A fusion protein of the gp130 and interleukin-6Rα ligand-binding domains acts as a potent interleukin-6 inhibitor

Journal of Biological Chemistry

Volumn 278, Issue 19, 2003, Pages 16968-16972

  Ancey, Cécile ^b   Küster, Andrea ^b   Haan, Serge ^b   Herrmann, Andreas ^b   Heinrich, Peter C ^a   Müller Newen, Gerhard ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOCHEMISTRY; PATIENT TREATMENT;

LIGANDS;

PROTEINS;

ACUTE PHASE PROTEIN; GLYCOPROTEIN GP 130; HYBRID PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA; STAT3 PROTEIN; UNCLASSIFIED DRUG; LEUKOCYTE ANTIGEN; LIGAND; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOTHERAPY; INSECT CELL; LIGAND BINDING; MOLECULAR CLONING; MOUSE; MULTIPLE MYELOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOPOROSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING; RHEUMATOID ARTHRITIS; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALIA; INSECTA;

ANIMALS; ANTIGENS, CD; CYTOKINE RECEPTOR GP130; INTERLEUKIN-6; LIGANDS; MEMBRANE GLYCOPROTEINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 0038607068     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300081200     Document Type: Article

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