muller G, Scheurich P, Wajant H. 1997. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80. J Immunol 158:2398-2404.
80. Xu H, Sethi JK, Hotamisligil GS. 1999. Tranamembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1. J Biol Chem 274:26287-26295.
81. Yamaguchi M, Murakami T, Tomimatsu T, Nishio Y, Mitsuda N, Kanzaki T, Kurachi H, Shima K, Aono T, Murata Y. 1998. Autocrine inhibition of leptin production by tumor necrosis factor-alpha (TNF-alpha) through TNF-alpha type-I receptor in vitro. Biochem Biophys Res Commun 244:30-34.
82. Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. 1997. Obesity increases sensitivity to endotoxin liver injury, implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 94:2557-2562.
83. Yarasheski KE, Zachwieja JJ, Morgan MM, Powderly WG, Santiago JV, Landt ML. 1997. Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity. Metabolism 46:303-305.
84. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsuing HM, Schoner BE, Wery J, Schevitz RW. 1997. Crystal structure of the obese protein leptin-E100. Nature 387:206-209.
85. Zhang HH, Kumar S, Barnett AH, Eggo MC. 2000. Ceiling culture of mature human adipocytes: use in studies of adipocyte functions. J Endocrinol 164:119-128.
86. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.