Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 33, 2008, Pages 11796-11801

  Wataya, Takafumi ^a,b   Ando, Satoshi ^a   Muguruma, Keiko ^a   Ikeda, Hanako ^a   Watanabe, Kiichi ^a   Eiraku, Mototsugu ^a   Kawada, Masako ^a   Takahashi, Jun ^b   Hashimoto, Nobuo ^b   Sasai, Yoshiki ^a,b  

^a RIKEN   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Chemically defined; Hypothalamus; Patterning; Vasopressin

Indexed keywords

GROWTH FACTOR; HOMEODOMAIN PROTEIN; INSULIN; PROTEIN BRN2; PROTEIN KINASE B; PROTEIN OTP; PROTEIN RAX; PROTEIN VAX1; TRANSCRIPTION FACTOR SIX3; VASOPRESSIN RECEPTOR;

ANIMAL CELL; ANTERIOR HYPOTHALAMUS; ARTICLE; CELL AGGREGATION; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; FLUORESCENCE ACTIVATED CELL SORTING; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; EMBRYONIC STEM CELLS; EYE PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HYPOTHALAMUS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 50149096140     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803078105     Document Type: Article

References (38)

1. Mizuseki K, et al. (2003) Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci USA 100:5828-5833.
2. Tropepe V, et al. (2001) Direct neural fate specification from embryonic stem cells: A primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30:65-78.
3. Wichterle H, Lieberam I, Porter JA, Jessell TM (2002) Directed differentiation of embryonic stem cells into motor neurons. Cell 110:385-397.
4. Watanabe K, et al. (2005) Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci 8:288-296.
5. Ying QL, et al. (2003) Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 21:183-186.
6. Goldsborough M, et al. (1998) Serum-free culture of murine embryonic stem (ES) cells. Focus 20:8-12.
7. Tao W, Lai E (1992) Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron 8:957-966.
8. Watanabe K, et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25:681-686.
9. Chiang C, et al. (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413.
10. Markakis EA (2002) Development of the neuroendocrine hypothalamus. Front Neuroendocrinol 23:257-291.
11. Lebkowski JS, et al. (2001) Human embryonic stem cells: Culture, differentiation, and genetic modification for regenerative medicine applications. Cancer J 7 (Suppl 2):S83-93.
12. Lagutin OV, et al. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev 17:368-379.
13. Furukawa T, Kozak CA, Cepko CL (1997) rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina. Proc Natl Acad Sci USA 94:3088-3093.
14. Ikeda H, et al. (2005) Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci USA 102:11331-11336.
15. Horsford DJ, et al. (2005) Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 132:177-187.
16. Hallonet M, Hollemann T, Pieler T, Gruss P (1999) Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev 13:3106-3114.
17. Oliver G, et al. (1995) Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development 121:4045-4055.
18. Sinha S, Chen JK (2006) Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol 2:29-30.
19. Acampora D, et al. (2000) The role of Otx and Otp genes in brain development. Int J Dev Biol 44:669-677.
20. Dellovade TL, et al. (2000) Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes. J Comp Neurol 423:579-589.
21. Alvarez-Bolado G, et al. (2000) Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus. Development 127:1029-1038.
22. Caverson MM, Ciriello J, Calaresu FR, Krukoff TL (1987) Distribution and morphology of vasopressin-, neurophysin II-, and oxytocin-immunoreactive cell bodies in the forebrain of the cat. J Comp Neurol 259:211-236.
23. Armstrong ME (2004) in The Rat Nervous System, ed Paxinos G (Academic Press, San Diego), pp 369-383.
24. Cisowska-Maciejewska A, Ciosek J (2005) Galanin influences vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of salt loaded rats. J Physiol Pharmacol 56:673-688.
25. Bjorklund A, Moore RY, Nobin A, Stenevi U (1973) The organization of tubero-hypophyseal and reticulo-infundibular catecholamine neuron systems in the rat brain. Brain Res 51:171-191.
26. Tong Q, et al. (2007) Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5:383-393.
27. Altman J, Bayer SA (1986) The Development of the Rat Hypothalamus (Springer-Verlag, Berlin), pp 10-26.
28. Maye P, et al. (2004) Hedgehog signaling is required for the differentiation of ES cells into neurectoderm. Dev Biol 265:276-290.
29. Belo JA, et al. (2000) Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis 26:265-270.
30. Rallu M, Corbin JG, Fishell G (2002) Parsing the prosencephalon. Nat Rev Neurosci 3:943-951.
31. Nordstrom U, Jessell TM, Edlund T (2002) Progressive induction of caudal neural character by graded Wnt signaling. Nat Neurosci 5:525-532.
32. Ohyama K, Ellis P, Kimura S, Placzek M (2005) Directed differentiation of neural cells to hypothalamic dopaminergic neurons. Development 132:5185-5197.
33. Freund C, et al. (2008) Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem Cells 26:724-733.
34. Desbois-Mouthon C, et al. (2001) Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation. Oncogene 20:252-259.
35. Puelles L, Rubenstein JL (2003) Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci 26:469-476.
36. Rubenstein JL, Shimamura K, Martinez S, Puelles L (1998) Regionalization of the prosencephalic neural plate. Annu Rev Neurosci 21:445-477.
37. Tessmar-Raible K, et al. (2007) Conserved sensory-neurosecretory cell types in annelid and fish forebrain: Insights into hypothalamus evolution. Cell 129:1389-1400.
38. Johansson BM, Wiles MV (1995) Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol 15:141-151.