Acyl glucuronidation and glucosidation of a new and selective endothelin ETA receptor antagonist in human liver microsomes

Drug Metabolism and Disposition

Volumn 31, Issue 1, 2003, Pages 37-45

  Tang, Cuyue ^a   Hochman, Jerome H ^a   Ma, Bennett ^a   Subramanian, Raju ^a   Vyas, Kamlesh P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ISOPROPYLAMINO 7 [4 METHOXY 2 (3 METHOXY 2 METHYLPROPYL) 5 (3,4 METHYLENEDIOXYPHENYL)]CYCLOPENTENO[1,2 B]PYRIDINE 6 CARBOXYLIC ACID; ENDOTHELIN A RECEPTOR ANTAGONIST; GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE; NUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE GLUCOSE;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONJUGATION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG GLUCURONIDATION; DRUG SELECTIVITY; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MICHAELIS CONSTANT; PRIORITY JOURNAL;

GLUCOSIDES; GLUCURONIC ACID; GLUCURONIDES; HUMANS; MICROSOMES, LIVER; PROTEIN ISOFORMS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; URIDINE DIPHOSPHATE GLUCOSE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 0038685822     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.1.37     Document Type: Article

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