Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites

Parasitology Research

Volumn 87, Issue 4, 2001, Pages 275-280

  Solana, H D ^a   Rodriguez, J A ^a   Lanusse, C E ^a  

^a UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; ALBENDAZOLE SULFOXIDE; ANTHELMINTIC AGENT; BENZIMIDAZOLE DERIVATIVE;

ARTICLE; ASCARIS SUUM; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSOL; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; ENANTIOMER; FASCIOLA HEPATICA; HELMINTHIASIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROSOME; MONIEZIA EXPANSA; NONHUMAN; PRIORITY JOURNAL; REDUCTION;

ASCARIS SUUM; CESTODA; FASCIOLA HEPATICA; HEPATICA; MONIEZIA EXPANSA; NEMATODA; TREMATODA; VERMES;

EID: 0035090015     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00008578     Document Type: Article

References (29)

1. In vivo and ex vivo uptake of albendazole and its sulphoxide metabolite by cestode parasites: Relationship with their kinetic behaviour in sheep
2. Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep
3. Sulfoxide reduction in relation to organophosphorus insecticide detoxification
4. Species differences in the generation of the chiral sulphoxide metabolite of albendazole in sheep and rats
5. Chiral behaviour of the metabolite albendazole sulphoxide in sheep, goats and cattle
6. Some properties of the sulphoxidases and sulphoxide reductases of the cestode Moniezia expansa, the nematode Ascaris suum and mouse liver
7. Sulfoxidation of albendazole by a cytochrome P-450-independent monooxigenase from rat liver microsomes
8. In vitro sulfoxidation of albendazole by ovine liver microsomes: Assay and frequency of various xenobiotics
9. The metabolism of benzimidazole anthelmintics
10. Anthelmintic resistance-the state of play
11. Mode of action of benzimidazoles
12. Activity of benzimidazole carbamates against L1210 mouse leukaemia cells: Correlation with in vitro tubulin polymerisation assay
13. Pharmacokinetic behaviour of netobimin and its metabolites in sheep
14. Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants
15. Metabolism of albendazole and albendazole sulphoxide by ruminal and ileal fluids of sheep and cattle
16. Comparative sulphoxidation of albendazole by sheep and cattle liver microsomes
17. Protein measurement with the Folin phenol reagent
18. Interaction of benzimidazole anthelmintics with Haemonchus contortus tubulin: Binding affinity and anthelmintic efficacy
19. The benzimidazole anthelmintic agents-a review
20. Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxigenases from rat liver microsome
21. A new in vitro assay of benzimidazole activity against adult Oesophagostomum dentatum
22. Xenobiotic metabolism in helminths
23. The role of the gut flora in the reduction of sulfoxide containing drugs
24. Liver sulphoxidative metabolism of albendazole in rat: Enantioselectity and effect of methimazole
25. Sulphoxidation of albendazole by the FAD-containing and cytochrome P-450 dependent mono-oxygenases from pig liver microsomes
26. Inducing effect of albendazole on rat liver drugs metabolising enzymes and metabolite pharmacokinetic
27. Mode of action of anticestodal agents
28. Influence of diet on the pattern of gastrointestinal biotransformation of netobimin and albendazole sulphoxide in sheep