DNA plasmid that codes for human Bcl-2 gene preserves axotomized Clarke's Nucleus neurons and reduces atrophy after spinal cord hemisection in adult rats

Journal of Comparative Neurology

Volumn 404, Issue 2, 1999, Pages 159-171

  Takahashi, Kosei ^a,b   Schwarz, Emily ^a   Ljubetic, Cecilia ^a   Murray, Marion ^a   Tessler, Alan ^a,c   Saavedra, Raul A ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; DNA vector; Neuronal rescue

Indexed keywords

DNA; FLUOROGOLD; LIPID; PROTEIN BCL 2;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE THERAPY; NONHUMAN; PLASMID; PRIORITY JOURNAL; RAT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY;

ANIMALS; ATROPHY; AXOTOMY; CELL SURVIVAL; DENERVATION; DNA; FEMALE; FLUORESCENT DYES; GENE EXPRESSION; GENES, BCL-2; GENES, REPORTER; HUMANS; LAC OPERON; NEURONS; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; STILBAMIDINES;

EID: 0033535123     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19990208)404:2<159::AID-CNE2>3.0.CO;2-E     Document Type: Article

References (48)

1. Adams JM, Cory S. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281:1322-1326.
2. Alberi S, Roggenbass M, de Bilbao F, Dubois-Dauphin M. 1996. Axotomized neonatal motoneurons overexpressing the bcl-2 proto-oncogene retain functional electrophysiological properties. Proc Natl Acad Sci USA 93:3978-3983.
3. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. 1995. Short protocols in molecular biology, 3rd Edition. New York: Wiley.
4. Beattie MS, Shuman SL, Bresnahan JC. 1998. Apoptosis and spinal cord injury. The Neuroscientist 4:163-171.
5. Bregman BS, Broude M, McAtte M, Kelley MS. 1998. Transplants and neurotrophic factors prevent atrophy of mature CNS neurons after spinal cord injury. Exp Neurol 149:13-27.
6. Cenni MC, Bonfanti L, Martinou JC, Ratto GM, Strettoi E, Maffei L. 1996. Long-term survival of retinal ganglion cells following optic nerve section in adult bcl2 transgenic mice. Eur J Neurosci 8:1735-1745.
7. Chen DF, Schneider GE, Martineu J-C, Tonegawa S. 1997. Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 385:434-439.
8. Coggeshall RE, Lekan HA. 1996. Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J Comp Neurol 364:6-15.
9. Coulpier M, Junier M-P, Peschanski M, Dreyfus PA. 1996. Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse. J Neurosci 16:5897-5904.
10. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. 1997. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nature Med 3:73-76.
11. Davies AM. 1995. The Bcl-2 family of proteins, and the regulation of neuronal survival. TINS 18:355-358.
12. de Medinaceli L. 1986. An anatomical landmark for procedures on rat thoracic spinal cord. Exp Neurol 91:404-408.
13. Garcia-Valenzuela E, Rayanade R, Perales JC, Davidson CA, Hanson RW, Sharma SC. 1997. Axon-mediated gene transfer of retinal ganglion cells in vivo. J Neurobiol 32:111-122.
14. Giehl KM, Schacht CM, Yan Q, Mestres P. 1997. GDNF is a trophic factor for adult rat corticospinal neurons and promotes their long-term survival after axotomy in vivo. Eur J Neurosci 9:2479-2489.
15. Glorioso JC, Bender MA, Goins WF, Fink DJ, DeLuca N. 1995. Herpes simplex virus as a gene-delivery vector for the central nervous system. In: Kaplitt MG, Loewy AD, editors. Viral vectors. New York: Academic Press. p 1-23.
16. Green DR. 1998. Apoptotic pathways: the road to ruin. Cell 94:695-698.
17. Green DR, Reed JC. 1998. Mitochondria and apoptosis. Science 281:1309-1312.
18. Hall ED, Smith SL, Oostveen JA. 1996. Inhibition of lipid peroxidation attenuates axotomy-induced apoptotic degeneration of facial motor neurons in neonatal rats. J Neurosci Res 44:293-299.
19. Hannas-Djebbara Z, Didier-Bazes M, Sacchettoni S, Prod'hon C, Jouvet M, Belin M-F, Jacquemont B. 1997. Transgene expression of plasmid DNAs directed by viral or neural promoters in the rat brain. Mol Brain Res 46:91-99.
20. Himes BT, Goldberger ME, Tessler A. 1994. Grafts of fetal central nervous system tissue rescue axotomized Clarke's nucleus neurons in adult and neonatal operates. J Comp Neurol 339:117-131.
21. Hockenbery DM, Oltvai ZN, Yin X-M, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
22. Imaoka T, Date I, Ohmoto T, Nagatsu T. 1998a. Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continous injection of a plasmid DNA-liposome complex. Hum Gene Ther 9:1093-1102.
23. Imaoka T, Date I, Ohmoto T, Yasuda T, Tsuda M. 1998b. In vivo gene transfer into the adult mammalian central nervous system by continuous injection of plasmid DNA-cationic liposome complex. Brain Res 780:119-128.
24. Kageyama R, Ishibashi M, Moriyoshi K. 1996. Gene delivery to the nervous system by direct injection of retroviral vector. In: Latchman D, editor. Genetic manipulation of the nervous system. New York: Academic Press. p 135-148.
25. Kang UJ. 1995. Genetic modification of cells with retrovirus vectors for grafting into the central nervous system. In: Kaplitt MG, Loewy AD, editors. Viral vectors. New York: Academic Press. p 211-237.
26. Kobayashi NR, Fan D-P, Giehl KM, Bedard AM, Wiegand SJ, Tetzlaff W. 1997. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Ta1-tubulin mRNA expression, and promote axonal regeneration. J Neurosci 17:9583-9595.
27. Kofler P, Wiesenhofer B, Rehrl C, Baier G, Stockhammer G, Humpel C. 1998 Liposome-mediated gene transfer into established CNS cell lines, primary glial cells, and in vivo. Cell Transplant 7:175-185.
28. Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowski MJ, Reed JC. 1995. Upregulation of bax protein levels in neurons following cerebral ischemia. J Neurosci 15:6364-6376.
29. Lawrence MS, Ho DY, Sun GH, Steinberg GK, Sapolsky RM. 1996. Overexpression of bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J Neurosci 16:486-496.
30. Liu Y, Himes BT, Moul J, Huang W, Chow SY, Tessler A, Fischer I. 1997. Application of recombinant adenovirus for in vivo gene delivery to spinal cord. Brain Res 768:19-29.
31. Martinou JC, Dubois-Dauphin M, Staple JK, Rodriquez I, Frankowski H, Missotten M, Albertini P, Talbot D, Catsicas S, Pietra C, Huarte J. 1994. Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-1030.
32. Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ. 1994. Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 120:301-311.
33. Oorschot DE. 1994. Are you using neuronal densities, synaptic densities or neurochemical densities as your definitive data? There is a better way to go. Prog Neurobiol 44:233-47.
34. Pettmann B, Henderson CE. 1998. Neuronal cell death. Cell 20:633-647.
35. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. 1997. A model for p53-induced apoptosis. Nature 389:300-305.
36. Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde Y-A. 1992. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 360:757-759.
37. Shibayama M, Hattori S, Himes BT, Murray M, Tessler A. 1998. Neurotrophin-3 prevents death of axotomized Clarke's nucleus neurons in adult rats. J Comp Neurol 390:102-111.
38. Shine HD, Woo SLC. 1996. Adenovirus-mediated gene therapy of tumors in the central nervous system. In: Latchman D, editor. Genetic manipulation of the nervous system. New York: Academic Press. p 53-71.
39. Tessler A, Fischer I, Giszter S, Himes ST, Miya D, Mori F, Murray M. 1996. Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats. In: Seil FJ, editor. Neuronal regeneration, reorganization, and repair. Philadelphia: Lippincott-Raven. p 291-303.
40. Thornberry NA, Lazebnik Y. 1998. Caspases: enemies within. Science 281:1312-1316.
41. Tsuda M, Imaoka T. 1996. Direct injection of plasmid DNA into the brain. In: Latchman D, editor. Genetic manipulation of the nervous system. New York: Academic Press. p 235-248.
42. Wu D, Wallen HD, Nunez G. 1997. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275:1126-1129.
43. Yachnis AT, Giovanini MA, Eskin TA, Reier PJ, Anderson DK. 1998. Developmental patterns of bcl-2 and bcl-x polypeptide expression in the human spinal cord. Exp Neurol 150:82-97.
44. Yan Q, Matheson C, Lopez OT. 1995. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373:341-344.
45. Yang K, Clifton GL, Haves RL. 1997a. Gene therapy for central nervous system injury: the use of cationic liposomes. J Neurotrauma 14:281-297.
46. Yang K, Mu X-S, Hayes RL, Qiu YH, Sorgi FL, Huang L, Clifton GL. 1997b. DC-Chol liposome-mediated gene transfer in rat spinal cord. Neuro-Report 8:2355-2358.
47. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G. 1997. Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomemb 29:185-193.
48. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405-413.