Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation

Transplantation

Volumn 90, Issue 2, 2010, Pages 160-167

  Riethmüller, Sebastian ^a   Ferrari Lacraz, Sylvie ^b   Müller, Markus K ^a   Raptis, Dimitri A ^a   Hadaya, Karine ^b   Rüsi, Barbara ^a   Laube, Guido ^c   Schneiter, Gregory ^b   Fehr, Thomas ^a   Villard, Jean ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Anti HLA antibodies; Donor specific antibodies; Kidney transplantation; Luminex crossmatch; Solid phase assay

Indexed keywords

BASILIXIMAB; CYCLOSPORIN; CYCLOSPORIN A; HLA A ANTIGEN; HLA ANTIBODY; HLA B ANTIGEN; HLA DR ANTIGEN; MYCOPHENOLIC ACID; PREDNISONE; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD GROUP TYPING; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIAGNOSTIC ACCURACY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; GLOMERULONEPHRITIS; HUMAN; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY POLYCYSTIC DISEASE; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; PROGNOSIS; PYELONEPHRITIS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ADULT; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSION; ISOANTIBODIES; KIDNEY TRANSPLANTATION; LIVING DONORS; LYMPHOCYTES; MALE; MIDDLE AGED; PROGNOSIS; REOPERATION; RETROSPECTIVE STUDIES; ROC CURVE; TISSUE DONORS;

EID: 77954953108     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181e36e08     Document Type: Article

References (44)

1. Morales-Buenrostro LE, Terasaki PI, Marino-Vazquez LA, et al. "Natural" human leukocyte antigen antibodies foundin nonalloimmunized healthy males. Transplantation 2008; 86: 1111.
2. McKenna RM, Takemoto SK, Terasaki PI. Anti-HLA antibodies after solid organ transplantation. Transplantation 2000; 69: 319.
3. Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969; 280: 735.
4. Bray RA, Lebeck LK, Gebel HM. The flow cytometric crossmatch. Dual-color analysis of T cell and B cell reactivities. Transplantation 1989; 48: 834.
5. Gebel HM, Bray RA. Sensitization and sensitivity: Defining the unsen-sitized patient. Transplantation 2000; 69: 1370.
6. Pei R, Wang G, Tarsitani C, et al. Simultaneous HLA Class I and Class II antibodies screening with flow cytometry. Hum Immunol 1998; 59: 313.
7. Pei R, Lee JH, Shih NJ, et al. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 2003; 75: 43.
8. El-Awar N, Lee J, Terasaki PI. HLA antibody identification with single antigen beads compared to conventional methods. Hum Immunol 2005; 66: 989.
9. Billen EV, Voorter CE, Christiaans MH, et al. Luminex donor-specific crossmatches. Tissue Antigens 2008; 71: 507.
10. Billen EV, Christiaans MH, van den Berg-Loonen EM. Clinical relevance of Luminex donor-specific crossmatches: Data from 165 renal transplants. Tissue Antigens 2009; 74: 205.
11. LeFor WM, Ackermann JR, Alveranga DY, et al. Flow cytometry cross-matching and primary cadaver kidney graft outcome: Relevance of T and B cell targets, historic sera and autologous controls. Clin Transplant 1996; 10(6 pt 2): 601.
12. Piazza A, Poggi E, Borrelli L, et al. Impact of donor-specific antibodies on chronic rejection occurrence and graft loss in renal transplantation: Posttransplant analysis using flow cytometric techniques. Transplantation 2001; 71: 1106.
13. Worthington JE, Martin S, Al-Husseini DM, et al. Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome. Transplantation 2003; 75: 1034.
14. Mao Q, Terasaki PI, Cai J, et al. Extremely high association between appearance ofHLA antibodies and failure of kidney graftsin afive-year longitudinal study. Am J Transplant 2007; 7: 864.
15. Gupta A, Iveson V, Varagunam M, et al. Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: Are they relevant? Transplantation 2008; 85: 1200.
16. Phelan D, Mohanakumar T, Ramachandran S, et al. Living donor renal transplantation in the presence of donor-specific human leukocyte antigen antibody detected by solid-phase assay. Hum Immunol 2009; 70: 584.
17. Lefaucheur C, Suberbielle-Boissel C, Hill GS, et al. Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation. Contrib Nephrol 2009; 162: 1.
18. Amico P, Honger G, Mayr M, et al. Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads. Transplantation 2009; 87: 1681.
19. Vlad G, Ho EK, Vasilescu ER, et al. Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival. Hum Immunol 2009; 70: 589.
20. van den Berg-Loonen EM, Billen EV, Voorter CE, et al. Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients. Transplantation 2008; 85: 1086.
21. Pei R, Lee J, Chen T, et al. Flow cytometric detection of HLA antibodies using a spectrum of microbeads. Hum Immunol 1999; 60: 1293.
22. Bray RA. Flow cytometry crossmatching for solid organ transplantation. Methods Cell Biol 1994; 41: 103.
23. Stegall MD, Gloor J, Winters JL, et al. A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levelsof donor specific alloantibody.Am JTransplant2006; 6:346.
24. Ferrari-Lacraz S, Aubert V, Buhler L, et al. Anti-HLA antibody repertoire after IVIg infusion in highly sensitized patients waiting for kidney transplantation. Swiss Med Wkly 2006; 136: 696.
25. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
26. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008; 8: 753.
27. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31.
28. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561.
29. Gebel HM, Bray RA, Nickerson P. Pre-transplant assessment of donor-reactive, HLA-specific antibodies in renal transplantation: Contraindication vs risk. Am J Transplant 2003; 3: 1488.
30. Eng HS, Bennett G, Tsiopelas E, et al. Anti-HLA donor-specific antibodies detected in positive B-cell crossmatches by Luminex predict late graft loss. Am J Transplant 2008; 8: 2335.
31. Ho EK, Vasilescu ER, Colovai AI, et al. Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantation. Transpl Immunol 2008; 20: 61.
32. Eng HS, Bennett G, Bardy P, et al. Clinical significance of anti-HLA antibodies detected by Luminex: Enhancing the interpretation of CDC-BXM and important post-transplantation monitoring tools. Hum Immunol 2009; 70: 595.
33. Patel AM, Pancoska C, Mulgaonkar S, et al. Renal transplantation in patients with pre-transplant donor-specific antibodies and negative flow cytometry crossmatches. Am J Transplant 2007; 7: 2371.
34. Opelz G, Claas FH. Which human leukocyte antigen antibodies are really clinically relevant? Hum Immunol 2009; 70: 561.
35. Gloor JM, Sethi S, Stegall MD, et al. Transplant glomerulopathy: Sub-clinical incidence and association with alloantibody. Am J Transplant 2007; 7: 2124.
36. Issa N, Cosio FG, Gloor JM, et al. Transplant glomerulopathy: Risk and prognosis related to anti-human leukocyte antigen class II antibody levels. Transplantation 2008; 86: 681.
37. Hidalgo LG, Campbell PM, Sis B, et al. De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvas-cular pathology and late graft failure. Am J Transplant 2009; 9: 2532.
38. Markus BH, Colson YL, Fung JJ, et al. HLA antigen expression on cultured human arterial endothelial cells. Tissue Antigens 1988; 32: 241.
39. Muczynski KA, Ekle DM, Coder DM, et al. Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: Characterization, isolation, and regulation of MHC class II expression. J Am Soc Nephrol 2003; 14: 1336.
40. Kerman RH, Susskind B, Buyse I, et al. Flow cytometry-detected IgG is not a contraindication to renal transplantation: IgM may be beneficial to outcome. Transplantation 1999; 68: 1855.
41. Delgado JC, Eckels DD. Positive B-cell only flow cytometric cross-match: Implications for renal transplantation. Exp Mol Pathol 2008; 85: 59.
42. Vaidya S, Cooper TY, Avandsalehi J, et al. Improved flow cytometric detection of HLA alloantibodies using pronase: Potential implications in renal transplantation. Transplantation 2001; 71: 422.
43. Sadeghi M, Daniel V, Weimer R, et al. Pre-transplant Th1 and post-transplant Th2 cytokine patterns are associated with early acute rejection in renal transplant recipients. Clin Transplant 2003; 17: 151.
44. Sadeghi M, Daniel V, Naujokat C, et al. Evidence for IFN-gamma up-and IL-4 downregulation late post-transplant in patients with good kidney graft outcome. Clin Transplant 2007; 21: 449.