From stem cells to neural networks: Recent advances and perspectives for neurodevelopmental disorders

Developmental Medicine and Child Neurology

Volumn 53, Issue 1, 2011, Pages 13-17

  Gaspard, Nicolas ^a   Vanderhaeghen, Pierre ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN DISEASE; CELL DIFFERENTIATION; CELL LINEAGE; CELL TYPE; DEVELOPMENTAL DISORDER; EMBRYONIC STEM CELL; EPIGENETICS; GENETIC DISORDER; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MENTAL FUNCTION; MOLECULAR MECHANICS; MOTOR CORTEX; NERVE CELL NETWORK; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATHOPHYSIOLOGY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; REVIEW; SOMATIC CELL; SPINAL CORD MOTONEURON; STEM CELL TRANSPLANTATION;

EID: 78650056304     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/j.1469-8749.2010.03827.x     Document Type: Review

References (45)

1. Gaspard N, Vanderhaeghen P. Mechanisms of neural specification from embryonic stem cells. Curr Opin Neurobiol 2010; 20: 37-43.
2. Altmann CR, Brivanlou AH. Neural patterning in the vertebrate embryo. Int Rev Cytol 2001; 203: 447-82.
3. Levine AJ, Brivanlou AH. Proposal of a model of mammalian neural induction. Dev Biol 2007; 308: 247-56.
4. Chambers I, Tomlinson SR. The transcriptional foundation of pluripotency. Development 2009; 136: 2311-22.
5. Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002; 110: 385-97.
6. Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 2000; 18: 675-9.
7. Murashov AK, Pak ES, Hendricks WA, et al. Directed differentiation of embryonic stem cells into dorsal interneurons. FASEB J 2005; 19: 252-4.
8. Su HL, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K, Sasai Y. Generation of cerebellar neuron precursors from embryonic stem cells. Dev Biol 2006; 290: 287-96.
9. Salero E, Hatten ME. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci USA 2007; 104: 2997-3002.
10. Wataya T, Ando S, Muguruma K, et al. Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci USA 2008; 105: 11796-801.
11. Eiraku M, Watanabe K, Matsuo-Takasaki M, et al. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 2008; 3: 519-32.
12. Gaspard N, Bouschet T, Hourez R, et al. An intrinsic mechanism of corticogenesis from embryonic stem cells. Nature 2008; 455: 351-7.
13. Gaspard N, Bouschet T, Herpoel A, Naeije G, Van Den Ameele J, Vanderhaeghen P. Generation of cortical neurons from mouse embryonic stem cells. Nat Protoc 2009; 4: 1454-63.
14. Jessell TM. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet 2000; 1: 20-9.
15. Watanabe K, Kamiya D, Nishiyama A, et al. Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci 2005; 8: 288-96.
16. Gaspard N, Gaillard A, Vanderhaeghen P. Making cortex in a dish: in vitro corticopoiesis from embryonic stem cells. Cell Cycle 2009; 8: 2491-6.
17. Kaas JH. The evolution of isocortex. Brain Behav Evol 1995; 46: 187-96.
18. Hockemeyer D, Soldner F, Beard C, et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol 2009; 27: 851-7.
19. Lacoste A, Berenshteyn F, Brivanlou AH. An efficient and reversible transposable system for gene delivery and lineage-specific differentiation in human embryonic stem cells. Cell Stem Cell 2009; 5: 332-42.
20. Osafune K, Caron L, Borowiak M, et al. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol 2008; 26: 313-5.
21. Adewumi O, Aflatoonian B, Ahrlund-Richter L, et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol 2007; 25: 803-16.
22. Mateizel I, De Temmerman N, Ullmann U, et al. Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders. Hum Reprod 2006; 21: 503-11.
23. Eiges R, Urbach A, Malcov M, et al. Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos. Cell Stem Cell 2007; 1: 568-77.
24. Frumkin T, Malcov M, Telias M, et al. Human embryonic stem cells carrying mutations for severe genetic disorders. In Vitro Cell Dev Biol Anim 2010; 46: 327-36.
25. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-76.
26. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-72.
27. Hotta A, Cheung AY, Farra N, et al. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods 2009; 6: 370-6.
28. Woltjen K, Michael IP, Mohseni P, et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009; 458: 766-70.
29. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009; 458: 771-5.
30. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008; 322: 945-9.
31. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322: 949-53.
32. Yusa K, Rad R, Takeda J, Bradley A. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 2009; 6: 363-9.
33. Dimos JT, Rodolfa KT, Niakan KK, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008; 321: 1218-21.
34. Ebert AD, Yu J, Rose FF Jr, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009; 457: 277-80.
35. Lee G, Papapetrou EP, Kim H, et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 2009; 461: 402-6.
36. Soldner F, Hockemeyer D, Beard C, et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009; 136: 964-77.
37. Park IH, Arora N, Huo H, et al. Disease-specific induced pluripotent stem cells. Cell 2008; 134: 877-86.
38. Hu BY, Zhang SC. Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc 2009; 4: 1295-304.
39. Pober BR. Williams-Beuren syndrome. N Engl J Med 2010; 362: 239-52.
40. Tassabehji M. Williams-Beuren syndrome: a challenge for genotype-phenotype correlations. Hum Mol Genet 2003; 12(Suppl. 2): R229-37.
41. Osborne LR. Animal models of Williams syndrome. Am J Med Genet C Semin Med Genet 2010; 154C: 209-19.
42. Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010; 463: 1035-41.
43. Hu BY, Weick JP, Yu J, et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci USA 2010; 107: 4335-40.
44. Gaillard A, Prestoz L, Dumartin B, et al. Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons. Nat Neurosci 2007; 10: 1294-9.
45. Wernig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci USA 2008; 105: 5856-61.