BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: Involvement of dual pathways

Neuropharmacology

Volumn 38, Issue 2, 1999, Pages 283-288

  Takei, Nobuyuki ^a,b,c,d   Tanaka, Osamu ^a   Endo, Yasuhisa ^a   Lindholm, Dan ^b   Hatanaka, Hiroshi ^c  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b UPPSALA UNIVERSITY   (Sweden)

^c OSAKA UNIVERSITY   (Japan)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

Apoptosis; BDNF; Ca2+ ionophore; MAP kinase; NT 3; PI3 kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MYCOTOXIN; NEUROTROPHIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; DOSE RESPONSE; DRUG INHIBITION; EMBRYO; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; CILIARY NEUROTROPHIC FACTOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; ENZYME INHIBITORS; FLAVONOIDS; IONOMYCIN; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTROPHIN 3; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR;

EID: 0033043308     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00189-0     Document Type: Article

References (30)

1. Barde, Y.-A., 1989. Trophic factors and neuronal survival. Neuron 2, 1525-1534.
2. 2+ elevation in hippocampal neurons. Neuroreport 4, 1303-1306.
3. Borasio, G.D., John, J., Wittinghofer, A., Barde, Y.-A., Sendtner, M., Heumann, R., 1989. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2, 1087-1096.
4. Cheng, B., Mattson, M.P., 1994. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res. 640, 56-67.
5. Dudek, H., Datta, S.R., Franke, T.F., Birnbaum, M.J., Yao, R., Cooper, G.M., Segal, R.A., Kaplan, D.R., Greenberg, M.E., 1997. Regulation of neuronal survival by the serin-threonine protein kinase Akt. Science 275, 661-665.
6. Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J., Saltiel, A.R., 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92, 7686-7689.
7. Frank, T.F., Kaplan, D.R., Cantley, L.C., Toker, A., 1997. Direct regulation of akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665-668.
8. Ghosh, A., Carnahan, J., Greenberg, M.E., 1994. Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263, 1618-1623.
9. Greenlund, L.J., Deckwerth, T.L., Johnson, E.M. Jr. (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron, 14, 303-315
10. 2+ ionophore-induced apoptosis in cultured rat cortical neurons. Biochem. Biophys. Res. Commun. 227, 513-518.
11. Ip, N.Y., Li, Y.P., van de Stadt, I., Panayotatos, N., Alderson, R.F., Lindsay, R.M., 1991. Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. J. Neurosci. 11, 3124-3134.
12. Ip, N.Y., McClain, J., Barrezyeta, N.X., Aldrich, T.H., Pan, L., Li, Y., Wiegand, S.J., Friedman, B., Davis, S., Yancopoulos, G.D., 1993. The a component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron 10, 89-102.
13. Ip, N.Y., Yancopoulos, G.D., 1996. The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu. Rev. Neurosci. 19, 491-515.
14. Kimura, K., Hattori, S., Kabuyama, Y., Shizawa, J., Takayanagi, S., Nakamura, S., Toki, S., Matsuda, Y., Onodera, K., Fukui, Y., 1994. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 18961-18967.
15. Kudo, Y., Ogura, A., 1986. Glutamate-induced increase in intracellular Ca2+ concentration in isolated hippocampal neurons. Br. J. Pharmacol. 89, 191-198.
16. Lindholm, D., Carroll, P., Tzimagiogis, G., Thoenen, H., 1996. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. Eur. J. Neurosci. 8, 1452-1460.
17. Lindsay, R.M., Wiegand, S.J., Altar, C.A., DiStefano, P.S., 1994. Neurotrophic factors: from molecule to man. Trends Neurosci. 17, 182-190.
18. Mattson, M.P., Murrain, M., Guthrie, P.B., Kater, S.B., 1989. Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture. J. Neurosci. 9, 3728-3740.
19. McAllister, A.K., Katz, L.C., Lo, D.C., 1996. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron 17, 1057-1064.
20. Nobes, C.D., Reppas, J.B., Markus, A., Tolkovsky, A.M., 1996. Active p21 Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons. Neuroscience 70, 1067-1079.
21. Nonomura, T., Kubo, T., Oka, T., Yamada, M., Enokido, Y., Hatanaka, H., 1996. Signaling pathways and survival effects of BDNF and NT-3 on cultured cerebellar granule cells. Dev. Brain Res. 97, 42-50.
22. Ohgoh, M., Kimura, M., Ogura, H., Katayama, K., Nishizawa, Y., 1998. Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support. Exp. Neurol. 149, 51-63.
23. 2+ oscillations in cultured hippocampal neurons. Brain Res. 778, 318-328.
24. Segal, R.A., Greenberg, M.E., 1996. Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19, 463-489.
25. +-induced apoptosis in cerebellar granule neurons. Dev. Brain Res. 101, 197-206.
26. 2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons. Brain Res. 652, 65-70.
27. 2+ ionophore-induced apoptotic cell death of cultured cortical neurons from embryonic rats. Neurosci. Lett. 192, 124-126.
28. Takei, N., Sasaoka, K., Higuchi, H., Endo, Y., Hatanaka, H., 1996. BDNF increases the expression of neuropeptide Y mRNA and promotes differentiation/maturation of neuropeptide Y-positive cultured cortical neurons from embryonic and postnatal rats. Mol. Brain Res. 37, 283-289.
29. Yao, R., Cooper, G.M., 1995. Requirement for phosphatidylinositol 3-kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.
30. Yamashita, K., Wiessner, C., Lindholm, D., Thoenen, H., Hossmann, K.A., 1997. Post-occlusion treatment with BDNF reduces infarct size in model of permanent occlusion of the middle cerebral artery in rat. Metab. Brain Dis. 12, 271-280.