A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on p-glycoprotein biologic functions

AAPS Journal

Volumn 12, Issue 4, 2010, Pages 548-555

  Crouthamel, Matthew H ^a   Wu, Daniel ^b   Yang, Ziping ^a,c   Ho, Rodney J Y ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

ABC transporter; Drug resistance; Genetic variation; MDR1; P glycoprotein; Polymorphism; Transporter

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYSTEINE; DOXORUBICIN; GLYCOPROTEIN P; LEUCINE; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; TOPOTECAN; VINBLASTINE; VINCRISTINE;

ARTICLE; CANCER RESISTANCE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG UPTAKE; ENZYME ACTIVITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; LEUKEMIA; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ADENOSINE TRIPHOSPHATASES; BLOTTING, WESTERN; CELL LINE; CYSTEINE; GENETIC VARIATION; HUMANS; LEUCINE; LEUKEMIA; MUTATION; P-GLYCOPROTEIN; PLASMIDS; RHODAMINE 123;

EID: 78649679997     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9216-y     Document Type: Article

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