Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130

Journal of Biological Chemistry

Volumn 283, Issue 40, 2008, Pages 27200-27207

  Tenhumberg, Stephanie ^a   Waetzig, Georg H ^b   Chalaris, Athena ^a   Rabe, Björn ^a   Seegert, Dirk ^b   Scheller, Jürgen ^a   Rose John, Stefan ^a   Grötzinger, Joachim ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b CONARIS Research Institute AG ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BINDING ENERGY; CELL MEMBRANES; CELL PROLIFERATION; GENE EXPRESSION; NUCLEAR MAGNETIC RESONANCE; ORGANIC ACIDS; STRUCTURAL OPTIMIZATION; THREE DIMENSIONAL;

ADDITIVE EFFECTS; BINDING AFFINITIES; CELLS LACKING; DIMENSIONAL STRUCTURES; DO-MAINS; IN VITRO; MOUSE MODELS; MUTEINS; NMR ANALYSES; PRE-REQUISITES; SIDE CHAINS; TRANSDUCING;

ELECTRIC LOAD MANAGEMENT;

GLYCOPROTEIN GP 130; INTERLEUKIN 6; ACUTE PHASE PROTEIN; IL6 PROTEIN, HUMAN; IL6R PROTEIN, HUMAN; IL6ST PROTEIN, HUMAN; INTERLEUKIN 6 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CHO CELL; CRICETULUS; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; IMMUNOLOGY; INFLAMMATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SOLUBILITY;

ACUTE-PHASE PROTEINS; ANIMALS; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; CYTOKINE RECEPTOR GP130; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; MICE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 55249092252     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803694200     Document Type: Article

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