Interaction of HIV-1 Reverse Transcriptase Ribonuclease H with an Acylhydrazone Inhibitor

Chemical Biology and Drug Design

Volumn 77, Issue 1, 2011, Pages 39-47

  Gong, Qingguo ^a   Menon, Lakshmi ^a   Ilina, Tatiana ^a   Miller, Lena G ^a   Ahn, Jinwoo ^a   Parniak, Michael A ^a   Ishima, Rieko ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Acylhydrazone; Enzyme; HIV; Inhibitor; NMR; Protein; Reverse transcriptase; Ribonuclease H

Indexed keywords

BHMP 07; DIHYDROXY BENZOYL NAPHTHYL HYDRAZONE; HYDRAZONE DERIVATIVE; RIBONUCLEASE H; RIBONUCLEASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; ENZYME ASSAY; ENZYME SPECIFICITY; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BENZOIC ACIDS; BINDING SITES; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; HYDRAZONES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78650081368     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2010.01052.x     Document Type: Article

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