Haemonchus contortus: The uptake and metabolism of closantel

International Journal for Parasitology

Volumn 27, Issue 3, 1997, Pages 313-319

  Rothwell, Jim ^a,b   Sangster, Nicholas ^b  

^a Elanco Animal Health   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

anthelmintic resistance; closantel; drug kinetics; Haemonchus contortus; nematode

Indexed keywords

CLOSANTEL; IVERMECTIN;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; DRUG RESISTANCE; HAEMONCHUS CONTORTUS; IN VITRO STUDY; NEMATODIASIS; NONHUMAN; PHARMACOKINETICS;

ANIMALS; ANTHELMINTICS; BIOLOGICAL TRANSPORT, ACTIVE; DRUG RESISTANCE; HAEMONCHIASIS; HAEMONCHUS; SALICYLANILIDES; SHEEP; SHEEP DISEASES;

HAEMONCHUS CONTORTUS; OVIS ARIES;

EID: 0030901902     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(96)00200-7     Document Type: Article

References (29)

1. Barrett J. 1989. Detoxification reactions in parasitic helminths. In: Comparative Biochemistry of Parasitic Helminths (Edited by Bennet E. M., Behm C & Bryant C.). pp. 109-114. Chapman and Hall, London.
2. Brophy P. M. & Barrett J. 1990. Strategies for detoxification of aldehydic products of lipid peroxidation in helminths. Molecular and Biochemical Parasitology 42: 205-212.
3. Brophy P. M., Crowley P. & Barrett J. 1990. Detoxification reactions of Fasciola hepatica cytosolic glututhione transferases. Molecular and Biochemical Parasitology 39: 155-162.
4. Brophy P. M., Southan C. & Barren J. 1989. Glutathione transferases in the tapeworm Moniezia expansa. Biochemical Journal 262: 939-946.
5. Brophy P. M., Papadopoulos A., Touraki M., Coles B., Korting W. & Barrett J. 1989. Purification of cytosolic glutathione transferases from Schistocephalus solidus (pleroceroid): interaction with anthelmintics and products of lipid peroxidation. Molecular and Biochemical Parasitology 36: 187-196.
6. Dash K. M. 1986. Control of helminthosis in lambs by strategic treatment with closantel and broad-spectrum anthelmintics. Australian Veterinary Journal 63: 4-8.
7. Davies J. 1994. Inactivation of antibiotics and the dissemination of resistance genes. Science 264: 375-382.
8. Douch P. G. C. 1979. The metabolism of the anthelmintics clioxanide and resorantel and related compounds in vitro by Moniezia expansa, Ascaris suum and mouse- and sheep-liver enzymes. Xenobiotica 9: 263-268.
9. Douch P. G. C. & Blair S. S. B. 1975. The metabolism of foreign compounds in the cestode, Monezia expansa, and the nematode Ascaris lumbricoides var. suum. Xenobiotica 5: 279-292.
10. Douch P. G. C. & Buchanan L. L. 1979. The metabolism of nitrophenolicand 5-arylazorhodanine anthelmintics by Ascaris suum, Moniezia expansa and by mouse- and sheep-liver enzymes. Xenobiotica 9: 467-474.
11. Douch P. G. C. & Gahagan H. M. 1977. The metabolism of niclosamide and related compounds by Moniezia expansa, Ascaris lumbricoides var. suum, and mouse- and sheep-liver enzymes. Xenobiotica 7: 301-307.
12. Ford J. M. & Hait W. N. 1990. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacological Reviews 42: 155-199.
13. Geary T. G., Sims S. M., Thomas E. M., Vanover L., Davis J. P., Winterrowd C. A., Klein R. D., Ho N. F. H. & Thompson D. P. 1993. Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Experimental Parasitology 77: 88-96.
14. Grogl M., Martin R. K., Oduola A. M. J., Milhous W. K. & Kyle D. E. 1991. Characteristics ofmultidrug resistance in Phismodium and Leishmania: detection of P-glycoprotein-like components. American Journal of Tropical Medicine and Hygiene 45: 98-111.
15. Hennessy D. R., Sangster N. C., Steel J. W. & Collins G. H. 1993. Comparative pharmacokinetic disposition of closantel in sheep and goats. Journal of Veterinary Pharmacology and Therapeutics 16: 254-260.
16. Krogstad D. J., Gluzman I. Y., Kyle D. E., Oduola A. M. J., Martin S. K., Milhous W. K. & Schlesinger P. H. 1987. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science 238: 1283-1285.
17. Le Jambre L. F., Gill J. H., Lenane I. J. & Lacey E. 1995. Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. International Journal for Parasitology 25: 691-698.
18. Lowry O. H., Rosebrough N. J., Farr A. E. & Randall R. J. 1951. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 193: 265-275.
19. McKellar Q. A. & Kinabo L. D. B. 1991. The pharmacology of flukicidal drugs. British Veterinary Journal 147: 306-321.
20. Michiels M., Meuldermans W. & Heykants J. 1987. The metabolism and fate of closantel (Flukiver) in sheep and cattle. Drug Metabolism Reviews 18: 235-251.
21. Miller C. M. D., Howell M. J. & Bora & J. C. 1994. Glutathione S-transferases as markers of salicylanilide resistance in isolates of Fasciola hepatica. International Journal for Parasitohgy 24: 533-542.
22. Nolan J. & Schnitzerling H. J. 1986. Drug resistance in arthropod parasites. In: Chemotherapy of Parasitic Diseases (Edited by Campbell W. C. & Rew R. S.), pp. 603-620. Plenum Press, New York.
23. Rainey P. & Santi D. V. 1984. Formycin B resistance in Leishmania. Biochemical Pharmacology 33: 1374-1377.
24. Rolfe P. F., Boray J. C., Fitzgibbon C., Parsons G., Kemsley P. & Sangster N. 1990. Closantel resistance in Haemonchus contortus from sheep. Australian Veterinary Journal 67: 29-31.
25. Rothwell J. T. & Sangster N. C. 1993. An in vitro assay utilising parasitic larval Haemonchus contortus to detect resistance to closantel and other anthelmintics. International Journal for Parasitology 23: 573-578.
26. Rothwell J. T., Sangster N., Conder G., Dobson R. J. & Johnson S. S. 1993. Kinetics of expulsion of Haemonchus contortus from sheep and jirds following treatment with closantel. International Journal for Parasitology 23: 885-889.
27. Samuelson J., Ayala P., Orozco E. & Wirth D. 1990. Emetine-resistant mutants of Entamoeba histolytica over-express mRNAs for multidrug resistance. Molecular and Biochemical Parasitology 38: 281-290.
28. Sangster N. C. 1996. Pharmacology of anthelmintic resistance. Parasitology 113: S201-216.
29. Van Wyk J. A., Gerber H. M. & Alvers R. M. R. 1982. Slight resistance to the residual effect of closantel in a field strain of Haemonchus contortus which showed an increased resistance after one selection in the laboratory. Onderstepoort Journal of Veterinary Research 49: 257-262.