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Volumn 49, Issue 9, 2008, Pages 734-740

Kinetics of γ-H2AX focus formation upon treatment of cells with UV light and alkylating agents

Author keywords

Alkylating agents; DNA double strand breaks; Phosphorylated H2AX; UV light

Indexed keywords

HISTONE H2AX; MESYLIC ACID METHYL ESTER; METHYLNITRONITROSOGUANIDINE;

EID: 58049204239     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20430     Document Type: Article
Times cited : (36)

References (42)
  • 1
    • 0038351916 scopus 로고    scopus 로고
    • Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin
    • Bardeleben R, Kaina B, Fritz G. 2003. Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin. Biochem Biophys Res Commun 307:401-407.
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 401-407
    • Bardeleben, R.1    Kaina, B.2    Fritz, G.3
  • 2
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. 2001. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276:42462-42467.
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 5
    • 1542438045 scopus 로고    scopus 로고
    • Mechanisms by which human cells bypass damaged bases during DNA replication after ultraviolet irradiation
    • Cleaver JE. 2002. Mechanisms by which human cells bypass damaged bases during DNA replication after ultraviolet irradiation. ScientificWorldJournal 2:1296-1305.
    • (2002) ScientificWorldJournal , vol.2 , pp. 1296-1305
    • Cleaver, J.E.1
  • 6
    • 0028801762 scopus 로고
    • Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - a case of imbalanced DNA repair
    • Coquerelle T, Dosch J, Kaina B. 1995. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - a case of imbalanced DNA repair. Mutat Res 336:9-17.
    • (1995) Mutat Res , vol.336 , pp. 9-17
    • Coquerelle, T.1    Dosch, J.2    Kaina, B.3
  • 7
    • 0032519468 scopus 로고    scopus 로고
    • In vitro analysis of UV-damage-induced inhibition of replication
    • Drissi R, Lee SH. 1998. In vitro analysis of UV-damage-induced inhibition of replication. Biochem J 330 (Pt 1):181-187.
    • (1998) Biochem J , vol.330 , Issue.PART 1 , pp. 181-187
    • Drissi, R.1    Lee, S.H.2
  • 8
    • 0036154027 scopus 로고    scopus 로고
    • Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells
    • Dunkern TR, Kaina B. 2002. Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells. Mol Biol Cell 13:348-361.
    • (2002) Mol Biol Cell , vol.13 , pp. 348-361
    • Dunkern, T.R.1    Kaina, B.2
  • 9
    • 0035921686 scopus 로고    scopus 로고
    • Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation
    • Dunkern TR, Fritz G, Kaina B. 2001. Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation. Oncogene 20:6026-6038.
    • (2001) Oncogene , vol.20 , pp. 6026-6038
    • Dunkern, T.R.1    Fritz, G.2    Kaina, B.3
  • 11
    • 0033813804 scopus 로고    scopus 로고
    • Immediate localized CDKN1A (p21) radiation response after damage produced by heavy-ion tracks
    • Jakob B, Scholz M, Taucher-Scholz G. 2000. Immediate localized CDKN1A (p21) radiation response after damage produced by heavy-ion tracks. Radiat Res 154:398-405.
    • (2000) Radiat Res , vol.154 , pp. 398-405
    • Jakob, B.1    Scholz, M.2    Taucher-Scholz, G.3
  • 12
    • 0021993043 scopus 로고
    • The interrelationship between SCE induction, cell survival, mutagenesis, aberration formation and DNA synthesis inhibition in V79 cells treated with N-methyl-N-nitrosourea or N-methyl- N′-nitro-N-nitrosoguanidine
    • Kaina B. 1985. The interrelationship between SCE induction, cell survival, mutagenesis, aberration formation and DNA synthesis inhibition in V79 cells treated with N-methyl-N-nitrosourea or N-methyl- N′-nitro-N-nitrosoguanidine. Mutat Res 142:49-54.
    • (1985) Mutat Res , vol.142 , pp. 49-54
    • Kaina, B.1
  • 13
    • 0032480042 scopus 로고    scopus 로고
    • Critical steps in alkylation-induced aberration formation
    • Kaina B. 1998. Critical steps in alkylation-induced aberration formation. Mutat Res 404:119-124.
    • (1998) Mutat Res , vol.404 , pp. 119-124
    • Kaina, B.1
  • 14
    • 2642574948 scopus 로고    scopus 로고
    • Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: A long road traveled and still a far way to go
    • Kaina B. 2004. Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: A long road traveled and still a far way to go. Cytogenet Genome Res 104:77-86.
    • (2004) Cytogenet Genome Res , vol.104 , pp. 77-86
    • Kaina, B.1
  • 15
    • 0027340278 scopus 로고
    • 6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines
    • 6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines. Environ Mol Mutagen 22:283-292.
    • (1993) Environ Mol Mutagen , vol.22 , pp. 283-292
    • Kaina, B.1    Fritz, G.2    Coquerelle, T.3
  • 16
    • 0019830466 scopus 로고
    • Mechanisms of inhibition of DNA replication by ultraviolet radiation in normal human and Xeroderma pigmentosum fibroblasts
    • Kaufmann WK, Cleaver JE. 1981. Mechanisms of inhibition of DNA replication by ultraviolet radiation in normal human and Xeroderma pigmentosum fibroblasts. J Mol Biol 149:171-187.
    • (1981) J Mol Biol , vol.149 , pp. 171-187
    • Kaufmann, W.K.1    Cleaver, J.E.2
  • 17
    • 0037039463 scopus 로고    scopus 로고
    • UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization
    • Limoli CL, Giedzinski E, Bonner WM, Cleaver JE. 2002. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci USA 99:233-238.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 233-238
    • Limoli, C.L.1    Giedzinski, E.2    Bonner, W.M.3    Cleaver, J.E.4
  • 18
    • 0024395794 scopus 로고
    • H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals
    • Mannironi C, Bonner WM, Hatch CL. 1989. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals. Nucleic Acids Res 17:9113-9126.
    • (1989) Nucleic Acids Res , vol.17 , pp. 9113-9126
    • Mannironi, C.1    Bonner, W.M.2    Hatch, C.L.3
  • 19
    • 33745607326 scopus 로고    scopus 로고
    • H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks
    • Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE. 2006. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci USA 103:9891-9896.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9891-9896
    • Marti, T.M.1    Hefner, E.2    Feeney, L.3    Natale, V.4    Cleaver, J.E.5
  • 21
    • 0032881389 scopus 로고    scopus 로고
    • DNA repair, DNA replication, and UV mutagenesis
    • McGregor WG. 1999. DNA repair, DNA replication, and UV mutagenesis. J Investig Dermatol Symp Proc 4:1-5.
    • (1999) J Investig Dermatol Symp Proc , vol.4 , pp. 1-5
    • McGregor, W.G.1
  • 22
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia telangiectasia and Rad-3 related protein (ATR) results in Seckel syndrome
    • O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. 2003. A splicing mutation affecting expression of ataxia telangiectasia and Rad-3 related protein (ATR) results in Seckel syndrome. Nat Genet 33:497-501.
    • (2003) Nat Genet , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 23
    • 0035117170 scopus 로고    scopus 로고
    • Quantitative comparison of anti-fading mounting media for confocal laser scanning microscopy
    • Ono M, Murakami T, Kudo A, Isshiki M, Sawada H, Segawa A. 2001. Quantitative comparison of anti-fading mounting media for confocal laser scanning microscopy. J Histochem Cytochem 49:305-312.
    • (2001) J Histochem Cytochem , vol.49 , pp. 305-312
    • Ono, M.1    Murakami, T.2    Kudo, A.3    Isshiki, M.4    Sawada, H.5    Segawa, A.6
  • 24
    • 0020063241 scopus 로고
    • The HeLa DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens
    • Painter RB, Howard R. 1982. The HeLa DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens. Mutat Res 92:427-437.
    • (1982) Mutat Res , vol.92 , pp. 427-437
    • Painter, R.B.1    Howard, R.2
  • 25
    • 13744258586 scopus 로고    scopus 로고
    • The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells
    • Pascucci B, Russo MT, Crescenzi M, Bignami M, Dogliotti E. 2005. The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Nucleic Acids Res 33:280-288.
    • (2005) Nucleic Acids Res , vol.33 , pp. 280-288
    • Pascucci, B.1    Russo, M.T.2    Crescenzi, M.3    Bignami, M.4    Dogliotti, E.5
  • 26
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10:886-895.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 29
    • 0028266506 scopus 로고
    • Increased DNA-repair capacity and the modulation of 2 proteins in and metallothionein overexpressing Chinese hamster cell line
    • Robson T, Grindley H, Hall A, Vormoor J, Lohrer H. 1994. Increased DNA-repair capacity and the modulation of 2 proteins in and metallothionein overexpressing Chinese hamster cell line. Mutat Res 314:143-157.
    • (1994) Mutat Res , vol.314 , pp. 143-157
    • Robson, T.1    Grindley, H.2    Hall, A.3    Vormoor, J.4    Lohrer, H.5
  • 30
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273:5858-5868.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 31
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. 1999. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146:905-916.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 32
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM. 2000. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 275:9390-9395.
    • (2000) J Biol Chem , vol.275 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 33
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • Rothkamm K, Lobrich M. 2003. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 100:5057-5062.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 34
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. 2000. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 151:1381-1390.
    • (2000) J Cell Biol , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 35
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody
    • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. 2002. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 158:486-492.
    • (2002) Radiat Res , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 36
    • 2442670292 scopus 로고    scopus 로고
    • Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
    • Stojic L, Mojas N, Cejka P, Di Pietro M, Ferrari S, Marra G, Jiricny J. 2004. Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev 18:1331-1344.
    • (2004) Genes Dev , vol.18 , pp. 1331-1344
    • Stojic, L.1    Mojas, N.2    Cejka, P.3    Di Pietro, M.4    Ferrari, S.5    Marra, G.6    Jiricny, J.7
  • 37
    • 0022990112 scopus 로고
    • Postreplication repair in ultraviolet-irradiated human fibroblasts: Formation and repair of DNA double-strand breaks
    • Wang TC, Smith KC. 1986. Postreplication repair in ultraviolet-irradiated human fibroblasts: Formation and repair of DNA double-strand breaks. Carcinogenesis 7:389-392.
    • (1986) Carcinogenesis , vol.7 , pp. 389-392
    • Wang, T.C.1    Smith, K.C.2
  • 38
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward IM, Chen J. 2001. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 276:47759-47762.
    • (2001) J Biol Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 39
    • 0019332014 scopus 로고
    • Histone 2B can be modified by the attachment of ubiquitin
    • West MH, Bonner WM. 1980. Histone 2B can be modified by the attachment of ubiquitin. Nucleic Acids Res 8:4671-4680.
    • (1980) Nucleic Acids Res , vol.8 , pp. 4671-4680
    • West, M.H.1    Bonner, W.M.2
  • 41
    • 0019971690 scopus 로고
    • Repair capability and the cellular age response for killing and mutation induction after UV
    • Wood RD, Burki HJ. 1982. Repair capability and the cellular age response for killing and mutation induction after UV. Mutat Res 95:505-514.
    • (1982) Mutat Res , vol.95 , pp. 505-514
    • Wood, R.D.1    Burki, H.J.2
  • 42
    • 33645979960 scopus 로고    scopus 로고
    • DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors
    • Zhou C, Li Z, Diao H, Yu Y, Zhu W, Dai Y, Chen FF, Yang J. 2006. DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors. Mutat Res 604:8-18.
    • (2006) Mutat Res , vol.604 , pp. 8-18
    • Zhou, C.1    Li, Z.2    Diao, H.3    Yu, Y.4    Zhu, W.5    Dai, Y.6    Chen, F.F.7    Yang, J.8


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