Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 40135-40147

  Glantschnig, Helmut ^a   Hampton, Richard A ^a   Lu, Ping ^a   Zhao, Jing Z ^a   Vitelli, Salvatore ^a   Huang, Lingyi ^a   Haytko, Peter ^a   Cusick, Tara ^a   Ireland, Cheryl ^a   Jarantow, Stephen W ^a   Ernst, Robin ^a   Wei, Nan ^a   Nantermet, Pascale ^a   Scott, Kevin R ^a   Fisher, John E ^a   Talamo, Fabio ^b   Orsatti, Laura ^b   Reszka, Alfred A ^a   Sandhu, Punam ^a   Kimmel, Donald ^a   Flores, Osvaldo ^a   Strohl, William ^a   An, Zhiqiang ^a   Wang, Fubao ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; BONE MASS; BONE TURNOVER; C-TERMINAL DOMAINS; CORTICAL BONE; DISEASE ETIOLOGY; DISEASE MODELS; IN-VITRO; IN-VIVO; INHIBITORY FUNCTION; NON-HUMAN PRIMATE; PATHWAY INHIBITORS; PHARMACOKINETIC PARAMETERS; RATE LIMITING; RODENT MODELS; TRABECULAR BONES;

MAMMALS; MONOCLONAL ANTIBODIES;

BONE;

DICKKOPF 1 PROTEIN; DICKKOPF 2 PROTEIN; DICKKOPF 4 PROTEIN; GLYCOPROTEIN; IMMUNOGLOBULIN G; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BONE DENSITY; BONE MASS; BONE STRUCTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DRUG HALF LIFE; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACACA; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; TRABECULAR BONE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; BONE DENSITY; BONE DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LDL-RECEPTOR RELATED PROTEINS; MACACA FASCICULARIS; MACACA MULATTA; MICE; OSTEOGENESIS;

MUS; PRIMATES; RODENTIA;

EID: 78650040987     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.166892     Document Type: Article

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