메뉴 건너뛰기




Volumn 10, Issue 7, 2010, Pages 512-519

STAT3 as a therapeutic target for glioblastoma

Author keywords

Cytokine; Glioblastoma; Glioblastoma stem cells; Growth factor; STAT3; STAT3 inhibitor

Indexed keywords

2,5 DIHYDROXYBENZENESULFONIC ACID; ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; CUCURBITACIN; JANUS KINASE 2 INHIBITOR; JSI 124; LEPTIN; LLL 3; MANUMYCIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PACLITAXEL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; S 31 201; SORAFENIB; STA 21; STAT3 PROTEIN; TOCILIZUMAB; UNCLASSIFIED DRUG; WP 1066;

EID: 78649815101     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152010793498636     Document Type: Article
Times cited : (36)

References (115)
  • 3
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen, P.Y.; Kesari, S. Malignant gliomas in adults. N. Engl. J.Med., 2008, 359(5), 492-507.
    • (2008) N. Engl. J.Med. , vol.359 , Issue.5 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 4
    • 38049144280 scopus 로고    scopus 로고
    • Glioblastoma multiforme: Evidence-based approachto therapy
    • Nicholas, M.K. Glioblastoma multiforme: evidence-based approachto therapy. Expert Rev. Anticancer Ther., 2007, 7(12 Suppl), S23-27.
    • (2007) Expert Rev. Anticancer Ther. , vol.7 , Issue.12 SUPPL.
    • Nicholas, M.K.1
  • 6
    • 70350525582 scopus 로고    scopus 로고
    • STAT3 regulation of glioblastoma pathogenesis
    • de la Iglesia, N.; Puram, S.V.; Bonni, A. STAT3 regulation of glioblastoma pathogenesis. Curr. Mol. Med., 2009, 9(5), 580-590.
    • (2009) Curr. Mol. Med. , vol.9 , Issue.5 , pp. 580-590
    • de la Iglesia, N.1    Puram, S.V.2    Bonni, A.3
  • 7
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
    • Brantley, E.C.; Benveniste, E.N. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas.Mol. Cancer Res., 2008, 6(5), 675-684.
    • (2008) Mol. Cancer Res. , vol.6 , Issue.5 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 8
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy, D.E.; Darnell, J.E., Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell. Biol., 2002, 3(9), 651-662.
    • (2002) Nat. Rev. Mol. Cell. Biol. , vol.3 , Issue.9 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 9
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle, T.E.; Frank, D.A. The role of STATs in apoptosis. Curr.Mol. Med., 2002, 2(4), 381- 392.
    • (2002) Curr.Mol. Med. , vol.2 , Issue.4 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 10
    • 21344435775 scopus 로고    scopus 로고
    • Mechanisms of disease: Insightsinto the emerging role of signal transducers and activators of transcription in cancer
    • Haura, E.B.; Turkson, J.; Jove, R. Mechanisms of disease: Insightsinto the emerging role of signal transducers and activators of transcription in cancer. Nat. Clin. Pract. Oncol., 2005, 2(6), 315-324.
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , Issue.6 , pp. 315-324
    • Haura, E.B.1    Turkson, J.2    Jove, R.3
  • 12
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptionalcontrol and their impact on cellular function
    • Bromberg, J.; Darnell, J.E., Jr. The role of STATs in transcriptionalcontrol and their impact on cellular function. Oncogene, 2000, 19(21), 2468-2473.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 13
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg, J. Stat proteins and oncogenesis. J. Clin. Invest., 2002, 109(9), 1139-1142.
    • (2002) J. Clin. Invest. , vol.109 , Issue.9 , pp. 1139-1142
    • Bromberg, J.1
  • 14
    • 0027441586 scopus 로고
    • Acute-phase response factor, a nuclear factor binding toacute-phase response elements, is rapidly activated by interleukin-6at the posttranslational level
    • Wegenka, U.M.; Buschmann, J.; Lutticken, C.; Heinrich, P.C.; Horn, F. Acute-phase response factor, a nuclear factor binding toacute-phase response elements, is rapidly activated by interleukin-6at the posttranslational level. Mol. Cell. Biol., 1993, 13(1), 276-288.
    • (1993) Mol. Cell. Biol. , vol.13 , Issue.1 , pp. 276-288
    • Wegenka, U.M.1    Buschmann, J.2    Lutticken, C.3    Heinrich, P.C.4    Horn, F.5
  • 15
    • 2942741268 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling pathway in humancolorectal carcinoma
    • Ma, X.T.; Wang, S.; Ye, Y.J.; Du, R.Y.; Cui, Z.R.; Somsouk, M.Constitutive activation of Stat3 signaling pathway in humancolorectal carcinoma. World J. Gastroenterol., 2004, 10(11), 1569-1573.
    • (2004) World J. Gastroenterol. , vol.10 , Issue.11 , pp. 1569-1573
    • Ma, X.T.1    Wang, S.2    Ye, Y.J.3    Du, R.Y.4    Cui, Z.R.5    Somsouk, M.6
  • 17
    • 16844373256 scopus 로고    scopus 로고
    • Aberrant Stat3signaling by interleukin-4 in malignant glioma cells: Involvementof IL-13Ralpha2
    • Rahaman, S.O.; Vogelbaum, M.A.; Haque, S.J. Aberrant Stat3signaling by interleukin-4 in malignant glioma cells: involvementof IL-13Ralpha2. Cancer Res., 2005, 65(7), 2956-2963.
    • (2005) Cancer Res. , vol.65 , Issue.7 , pp. 2956-2963
    • Rahaman, S.O.1    Vogelbaum, M.A.2    Haque, S.J.3
  • 18
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer--new molecular targetscome of age
    • Yu, H.; Jove, R. The STATs of cancer--new molecular targetscome of age. Nat. Rev. Cancer, 2004, 4(2), 97-105.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 21
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 isrequired for proliferation and maintenance of multipotency inglioblastoma stem cells
    • Sherry, M.M.; Reeves, A.; Wu, J.K.; Cochran, B.H. STAT3 isrequired for proliferation and maintenance of multipotency inglioblastoma stem cells. Stem Cells, 2009, 27(10), 2383-2392.
    • (2009) Stem Cells , vol.27 , Issue.10 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 22
    • 0029960028 scopus 로고    scopus 로고
    • Dominant negative stat3mutant inhibits interleukin-6-induced Jak- STAT signaltransduction
    • Kaptein, A.; Paillard, V.; Saunders, M. Dominant negative stat3mutant inhibits interleukin-6-induced Jak- STAT signaltransduction. J. Biol. Chem., 1996, 271(11), 5961-5964.
    • (1996) J. Biol. Chem. , vol.271 , Issue.11 , pp. 5961-5964
    • Kaptein, A.1    Paillard, V.2    Saunders, M.3
  • 23
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serinephosphorylation
    • Wen, Z.; Zhong, Z.; Darnell, J.E., Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serinephosphorylation. Cell, 1995, 82(2), 241-250.
    • (1995) Cell , vol.82 , Issue.2 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 25
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu, H.; Pardoll, D.; Jove, R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer, 2009, 9(11), 798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 26
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through thegp130/Jak/STAT pathway
    • Heinrich, P.C.; Behrmann, I.; Muller-Newen, G.; Schaper, F.; Graeve, L. Interleukin-6-type cytokine signalling through thegp130/Jak/STAT pathway. Biochem. J., 1998, 334 (Pt 2), 297-314.
    • (1998) Biochem. J. , vol.334 , Issue.PART 2 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 27
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signaltransducer, gp130
    • Hibi, M.; Murakami, M.; Saito, M.; Hirano, T.; Taga, T.; Kishimoto, T. Molecular cloning and expression of an IL-6 signaltransducer, gp130. Cell, 1990, 63(6), 1149-1157.
    • (1990) Cell , vol.63 , Issue.6 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Taga, T.5    Kishimoto, T.6
  • 29
    • 0028931604 scopus 로고
    • Choice of STATs and other substratesspecified by modular tyrosine-based motifs in cytokine receptors
    • Stahl, N.; Farruggella, T.J.; Boulton, T.G.; Zhong, Z.; Darnell, J.E., Jr.; Yancopoulos, G.D. Choice of STATs and other substratesspecified by modular tyrosine-based motifs in cytokine receptors.Science, 1995, 267(5202), 1349-1353.
    • (1995) Science , vol.267 , Issue.5202 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell Jr., J.E.5    Yancopoulos, G.D.6
  • 30
    • 0029887373 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signaltransducer gp130. I. Definition of a novel phosphotyrosine motifmediating STAT1 activation
    • Gerhartz, C.; Heesel, B.; Sasse, J.; Hemmann, U.; Landgraf, C.; Schneider-Mergener, J.; Horn, F.; Heinrich, P.C.; Graeve, L. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signaltransducer gp130. I. Definition of a novel phosphotyrosine motifmediating STAT1 activation. J. Biol. Chem., 1996, 271(22), 12991-12998.
    • (1996) J. Biol. Chem. , vol.271 , Issue.22 , pp. 12991-12998
    • Gerhartz, C.1    Heesel, B.2    Sasse, J.3    Hemmann, U.4    Landgraf, C.5    Schneider-Mergener, J.6    Horn, F.7    Heinrich, P.C.8    Graeve, L.9
  • 31
    • 0029991793 scopus 로고    scopus 로고
    • Differential activation of acute phaseresponse factor/Stat3 and Stat1 via the cytoplasmic domain of theinterleukin 6 signal transducer gp130. II. Src homology SH2domains define the specificity of stat factor activation
    • Hemmann, U.; Gerhartz, C.; Heesel, B.; Sasse, J.; Kurapkat, G.; Grotzinger, J.; Wollmer, A.; Zhong, Z.; Darnell, J.E., Jr.; Graeve, L.; Heinrich, P.C.; Horn, F. Differential activation of acute phaseresponse factor/Stat3 and Stat1 via the cytoplasmic domain of theinterleukin 6 signal transducer gp130. II. Src homology SH2domains define the specificity of stat factor activation. J. Biol.Chem., 1996, 271(22), 12999-13007.
    • (1996) J. Biol.Chem. , vol.271 , Issue.22 , pp. 12999-13007
    • Hemmann, U.1    Gerhartz, C.2    Heesel, B.3    Sasse, J.4    Kurapkat, G.5    Grotzinger, J.6    Wollmer, A.7    Zhong, Z.8    Darnell Jr., J.E.9    Graeve, L.10    Heinrich, P.C.11    Horn, F.12
  • 33
    • 68049135501 scopus 로고    scopus 로고
    • Regulation of cytokine signaling by the SOCS and Spred family proteins
    • Yoshimura, A. Regulation of cytokine signaling by the SOCS and Spred family proteins. Keio. J. Med., 2009, 58(2), 73-83.
    • (2009) Keio. J. Med. , vol.58 , Issue.2 , pp. 73-83
    • Yoshimura, A.1
  • 34
    • 34249660614 scopus 로고    scopus 로고
    • SOCS proteins, cytokinesignalling and immune regulation
    • Yoshimura, A.; Naka, T.; Kubo, M. SOCS proteins, cytokinesignalling and immune regulation. Nat. Rev. Immunol., 2007, 7(6), 454-465.
    • (2007) Nat. Rev. Immunol. , vol.7 , Issue.6 , pp. 454-465
    • Yoshimura, A.1    Naka, T.2    Kubo, M.3
  • 35
    • 0242407711 scopus 로고    scopus 로고
    • Negativeregulation of cytokine signaling influences inflammation
    • Yoshimura, A.; Mori, H.; Ohishi, M.; Aki, D.; Hanada, T. Negativeregulation of cytokine signaling influences inflammation. Curr.Opin. Immunol., 2003, 15(6), 704-708.
    • (2003) Curr.Opin. Immunol. , vol.15 , Issue.6 , pp. 704-708
    • Yoshimura, A.1    Mori, H.2    Ohishi, M.3    Aki, D.4    Hanada, T.5
  • 36
    • 52949096859 scopus 로고    scopus 로고
    • The function of Stat3 in tumorcells and their microenvironment
    • Groner, B.; Lucks, P.; Borghouts, C. The function of Stat3 in tumorcells and their microenvironment. Semin. Cell. Dev. Biol., 2008, 19(4), 341-350.
    • (2008) Semin. Cell. Dev. Biol. , vol.19 , Issue.4 , pp. 341-350
    • Groner, B.1    Lucks, P.2    Borghouts, C.3
  • 38
    • 0035907245 scopus 로고    scopus 로고
    • Cyclin D1 repressesSTAT3 activation through a Cdk4-independent mechanism
    • Bienvenu, F.; Gascan, H.; Coqueret, O. Cyclin D1 repressesSTAT3 activation through a Cdk4-independent mechanism. J. Biol.Chem., 2001, 276(20), 16840-16847.
    • (2001) J. Biol.Chem. , vol.276 , Issue.20 , pp. 16840-16847
    • Bienvenu, F.1    Gascan, H.2    Coqueret, O.3
  • 40
    • 0037408535 scopus 로고    scopus 로고
    • Analysis of signal transducer and activator of transcription 3 (Stat 3) pathwayin multiple myeloma: Stat 3 activation and cyclin D1 dysregulationare mutually exclusive events
    • Quintanilla-Martinez, L.; Kremer, M.; Specht, K.; Calzada-Wack, J.; Nathrath, M.; Schaich, R.; Hofler, H.; Fend, F. Analysis of signal transducer and activator of transcription 3 (Stat 3) pathwayin multiple myeloma: Stat 3 activation and cyclin D1 dysregulationare mutually exclusive events. Am. J. Pathol., 2003, 162(5), 1449-1461.
    • (2003) Am. J. Pathol. , vol.162 , Issue.5 , pp. 1449-1461
    • Quintanilla-Martinez, L.1    Kremer, M.2    Specht, K.3    Calzada-Wack, J.4    Nathrath, M.5    Schaich, R.6    Hofler, H.7    Fend, F.8
  • 41
    • 34247244657 scopus 로고    scopus 로고
    • The MicroRNA let-7a modulates interleukin-6-dependentSTAT-3 survival signaling in malignant human cholangiocytes
    • Meng, F.; Henson, R.; Wehbe-Janek, H.; Smith, H.; Ueno, Y.; Patel, T. The MicroRNA let-7a modulates interleukin-6-dependentSTAT-3 survival signaling in malignant human cholangiocytes. J.Biol. Chem., 2007, 282(11), 8256-8264.
    • (2007) J.Biol. Chem. , vol.282 , Issue.11 , pp. 8256-8264
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Smith, H.4    Ueno, Y.5    Patel, T.6
  • 42
    • 28544438023 scopus 로고    scopus 로고
    • Activatedepidermal growth factor receptor-Stat-3 signaling promotes tumorsurvival in vivo in non-small cell lung cancer
    • Haura, E.B.; Zheng, Z.; Song, L.; Cantor, A.; Bepler, G. Activatedepidermal growth factor receptor-Stat-3 signaling promotes tumorsurvival in vivo in non-small cell lung cancer. Clin. Cancer Res., 2005, 11(23), 8288-8294.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.23 , pp. 8288-8294
    • Haura, E.B.1    Zheng, Z.2    Song, L.3    Cantor, A.4    Bepler, G.5
  • 44
    • 25444454543 scopus 로고    scopus 로고
    • New and old functions of STAT3: A pivotal targetfor individualized treatment of cancer
    • Inghirami, G.; Chiarle, R.; Simmons, W.J.; Piva, R.; Schlessinger, K.; Levy, D.E. New and old functions of STAT3: a pivotal targetfor individualized treatment of cancer. Cell Cycle, 2005, 4(9), 1131-1133.
    • (2005) Cell Cycle , vol.4 , Issue.9 , pp. 1131-1133
    • Inghirami, G.1    Chiarle, R.2    Simmons, W.J.3    Piva, R.4    Schlessinger, K.5    Levy, D.E.6
  • 45
    • 21344436180 scopus 로고    scopus 로고
    • Malignant transformation but notnormal cell growth depends on signal transducer and activator of transcription 3
    • Schlessinger, K.; Levy, D.E. Malignant transformation but notnormal cell growth depends on signal transducer and activator of transcription 3. Cancer Res., 2005, 65(13), 5828-5834.
    • (2005) Cancer Res. , vol.65 , Issue.13 , pp. 5828-5834
    • Schlessinger, K.1    Levy, D.E.2
  • 46
    • 35348893870 scopus 로고    scopus 로고
    • Targeting the cytoplasmic and nuclearfunctions of signal transducers and activators of transcription 3 forcancer therapy
    • Germain, D.; Frank, D.A. Targeting the cytoplasmic and nuclearfunctions of signal transducers and activators of transcription 3 forcancer therapy. Clin. Cancer Res., 2007, 13(19), 5665-5669.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.19 , pp. 5665-5669
    • Germain, D.1    Frank, D.A.2
  • 49
    • 85047699773 scopus 로고    scopus 로고
    • p53 regulates Stat3phosphorylation and DNA binding activity in human prostatecancer cells expressing constitutively active Stat3
    • Lin, J.; Tang, H.; Jin, X.; Jia, G.; Hsieh, J.T. p53 regulates Stat3phosphorylation and DNA binding activity in human prostatecancer cells expressing constitutively active Stat3. Oncogene, 2002, 21(19), 3082-3088.
    • (2002) Oncogene , vol.21 , Issue.19 , pp. 3082-3088
    • Lin, J.1    Tang, H.2    Jin, X.3    Jia, G.4    Hsieh, J.T.5
  • 51
    • 0032525155 scopus 로고    scopus 로고
    • Multiple routes to astrocytic differentiationin the CNS
    • Rajan, P.; McKay, R.D. Multiple routes to astrocytic differentiationin the CNS. J. Neurosci., 1998, 18(10), 3620-3629.
    • (1998) J. Neurosci. , vol.18 , Issue.10 , pp. 3620-3629
    • Rajan, P.1    McKay, R.D.2
  • 52
    • 33746397211 scopus 로고    scopus 로고
    • Non-cell- autonomous action of STAT3in maintenance of neural precursor cells in the mouse neocortex
    • Yoshimatsu, T.; Kawaguchi, D.; Oishi, K.; Takeda, K.; Akira, S.; Masuyama, N.; Gotoh, Y. Non-cell- autonomous action of STAT3in maintenance of neural precursor cells in the mouse neocortex.Development, 2006, 133(13), 2553-2563.
    • (2006) Development , vol.133 , Issue.13 , pp. 2553-2563
    • Yoshimatsu, T.1    Kawaguchi, D.2    Oishi, K.3    Takeda, K.4    Akira, S.5    Masuyama, N.6    Gotoh, Y.7
  • 53
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively activeStat3 suppresses proliferation and induces apoptosis inglioblastoma multiforme cells
    • Rahaman, S.O.; Harbor, P.C.; Chernova, O.; Barnett, G.H.; Vogelbaum, M.A.; Haque, S.J. Inhibition of constitutively activeStat3 suppresses proliferation and induces apoptosis inglioblastoma multiforme cells. Oncogene, 2002, 21(55), 8404-8413.
    • (2002) Oncogene , vol.21 , Issue.55 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 54
    • 3042748279 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi induces apoptosis inastrocytoma cells
    • Konnikova, L.; Kotecki, M.; Kruger, M.M.; Cochran, B.H.Knockdown of STAT3 expression by RNAi induces apoptosis inastrocytoma cells. BMC Cancer, 2003, 3, 23.
    • (2003) BMC Cancer , vol.3 , pp. 23
    • Konnikova, L.1    Kotecki, M.2    Kruger, M.M.3    Cochran, B.H.4
  • 55
    • 78449312044 scopus 로고    scopus 로고
    • STAT3 tyrosine phosphorylation influences survival inglioblastoma
    • (in press). DOI:10.1007/S11060-010-0195-8
    • Birner, P.; Toumangelova-Uzeir, K.; Natchev, S.; Guentchev, M. STAT3 tyrosine phosphorylation influences survival inglioblastoma. J. Neurooncol., 2010, (in press). DOI:10.1007/S11060-010-0195-8.
    • (2010) J. Neurooncol.
    • Birner, P.1    Toumangelova-Uzeir, K.2    Natchev, S.3    Guentchev, M.4
  • 57
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya, T.; Morrison, S.J.; Clarke, M.F.; Weissman, I.L. Stem cells, cancer, and cancer stem cells. Nature, 2001, 414(6859), 105-111.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 60
    • 77953207270 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi suppresses growth and inducesapoptosis and differentiation in glioblastoma stem cells
    • Li, G.H.; Wei, H.; Lv, S.Q.; Ji, H.; Wang, D.L. Knockdown of STAT3 expression by RNAi suppresses growth and inducesapoptosis and differentiation in glioblastoma stem cells. Int. J.Oncol., 2010, 37(1), 103-110.
    • (2010) Int. J.Oncol. , vol.37 , Issue.1 , pp. 103-110
    • Li, G.H.1    Wei, H.2    Lv, S.Q.3    Ji, H.4    Wang, D.L.5
  • 61
    • 77950231070 scopus 로고    scopus 로고
    • CD44 attenuates activation of thehippo signaling pathway and is a prime therapeutic target forglioblastoma
    • Xu, Y.; Stamenkovic, I.; Yu, Q. CD44 attenuates activation of thehippo signaling pathway and is a prime therapeutic target forglioblastoma. Cancer Res., 2010, 70(6), 2455-2464.
    • (2010) Cancer Res. , vol.70 , Issue.6 , pp. 2455-2464
    • Xu, Y.1    Stamenkovic, I.2    Yu, Q.3
  • 63
    • 67449123326 scopus 로고    scopus 로고
    • Acetylation and activation of STAT3 mediated by nuclear translocation of CD44
    • Lee, J.L.; Wang, M.J.; Chen, J.Y. Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. J. Cell. Biol., 2009, 185(6), 949-957.
    • (2009) J. Cell. Biol. , vol.185 , Issue.6 , pp. 949-957
    • Lee, J.L.1    Wang, M.J.2    Chen, J.Y.3
  • 70
    • 35348961447 scopus 로고    scopus 로고
    • STAT3 signaling and the hyper-IgEsyndrome
    • Levy, D.E.; Loomis, C.A. STAT3 signaling and the hyper-IgEsyndrome. N. Engl. J. Med., 2007, 357(16), 1655-1658.
    • (2007) N. Engl. J. Med. , vol.357 , Issue.16 , pp. 1655-1658
    • Levy, D.E.1    Loomis, C.A.2
  • 72
    • 77950626754 scopus 로고    scopus 로고
    • A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome
    • Papanastasiou, A.D.; Mantagos, S.; Papanastasiou, D.A.; Zarkadis, I.K. A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome. Mol.Immunol., 2010, 47(7-8), 1629-1634.
    • (2010) Mol.Immunol. , vol.47 , Issue.7-8 , pp. 1629-1634
    • Papanastasiou, A.D.1    Mantagos, S.2    Papanastasiou, D.A.3    Zarkadis, I.K.4
  • 73
    • 41149131755 scopus 로고    scopus 로고
    • STAT3 mutation identified in patients with Hyper-IgEsyndrome
    • Picard, C. STAT3 mutation identified in patients with Hyper-IgEsyndrome. Med. Sci. (Paris), 2008, 24(3), 242-243.
    • (2008) Med. Sci. (Paris) , vol.24 , Issue.3 , pp. 242-243
    • Picard, C.1
  • 74
    • 59849121375 scopus 로고    scopus 로고
    • Insights into the role of STAT3 in human lymphocyte differentiation as revealed by thehyper-IgE syndrome
    • Tangye, S.G.; Cook, M.C.; Fulcher, D.A. Insights into the role of STAT3 in human lymphocyte differentiation as revealed by thehyper-IgE syndrome. J. Immunol., 2009, 182(1), 21-28.
    • (2009) J. Immunol. , vol.182 , Issue.1 , pp. 21-28
    • Tangye, S.G.1    Cook, M.C.2    Fulcher, D.A.3
  • 75
    • 60749113901 scopus 로고    scopus 로고
    • STAT3single-nucleotide polymorphisms and STAT3 mutations associatedwith hyper-IgE syndrome are not responsible for increased serumIgE serum levels in asthma families
    • Wjst, M.; Lichtner, P.; Meitinger, T.; Grimbacher, B. STAT3single-nucleotide polymorphisms and STAT3 mutations associatedwith hyper-IgE syndrome are not responsible for increased serumIgE serum levels in asthma families. Eur. J. Hum. Genet., 2009, 17(3), 352-356.
    • (2009) Eur. J. Hum. Genet. , vol.17 , Issue.3 , pp. 352-356
    • Wjst, M.1    Lichtner, P.2    Meitinger, T.3    Grimbacher, B.4
  • 77
    • 77953519151 scopus 로고    scopus 로고
    • Hyper-IgE syndromewith STAT3 mutation: A case report in Mainland China
    • Xie, L.; Hu, X.; Li, Y.; Zhang, W.; Chen, L. Hyper-IgE syndromewith STAT3 mutation: a case report in Mainland China. Clin. Dev.Immunol., 2010, 2010, 289873.
    • (2010) Clin. Dev.Immunol. , vol.2010 , pp. 289873
    • Xie, L.1    Hu, X.2    Li, Y.3    Zhang, W.4    Chen, L.5
  • 78
    • 0033402420 scopus 로고    scopus 로고
    • Interleukin-6 expression and regulation in astrocytes
    • Van Wagoner, N.J.; Benveniste, E.N. Interleukin-6 expression and regulation in astrocytes. J. Neuroimmunol., 1999, 100(1-2), 124-139.
    • (1999) J. Neuroimmunol. , vol.100 , Issue.1-2 , pp. 124-139
    • Van Wagoner, N.J.1    Benveniste, E.N.2
  • 79
    • 79952189567 scopus 로고    scopus 로고
    • IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines
    • (in press) DOI: 10.1007/s11060-010- 0158-0
    • Liu, Q.; Li, G.; Li, R.; Shen, J.; He, Q.; Deng, L.; Zhang, C.; Zhang, J. IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines. J. Neurooncol., 2010,(in press) DOI: 10.1007/s11060-010- 0158-0.
    • (2010) J. Neurooncol.
    • Liu, Q.1    Li, G.2    Li, R.3    Shen, J.4    He, Q.5    Deng, L.6    Zhang, C.7    Zhang, J.8
  • 80
    • 77951735629 scopus 로고    scopus 로고
    • IL-6augments the invasiveness of U87MG human glioblastomamultiforme cells via up-regulation of MMP-2 and fascin-1
    • Li, R.; Li, G.; Deng, L.; Liu, Q.; Dai, J.; Shen, J.; Zhang, J. IL-6augments the invasiveness of U87MG human glioblastomamultiforme cells via up-regulation of MMP-2 and fascin-1. Oncol.Rep., 2010, 23(6), 1553-1559.
    • (2010) Oncol.Rep. , vol.23 , Issue.6 , pp. 1553-1559
    • Li, R.1    Li, G.2    Deng, L.3    Liu, Q.4    Dai, J.5    Shen, J.6    Zhang, J.7
  • 81
    • 17844396959 scopus 로고    scopus 로고
    • Interleukin-6induces transcriptional activation of vascular endothelial growthfactor (VEGF) in astrocytes in vivo and regulates VEGF promoteractivity in glioblastoma cells via direct interaction between STAT3and Sp1
    • Loeffler, S.; Fayard, B.; Weis, J.; Weissenberger, J. Interleukin-6induces transcriptional activation of vascular endothelial growthfactor (VEGF) in astrocytes in vivo and regulates VEGF promoteractivity in glioblastoma cells via direct interaction between STAT3and Sp1. Int. J. Cancer, 2005, 115(2), 202-213.
    • (2005) Int. J. Cancer , vol.115 , Issue.2 , pp. 202-213
    • Loeffler, S.1    Fayard, B.2    Weis, J.3    Weissenberger, J.4
  • 83
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growthfactor receptor gene in malignant gliomas is invariably associatedwith gene amplification
    • Wong, A.J.; Bigner, S.H.; Bigner, D.D.; Kinzler, K.W.; Hamilton, S.R.; Vogelstein, B. Increased expression of the epidermal growthfactor receptor gene in malignant gliomas is invariably associatedwith gene amplification. Proc. Natl. Acad. Sci. USA, 1987, 84(19), 6899-6903.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , Issue.19 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3    Kinzler, K.W.4    Hamilton, S.R.5    Vogelstein, B.6
  • 84
    • 58149144782 scopus 로고    scopus 로고
    • Constitutively activatedSTAT3 frequently coexpresses with epidermal growth factorreceptor in high-grade gliomas and targeting STAT3 sensitizesthem to Iressa and alkylators
    • Lo, H.W.; Cao, X.; Zhu, H.; Ali-Osman, F. Constitutively activatedSTAT3 frequently coexpresses with epidermal growth factorreceptor in high-grade gliomas and targeting STAT3 sensitizesthem to Iressa and alkylators. Clin. Cancer Res., 2008, 14(19), 6042-6054.
    • (2008) Clin. Cancer Res. , vol.14 , Issue.19 , pp. 6042-6054
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4
  • 85
    • 27744535984 scopus 로고    scopus 로고
    • PI3K-AKT pathway negatively controls EGFR-dependentDNA-binding activity of Stat3 in glioblastoma multiforme cells
    • Ghosh, M.K.; Sharma, P.; Harbor, P.C.; Rahaman, S.O.; Haque, S.J. PI3K-AKT pathway negatively controls EGFR-dependentDNA-binding activity of Stat3 in glioblastoma multiforme cells.Oncogene, 2005, 24(49), 7290-7300.
    • (2005) Oncogene , vol.24 , Issue.49 , pp. 7290-7300
    • Ghosh, M.K.1    Sharma, P.2    Harbor, P.C.3    Rahaman, S.O.4    Haque, S.J.5
  • 87
    • 77349125856 scopus 로고    scopus 로고
    • MicroRNA-21 inhibitorsensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN- wild type) to taxol
    • Ren, Y.; Zhou, X.; Mei, M.; Yuan, X.B.; Han, L.; Wang, G.X.; Jia, Z.F.; Xu, P.; Pu, P.Y.; Kang, C.S. MicroRNA-21 inhibitorsensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN- wild type) to taxol. BMC Cancer, 2010, 10, 27.
    • (2010) BMC Cancer , vol.10 , pp. 27
    • Ren, Y.1    Zhou, X.2    Mei, M.3    Yuan, X.B.4    Han, L.5    Wang, G.X.6    Jia, Z.F.7    Xu, P.8    Pu, P.Y.9    Kang, C.S.10
  • 88
    • 2442657794 scopus 로고    scopus 로고
    • Thesynthetic ligand of peroxisome proliferator-activated receptorgammaciglitazone affects human glioblastoma cell lines
    • Strakova, N.; Ehrmann, J.; Dzubak, P.; Bouchal, J.; Kolar, Z. Thesynthetic ligand of peroxisome proliferator-activated receptorgammaciglitazone affects human glioblastoma cell lines. J.Pharmacol. Exp. Ther., 2004, 309(3), 1239-1247.
    • (2004) J.Pharmacol. Exp. Ther. , vol.309 , Issue.3 , pp. 1239-1247
    • Strakova, N.1    Ehrmann, J.2    Dzubak, P.3    Bouchal, J.4    Kolar, Z.5
  • 89
    • 17044375811 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPAR)agonists affect cell viability, apoptosis and expression of cell cyclerelated proteins in cell lines of glial brain tumors
    • Strakova, N.; Ehrmann, J.; Bartos, J.; Malikova, J.; Dolezel, J.; Kolar, Z. Peroxisome proliferator-activated receptors (PPAR)agonists affect cell viability, apoptosis and expression of cell cyclerelated proteins in cell lines of glial brain tumors. Neoplasma, 2005, 52(2), 126-136.
    • (2005) Neoplasma , vol.52 , Issue.2 , pp. 126-136
    • Strakova, N.1    Ehrmann, J.2    Bartos, J.3    Malikova, J.4    Dolezel, J.5    Kolar, Z.6
  • 91
    • 33751159640 scopus 로고    scopus 로고
    • Inhibition of invivo glioma growth and invasion by peroxisome proliferatoractivatedreceptor gamma agonist treatment
    • Grommes, C.; Landreth, G.E.; Sastre, M.; Beck, M.; Feinstein, D.L.; Jacobs, A.H.; Schlegel, U.; Heneka, M.T. Inhibition of invivo glioma growth and invasion by peroxisome proliferatoractivatedreceptor gamma agonist treatment. Mol. Pharmacol., 2006, 70(5), 1524-1533.
    • (2006) Mol. Pharmacol. , vol.70 , Issue.5 , pp. 1524-1533
    • Grommes, C.1    Landreth, G.E.2    Sastre, M.3    Beck, M.4    Feinstein, D.L.5    Jacobs, A.H.6    Schlegel, U.7    Heneka, M.T.8
  • 92
    • 57449095814 scopus 로고    scopus 로고
    • PPARgamma agonists inhibit growthand expansion of CD133+ brain tumour stem cells
    • Chearwae, W.; Bright, J.J. PPARgamma agonists inhibit growthand expansion of CD133+ brain tumour stem cells. Br. J. Cancer, 2008, 99(12), 2044-2053.
    • (2008) Br. J. Cancer , vol.99 , Issue.12 , pp. 2044-2053
    • Chearwae, W.1    Bright, J.J.2
  • 93
    • 59749101577 scopus 로고    scopus 로고
    • Expression of STATs and their inhibitors SOCS and PIAS in braintumors. In vitro and in vivo study
    • Ehrmann, J.; Strakova, N.; Vrzalikova, K.; Hezova, R.; Kolar, Z. Expression of STATs and their inhibitors SOCS and PIAS in braintumors. In vitro and in vivo study. Neoplasma, 2008, 55(6), 482-487.
    • (2008) Neoplasma , vol.55 , Issue.6 , pp. 482-487
    • Ehrmann, J.1    Strakova, N.2    Vrzalikova, K.3    Hezova, R.4    Kolar, Z.5
  • 94
    • 51049089073 scopus 로고    scopus 로고
    • Loss of proteininhibitors of activated STAT-3 expression in glioblastomamultiforme tumors: Implications for STAT-3 activation and geneexpression
    • Brantley, E.C.; Nabors, L.B.; Gillespie, G.Y.; Choi, Y.H.; Palmer, C.A.; Harrison, K.; Roarty, K.; Benveniste, E.N. Loss of proteininhibitors of activated STAT-3 expression in glioblastomamultiforme tumors: implications for STAT-3 activation and geneexpression. Clin. Cancer Res., 2008, 14(15), 4694- 4704.
    • (2008) Clin. Cancer Res. , vol.14 , Issue.15 , pp. 4694-4704
    • Brantley, E.C.1    Nabors, L.B.2    Gillespie, G.Y.3    Choi, Y.H.4    Palmer, C.A.5    Harrison, K.6    Roarty, K.7    Benveniste, E.N.8
  • 96
    • 14244265590 scopus 로고    scopus 로고
    • Epidemiology and etiology of gliomas
    • Ohgaki, H.; Kleihues, P. Epidemiology and etiology of gliomas.Acta Neuropathol, 2005, 109(1), 93-108.
    • (2005) Acta Neuropathol , vol.109 , Issue.1 , pp. 93-108
    • Ohgaki, H.1    Kleihues, P.2
  • 97
    • 38449099334 scopus 로고    scopus 로고
    • Molecular mechanism of lipopolysaccharideinducedSOCS-3 gene expression in macrophages and microglia
    • Qin, H.; Roberts, K.L.; Niyongere, S.A.; Cong, Y.; Elson, C.O.; Benveniste, E.N. Molecular mechanism of lipopolysaccharideinducedSOCS-3 gene expression in macrophages and microglia. J.Immunol., 2007, 179(9), 5966-5976.
    • (2007) J.Immunol. , vol.179 , Issue.9 , pp. 5966-5976
    • Qin, H.1    Roberts, K.L.2    Niyongere, S.A.3    Cong, Y.4    Elson, C.O.5    Benveniste, E.N.6
  • 100
    • 27144540201 scopus 로고    scopus 로고
    • SOCS-3 is frequently methylated in head and neck squamouscell carcinoma and its precursor lesions and causes growthinhibition
    • Weber, A.; Hengge, U.R.; Bardenheuer, W.; Tischoff, I.; Sommerer, F.; Markwarth, A.; Dietz, A.; Wittekind, C.; Tannapfel, A. SOCS-3 is frequently methylated in head and neck squamouscell carcinoma and its precursor lesions and causes growthinhibition. Oncogene, 2005, 24(44), 6699-6708.
    • (2005) Oncogene , vol.24 , Issue.44 , pp. 6699-6708
    • Weber, A.1    Hengge, U.R.2    Bardenheuer, W.3    Tischoff, I.4    Sommerer, F.5    Markwarth, A.6    Dietz, A.7    Wittekind, C.8    Tannapfel, A.9
  • 103
  • 104
    • 57349117068 scopus 로고    scopus 로고
    • STAT3 silencing with lentivirus inhibits growth and inducesapoptosis and differentiation of U251 cells
    • Li, G.H.; Wei, H.; Chen, Z.T.; Lv, S.Q.; Yin, C.L.; Wang, D.L.STAT3 silencing with lentivirus inhibits growth and inducesapoptosis and differentiation of U251 cells. J. Neurooncol., 2009, 91(2), 165-174.
    • (2009) J. Neurooncol. , vol.91 , Issue.2 , pp. 165-174
    • Li, G.H.1    Wei, H.2    Chen, Z.T.3    Lv, S.Q.4    Yin, C.L.5    Wang, D.L.6
  • 105
    • 79952189765 scopus 로고    scopus 로고
    • Inhibition of the JAK-2/STAT3signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
    • (in press) DOI:10.1007/s11060-010-0273-y
    • Senft, C.; Priester, M.; Polacin, M.; Schroder, K.; Seifert, V.; Kogel, D.; Weissenberger, J. Inhibition of the JAK-2/STAT3signaling pathway impedes the migratory and invasive potential of human glioblastoma cells. J. Neurooncol., 2010, (in press) DOI:10.1007/s11060-010-0273-y
    • (2010) J. Neurooncol.
    • Senft, C.1    Priester, M.2    Polacin, M.3    Schroder, K.4    Seifert, V.5    Kogel, D.6    Weissenberger, J.7
  • 106
    • 67949089533 scopus 로고    scopus 로고
    • Aspirin induces apoptosis through the blockade of IL-6-STAT3signaling pathway in human glioblastoma A172 cells
    • Kim, S.R.; Bae, M.K.; Kim, J.Y.; Wee, H.J.; Yoo, M.A.; Bae, S.K.Aspirin induces apoptosis through the blockade of IL-6-STAT3signaling pathway in human glioblastoma A172 cells. Biochem.Biophys. Res. Commun., 2009, 387(2), 342-347.
    • (2009) Biochem.Biophys. Res. Commun. , vol.387 , Issue.2 , pp. 342-347
    • Kim, S.R.1    Bae, M.K.2    Kim, J.Y.3    Wee, H.J.4    Yoo, M.A.5    Bae, S.K.6
  • 107
    • 33645767865 scopus 로고    scopus 로고
    • Dobesilate inhibits theactivation of signal transducer and activator of transcription 3, and the expression of cyclin D1 and bcl-XL in glioma cells
    • Cuevas, P.; Diaz-Gonzalez, D.; Sanchez, I.; Lozano, R.M.; Gimenez-Gallego, G.; Dujovny, M. Dobesilate inhibits theactivation of signal transducer and activator of transcription 3, and the expression of cyclin D1 and bcl-XL in glioma cells. Neurol.Res., 2006, 28(2), 127-130.
    • (2006) Neurol.Res. , vol.28 , Issue.2 , pp. 127-130
    • Cuevas, P.1    Diaz-Gonzalez, D.2    Sanchez, I.3    Lozano, R.M.4    Gimenez-Gallego, G.5    Dujovny, M.6
  • 108
    • 49749129612 scopus 로고    scopus 로고
    • JSI-124 inhibits glioblastoma multiforme cell proliferation throughG(2)/M cell cycle arrest and apoptosis augment
    • Su, Y.; Li, G.; Zhang, X.; Gu, J.; Zhang, C.; Tian, Z.; Zhang, J. JSI-124 inhibits glioblastoma multiforme cell proliferation throughG(2)/M cell cycle arrest and apoptosis augment. Cancer Biol.Ther., 2008, 7(8), 1243-1249.
    • (2008) Cancer Biol.Ther. , vol.7 , Issue.8 , pp. 1243-1249
    • Su, Y.1    Li, G.2    Zhang, X.3    Gu, J.4    Zhang, C.5    Tian, Z.6    Zhang, J.7
  • 110
    • 67649842379 scopus 로고    scopus 로고
    • Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen speciesgeneration
    • Dixit, D.; Sharma, V.; Ghosh, S.; Koul, N.; Mishra, P.K.; Sen, E.Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen speciesgeneration. Free Radic. Biol. Med., 2009, 47(4), 364-374.
    • (2009) Free Radic. Biol. Med. , vol.47 , Issue.4 , pp. 364-374
    • Dixit, D.1    Sharma, V.2    Ghosh, S.3    Koul, N.4    Mishra, P.K.5    Sen, E.6
  • 112
    • 77950833182 scopus 로고    scopus 로고
    • Sorafenib induces growth arrestand apoptosis of human glioblastoma cells through thedephosphorylation of signal transducers and activators of transcription 3
    • Yang, F.; Brown, C.; Buettner, R.; Hedvat, M.; Starr, R.; Scuto, A.; Schroeder, A.; Jensen, M.; Jove, R. Sorafenib induces growth arrestand apoptosis of human glioblastoma cells through thedephosphorylation of signal transducers and activators of transcription 3. Mol. Cancer Ther., 2010, 9(4), 953-962.
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.4 , pp. 953-962
    • Yang, F.1    Brown, C.2    Buettner, R.3    Hedvat, M.4    Starr, R.5    Scuto, A.6    Schroeder, A.7    Jensen, M.8    Jove, R.9
  • 113
    • 68849107757 scopus 로고    scopus 로고
    • Antitumor effect of humanized anti-interleukin-6 receptor antibody(tocilizumab) on glioma cell proliferation. Laboratoryinvestigation
    • Kudo, M.; Jono, H.; Shinriki, S.; Yano, S.; Nakamura, H.; Makino, K.; Hide, T.; Muta, D.; Ueda, M.; Ota, K.; Ando, Y.; Kuratsu, J. Antitumor effect of humanized anti-interleukin-6 receptor antibody(tocilizumab) on glioma cell proliferation. Laboratoryinvestigation. J. Neurosurg., 2009, 111(2), 219-225.
    • (2009) J. Neurosurg. , vol.111 , Issue.2 , pp. 219-225
    • Kudo, M.1    Jono, H.2    Shinriki, S.3    Yano, S.4    Nakamura, H.5    Makino, K.6    Hide, T.7    Muta, D.8    Ueda, M.9    Ota, K.10    Ando, Y.11    Kuratsu, J.12
  • 114
    • 35448979864 scopus 로고    scopus 로고
    • A novel small moleculeinhibitor of signal transducers and activators of transcription 3reverses immune tolerance in malignant glioma patients
    • Hussain, S.F.; Kong, L.Y.; Jordan, J.; Conrad, C.; Madden, T.; Fokt, I.; Priebe, W.; Heimberger, A.B. A novel small moleculeinhibitor of signal transducers and activators of transcription 3reverses immune tolerance in malignant glioma patients. CancerRes., 2007, 67(20), 9630-9636.
    • (2007) CancerRes. , vol.67 , Issue.20 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.Y.2    Jordan, J.3    Conrad, C.4    Madden, T.5    Fokt, I.6    Priebe, W.7    Heimberger, A.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.