메뉴 건너뛰기




Volumn 11, Issue 1, 2011, Pages 55-66

Immune monitoring of pancreatic islet graft: Towards a better understanding, detection and treatment of harmful events

Author keywords

alloimmunity; autoimmunity; immune monitoring; immunosuppression; islet transplantation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALLOANTIBODY; AUTOANTIBODY; CD20 ANTIBODY; CD30 ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; GRANZYME B; HLA A2 ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; IMMUNOGLOBULIN; INSULIN ANTIBODY; INSULINOMA ASSOCIATED PROTEIN 2 ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; T LYMPHOCYTE RECEPTOR; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 78650056944     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2011.536530     Document Type: Review
Times cited : (24)

References (96)
  • 1
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-8
    • (2000) N Engl J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3
  • 2
    • 33745244128 scopus 로고    scopus 로고
    • Sequential kidney/islet transplantation: Efficacy and safety assessment of a steroid-free immunosuppression protocol
    • Toso C, Baertschiger R, Morel P, et al. Sequential kidney/islet transplantation: Efficacy and safety assessment of a steroid-free immunosuppression protocol. Am J Transplant 2006;6:1049-58
    • (2006) Am J Transplant , vol.6 , pp. 1049-1058
    • Toso, C.1    Baertschiger, R.2    Morel, P.3
  • 3
    • 21344462346 scopus 로고    scopus 로고
    • Five-year follow-up after clinical islet transplantation
    • Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005;54:2060-9
    • (2005) Diabetes , vol.54 , pp. 2060-2069
    • Ryan, E.A.1    Paty, B.W.2    Senior, P.A.3
  • 4
    • 18244364592 scopus 로고    scopus 로고
    • Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: Implications for intrahepatic grafts
    • Barshes NR, Wyllie S, Goss JA. Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: Implications for intrahepatic grafts. J Leukoc Biol 2005;77:587-97
    • (2005) J Leukoc Biol , vol.77 , pp. 587-597
    • Barshes, N.R.1    Wyllie, S.2    Goss, J.A.3
  • 5
    • 0032971910 scopus 로고    scopus 로고
    • Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients
    • Roep BO, Stobbe I, Duinkerken G, et al. Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients. Diabetes 1999;48:484-90
    • (1999) Diabetes , vol.48 , pp. 484-490
    • Roep, B.O.1    Stobbe, I.2    Duinkerken, G.3
  • 6
    • 43049130746 scopus 로고    scopus 로고
    • Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells
    • Monti P, Scirpoli M, Maffi P, et al. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest 2008;118:1806-14
    • (2008) J Clin Invest , vol.118 , pp. 1806-1814
    • Monti, P.1    Scirpoli, M.2    Maffi, P.3
  • 7
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by beta cell regeneration
    • Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 2007;117:2553-61
    • (2007) J Clin Invest , vol.117 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 8
    • 34247372296 scopus 로고    scopus 로고
    • Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation
    • Campbell PM, Salam A, Ryan EA, et al. Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation. Am J Transplant 2007;7:1242-8
    • (2007) Am J Transplant , vol.7 , pp. 1242-1248
    • Campbell, P.M.1    Salam, A.2    Ryan, E.A.3
  • 9
    • 84986235537 scopus 로고    scopus 로고
    • Impact of different induction therapies on long term durability of insulin independence after clinical islet transplantation
    • Shapiro AMJ, Koh A, Salam A, et al. Impact of different induction therapies on long term durability of insulin independence after clinical islet transplantation. Am J Transplant 2008;8(Suppl 2):234
    • (2008) Am J Transplant , vol.8 , Issue.SUPPL.2 , pp. 234
    • Shapiro, A.M.J.1    Koh, A.2    Salam, A.3
  • 10
    • 78650048105 scopus 로고    scopus 로고
    • Outcomes following alemtuzumab induction in clinical islet transplantation
    • Shapiro AMJ, Koh A, Kin T, et al. Outcomes following alemtuzumab induction in clinical islet transplantation. Am J Transplant 2008;8(Suppl 2):235
    • (2008) Am J Transplant , vol.8 , Issue.SUPPL.2 , pp. 235
    • Shapiro, A.M.J.1    Koh, A.2    Kin, T.3
  • 11
    • 51849148749 scopus 로고    scopus 로고
    • Islet Allograft survival in type 1 diabetics using a calcineurin-free protocol based on efalizumab and sirolimus
    • Posselt A, Szot G, Frassetto L, et al. Islet Allograft survival in type 1 diabetics using a calcineurin-free protocol based on efalizumab and sirolimus. Am J Transplant 2008;8(Suppl 2):235
    • (2008) Am J Transplant , vol.8 , Issue.SUPPL.2 , pp. 235
    • Posselt, A.1    Szot, G.2    Frassetto, L.3
  • 12
    • 53749089122 scopus 로고    scopus 로고
    • Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes
    • Bellin MD, Kandaswamy R, Parkey J, et al. Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes. Am J Transplant 2008;8:2463-70
    • (2008) Am J Transplant , vol.8 , pp. 2463-2470
    • Bellin, M.D.1    Kandaswamy, R.2    Parkey, J.3
  • 13
    • 0031978569 scopus 로고    scopus 로고
    • IA-2 antibodies are only positive in association with GAD 65 and islet cell antibodies in islet transplanted insulin-dependent diabetes mellitus patients
    • Jaeger C, Brendel MD, Hering BJ, et al. IA-2 antibodies are only positive in association with GAD 65 and islet cell antibodies in islet transplanted insulin-dependent diabetes mellitus patients. Transplant Proc 1998;30:659-60
    • (1998) Transplant Proc , vol.30 , pp. 659-660
    • Jaeger, C.1    Brendel, M.D.2    Hering, B.J.3
  • 14
    • 0035515764 scopus 로고    scopus 로고
    • Autoantibody response to islet transplantation in type 1 diabetes
    • Bosi E, Braghi S, Maffi P, et al. Autoantibody response to islet transplantation in type 1 diabetes. Diabetes 2001;50:2464-71
    • (2001) Diabetes , vol.50 , pp. 2464-2471
    • Bosi, E.1    Braghi, S.2    Maffi, P.3
  • 15
    • 29444433680 scopus 로고    scopus 로고
    • Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes
    • Pinkse GGM, Tysma OHM, Bergen CAM, et al. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA 2005;102:18425-30
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18425-18430
    • Pinkse, G.G.M.1    Tysma, O.H.M.2    Bergen, C.A.M.3
  • 16
    • 58149310848 scopus 로고    scopus 로고
    • Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation
    • Toso C, Edgar R, Pawlick R, et al. Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation. Transpl Int 2009;22:182-91
    • (2009) Transpl Int , vol.22 , pp. 182-191
    • Toso, C.1    Edgar, R.2    Pawlick, R.3
  • 17
    • 72449153380 scopus 로고    scopus 로고
    • Positron emission tomography in clinical islet transplantation
    • Eriksson O, Eich T, Sundin A, et al. Positron emission tomography in clinical islet transplantation. Am J Transplant 2009;9:2816-24
    • (2009) Am J Transplant , vol.9 , pp. 2816-2824
    • Eriksson, O.1    Eich, T.2    Sundin, A.3
  • 18
    • 0036097472 scopus 로고    scopus 로고
    • Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia
    • Biarnes M, Montolio M, Nacher V, et al. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002;51:66-72
    • (2002) Diabetes , vol.51 , pp. 66-72
    • Biarnes, M.1    Montolio, M.2    Nacher, V.3
  • 19
    • 76949108695 scopus 로고    scopus 로고
    • Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes
    • Kaddis JS, Danobeitia JS, Niland JC, et al. Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Am J Transplant 2010;10:646-56
    • (2010) Am J Transplant , vol.10 , pp. 646-656
    • Kaddis, J.S.1    Danobeitia, J.S.2    Niland, J.C.3
  • 20
    • 0036265150 scopus 로고    scopus 로고
    • Factors affecting human islet of Langerhans isolation yields
    • Toso C, Oberholzer J, Ris F, et al. Factors affecting human islet of Langerhans isolation yields. Transplant Proc 2002;34:826-7
    • (2002) Transplant Proc , vol.34 , pp. 826-827
    • Toso, C.1    Oberholzer, J.2    Ris, F.3
  • 21
    • 0037090953 scopus 로고    scopus 로고
    • Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability
    • Lakey JRT, Kneteman NM, Rajotte RV, et al. Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability. Transplantation 2002;73:1106-10
    • (2002) Transplantation , vol.73 , pp. 1106-1110
    • Lakey, J.R.T.1    Kneteman, N.M.2    Rajotte, R.V.3
  • 23
    • 77958610648 scopus 로고    scopus 로고
    • Comparison of modified Celsior solution and M-Kyoto solution for pancreas preservation in human islet isolation
    • Noguchi H, Naziruddin B, Onaca N, et al. Comparison of modified Celsior solution and M-Kyoto solution for pancreas preservation in human islet isolation. Cell Transplant 2010;19:751-8
    • (2010) Cell Transplant , vol.19 , pp. 751-758
    • Noguchi, H.1    Naziruddin, B.2    Onaca, N.3
  • 24
    • 3242786441 scopus 로고    scopus 로고
    • Extracellular matrix protects pancreatic beta-cells against apoptosis: Role of short- and long-term signaling pathways
    • Hammar E, Parnaud G, Bosco D, et al. Extracellular matrix protects pancreatic beta-cells against apoptosis: Role of short- and long-term signaling pathways. Diabetes 2004;53:2034-41
    • (2004) Diabetes , vol.53 , pp. 2034-2041
    • Hammar, E.1    Parnaud, G.2    Bosco, D.3
  • 25
    • 33745303353 scopus 로고    scopus 로고
    • Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix
    • Parnaud G, Hammar E, Rouiller DG, et al. Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. Diabetes 2006;55:1413-20
    • (2006) Diabetes , vol.55 , pp. 1413-1420
    • Parnaud, G.1    Hammar, E.2    Rouiller, D.G.3
  • 26
    • 0043167780 scopus 로고    scopus 로고
    • Inflammatory mediators expressed in human islets of Langerhans: Implications for islet transplantation
    • Johansson U, Olsson A, Gabrielsson S, et al. Inflammatory mediators expressed in human islets of Langerhans: Implications for islet transplantation. Biochem Biophys Res Commun 2003;308:474-9
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 474-479
    • Johansson, U.1    Olsson, A.2    Gabrielsson, S.3
  • 27
    • 77951034707 scopus 로고    scopus 로고
    • Resolvin E1 reduces proinflammatory markers in human pancreatic islets in vitro
    • Lund T, Mangsbo SM, Scholz H, et al. Resolvin E1 reduces proinflammatory markers in human pancreatic islets in vitro. Exp Clin Endocrinol Diabetes 2010;118:237-44
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 237-244
    • Lund, T.1    Mangsbo, S.M.2    Scholz, H.3
  • 28
    • 20044371024 scopus 로고    scopus 로고
    • Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation
    • Johansson H, Lukinius A, Moberg L, et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 2005;54:1755-62
    • (2005) Diabetes , vol.54 , pp. 1755-1762
    • Johansson, H.1    Lukinius, A.2    Moberg, L.3
  • 29
    • 0037153731 scopus 로고    scopus 로고
    • Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
    • Moberg L, Johansson H, Lukinius A, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002;360:2039-45
    • (2002) Lancet , vol.360 , pp. 2039-2045
    • Moberg, L.1    Johansson, H.2    Lukinius, A.3
  • 30
    • 33644904863 scopus 로고    scopus 로고
    • Low molecular weight dextran sulfate: A strong candidate drug to block IBMIR in clinical islet transplantation
    • Johansson H, Goto M, Dufrane D, et al. Low molecular weight dextran sulfate: A strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant 2006;6:305-12
    • (2006) Am J Transplant , vol.6 , pp. 305-312
    • Johansson, H.1    Goto, M.2    Dufrane, D.3
  • 31
    • 56749173545 scopus 로고    scopus 로고
    • Optimal implantation site for pancreatic islet transplantation
    • Merani S, Toso C, Emamaullee J, Shapiro AMJ. Optimal implantation site for pancreatic islet transplantation. Br J Surg 2008;95:1449-61
    • (2008) Br J Surg , vol.95 , pp. 1449-1461
    • Merani, S.1    Toso, C.2    Emamaullee, J.3    Shapiro, A.M.J.4
  • 32
    • 25444463829 scopus 로고    scopus 로고
    • Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood
    • Moberg L, Korsgren O, Nilsson B. Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood. Clin Exp Immunol 2005;142:125-31
    • (2005) Clin Exp Immunol , vol.142 , pp. 125-131
    • Moberg, L.1    Korsgren, O.2    Nilsson, B.3
  • 33
    • 10744233687 scopus 로고    scopus 로고
    • Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: Implications for clinical islet transplantation
    • Moberg L, Olsson A, Berne C, et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: Implications for clinical islet transplantation. Transplantation 2003;76:1285-8
    • (2003) Transplantation , vol.76 , pp. 1285-1288
    • Moberg, L.1    Olsson, A.2    Berne, C.3
  • 34
    • 45449088151 scopus 로고    scopus 로고
    • Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo
    • Lund T, Fosby B, Korsgren O, et al. Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo. Transpl Int 2008;2:669-78
    • (2008) Transpl Int , vol.2 , pp. 669-678
    • Lund, T.1    Fosby, B.2    Korsgren, O.3
  • 35
    • 0036094994 scopus 로고    scopus 로고
    • Human pancreatic islets produce and secrete MCP-1/CCL2: Relevance in human islet transplantation
    • Piemonti L, Leone BE, Nano R, et al. Human pancreatic islets produce and secrete MCP-1/CCL2: Relevance in human islet transplantation. Diabetes 2002;51:55-65
    • (2002) Diabetes , vol.51 , pp. 55-65
    • Piemonti, L.1    Leone, B.E.2    Nano, R.3
  • 36
    • 66849132584 scopus 로고    scopus 로고
    • Innate immunity and heat shock response in islet transplantation
    • Lai Y, Chen C, Linn T. Innate immunity and heat shock response in islet transplantation. Clin Exp Immunol 2009;157:1-8
    • (2009) Clin Exp Immunol , vol.157 , pp. 1-8
    • Lai, Y.1    Chen, C.2    Linn, T.3
  • 37
    • 4644233237 scopus 로고    scopus 로고
    • Response of human islets to isolation stress and the effect of antioxidant treatment
    • Bottino R, Balamurugan AN, Tse H, et al. Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 2004;53:2559-68
    • (2004) Diabetes , vol.53 , pp. 2559-2568
    • Bottino, R.1    Balamurugan, A.N.2    Tse, H.3
  • 38
    • 58149339700 scopus 로고    scopus 로고
    • The role of macrophage migration inhibitory factor in mouse islet transplantation
    • Toso C, Serre-Beinier V, Emamaullee J, et al. The role of macrophage migration inhibitory factor in mouse islet transplantation. Transplantation 2008;86:1361-9
    • (2008) Transplantation , vol.86 , pp. 1361-1369
    • Toso, C.1    Serre-Beinier, V.2    Emamaullee, J.3
  • 39
    • 0029821899 scopus 로고    scopus 로고
    • Vulnerability of islets in the immediate posttransplantation period Dynamic changes in structure and function
    • Davalli AM, Scaglia L, Zangen DH, et al. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 1996;45:1161-7
    • (1996) Diabetes , vol.45 , pp. 1161-1167
    • Davalli, A.M.1    Scaglia, L.2    Zangen, D.H.3
  • 40
    • 33947391397 scopus 로고    scopus 로고
    • Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation
    • Montolio M, Biarnes M, Tellez N, et al. Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation. J Endocrinol 2007;192:169-77
    • (2007) J Endocrinol , vol.192 , pp. 169-177
    • Montolio, M.1    Biarnes, M.2    Tellez, N.3
  • 41
    • 20144377111 scopus 로고    scopus 로고
    • Macrophage depletion prolongs discordant but not concordant islet xenograft survival
    • Andres A, Toso C, Morel P, et al. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. Transplantation 2005;79:543-9
    • (2005) Transplantation , vol.79 , pp. 543-549
    • Andres, A.1    Toso, C.2    Morel, P.3
  • 42
    • 0031890972 scopus 로고    scopus 로고
    • Transplantation of allogeneic islets of Langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation
    • Bottino R, Fernandez LA, Ricordi C, et al. Transplantation of allogeneic islets of Langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998;47:316-23
    • (1998) Diabetes , vol.47 , pp. 316-323
    • Bottino, R.1    Fernandez, L.A.2    Ricordi, C.3
  • 43
    • 80051757947 scopus 로고    scopus 로고
    • Detecting rejection after mouse islet transplantation utilizing islet protein-stimulated ELISPOT
    • In press
    • Toso C, Pawlick R, Lacotte S, et al. Detecting rejection after mouse islet transplantation utilizing islet protein-stimulated ELISPOT. Cell Transplantation (In press)
    • Cell Transplantation
    • Toso, C.1    Pawlick, R.2    Lacotte, S.3
  • 44
    • 77954953108 scopus 로고    scopus 로고
    • Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation
    • Riethmuller S, Ferrari-Lacraz S, Muller MK, et al. Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation. Transplantation 2010;90:160-7
    • (2010) Transplantation , vol.90 , pp. 160-167
    • Riethmuller, S.1    Ferrari-Lacraz, S.2    Muller, M.K.3
  • 45
    • 33746447618 scopus 로고    scopus 로고
    • A significant role for histocompatibility in human islet transplantation
    • Mohanakumar T, Narayanan K, Desai N, et al. A significant role for histocompatibility in human islet transplantation. Transplantation 2006;82:180-7
    • (2006) Transplantation , vol.82 , pp. 180-187
    • Mohanakumar, T.1    Narayanan, K.2    Desai, N.3
  • 46
    • 49249099606 scopus 로고    scopus 로고
    • Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation
    • Ferrari-Lacraz S, Berney T, Morel P, et al. Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation. Transplantation 2008;86:357-9
    • (2008) Transplantation , vol.86 , pp. 357-359
    • Ferrari-Lacraz, S.1    Berney, T.2    Morel, P.3
  • 47
    • 34548301634 scopus 로고    scopus 로고
    • High risk of sensitization after failed islet transplantation
    • Campbell PM, Senior PA, Salam A, et al. High risk of sensitization after failed islet transplantation. Am J Transplant 2007;7:2311-17
    • (2007) Am J Transplant , vol.7 , pp. 2311-2317
    • Campbell, P.M.1    Senior, P.A.2    Salam, A.3
  • 48
    • 37349119759 scopus 로고    scopus 로고
    • Allosensitization of islet allograft recipients
    • Cardani R, Pileggi A, Ricordi C, et al. Allosensitization of islet allograft recipients. Transplantation 2007;84:1413-27
    • (2007) Transplantation , vol.84 , pp. 1413-1427
    • Cardani, R.1    Pileggi, A.2    Ricordi, C.3
  • 49
    • 12644298653 scopus 로고    scopus 로고
    • Sensitization to HLA antigens in islet recipients with failing transplants
    • Olack BJ, Swanson CJ, Flavin KS, et al. Sensitization to HLA antigens in islet recipients with failing transplants. Transplant Proc 1997;29:2268-9
    • (1997) Transplant Proc , vol.29 , pp. 2268-2269
    • Olack, B.J.1    Swanson, C.J.2    Flavin, K.S.3
  • 50
    • 27844497989 scopus 로고    scopus 로고
    • Development of anti-human leukocyte antigen class 1 antibodies following allogeneic islet cell transplantation
    • Lobo PI, Spencer C, Simmons WD, et al. Development of anti-human leukocyte antigen class 1 antibodies following allogeneic islet cell transplantation. Transplant Proc 2005;37:3438-40
    • (2005) Transplant Proc , vol.37 , pp. 3438-3440
    • Lobo, P.I.1    Spencer, C.2    Simmons, W.D.3
  • 51
    • 34447115728 scopus 로고    scopus 로고
    • Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity
    • Rickels MR, Kamoun M, Kearns J, et al. Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity. J Clin Endocrinol Metab 2007;92:2410-14
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2410-2414
    • Rickels, M.R.1    Kamoun, M.2    Kearns, J.3
  • 52
    • 67650935057 scopus 로고    scopus 로고
    • Evidence for humoral rejection of a pancreatic islet graft and rescue with rituximab and IV immunoglobulin therapy
    • Kessler L, Parissiadis A, Bayle F, et al. Evidence for humoral rejection of a pancreatic islet graft and rescue with rituximab and IV immunoglobulin therapy. Am J Transplant 2009;9:1961-6
    • (2009) Am J Transplant , vol.9 , pp. 1961-1966
    • Kessler, L.1    Parissiadis, A.2    Bayle, F.3
  • 53
    • 0028237147 scopus 로고
    • Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease
    • Tuomilehto J, Zimmet P, Mackay IR, et al. Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 1994;343:1383-5
    • (1994) Lancet , vol.343 , pp. 1383-1385
    • Tuomilehto, J.1    Zimmet, P.2    Mackay, I.R.3
  • 54
    • 0030175880 scopus 로고    scopus 로고
    • Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes
    • Verge CF, Gianani R, Kawasaki E, et al. Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes. J Autoimmun 1996;9:379-83
    • (1996) J Autoimmun , vol.9 , pp. 379-383
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3
  • 55
    • 70349635504 scopus 로고    scopus 로고
    • Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients
    • Hilbrands R, Huurman VAL, Gillard P, et al. Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients. Diabetes 2009;58:2267-76
    • (2009) Diabetes , vol.58 , pp. 2267-2276
    • Hilbrands, R.1    Huurman, V.A.L.2    Gillard, P.3
  • 56
    • 0033043975 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase antibodies are more frequent than islet cell antibodies in islet transplanted IDDM patients and persist or occur despite immunosuppression
    • Jaeger C, Hering BJ, Hatziagelaki E, et al. Glutamic acid decarboxylase antibodies are more frequent than islet cell antibodies in islet transplanted IDDM patients and persist or occur despite immunosuppression. J Mol Med 1999;77:45-8
    • (1999) J Mol Med , vol.77 , pp. 45-48
    • Jaeger, C.1    Hering, B.J.2    Hatziagelaki, E.3
  • 57
    • 6844239526 scopus 로고    scopus 로고
    • Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: Graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft
    • Keymeulen B, Ling Z, Gorus FK, et al. Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: Graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 1998;41:452-9
    • (1998) Diabetologia , vol.41 , pp. 452-459
    • Keymeulen, B.1    Ling, Z.2    Gorus, F.K.3
  • 58
    • 13844265752 scopus 로고    scopus 로고
    • Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes
    • Hering BJ, Kandaswamy R, Ansite JD, et al. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 2005;293:830-5
    • (2005) JAMA , vol.293 , pp. 830-835
    • Hering, B.J.1    Kandaswamy, R.2    Ansite, J.D.3
  • 59
    • 0035807589 scopus 로고    scopus 로고
    • Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency
    • Martin S, Wolf-Eichbaum D, Duinkerken G, et al. Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med 2001;345:1036-40
    • (2001) N Engl J Med , vol.345 , pp. 1036-1040
    • Martin, S.1    Wolf-Eichbaum, D.2    Duinkerken, G.3
  • 60
    • 22144445286 scopus 로고    scopus 로고
    • Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients
    • van Kampen CA, van de Linde P, Duinkerken G, et al. Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients. Transplantation 2005;80:118-26
    • (2005) Transplantation , vol.80 , pp. 118-126
    • Van Kampen, C.A.1    Van De Linde, P.2    Duinkerken, G.3
  • 61
    • 43049150180 scopus 로고    scopus 로고
    • Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation
    • Huurman VAL, Hilbrands R, Pinkse GGM, et al. Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS ONE 2008;3:e2435
    • (2008) PLoS ONE , vol.3
    • Huurman, V.A.L.1    Hilbrands, R.2    Pinkse, G.G.M.3
  • 62
    • 58849105854 scopus 로고    scopus 로고
    • Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation
    • Huurman VAL, Velthuis JHL, Hilbrands R, et al. Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation. Am J Transplant 2009;9:382-8
    • (2009) Am J Transplant , vol.9 , pp. 382-388
    • Huurman, V.A.L.1    Velthuis, J.H.L.2    Hilbrands, R.3
  • 63
    • 0032758644 scopus 로고    scopus 로고
    • Tolerance to kidney allograft transplanted into type I diabetic patients persists after in vivo challenge with pancreatic islet allografts that express repeated mismatches
    • Stobbe I, Duinkerken G, van Rood JJ, et al. Tolerance to kidney allograft transplanted into type I diabetic patients persists after in vivo challenge with pancreatic islet allografts that express repeated mismatches. Diabetologia 1999;42:1379-80
    • (1999) Diabetologia , vol.42 , pp. 1379-1380
    • Stobbe, I.1    Duinkerken, G.2    Van Rood, J.J.3
  • 64
    • 61849097838 scopus 로고    scopus 로고
    • Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation
    • Roelen DL, Huurman VAL, Hilbrands R, et al. Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation. Clin Exp Immunol 2009;156:141-8
    • (2009) Clin Exp Immunol , vol.156 , pp. 141-148
    • Roelen, D.L.1    Huurman, V.A.L.2    Hilbrands, R.3
  • 65
    • 0027261281 scopus 로고
    • Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506
    • Roelen DL, van Bree FP, Schanz U, et al. Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506. Transplantation 1993;56:190-5
    • (1993) Transplantation , vol.56 , pp. 190-195
    • Roelen, D.L.1    Van Bree, F.P.2    Schanz, U.3
  • 66
    • 77951983004 scopus 로고    scopus 로고
    • Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
    • Velthuis JH, Unger WW, Abreu JRF, et al. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010;59:1721-30
    • (2010) Diabetes , vol.59 , pp. 1721-1730
    • Velthuis, J.H.1    Unger, W.W.2    Abreu, J.R.F.3
  • 67
    • 77951168859 scopus 로고    scopus 로고
    • Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells
    • Vendrame F, Pileggi A, Laughlin E, et al. Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes 2010;59:947-57
    • (2010) Diabetes , vol.59 , pp. 947-957
    • Vendrame, F.1    Pileggi, A.2    Laughlin, E.3
  • 68
    • 33748690103 scopus 로고    scopus 로고
    • Assessing relative risks of infection and rejection: A meta-analysis using an immune function assay
    • Kowalski RJ, Post DR, Mannon RB, et al. Assessing relative risks of infection and rejection: A meta-analysis using an immune function assay. Transplantation 2006;82:663-8
    • (2006) Transplantation , vol.82 , pp. 663-668
    • Kowalski, R.J.1    Post, D.R.2    Mannon, R.B.3
  • 69
    • 67649172198 scopus 로고    scopus 로고
    • Using an immune functional assay to differentiate acute cellular rejection from recurrent hepatitis C in liver transplant patients
    • Cabrera R, Ararat M, Soldevila-Pico C, et al. Using an immune functional assay to differentiate acute cellular rejection from recurrent hepatitis C in liver transplant patients. Liver Transpl 2009;15:216-22
    • (2009) Liver Transpl , vol.15 , pp. 216-222
    • Cabrera, R.1    Ararat, M.2    Soldevila-Pico, C.3
  • 70
    • 67649588841 scopus 로고    scopus 로고
    • Experience with immune monitoring in lung transplant recipients: Correlation of low immune function with infection
    • Husain S, Raza K, Pilewski JM, et al. Experience with immune monitoring in lung transplant recipients: Correlation of low immune function with infection. Transplantation 2009;87:1852-7
    • (2009) Transplantation , vol.87 , pp. 1852-1857
    • Husain, S.1    Raza, K.2    Pilewski, J.M.3
  • 71
    • 4344584830 scopus 로고    scopus 로고
    • Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: Elevation precedes clinical evidence of rejection
    • Han D, Xu X, Baidal D, et al. Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: Elevation precedes clinical evidence of rejection. Diabetes 2004;53:2281-90
    • (2004) Diabetes , vol.53 , pp. 2281-2290
    • Han, D.1    Xu, X.2    Baidal, D.3
  • 72
    • 0036313598 scopus 로고    scopus 로고
    • Molecular detection of circulating beta-cells after islet transplantation
    • Ritz-Laser B, Oberholzer J, Toso C, et al. Molecular detection of circulating beta-cells after islet transplantation. Diabetes 2002;51:557-61
    • (2002) Diabetes , vol.51 , pp. 557-561
    • Ritz-Laser, B.1    Oberholzer, J.2    Toso, C.3
  • 73
    • 33745332679 scopus 로고    scopus 로고
    • Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control
    • Berney T, Mamin A, James Shapiro AM, et al. Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control. Am J Transplant 2006;6:1704-11
    • (2006) Am J Transplant , vol.6 , pp. 1704-1711
    • Berney, T.1    Mamin, A.2    James Shapiro, A.M.3
  • 74
    • 0034142222 scopus 로고    scopus 로고
    • Highly altered V beta repertoire of T cells infiltrating long-term rejected kidney allografts
    • Gagne K, Brouard S, Giral M, et al. Highly altered V beta repertoire of T cells infiltrating long-term rejected kidney allografts. J Immunol 2000;164:1553-63
    • (2000) J Immunol , vol.164 , pp. 1553-1563
    • Gagne, K.1    Brouard, S.2    Giral, M.3
  • 75
    • 34848857054 scopus 로고    scopus 로고
    • Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
    • Brouard S, Mansfield E, Braud C, et al. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci USA 2007;104:15448-53
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15448-15453
    • Brouard, S.1    Mansfield, E.2    Braud, C.3
  • 76
    • 73249144602 scopus 로고    scopus 로고
    • Functional genomic analysis of peripheral blood during early acute renal allograft rejection
    • Gunther OP, Balshaw RF, Scherer A, et al. Functional genomic analysis of peripheral blood during early acute renal allograft rejection. Transplantation 2009;88:942-51
    • (2009) Transplantation , vol.88 , pp. 942-951
    • Gunther, O.P.1    Balshaw, R.F.2    Scherer, A.3
  • 77
    • 0037442068 scopus 로고    scopus 로고
    • Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejection
    • Pelzl S, Opelz G, Daniel V, et al. Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejection. Transplantation 2003;75:421-3
    • (2003) Transplantation , vol.75 , pp. 421-423
    • Pelzl, S.1    Opelz, G.2    Daniel, V.3
  • 78
    • 33947578222 scopus 로고    scopus 로고
    • Post-transplant HLA class II antibodies and high soluble CD30 levels are independently associated with poor kidney graft survival
    • Langan LL, Park LP, Hughes TL, et al. Post-transplant HLA class II antibodies and high soluble CD30 levels are independently associated with poor kidney graft survival. Am J Transplant 2007;7:847-56
    • (2007) Am J Transplant , vol.7 , pp. 847-856
    • Langan, L.L.1    Park, L.P.2    Hughes, T.L.3
  • 79
    • 49649119956 scopus 로고    scopus 로고
    • Activated effector and memory T cells contribute to circulating sCD30: Potential marker for islet allograft rejection
    • Saini D, Ramachandran S, Nataraju A, et al. Activated effector and memory T cells contribute to circulating sCD30: Potential marker for islet allograft rejection. Am J Transplant 2008;8:1798-808
    • (2008) Am J Transplant , vol.8 , pp. 1798-1808
    • Saini, D.1    Ramachandran, S.2    Nataraju, A.3
  • 80
    • 77956060537 scopus 로고    scopus 로고
    • Relative reductions in soluble CD30 levels post-transplant predict acute graft function in islet allograft recipients receiving three different immunosuppression protocols
    • Hire K, Hering B, Bansal-Pakala P. Relative reductions in soluble CD30 levels post-transplant predict acute graft function in islet allograft recipients receiving three different immunosuppression protocols. Transpl Immunol 2010;23:209-14
    • (2010) Transpl Immunol , vol.23 , pp. 209-214
    • Hire, K.1    Hering, B.2    Bansal-Pakala, P.3
  • 81
    • 69549118444 scopus 로고    scopus 로고
    • Pretransplant pharmacodynamic analysis of immunosuppressive agents using CFSE-based T-cell proliferation assay
    • Kurata Y, Kato M, Kuzuya T, et al. Pretransplant pharmacodynamic analysis of immunosuppressive agents using CFSE-based T-cell proliferation assay. Clin Pharmacol Ther 2009;86:285-9
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 285-289
    • Kurata, Y.1    Kato, M.2    Kuzuya, T.3
  • 82
    • 21844440052 scopus 로고    scopus 로고
    • Tuning immune responses: Diversity and adaptation of the immunological synapse
    • Friedl P, den Boer AT, Gunzer M. Tuning immune responses: Diversity and adaptation of the immunological synapse. Nat Rev Immunol 2005;5:532-45
    • (2005) Nat Rev Immunol , vol.5 , pp. 532-545
    • Friedl, P.1    Den Boer, A.T.2    Gunzer, M.3
  • 83
    • 34548738327 scopus 로고    scopus 로고
    • Quality of life after islet transplant: Impact of the number of islet infusions and metabolic outcome
    • Toso C, Shapiro AMJ, Bowker S, et al. Quality of life after islet transplant: Impact of the number of islet infusions and metabolic outcome. Transplantation 2007;84:664-6
    • (2007) Transplantation , vol.84 , pp. 664-666
    • Toso, C.1    Shapiro, A.M.J.2    Bowker, S.3
  • 84
    • 66449115776 scopus 로고    scopus 로고
    • Quality of life after islet transplantation: Data from the GRAGIL 1 and 2 trials
    • Benhamou PY, Milliat-Guittard L, Wojtusciszyn A, et al. Quality of life after islet transplantation: Data from the GRAGIL 1 and 2 trials. Diabet Med 2009;26:617-21
    • (2009) Diabet Med , vol.26 , pp. 617-621
    • Benhamou, P.Y.1    Milliat-Guittard, L.2    Wojtusciszyn, A.3
  • 85
    • 33645455798 scopus 로고    scopus 로고
    • Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogeneic cell bank
    • Andree H, Nickel P, Nasiadko C, et al. Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogeneic cell bank. J Am Soc Nephrol 2006;17:573-80
    • (2006) J Am Soc Nephrol , vol.17 , pp. 573-580
    • Andree, H.1    Nickel, P.2    Nasiadko, C.3
  • 86
    • 10644278692 scopus 로고    scopus 로고
    • Enzyme-linked immunosorbent spot assay for donor-reactive interferon-gamma-producing cells identifies T-cell presensitization and correlates with graft function at 6 and 12 months in renal-transplant recipients
    • Nickel P, Presber F, Bold G, et al. Enzyme-linked immunosorbent spot assay for donor-reactive interferon-gamma-producing cells identifies T-cell presensitization and correlates with graft function at 6 and 12 months in renal-transplant recipients. Transplantation 2004;78:1640-6
    • (2004) Transplantation , vol.78 , pp. 1640-1646
    • Nickel, P.1    Presber, F.2    Bold, G.3
  • 87
    • 20044366536 scopus 로고    scopus 로고
    • Positron-emission tomography imaging of early events after transplantation of islets of Langerhans
    • Toso C, Zaidi H, Morel P, et al. Positron-emission tomography imaging of early events after transplantation of islets of Langerhans. Transplantation 2005;79:353-5
    • (2005) Transplantation , vol.79 , pp. 353-355
    • Toso, C.1    Zaidi, H.2    Morel, P.3
  • 88
    • 39649097811 scopus 로고    scopus 로고
    • Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling
    • Toso C, Vallee J, Morel P, et al. Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling. Am J Transplant 2008;8:701-6
    • (2008) Am J Transplant , vol.8 , pp. 701-706
    • Toso, C.1    Vallee, J.2    Morel, P.3
  • 89
    • 34347207280 scopus 로고    scopus 로고
    • Visualization of early engraftment in clinical islet transplantation by positron-emission tomography
    • Eich T, Eriksson O, Lundgren T. Visualization of early engraftment in clinical islet transplantation by positron-emission tomography. N Engl J Med 2007;356:2754-5
    • (2007) N Engl J Med , vol.356 , pp. 2754-2755
    • Eich, T.1    Eriksson, O.2    Lundgren, T.3
  • 90
    • 73349107801 scopus 로고    scopus 로고
    • Histologic graft assessment after clinical islet transplantation
    • Toso C, Isse K, Demetris A, et al. Histologic graft assessment after clinical islet transplantation. Transplantation 2009;88:1286-93
    • (2009) Transplantation , vol.88 , pp. 1286-1293
    • Toso, C.1    Isse, K.2    Demetris, A.3
  • 91
    • 78650062375 scopus 로고    scopus 로고
    • Open-label investigation of the safety and effectiveness of DIABECELL(R) in patients with type i diabetes mellitus Bethesda MD: ClinicalTrials.gov, Available from:[Last accessed 1 November 2010]
    • Open-label investigation of the safety and effectiveness of DIABECELL(R) in patients with type i diabetes mellitus. Bethesda MD: ClinicalTrials.gov, 2010. Available from: Http://clinicaltrials. gov/ct2/show/NCT00940173? term=DIABECELL&rank=1 [Last accessed 1 November 2010]
    • (2010)
  • 92
    • 78650070200 scopus 로고    scopus 로고
    • Safety and efficacy study of encapsulated human islets allotransplantation to treat type 1 diabetes,Bethesda MD: ClinicalTrials.gov, 210,Available from:[Last accessed 1 November 2010]
    • Safety and efficacy study of encapsulated human islets allotransplantation to treat type 1 diabetes. Bethesda MD: ClinicalTrials.gov, 210. Available from: Http://clinicaltrials.gov/ct2/show/ NCT00790257?term=islet+ encapsulation&rank=1 [Last accessed 1 November 2010]
  • 93
    • 77953825835 scopus 로고    scopus 로고
    • In vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation
    • Veriter S, Mergen J, Goebbels R, et al. In vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation. Tissue Eng Part A 2010;16:1503-13
    • (2010) Tissue Eng Part A , vol.16 , pp. 1503-1513
    • Veriter, S.1    Mergen, J.2    Goebbels, R.3
  • 94
    • 73649089311 scopus 로고    scopus 로고
    • Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: In vitro and in vivo studies
    • De Carlo E, Baiguera S, Conconi MT, et al. Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: In vitro and in vivo studies. Int J Mol Med 2010;25:195-202
    • (2010) Int J Mol Med , vol.25 , pp. 195-202
    • De Carlo, E.1    Baiguera, S.2    Conconi, M.T.3
  • 95
    • 77951103786 scopus 로고    scopus 로고
    • Integrins and extracellular matrices in pancreatic tissue engineering
    • Krishnamurthy M, Wang R. Integrins and extracellular matrices in pancreatic tissue engineering. Front Biosci (Schol Ed) 2009;1:477-91
    • (2009) Front Biosci (Schol Ed) , vol.1 , pp. 477-491
    • Krishnamurthy, M.1    Wang, R.2
  • 96
    • 22844438322 scopus 로고    scopus 로고
    • Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients
    • Augustine JJ, Siu DS, Clemente MJ, et al. Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients. Am J Transplant 2005;5:1971-5
    • (2005) Am J Transplant , vol.5 , pp. 1971-1975
    • Augustine, J.J.1    Siu, D.S.2    Clemente, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.