Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury

Journal of Neurotrauma

Volumn 17, Issue 3, 2000, Pages 203-218

  Hayashi, Mito ^a   Ueyama, Takashi ^a   Nemoto, Kiyomitsu ^b   Tamaki, Tetsuya ^a   Senba, Emiko ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Acute spinal cord injury; Cytokines; Glucocorticoid; Immediate early genes; In situ hybridization; Neurotrophins

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; GLUCOCORTICOID; INTERLEUKIN 1BETA; MESSENGER RNA; METHYLPREDNISOLONE; NERVE GROWTH FACTOR; NEUROTROPHIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMEDIATE EARLY GENE; MALE; MOTONEURON; NERVE FIBER REGENERATION; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY;

EID: 0034119666     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2000.17.203     Document Type: Article

References (74)

1. AIHARA, N., HALL, J.J., PITTS, L.H., FUKUDA, K., and NOBLE, L.J. (1995). Altered immunoexpression of microglia and macrophages after mild head injury. J. Neurotrauma 12, 53-63.
2. ALOISI, F., CARE, A., BORSELLINO, G., et al. (1992). Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-I beta and tumor necrosis factor-alpha. J. Immunol. 149, 2358-2366.
3. ANGEL, P., ALLEGRETTO, E.A., OKINO, S.T., et al. (1988). Oncogene jun encodes a sequence-specific trans-activator similar to AP-I. Nature 332, 166-171.
4. ARAUJO, D.M., and COTMAN, C.W. (1993). Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors. Brain Res. 600, 49-55.
5. BRACKEN, M.B., SHEPARD, M.J., COLLINS, W.F., JR., et al. (1992). Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J. Neurosurg. 76, 23-31.
6. BRACKEN, M.B., SHEPARD, M.J., COLLINS, W.F., et al. (1990). A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N. Engl. J. Med. 322, 1405-1411.
7. BUTTINI, M., SAUTER, A., and BODDEKE, H.W. (1994). Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat. Mol. Brain Res. 23, 126-134.
8. CAVAILLON, J.M. (1993). Contribution of cytokines to inflammatory mechanisms. Pathol. Biol. 41, 799-811.
9. CHAO, M.V. (1994). The p75 neurotrophin receptor. J. Neurobiol. 25, 1373-1385.
10. CHAO, C.C., HU, S., EHRLICH, L., and PETERSON, P.K. (1995). Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav. Immunol. 9, 355-365.
11. CHIU, R., BOYLE, W.J., MEEK, J., SMEAL, T., HUNTER, T., and KARIN, M. (1988). The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-I responsive genes. Cell 54, 541-552.
12. CROWE, M.J., BRESNAHAN, J.C., SHUMAN, S.L., MASTERS, J.N., and BEATTIE, M.S. (1997). Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat. Med. 3, 73-76.
13. CURRAN, T., GORDON, M.B., RUBINO, K.L., and SAMBUCETTI, L.C. (1987). Isolation and characterization of the c-fos (rat) cDNA and analysis of post-translational modification in vitro. Oncogene 2, 79-84.
14. DREYFUS, C.F., RACEY, B., MENDAZA, G., DAI, X., FRIEDMAN, W.J., and BLACK, I.B. (1996). Neurotrophins are expressed by adult spinal cord astrocytes in vivo. Soc. Neurosci. Abstr. 22, 303.
15. DUCKER, T.B., and ZEIDMAN, S.M. (1994). Spinal cord injury. Role of steroid therapy. Spine 19, 2281-2287.
16. FAROOQUE, M., BADONIC, T., OLSSON, Y., and HOLTZ, A. (1995). Astrocytic reaction after graded spinal cord compression in rats: immunohistochemical studies on glial fibrillary acidic protein and vimentin. J. Neurotrauma 12, 41-52.
17. FERNANDEZ, E., PALLINI, R., LAURETTI, L., MERCANTI, D., SERRA, A., and CALISSANO, P. (1993). Spinal cord transection in adult rats: effects of local infusion of nerve growth factor on the corticospinal tract axons. Neurosurgery 33, 889-893.
18. FLETCHER, J., REDDI, K., POOLE, S., et al. (1997). Interactions between periodontopathogenic bacteria and cytokines. J. Periodontal Res. 32, 200-205.
19. FRIEDMAN, W.J., ALTIOK, N., FREDHOLM, B.B., and PERSSON, H. (1992). Mechanisms of nerve growth factor mRNA regulation by interleukin-1 beta in hippocampal cultures: role of second messengers. J. Neurosci. Res. 33, 37-46.
20. FRISEN, J., ARVIDSSON, U., LINDHOLM, T., et al. (1993). trkC expression in the injured rat spinal cord. Neuroreport 5, 349-352.
21. FRISEN, J., VERGE, V.M., CULLHEIM, S., et al. (1992). Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord. Proc. Natl. Acad. Sci. U.S.A. 89, 11282-11286.
22. GRILL, R., MURAI, K., BLESCH, A., GAGE, F.H., and TUSZYNSKI, M.H. (1997). Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J. Neurosci. 17, 5560-5572.
23. GUTH, L., ZHANG, Z., DIPROSPERO, N.A., JOUBIN, K., and FITCH, M.T. (1994). Spinal cord injury in the rat: treatment with bacterial lipopolysaccharide and indomethacin enhances cellular repair and locomotor function. Exp. Neurol. 126, 76-87.
24. HALL, E.D. (1993). The effects of glucocorticoid and nonglucocorticoid steroids on acute neuronal degeneration. Adv. Neurol. 59, 241-248.
25. HALL, E.D., and BRAUGHLER, J.M. (1986). Role of lipid peroxidation in post-traumatic spinal cord degeneration: a review. Cent. Nerv. Syst. Trauma 3, 281-294.
26. HAYASHI, M., UEYAMA, T., TAMAKI, T., and SENBA, E. (1997). Expression of neurotrophin and IL-1 beta mRNAs following spinal cord injury and the effects of methylprednisolone treatment. Kaibogaku Zasshi 72, 209-213.
27. HENGERER, B., LINDHOLM, D., HEUMANN, R., RUTHER, U., WAGNER, E.F., and THOENEN, H. (1990). Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos. Proc. Natl. Acad. Sci. U.S.A. 87, 3899-3903.
28. HOPKINS, S.J., and ROTHWELL, N.J. (1995). Cytokines and the nervous system. I. Expression and recognition. Trends Neurosci. 18, 83-88.
29. IKEDA, K., KINOSHITA, M., TAGAYA, N., et al. (1996a). Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease. Brain Res. 726, 91-97.
30. IKEDA, K., IWASAKI, Y., SHIOJIMA, T., and KINOSHITA, M. (1996b). Neuroprotective effect of various cytokines on developing spinal motoneurons following axotomy. J. Neurol. Sci. 135, 109-113.
31. IVACKO, J.A., SUN, R., and SILVERSTEIN, F.S. (1996). Hypoxic-ischemic brain injury induces an acute microglial reaction in perinatal rats. Pediatr. Res. 39, 39-41.
32. JOHNSON, E.M., JR., TANIUCHI, M., and DISTEFANO, P.S. (1988). Expression and possible function of nerve growth factor receptors on Schwann cells. Trends Neurosci. 11, 299-304.
33. KLEIN, R., PARADA, L.F., COULIER, F., and BARBACID, M. (1989). trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. E.M.B.O. J. 8, 3701-3709.
34. KRAUS, K.H. (1996). The pathophysiology of spinal cord injury and its clinical implications. Semin. Vet. Med. Surg. 11, 201-207.
35. LAMBALLE, F., KLEIN, R., and BARBACID, M. (1991). trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, 967-979.
36. LAMPH, W.W., WAMSLEY, P., SASSONE-CORSI, P., and VERMA, I.M. (1988). Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature 334, 629-631.
37. LAPCHAK, P.A., ARAUJO, D.M., and HEFTI, F. (1993). Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience 53, 297-301.
38. LINDHOLM, D., HEUMANN, R., MEYER, M., and THOENEN, H. (1987). Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330, 658-659.
39. LINDVALL, O., KOKAIA, Z., BENGZON, J., ELMER, E., and KOKAIA, M. (1994). Neurotrophins and brain insults. Trends Neurosci. 17, 490-496.
40. LIU, X.Z., XU, X.M., HU, R., et al. (1997). Neuronal and glial apoptosis after traumatic spinal cord injury. J. Neurosci. 17, 5395-5406.
41. McLAURIN, J., D'SOUZA, S., STEWART, J., et al. (1995). Effect of tumor necrosis factor alpha and beta on human oligodendrocytes and neurons in culture. Int. J. Dev. Neurosci. 13, 369-381.
42. McMAHON, S.B., and MONROE, J.G. (1992). Role of primary response genes in generating cellular responses to growth factors. F.A.S.E.B. J. 6, 2707-2715.
43. MEAKIN, S.O., SUTER, U., DRINKWATER, C.C., WELCHER, A.A., and SHOOTER, E.M. (1992). The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc. Natl. Acad. Sci. U.S.A. 89, 2374-2378.
44. MEGYERI, P., ABRAHAM, C.S., TEMESVARI, P., KOVACS, J., VAS, T., and SPEER, C.P. (1992). Recombinant human tumor necrosis factor alpha constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets. Neurosci. Lett. 148, 137-140.
45. MERRILL, J.E., and BENVENISTE, E.N. (1996). Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19, 331-338.
46. MURPHY, P.G., GRONDIN, J., ALTARES, M., and RICHARDSON, P.M. (1995). Induction of interleukin-6 in axotomized sensory neurons. J. Neurosci. 15, 5130-5138.
47. MURPHY, S., LIN, H.L., and PARK, S.K. (1995). Cytokine-induced expression of type II nitric oxide synthase in astrocytes is downregulated by ATP and glutamate. Glia 15, 77-82.
48. NAKAHARA, Y., GAGE, F.H., and TUSZYNSKI, M.H. (1996). Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant. 5, 191-204.
49. NEMOTO, K., FUKAMACHI, K., NEMOTO, F., et al. (1998). Gene expression of neurotrophin and their receptors in cultured rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 245, 284-288.
50. NEMOTO, K., SEKIMOTO, M., FUKAMACHI, K., et al. (1999). A possible mechanism of TPA-mediated downregulation of neurotrophin-3 gene expression in rat culture vascular smooth muscle cells. Mol. Brain Res. 68, 186-189.
51. NOVIKOV, L., NOVIKOVA, L., and KELLERTH, J.O. (1995). Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion. Neurosci. Lett. 200, 45-48.
52. NOVIKOVA, L., NOVIKOV, L., and KELLERTH, J.O. (1996). Brain-derived neurotrophic factor reduces necrotic zone and supports neuronal survival after spinal cord hemi-section in adult rats. Neurosci. Lett. 220, 203-206.
53. PSHENICHKIN, S.P., SZEKELY, A.M., and WISE, B.C. (1994). Transcriptional and posttranscriptional mechanisms involved in the interleukin-1, steroid, and protein kinase C regulation of nerve growth factor in cortical astrocytes. J. Neurochem. 63, 419-428.
54. RADEKE, M.J., MISKO, T.P., HSU, C., HERZENBERG, L.A., and SHOOTER, E.M. (1987). Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325, 593-597.
55. REYNOLDS, M.E., BRUNELLO, N., MOCCHETTI, I., and WRATHALL, J.R. (1991). Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization. Brain Res. 559, 149-153.
56. ROBERTSON, H.A. (1992). Immediate-early genes, neuronal plasticity, and memory. Biochem. Cell Biol. 70, 729-737.
57. ROTHWELL, N.J., and HOPKINS, S.J. (1995). Cytokines and the nervous system. II. Actions and mechanisms of action. Trends Neurosci. 18, 130-136.
58. SASSONE-CORSI, P., RANSONE, L.J., LAMPH, W.W., and VERMA, I.M. (1988). Direct interaction between fos and jun nuclear oncoproteins: role of the "leucine zipper" domain. Nature 336, 692-695.
59. SAWADA, M., SUZUMURA, A., and MARUNOUCHI, T. (1992). TNF alpha induces IL-6 production by astrocytes but not by microglia. Brain Res. 583, 296-299.
60. SCHLUTER, D., KAEFER, N., HOF, H., WIESTLER, O.D., and DECKERT-SCHLUTER, M. (1997). Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain. Am. J. Pathol. 150, 1021-1035.
61. SCHNELL, L., SCHNEIDER, R., KOLBECK, R., BARDE, Y.A., and SCHWAB, M.E. (1994). Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367, 170-173.
62. SEGAL, J.L. (1993). Spinal cord injury: are interleukins a molecular link between neuronal damage and ensuing pathobiology? Perspect. Biol. Med. 36, 222-240.
63. SEGAL, J.L., and BRUNNEMANN, S.R. (1993). Circulating levels of soluble interleukin 2 receptors are elevated in the sera of humans with spinal cord injury. J. Am. Paraplegia Soc. 16, 30-33.
64. SENBA, E., and UEYAMA, T. (1997). Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat. Neurosci. Res. 29, 183-207.
65. SIMMONS, M.L., and MURPHY, S. (1994). Roles for protein kinases in the induction of nitric oxide synthase in astrocytes. Glia 11, 227-234.
66. SIMMONS, D.M., ARRIZA, J.L., and SWANSON, L.W. (1989). A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-strand RNA probes. J. Histotechnol. 12, 169-181.
67. STRIJBOS, P.J., and ROTHWELL, N.J. (1995). Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci. 15, 3468-3474.
68. TALLEY, A.K., DEWHURST, S., PERRY, S.W., et al. (1995). Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Mol. Cell Biol. 15, 2359-2366.
69. TERADA, L.S., WILLINGHAM, I.R., GUIDOT, D.M., SHIBAO, G.N., KINDT, G.W., and REPINE, J.E. (1992). Tungsten treatment prevents tumor necrosis factor-induced injury of brain endothelial cells. Inflammation 16, 13-19.
70. WAGNER, J.A. (1996). Is IL-6 both a cytokine and a neurotrophic factor? J. Exp. Med. 183, 2417-2419.
71. WANG, C.X., NUTTIN, B., HEREMANS, H., DOM, R., and GYBELS, J. (1996). Production of tumor necrosis factor in spinal cord following traumatic injury in rats. J. Neuroimmunol. 69, 151-156.
72. XU, J., QU, Z.X., HOGAN, E.L., and PEROT, P.L., JR. (1992). Protective effect of methylprednisolone on vascular injury in rat spinal cord injury. J. Neurotrauma 9, 245-253.
73. YAKOVLEV, A.G., and FADEN, A.I. (1994). Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury. Mol. Chem. Neuropathol. 23, 179-190.
74. YOSHIDA, K., and GAGE, F.H. (1992). Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res. 569, 14-25.