-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7:11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
3
-
-
42949130656
-
AMPK and Raptor: Matching cell growth to energy supply
-
Hardie DG. AMPK and Raptor: matching cell growth to energy supply. Mol Cell 2008; 30:263-5.
-
(2008)
Mol Cell
, vol.30
, pp. 263-265
-
-
Hardie, D.G.1
-
4
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004; 101:3329-35.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
-
5
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6:91-9.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
-
6
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1:15-25. (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
7
-
-
77956401999
-
Metformin and other biguanides in oncology: Advancing the research agenda
-
Phila Pa
-
Pollak M. Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila Pa) 2010; 3:1060-5.
-
(2010)
Cancer Prev Res
, vol.3
, pp. 1060-1065
-
-
Pollak, M.1
-
8
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant DA, Duran RV, Gottlieb E. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 2010; 10:267-77.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Duran, R.V.2
Gottlieb, E.3
-
9
-
-
78649858143
-
AMPK as a therapeutic target in renal cell carcinoma
-
Woodard J, Joshi S, Viollet B, Hay N, Platanias LC. AMPK as a therapeutic target in renal cell carcinoma. Cancer Biol Ther 2010; 10:1168-77.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 1168-1177
-
-
Woodard, J.1
Joshi, S.2
Viollet, B.3
Hay, N.4
Platanias, L.C.5
-
10
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
-
DOI 10.1074/jbc.275.1.223
-
El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000; 275:223-8. (Pubitemid 30038975)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.1
, pp. 223-228
-
-
El-Mir, M.-Y.1
Nogueira, V.2
Fontaine, E.3
Averet, N.4
Rigoulet, M.5
Leverve, X.6
-
11
-
-
33751284806
-
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
-
DOI 10.1158/0008-5472.CAN-06-1500
-
Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006; 66:10269-73. (Pubitemid 44799743)
-
(2006)
Cancer Research
, vol.66
, Issue.21
, pp. 10269-10273
-
-
Zakikhani, M.1
Dowling, R.2
Fantus, I.G.3
Sonenberg, N.4
Pollak, M.5
-
12
-
-
36348950449
-
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
-
DOI 10.1158/0008-5472.CAN-07-2310
-
Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 2007; 67:10804-12. (Pubitemid 350145909)
-
(2007)
Cancer Research
, vol.67
, Issue.22
, pp. 10804-10812
-
-
Dowling, R.J.O.1
Zakikhani, M.2
Fantus, I.G.3
Pollak, M.4
Sonenberg, N.5
-
13
-
-
77956415337
-
Metformin prevents tobacco carcinogen - Induced lung tumorigenesis
-
Phila Pa
-
Memmott RM, Mercado JR, Maier CR, Kawabata S, Fox SD, Dennis PA. Metformin prevents tobacco carcinogen - induced lung tumorigenesis. Cancer Prev Res (Phila Pa) 2010; 3:1066-76.
-
(2010)
Cancer Prev Res
, vol.3
, pp. 1066-1076
-
-
Memmott, R.M.1
Mercado, J.R.2
Maier, C.R.3
Kawabata, S.4
Fox, S.D.5
Dennis, P.A.6
-
14
-
-
77950434375
-
Targeting the translational machinery as a novel treatment strategy for hematologic malignancies
-
Hagner PR, Schneider A, Gartenhaus RB. Targeting the translational machinery as a novel treatment strategy for hematologic malignancies. Blood 2010; 115:2127-35.
-
(2010)
Blood
, vol.115
, pp. 2127-2135
-
-
Hagner, P.R.1
Schneider, A.2
Gartenhaus, R.B.3
-
15
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007; 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
16
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009; 137:873-86.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
-
17
-
-
78549283186
-
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
-
in press
-
Green AS, Chapuis N, Maciel TT, Willems L, Lambert M, Arnoult C, et al. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood 2010; in press.
-
(2010)
Blood
-
-
Green, A.S.1
Chapuis, N.2
Maciel, T.T.3
Willems, L.4
Lambert, M.5
Arnoult, C.6
-
18
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, et al. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 2002; 4:699-704.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
-
19
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003; 13:1259-68.
-
(2003)
Curr Biol
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
20
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 2003; 5:578-81.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
21
-
-
59749096847
-
Therapeutic targeting of mTOR in tuberous sclerosis
-
Sampson JR. Therapeutic targeting of mTOR in tuberous sclerosis. Biochem Soc Trans 2009; 37:259-64.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 259-264
-
-
Sampson, J.R.1
-
22
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
DOI 10.1038/ng1494
-
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19-24. (Pubitemid 40070934)
-
(2005)
Nature Genetics
, vol.37
, Issue.1
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
23
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4:648-57.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
24
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002; 4:658-65.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
25
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol 2005; 15:702-13.
-
(2005)
Curr Biol
, vol.15
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
26
-
-
51649115883
-
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 upregulation in renal cell carcinoma
-
Woodard J, Sassano A, Hay N, Platanias LC. Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 upregulation in renal cell carcinoma. Clin Cancer Res 2008; 14:4640-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4640-4649
-
-
Woodard, J.1
Sassano, A.2
Hay, N.3
Platanias, L.C.4
-
27
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 2005; 280:32081-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
28
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30:214-26.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
29
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002; 62:3659-62.
-
(2002)
Cancer Res
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
-
30
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007; 448:807-10.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
-
31
-
-
64549113040
-
Somatic LKB1 mutations promote cervical cancer progression
-
Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, et al. Somatic LKB1 mutations promote cervical cancer progression. PLoS One 2009; 4:5137.
-
(2009)
PLoS One
, vol.4
, pp. 5137
-
-
Wingo, S.N.1
Gallardo, T.D.2
Akbay, E.A.3
Liang, M.C.4
Contreras, C.M.5
Boren, T.6
-
32
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
-
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 2008; 412:211-21.
-
(2008)
Biochem J
, vol.412
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, N.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
-
33
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell 2000; 100:387-90.
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
|