메뉴 건너뛰기




Volumn 30, Issue 12, 2010, Pages 865-873

Targeting the glycoprotein 130 receptor subunit to control pain and inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ALD 518; ALD518; CILIARY NEUROTROPHIC FACTOR; ELASTIN; GLYCOPROTEIN GP 130; HYBRID PROTEIN; INTERLEUKIN 11; INTERLEUKIN 11 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR ALPHA; JANUS KINASE 1; JANUS KINASE 2; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; ONCOSTATIN M; POLYETHYLENE; STAT3 PROTEIN; TOCILIZUMAB; TYROSINE; UNCLASSIFIED DRUG;

EID: 78650001998     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2010.0035     Document Type: Review
Times cited : (8)

References (52)
  • 1
    • 0038607068 scopus 로고    scopus 로고
    • A fusion protein of the gp130 and IL-6Ralpha ligand-binding domains acts as a potent IL-6 inhibitor
    • Ancey C, Kuster A, Haan S, Herrmann A, Heinrich PC, Muller- Newen G. 2003. A fusion protein of the gp130 and IL-6Ralpha ligand-binding domains acts as a potent IL-6 inhibitor. J Biol Chem 278(19):16968-16972.
    • (2003) J. Biol. Chem. , vol.278 , Issue.19 , pp. 16968-16972
    • Ancey, C.1    Kuster, A.2    Haan, S.3    Herrmann, A.4    Heinrich, P.C.5    Muller- Newen, G.6
  • 4
    • 0032922590 scopus 로고    scopus 로고
    • Blocking signaling through the gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity
    • Borsellino N, Bonavida B, Ciliberto G, Toniatti C, Travali S, D'Alessandro N. 1999. Blocking signaling through the gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity. Cancer 85(1):134-144.
    • (1999) Cancer , vol.85 , Issue.1 , pp. 134-144
    • Borsellino, N.1    Bonavida, B.2    Ciliberto, G.3    Toniatti, C.4    Travali, S.5    D'Alessandro, N.6
  • 5
    • 71649084751 scopus 로고    scopus 로고
    • A phase I pharmacokinetic PK and preliminary efficacy assessment of ALD518 a humanized anti-IL-6 antibody in patients with advanced cancer
    • Clarke SJ, Smith JT, Gebbie C, Sweeney C, Olszewski N. 2009. A phase I, pharmacokinetic (PK), and preliminary efficacy assessment of ALD518, a humanized anti-IL-6 antibody, in patients with advanced cancer. J Clin Oncol (Meeting Abstracts) 27(15S):3025.
    • (2009) J. Clin. Oncol. Meeting Abstracts , vol.27 , Issue.15 S , pp. 3025
    • Clarke, S.J.1    Smith, J.T.2    Gebbie, C.3    Sweeney, C.4    Olszewski, N.5
  • 6
    • 23944471116 scopus 로고    scopus 로고
    • Pathological role of IL-6 in the experimental allergic bronchial asthma in mice
    • Doganci A, Sauer K, Karwot R, Finotto S. 2005. Pathological role of IL-6 in the experimental allergic bronchial asthma in mice. Clin Rev Allergy Immunol 28(3):257-270.
    • (2005) Clin. Rev. Allergy Immunol. , vol.28 , Issue.3 , pp. 257-270
    • Doganci, A.1    Sauer, K.2    Karwot, R.3    Finotto, S.4
  • 7
    • 34249669178 scopus 로고    scopus 로고
    • The role of interleukin-6 in development and progression of atherosclerosis
    • Dubinski A, Zdrojewicz Z. 2007. [The role of interleukin-6 in development and progression of atherosclerosis]. Pol Merkur Lekarski 22(130):291-294.
    • (2007) Pol. Merkur. Lekarski. , vol.22 , Issue.130 , pp. 291-294
    • Dubinski, A.1    Zdrojewicz, Z.2
  • 8
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: Results from a 24-week multicentre randomised placebo controlled trial
    • Emery P, Keystone E, Tony HP, Cantagrel A, van Vollenhoven R, Sanchez A, Alecock E, Lee J, Kremer J. 2008. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: results from a 24-week multicentre randomised placebo controlled trial. Ann Rheum Dis 67(11):1516-1523.
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3    Cantagrel, A.4    Van Vollenhoven, R.5    Sanchez, A.6    Alecock, E.7    Lee, J.8    Kremer, J.9
  • 9
    • 0035898315 scopus 로고    scopus 로고
    • Defective gp130-mediated signal transducer and activator of transcription STAT signaling results in degenerative joint disease gastrointestinal ulceration and failure of uterine implantation
    • Ernst M, Inglese M, Waring P, Campbell I, Bao S, Clay F, Alexander W, Wicks I, Tarlinton D, Novak U, Heath J, Dunn A. 2001. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med 194(2):189-203.
    • (2001) J. Exp. Med. , vol.194 , Issue.2 , pp. 189-203
    • Ernst, M.1    Inglese, M.2    Waring, P.3    Campbell, I.4    Bao, S.5    Clay, F.6    Alexander, W.7    Wicks, I.8    Tarlinton, D.9    Novak, U.10    Heath, J.11    Dunn, A.12
  • 10
    • 34147159710 scopus 로고    scopus 로고
    • Gp130 receptor ligands as potential therapeutic targets for obesity
    • Febbraio MA. 2007. gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest 117(4):841-849.
    • (2007) J. Clin. Invest. , vol.117 , Issue.4 , pp. 841-849
    • Febbraio, M.A.1
  • 13
    • 0038642195 scopus 로고    scopus 로고
    • IL-6 type cytokine receptor complexes: Hexamer tetramer or both
    • Grotzinger J, Kernebeck T, Kallen KJ, Rose-John S. 1999. IL-6 type cytokine receptor complexes: hexamer, tetramer or both? Biol Chem 380(7-8):803-813.
    • (1999) Biol. Chem. , vol.380 , Issue.7-8 , pp. 803-813
    • Grotzinger, J.1    Kernebeck, T.2    Kallen, K.J.3    Rose-John, S.4
  • 14
    • 0029914433 scopus 로고    scopus 로고
    • Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor interleukin-6 interleukin-11 leukemia inhibitory factor or oncostatin M
    • Gu ZJ, Wijdenes J, Zhang XG, Hallet MM, Clement C, Klein B. 1996. Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M. J Immunol Methods 190(1):21-27.
    • (1996) J. Immunol. Methods , vol.190 , Issue.1 , pp. 21-27
    • Gu, Z.J.1    Wijdenes, J.2    Zhang, X.G.3    Hallet, M.M.4    Clement, C.5    Klein, B.6
  • 15
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signaling through the gp130 Jak STAT pathway
    • Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. 1998. Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway. Biochem J 334 (Pt 2): 297-314.
    • (1998) Biochem. J. , vol.334 , Issue.PART 2 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 16
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer gp130
    • Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. 1990. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63(6):1149-1157.
    • (1990) Cell. , vol.63 , Issue.6 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Taga, T.5    Kishimoto, T.6
  • 17
    • 15844420218 scopus 로고    scopus 로고
    • Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists
    • Hudson KR, Vernallis AB, Heath JK. 1996. Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists. J Biol Chem 271(20):11971-11978.
    • (1996) J. Biol. Chem. , vol.271 , Issue.20 , pp. 11971-11978
    • Hudson, K.R.1    Vernallis, A.B.2    Heath, J.K.3
  • 19
    • 38549161562 scopus 로고    scopus 로고
    • Fc-based cytokines: Prospects for engineering superior therapeutics
    • Jazayeri JA, Carroll GJ. 2008. Fc-based cytokines: prospects for engineering superior therapeutics. BioDrugs 22(1):11-26.
    • (2008) Bio. Drugs , vol.22 , Issue.1 , pp. 11-26
    • Jazayeri, J.A.1    Carroll, G.J.2
  • 23
    • 0029084805 scopus 로고
    • Interleukin-6 family of cytokines and gp130
    • Kishimoto T, Akira S, Narazaki M, Taga T. 1995. Interleukin-6 family of cytokines and gp130. Blood 86(4):1243-1254.
    • (1995) Blood , vol.86 , Issue.4 , pp. 1243-1254
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 24
    • 33644755633 scopus 로고    scopus 로고
    • Interleukin-6 and diabetes: The good the bad or the indifferent
    • Kristiansen OP, Mandrup-Poulsen T. 2005. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 54 Suppl 2:S114-S124.
    • (2005) Diabetes , vol.54 , Issue.2
    • Kristiansen, O.P.1    Mandrup-Poulsen, T.2
  • 25
    • 41049090255 scopus 로고    scopus 로고
    • Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset
    • Laaksovirta H, Soinila S, Hukkanen V, RÖyttä M, Soilu-Hänninen M. 2008. Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset. Eur J Neurol 15(4):355-359.
    • (2008) Eur. J. Neurol. , vol.15 , Issue.4 , pp. 355-359
    • Laaksovirta, H.1    Soinila, S.2    Hukkanen, V.3    Röyttä, M.4    Soilu-Hänninen, M.5
  • 26
    • 63349085786 scopus 로고    scopus 로고
    • Capsaicin inhibits the IL-6 STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress
    • Lee HK, Seo IA, Shin YK, Park JW, Suh DJ, Park HT. 2009. Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochem Biophys Res Commun 382(2):445-450.
    • (2009) Biochem. Biophys. Res. Commun. , vol.382 , Issue.2 , pp. 445-450
    • Lee, H.K.1    Seo, I.A.2    Shin, Y.K.3    Park, J.W.4    Suh, D.J.5    Park, H.T.6
  • 27
    • 3943103442 scopus 로고    scopus 로고
    • RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells
    • Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC. 2004. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate 60(4):303-309.
    • (2004) Prostate , vol.60 , Issue.4 , pp. 303-309
    • Lee, S.O.1    Lou, W.2    Qureshi, K.M.3    Mehraein-Ghomi, F.4    Trump, D.L.5    Gao, A.C.6
  • 28
    • 33748747042 scopus 로고    scopus 로고
    • Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: Purification via inverse transition cycling
    • Lin M, Rose-John S, Grotzinger J, Conrad U, Scheller J. 2006. Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling. Biochem J 398(3):577-583.
    • (2006) Biochem. J. , vol.398 , Issue.3 , pp. 577-583
    • Lin, M.1    Rose-John, S.2    Grotzinger, J.3    Conrad, U.4    Scheller, J.5
  • 29
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to diseasemodifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL, Mysler EF, da Silva NA, Alecock E, Woodworth T, Gomez-Reino JJ. 2008. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to diseasemodifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum 58(10):2968-2980.
    • (2008) Arthritis. Rheum. , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3    Mysler, E.F.4    Da Silva, N.A.5    Alecock, E.6    Woodworth, T.7    Gomez-Reino, J.J.8
  • 32
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • NarazakiM, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, Yancopoulos GD, Taga T, Kishimoto T. 1993. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82(4):1120-1126.
    • (1993) Blood , vol.82 , Issue.4 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3    Ohsugi, Y.4    Fukui, H.5    Koishihara, Y.6    Yancopoulos, G.D.7    Taga, T.8    Kishimoto, T.9
  • 34
    • 0033762619 scopus 로고    scopus 로고
    • Anti-interleukin 6 receptor antibody treatment in rheumatic disease
    • Nishimoto N, Kishimoto T, Yoshizaki K. 2000. Anti-interleukin 6 receptor antibody treatment in rheumatic disease. Ann Rheum Dis 59(suppl):i21-i27.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL.
    • Nishimoto, N.1    Kishimoto, T.2    Yoshizaki, K.3
  • 35
  • 37
    • 0034672091 scopus 로고    scopus 로고
    • Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation
    • Pflanz S, Kurth I, Grotzinger J, Heinrich PC, Muller-Newen G. 2000. Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation. J Immunol 165(12):7042-7049.
    • (2000) J. Immunol. , vol.165 , Issue.12 , pp. 7042-7049
    • Pflanz, S.1    Kurth, I.2    Grotzinger, J.3    Heinrich, P.C.4    Muller-Newen, G.5
  • 41
    • 4944250270 scopus 로고    scopus 로고
    • Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy
    • Selander KS, Li L, Watson L, Merrell M, Dahmen H, Heinrich PC, Muller-Newen G, Harris KW. 2004. Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy. Cancer Res 64(19):6924-6933.
    • (2004) Cancer Res. , vol.64 , Issue.19 , pp. 6924-6933
    • Selander, K.S.1    Li, L.2    Watson, L.3    Merrell, M.4    Dahmen, H.5    Heinrich, P.C.6    Muller-Newen, G.7    Harris, K.W.8
  • 43
    • 0034614643 scopus 로고    scopus 로고
    • Parthenolide inhibits activation of signal transducers and activators of transcription STATs induced by cytokines of the IL-6 family
    • Sobota R, Szwed M, Kasza A, Bugno M, Kordula T. 2000. Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family. Biochem Biophys Res Commun 267(1):329-333.
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , Issue.1 , pp. 329-333
    • Sobota, R.1    Szwed, M.2    Kasza, A.3    Bugno, M.4    Kordula, T.5
  • 44
    • 2942752122 scopus 로고    scopus 로고
    • Rationale for interleukin-6 blockade in systemic lupus erythematosus
    • DOI 10.1191/0961203304lu1023oa
    • Tackey E, Lipsky PE, Illei GG. 2004. Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus 13(5):339-343. (Pubitemid 38788493)
    • (2004) Lupus , vol.13 , Issue.5 , pp. 339-343
    • Tackey, E.1    Lipsky, P.E.2    Illei, G.G.3
  • 48
    • 0034880223 scopus 로고    scopus 로고
    • Gp130-specific antisense oligonucleotides inhibit IL-6 signal inducing JUNB mRNAtranscription in the human heptatoma cell line HEPG2
    • Varga VL, Fü lÖp AK, Holub MC, Tó th S, Szalai C, Falus A. 2001. Gp130-specific antisense oligonucleotides inhibit IL-6 signal inducing JUNB mRNAtranscription in the human heptatoma cell line, HEPG2. Cell Biol Int 25(8):835-840.
    • (2001) Cell. Biol. Int. , vol.25 , Issue.8 , pp. 835-840
    • Varga, V.L.1    Fülöp, A.K.2    Holub, M.C.3    Tóth, S.4    Szalai, C.5    Falus, A.6
  • 49
    • 0030856734 scopus 로고    scopus 로고
    • An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor cardiotrophin-1 ciliary neurotrophic factor and oncostatin M
    • Vernallis AB, Hudson KR, Heath JK. 1997. An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M. J Biol Chem 272(43):26947-26952.
    • (1997) J. Biol. Chem. , vol.272 , Issue.43 , pp. 26947-26952
    • Vernallis, A.B.1    Hudson, K.R.2    Heath, J.K.3
  • 50
    • 50949096570 scopus 로고    scopus 로고
    • T40214 PEI complex: A potent therapeutics for prostate cancer that targets STAT3 signaling
    • Weerasinghe P, Li Y, Guan Y, Zhang R, Tweardy DJ, Jing N. 2008. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate 68(13):1430-1442.
    • (2008) Prostate. , vol.68 , Issue.13 , pp. 1430-1442
    • Weerasinghe, P.1    Li, Y.2    Guan, Y.3    Zhang, R.4    Tweardy, D.J.5    Jing, N.6
  • 51
    • 48949120015 scopus 로고    scopus 로고
    • Interleukin-6 as a pathogenic factor of systemiconset juvenile idiopathic arthritis
    • Yokota S. 2008. [Interleukin-6 as a pathogenic factor of systemiconset juvenile idiopathic arthritis]. Nihon Rinsho Meneki Gakkai Kaishi 31(2):99-103.
    • (2008) Nihon. Rinsho. Meneki. Gakkai. Kaishi. , vol.31 , Issue.2 , pp. 99-103
    • Yokota, S.1
  • 52
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. 2009. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9(11):798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.