-
1
-
-
0035081475
-
Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein
-
Selkoe DJ (2001) Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis 3:75-80.
-
(2001)
J Alzheimers Dis
, vol.3
, pp. 75-80
-
-
Selkoe, D.J.1
-
2
-
-
11844260044
-
Structure and function of amyloid in Alzheimer's disease
-
DOI 10.1016/j.pneurobio.2004.10.004, PII S0301008204001972
-
Morgan C, Colombres M, Nunez MT, Inestrosa NC (2004) Structure and function of amyloid in Alzheimer's disease. Prog Neurobiol 74:323-349. (Pubitemid 40092735)
-
(2004)
Progress in Neurobiology
, vol.74
, Issue.6
, pp. 323-349
-
-
Morgan, C.1
Colombres, M.2
Nunez, M.T.3
Inestrosa, N.C.4
-
3
-
-
0030794309
-
Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity
-
DOI 10.1073/pnas.94.17.9412
-
Hertel C, Terzi E, Hauser N, Jakob-Rotne R, Seelig J, Kemp JA (1997) Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity. Proc Natl Acad Sci USA 94:9412-9416. (Pubitemid 27357843)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.17
, pp. 9412-9416
-
-
Hertel, C.1
Terzi, E.2
Hauser, N.3
Jakob-Rotne, R.4
Seelig, J.5
Kemp, J.A.6
-
4
-
-
34548291359
-
Surface structure of amyloid-beta fibrils contributes to cytotoxicity
-
Yoshiike Y, Akagi T, Takashima A (2007) Surface structure of amyloid-beta fibrils contributes to cytotoxicity. Biochemistry 46:9805-9812.
-
(2007)
Biochemistry
, vol.46
, pp. 9805-9812
-
-
Yoshiike, Y.1
Akagi, T.2
Takashima, A.3
-
5
-
-
12844266117
-
The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity
-
Butterfield DA, Boyd-Kimball D (2005) The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity. Biochim Biophys Acta 1703:149-156.
-
(2005)
Biochim Biophys Acta
, vol.1703
, pp. 149-156
-
-
Butterfield, D.A.1
Boyd-Kimball, D.2
-
6
-
-
10844269704
-
Role of phenylalanine 20 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity
-
Boyd-Kimball D, Mohmmad Abdul H, Reed T, Sultana R, Butterfield DA (2004) Role of phenylalanine 20 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity. Chem Res Toxicol 17:1743-1749.
-
(2004)
Chem Res Toxicol
, vol.17
, pp. 1743-1749
-
-
Boyd-Kimball, D.1
Mohmmad Abdul, H.2
Reed, T.3
Sultana, R.4
Butterfield, D.A.5
-
7
-
-
33751076517
-
Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity
-
Diaz JC, Linnehan J, Pollard H, Arispe N (2006) Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity. Biol Res 39:447-460.
-
(2006)
Biol Res
, vol.39
, pp. 447-460
-
-
Diaz, J.C.1
Linnehan, J.2
Pollard, H.3
Arispe, N.4
-
8
-
-
33746925586
-
Binding of amyloid beta-peptide to ganglioside micelles is dependent on histidine-13
-
Williamson MP, Suzuki Y, Bourne NT, Asakura T (2006) Binding of amyloid beta-peptide to ganglioside micelles is dependent on histidine-13. Biochem J 397:483-490.
-
(2006)
Biochem J
, vol.397
, pp. 483-490
-
-
Williamson, M.P.1
Suzuki, Y.2
Bourne, N.T.3
Asakura, T.4
-
9
-
-
0035827681
-
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
-
Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ (2001) Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J Biol Chem 276: 20466-20473.
-
(2001)
J Biol Chem
, vol.276
, pp. 20466-20473
-
-
Curtain, C.C.1
Ali, F.2
Volitakis, I.3
Cherny, R.A.4
Norton, R.S.5
Beyreuther, K.6
Barrow, C.J.7
Masters, C.L.8
Bush, A.I.9
Barnham, K.J.10
-
10
-
-
0034702813
-
Correlation of beta-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes
-
Kremer JJ, Pallitto MM, Sklansky DJ, Murphy RM (2000) Correlation of beta-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes. Biochemistry 39:10309-10318.
-
(2000)
Biochemistry
, vol.39
, pp. 10309-10318
-
-
Kremer, J.J.1
Pallitto, M.M.2
Sklansky, D.J.3
Murphy, R.M.4
-
11
-
-
33751516396
-
Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure
-
Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE (2006) Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J Gen Physiol 128:637-647.
-
(2006)
J Gen Physiol
, vol.128
, pp. 637-647
-
-
Sokolov, Y.1
Kozak, J.A.2
Kayed, R.3
Chanturiya, A.4
Glabe, C.5
Hall, J.E.6
-
12
-
-
0029117593
-
Sulfonated dyes attenuate the toxic effects of beta-amyloid in a structure-specific fashion
-
Pollack SJ, Sadler, II, Hawtin SR, Tailor VJ, Shearman MS (1995) Sulfonated dyes attenuate the toxic effects of beta-amyloid in a structure-specific fashion. Neurosci Lett 197:211-214.
-
(1995)
Neurosci Lett
, vol.197
, pp. 211-214
-
-
Pollack, S.J.1
Sadler, I.I.2
Hawtin, S.R.3
Tailor, V.J.4
Shearman, M.S.5
-
13
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
-
Lorenzo A, Yankner BA (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91:12243-12247.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
14
-
-
0028588694
-
Congo red protects against toxicity of beta-amyloid peptides on rat hippocampal neurones
-
Burgevin MC, Passat M, Daniel N, Capet M, Doble A (1994) Congo red protects against toxicity of beta-amyloid peptides on rat hippocampal neurones. Neuroreport 5:2429-2432.
-
(1994)
Neuroreport
, vol.5
, pp. 2429-2432
-
-
Burgevin, M.C.1
Passat, M.2
Daniel, N.3
Capet, M.4
Doble, A.5
-
15
-
-
0141642253
-
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease
-
Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M (2003) Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem 87:172-181.
-
(2003)
J Neurochem
, vol.87
, pp. 172-181
-
-
Ono, K.1
Yoshiike, Y.2
Takashima, A.3
Hasegawa, K.4
Naiki, H.5
Yamada, M.6
-
16
-
-
33847025338
-
The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure
-
Hirohata M, Hasegawa K, Tsutsumi-Yasuhara S, Ohhashi Y, Ookoshi T, Ono K, Yamada M, Naiki H (2007) The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure. Biochemistry 46:1888-1899.
-
(2007)
Biochemistry
, vol.46
, pp. 1888-1899
-
-
Hirohata, M.1
Hasegawa, K.2
Tsutsumi-Yasuhara, S.3
Ohhashi, Y.4
Ookoshi, T.5
Ono, K.6
Yamada, M.7
Naiki, H.8
-
18
-
-
7444227078
-
Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells
-
DOI 10.1111/j.1600-079X.2004.00164.x
-
Feng Z, Zhang JT (2004) Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells. J Pineal Res 37:257-266. (Pubitemid 39457047)
-
(2004)
Journal of Pineal Research
, vol.37
, Issue.4
, pp. 257-266
-
-
Feng, Z.1
Zhang, J.-T.2
-
19
-
-
1842453822
-
Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures
-
Liu Q, Zhao B (2004) Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol 141:746-754.
-
(2004)
Br J Pharmacol
, vol.141
, pp. 746-754
-
-
Liu, Q.1
Zhao, B.2
-
20
-
-
0035251678
-
Nicotine and amyloid formation
-
Zeng H, Zhang Y, Peng L, Shao H, Menon NK, Yang J, Salomon AR, Freidland RP, Zagorski MG (2001) Nicotine and amyloid formation. Biol Psychiatry 49:248-257.
-
(2001)
Biol Psychiatry
, vol.49
, pp. 248-257
-
-
Zeng, H.1
Zhang, Y.2
Peng, L.3
Shao, H.4
Menon, N.K.5
Yang, J.6
Salomon, A.R.7
Freidland, R.P.8
Zagorski, M.G.9
-
21
-
-
0023951465
-
Intravenous nicotine in Alzheimer's disease: A pilot study
-
Berl
-
Newhouse PA, Sunderland T, Tariot PN, Blumhardt CL, Weingartner H, Mellow A, Murphy DL (1988) Intravenous nicotine in Alzheimer's disease: a pilot study. Psychopharmacology (Berl) 95:171-175.
-
(1988)
Psychopharmacology
, vol.95
, pp. 171-175
-
-
Newhouse, P.A.1
Sunderland, T.2
Tariot, P.N.3
Blumhardt, C.L.4
Weingartner, H.5
Mellow, A.6
Murphy, D.L.7
-
22
-
-
77649274462
-
Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease
-
Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada K, Yamamoto A, Tooyama I (2010) Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease. Biomaterials 31:4179-4185.
-
(2010)
Biomaterials
, vol.31
, pp. 4179-4185
-
-
Yanagisawa, D.1
Shirai, N.2
Amatsubo, T.3
Taguchi, H.4
Hirao, K.5
Urushitani, M.6
Morikawa, S.7
Inubushi, T.8
Kato, M.9
Kato, F.10
Morino, K.11
Kimura, H.12
Nakano, I.13
Yoshida, C.14
Okada, T.15
Sano, M.16
Wada, Y.17
Wada, K.18
Yamamoto, A.19
Tooyama, I.20
more..
-
23
-
-
68349148206
-
Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons
-
Qin XY, Cheng Y, Cui J, Zhang Y, Yu LC (2009) Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons. Neurosci Lett 463:158-161.
-
(2009)
Neurosci Lett
, vol.463
, pp. 158-161
-
-
Qin, X.Y.1
Cheng, Y.2
Cui, J.3
Zhang, Y.4
Yu, L.C.5
-
24
-
-
0032899322
-
Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay
-
Klunk WE, Jacob RF, Mason RP (1999) Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay. Anal Biochem 266:66-76.
-
(1999)
Anal Biochem
, vol.266
, pp. 66-76
-
-
Klunk, W.E.1
Jacob, R.F.2
Mason, R.P.3
-
25
-
-
0032571381
-
Inhibition of Alzheimer beta-fibrillogenesis by melatonin
-
Papp olla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J (1998) Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J Biol Chem 273:7185-7188.
-
(1998)
J Biol Chem
, vol.273
, pp. 7185-7188
-
-
Papp Olla, M.1
Bozner, P.2
Soto, C.3
Shao, H.4
Robakis, N.K.5
Zagorski, M.6
Frangione, B.7
Ghiso, J.8
-
27
-
-
1442351177
-
Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease
-
Verdier Y, Penke B (2004) Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease. Curr Protein Pept Sci 5:19-31.
-
(2004)
Curr Protein Pept Sci
, vol.5
, pp. 19-31
-
-
Verdier, Y.1
Penke, B.2
-
28
-
-
33744918267
-
Molecular orbital basis for yellow curry spice curcumin's prevention of Alzheimer's disease
-
Balasubramanian K (2006) Molecular orbital basis for yellow curry spice curcumin's prevention of Alzheimer's disease. J Agric Food Chem 54:3512-3520.
-
(2006)
J Agric Food Chem
, vol.54
, pp. 3512-3520
-
-
Balasubramanian, K.1
-
29
-
-
61549108314
-
Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange
-
Zhang A, Qi W, Good TA, Fernandez EJ (2009) Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange. Biophys J 96:1091-1104.
-
(2009)
Biophys J
, vol.96
, pp. 1091-1104
-
-
Zhang, A.1
Qi, W.2
Good, T.A.3
Fernandez, E.J.4
-
30
-
-
0042572518
-
Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure
-
Wang SS, Tobler SA, Good TA, Fernandez EJ (2003) Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure. Biochemistry 42:9507-9514.
-
(2003)
Biochemistry
, vol.42
, pp. 9507-9514
-
-
Wang, S.S.1
Tobler, S.A.2
Good, T.A.3
Fernandez, E.J.4
-
31
-
-
30744433878
-
Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils
-
Petkova AT, Yau WM, Tycko R (2006) Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry 45:498-512.
-
(2006)
Biochemistry
, vol.45
, pp. 498-512
-
-
Petkova, A.T.1
Yau, W.M.2
Tycko, R.3
-
32
-
-
33845873363
-
Development and validation of a modular, extensible docking program: DOCK 5
-
Moustakas DT, Lang PT, Pegg S, Pettersen E, Kuntz ID, Brooijmans N, Rizzo RC (2006) Development and validation of a modular, extensible docking program: DOCK 5. J Comput Aided Mol Des 20:601-619.
-
(2006)
J Comput Aided Mol Des
, vol.20
, pp. 601-619
-
-
Moustakas, D.T.1
Lang, P.T.2
Pegg, S.3
Pettersen, E.4
Kuntz, I.D.5
Brooijmans, N.6
Rizzo, R.C.7
-
33
-
-
69249155714
-
Kinetic study of beta-amyloid residue accessibility using reductive alkylation and mass spectrometry
-
Ramos I, Fabris D, Qi W, Fernandez EJ, Good TA (2009) Kinetic study of beta-amyloid residue accessibility using reductive alkylation and mass spectrometry. Biotechnol Bioeng 104:181-192.
-
(2009)
Biotechnol Bioeng
, vol.104
, pp. 181-192
-
-
Ramos, I.1
Fabris, D.2
Qi, W.3
Fernandez, E.J.4
Good, T.A.5
-
34
-
-
0034816835
-
Exposing asymmetry between monomers in Alzheimer's amyloid fibrils via reductive alkylation of lysine residues
-
Iwata K, Eyles SJ, Lee JP (2001) Exposing asymmetry between monomers in Alzheimer's amyloid fibrils via reductive alkylation of lysine residues. J Am Chem Soc 123:6728-6729.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 6728-6729
-
-
Iwata, K.1
Eyles, S.J.2
Lee, J.P.3
-
35
-
-
33746781304
-
Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange - Mass spectrometry with on-line proteolytic fragmentation
-
Kheterpal I, Chen M, Cook KD, Wetzel R (2006) Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange - mass spectrometry with on-line proteolytic fragmentation. J Mol Biol 361:785-795.
-
(2006)
J Mol Biol
, vol.361
, pp. 785-795
-
-
Kheterpal, I.1
Chen, M.2
Cook, K.D.3
Wetzel, R.4
-
36
-
-
0021207287
-
Reductive alkylation of proteins
-
Means GE (1984) Reductive alkylation of proteins. J Protein Chem 3:121-130.
-
(1984)
J Protein Chem
, vol.3
, pp. 121-130
-
-
Means, G.E.1
-
37
-
-
0032849874
-
Quantification of beta-sheet amyloid fibril structures with thioflavin T
-
LeVine H, III (1999) Quantification of beta-sheet amyloid fibril structures with thioflavin T. Methods Enzymol 309:274-284.
-
(1999)
Methods Enzymol
, vol.309
, pp. 274-284
-
-
LeVine III, H.1
-
38
-
-
33745727582
-
Oxidative stress in Alzheimer's disease
-
Chauhan V, Chauhan A (2006) Oxidative stress in Alzheimer's disease. Pathophysiology 13:195-208.
-
(2006)
Pathophysiology
, vol.13
, pp. 195-208
-
-
Chauhan, V.1
Chauhan, A.2
-
39
-
-
0037117310
-
Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity
-
Kanski J, Varadarajan S, Aksenova M, Butterfield DA (2002) Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity. Biochim Biophys Acta 1586:190-198.
-
(2002)
Biochim Biophys Acta
, vol.1586
, pp. 190-198
-
-
Kanski, J.1
Varadarajan, S.2
Aksenova, M.3
Butterfield, D.A.4
-
40
-
-
9444284334
-
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid
-
Barnham KJ, Haeffner F, Ciccotosto GD, Curtain CC, Tew D, Mavros C, Beyreuther K, Carrington D, Masters CL, Cherny RA, Cappai R, Bush A (2004) Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. FASEB J 18:1427-1429.
-
(2004)
FASEB J
, vol.18
, pp. 1427-1429
-
-
Barnham, K.J.1
Haeffner, F.2
Ciccotosto, G.D.3
Curtain, C.C.4
Tew, D.5
Mavros, C.6
Beyreuther, K.7
Carrington, D.8
Masters, C.L.9
Cherny, R.A.10
Cappai, R.11
Bush, A.12
-
41
-
-
57449091884
-
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils
-
Paravastu AK, Leapman RD, Yau WM, Tycko R (2008) Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci USA 105:18349-18354.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18349-18354
-
-
Paravastu, A.K.1
Leapman, R.D.2
Yau, W.M.3
Tycko, R.4
-
42
-
-
59749105286
-
Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity
-
Hosokawa-Muto J, Kamatari YO, Nakamura HK, Kuwata K (2009) Variety of antiprion compounds discovered through an in silico screen based on cellular-form prion protein structure: Correlation between antiprion activity and binding affinity. Antimicrob Agents Chemother 53:765-771.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 765-771
-
-
Hosokawa-Muto, J.1
Kamatari, Y.O.2
Nakamura, H.K.3
Kuwata, K.4
-
43
-
-
3242759016
-
Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking
-
Jozwiak K, Ravichandran S, Collins JR, Wainer IW (2004) Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking. J Med Chem 47:4008-4021.
-
(2004)
J Med Chem
, vol.47
, pp. 4008-4021
-
-
Jozwiak, K.1
Ravichandran, S.2
Collins, J.R.3
Wainer, I.W.4
-
44
-
-
48449094112
-
Conformer selection and induced fit in flexible backbone protein-protein docking using computational and NMR ensembles
-
Chaudhury S, Gray JJ (2008) Conformer selection and induced fit in flexible backbone protein-protein docking using computational and NMR ensembles. J Mol Biol 381:1068-1087.
-
(2008)
J Mol Biol
, vol.381
, pp. 1068-1087
-
-
Chaudhury, S.1
Gray, J.J.2
-
45
-
-
33847385451
-
A rapid method to measure beta-amyloid induced neurotoxicity in vitro
-
Patel D, Good T (2007) A rapid method to measure beta-amyloid induced neurotoxicity in vitro. J Neurosci Methods 161:1-10.
-
(2007)
J Neurosci Methods
, vol.161
, pp. 1-10
-
-
Patel, D.1
Good, T.2
-
46
-
-
33947719234
-
Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway
-
Lee S, Fernandez EJ, Good TA (2007) Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway. Protein Sci 16:723-732.
-
(2007)
Protein Sci
, vol.16
, pp. 723-732
-
-
Lee, S.1
Fernandez, E.J.2
Good, T.A.3
-
47
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J (1999) Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155:853-862.
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
48
-
-
36849084640
-
Evidence of fibril-like beta-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's beta-amyloid
-
Chimon S, Shaibat MA, Jones CR, Calero DC, Aizezi B, Ishii Y (2007) Evidence of fibril-like beta-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's beta-amyloid. Nat Struct Mol Biol 14:1157-1164.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1157-1164
-
-
Chimon, S.1
Shaibat, M.A.2
Jones, C.R.3
Calero, D.C.4
Aizezi, B.5
Ishii, Y.6
-
49
-
-
57649148788
-
Structural classification of toxic amyloid oligomers
-
Glabe CG (2008) Structural classification of toxic amyloid oligomers. J Biol Chem 283(44):29639-29643.
-
(2008)
J Biol Chem
, vol.283
, Issue.44
, pp. 29639-29643
-
-
Glabe, C.G.1
-
50
-
-
0037459254
-
A kinetic analysis of the mechanism of beta-amyloid induced G protein activation
-
Wang SS, Kazantzi V, Good TA (2003) A kinetic analysis of the mechanism of beta-amyloid induced G protein activation. J Theor Biol 221:269-278.
-
(2003)
J Theor Biol
, vol.221
, pp. 269-278
-
-
Wang, S.S.1
Kazantzi, V.2
Good, T.A.3
-
51
-
-
1542600164
-
Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis
-
Williams AD, Portelius E, Kheterpal I, Guo JT, Cook KD, Xu Y, Wetzel R (2004) Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis. J Mol Biol 335:833-842.
-
(2004)
J Mol Biol
, vol.335
, pp. 833-842
-
-
Williams, A.D.1
Portelius, E.2
Kheterpal, I.3
Guo, J.T.4
Cook, K.D.5
Xu, Y.6
Wetzel, R.7
-
52
-
-
0038309560
-
Analysis of accessible surface of residues in proteins
-
Lins L, Thomas A, Brasseur R (2003) Analysis of accessible surface of residues in proteins. Protein Sci 12:1406-1417.
-
(2003)
Protein Sci
, vol.12
, pp. 1406-1417
-
-
Lins, L.1
Thomas, A.2
Brasseur, R.3
-
54
-
-
0028964374
-
Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors
-
Rose PM, Krystek SR,Jr, Patel PS, Liu EC, Lynch JS, Lach DA, Fisher SM, Webb ML (1995) Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors. FEBS Lett 361:243-249.
-
(1995)
FEBS Lett
, vol.361
, pp. 243-249
-
-
Rose, P.M.1
Krystek Jr., S.R.2
Patel, P.S.3
Liu, E.C.4
Lynch, J.S.5
Lach, D.A.6
Fisher, S.M.7
Webb, M.L.8
-
55
-
-
0028336960
-
Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity
-
Krystek SR,Jr, Patel PS, Rose PM, Fisher SM, Kienzle BK, Lach DA, Liu EC, Lynch JS, Novotny J, Webb ML (1994) Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity. J Biol Chem 269:12383-12386.
-
(1994)
J Biol Chem
, vol.269
, pp. 12383-12386
-
-
Krystek Jr., S.R.1
Patel, P.S.2
Rose, P.M.3
Fisher, S.M.4
Kienzle, B.K.5
Lach, D.A.6
Liu, E.C.7
Lynch, J.S.8
Novotny, J.9
Webb, M.L.10
-
56
-
-
0030903883
-
A mutation changes ligand selectivity and transmembrane signaling preference of the neurokinin-1 receptor
-
Riitano D, Werge TM, Costa T (1997) A mutation changes ligand selectivity and transmembrane signaling preference of the neurokinin-1 receptor. J Biol Chem 272:7646-7655.
-
(1997)
J Biol Chem
, vol.272
, pp. 7646-7655
-
-
Riitano, D.1
Werge, T.M.2
Costa, T.3
-
57
-
-
0033982868
-
Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology
-
Schetz JA, Benjamin PS, Sibley DR (2000) Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol 57:144-152.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 144-152
-
-
Schetz, J.A.1
Benjamin, P.S.2
Sibley, D.R.3
-
58
-
-
33845192482
-
Congo red and protein aggregation in neurodegenerative diseases
-
Frid P, Anisimov SV, Popovic N (2007) Congo red and protein aggregation in neurodegenerative diseases. Brain Res Rev 53:135-160.
-
(2007)
Brain Res Rev
, vol.53
, pp. 135-160
-
-
Frid, P.1
Anisimov, S.V.2
Popovic, N.3
-
59
-
-
33846781516
-
Dual binding modes of Congo red to amyloid protofibril surface observed in molecular dynamics simulations
-
Wu C, Wang Z, Lei H, Zhang W, Duan Y (2007) Dual binding modes of Congo red to amyloid protofibril surface observed in molecular dynamics simulations. J Am Chem Soc 129:1225-1232.
-
(2007)
J Am Chem Soc
, vol.129
, pp. 1225-1232
-
-
Wu, C.1
Wang, Z.2
Lei, H.3
Zhang, W.4
Duan, Y.5
-
60
-
-
0024352110
-
Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation
-
Klunk WE, Pettegrew JW, Abraham DJ (1989) Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. J Histochem Cytochem 37:1273-1281.
-
(1989)
J Histochem Cytochem
, vol.37
, pp. 1273-1281
-
-
Klunk, W.E.1
Pettegrew, J.W.2
Abraham, D.J.3
-
61
-
-
0033798946
-
Histidine residues underlie Congo red binding to a beta analogs
-
Inouye H, Nguyen JT, Fraser PE, Shinchuk LM, Packard AB, Kirschner DA (2000) Histidine residues underlie Congo red binding to A beta analogs. Amyloid 7:179-188.
-
(2000)
Amyloid
, vol.7
, pp. 179-188
-
-
Inouye, H.1
Nguyen, J.T.2
Fraser, P.E.3
Shinchuk, L.M.4
Packard, A.B.5
Kirschner, D.A.6
-
62
-
-
21244492425
-
Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils
-
Ye L, Morgenstern JL, Gee AD, Hong G, Brown J, Lockhart A (2005) Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils. J Biol Chem 280:23599-23604.
-
(2005)
J Biol Chem
, vol.280
, pp. 23599-23604
-
-
Ye, L.1
Morgenstern, J.L.2
Gee, A.D.3
Hong, G.4
Brown, J.5
Lockhart, A.6
-
63
-
-
12244249201
-
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils
-
Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R (2005) Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 307:262-265.
-
(2005)
Science
, vol.307
, pp. 262-265
-
-
Petkova, A.T.1
Leapman, R.D.2
Guo, Z.3
Yau, W.M.4
Mattson, M.P.5
Tycko, R.6
-
64
-
-
66149140617
-
Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure
-
Paravastu AK, Qahwash I, Leapman RD, Meredith SC, Tycko R (2009) Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci USA 106:7443-7448.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 7443-7448
-
-
Paravastu, A.K.1
Qahwash, I.2
Leapman, R.D.3
Meredith, S.C.4
Tycko, R.5
-
65
-
-
78649674130
-
-
Version 6.2. University of California, San Francisco, USA
-
Lang PT, Moustakas D, Brozell S, Carrascal N, Mukherjee S, Pegg S, Raha K, Shivakumar D, Rizzo R, Case D, Shoichet B, Kuntz I (2008) DOCK, Version 6.2. University of California, San Francisco, USA.
-
(2008)
DOCK
-
-
Lang, P.T.1
Moustakas, D.2
Brozell, S.3
Carrascal, N.4
Mukherjee, S.5
Pegg, S.6
Raha, K.7
Shivakumar, D.8
Rizzo, R.9
Case, D.10
Shoichet, B.11
Kuntz, I.12
-
66
-
-
3242886771
-
PDB2PQR: An automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
-
Web Server issue
-
Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA (2004) PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res 32(Web Server issue):W665-W667.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Dolinsky, T.J.1
Nielsen, J.E.2
McCammon, J.A.3
Baker, N.A.4
-
67
-
-
57349090665
-
Very fast prediction and rationalization of pKa valu for protein-ligand complexes
-
Bas DC, Rogers DM, Jensen JH (2008) Very fast prediction and rationalization of pKa valu for protein-ligand complexes. Proteins 73:765-783.
-
(2008)
Proteins
, vol.73
, pp. 765-783
-
-
Bas, D.C.1
Rogers, D.M.2
Jensen, J.H.3
-
68
-
-
13844312649
-
ZINC - A free database of commercially available compounds for virtual screening
-
Irwin JJ, Shoichet BK (2005) ZINC - a free database of commercially available compounds for virtual screening. J Chem Inf Model 45:177-182.
-
(2005)
J Chem Inf Model
, vol.45
, pp. 177-182
-
-
Irwin, J.J.1
Shoichet, B.K.2
-
69
-
-
27944507949
-
ChemDB: A public database of small molecules and related chemoinformatics resources
-
Chen J, Swamidass SJ, Dou Y, Bruand J, Baldi P (2005) ChemDB: a public database of small molecules and related chemoinformatics resources. Bioinformatics 21:4133-4139.
-
(2005)
Bioinformatics
, vol.21
, pp. 4133-4139
-
-
Chen, J.1
Swamidass, S.J.2
Dou, Y.3
Bruand, J.4
Baldi, P.5
-
70
-
-
33748538349
-
Automatic atom type and bond type perception in molecular mechanical calculations
-
Wang J,Wang W, Kollman PA, Case DA (2006) Automatic atom type and bond type perception in molecular mechanical calculations. J Mol Graph Model 25:247-260.
-
(2006)
J Mol Graph Model
, vol.25
, pp. 247-260
-
-
Wang, J.1
Wang, W.2
Kollman, P.A.3
Case, D.A.4
-
71
-
-
4444221565
-
UCSF Chimera - A visualization system for exploratory research and analysis
-
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25:1605-1612.
-
(2004)
J Comput Chem
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
72
-
-
78649678469
-
-
version 2.3.1. New Mexico: OpenEye Scientific Software Inc.
-
ROCS, version 2.3.1. New Mexico: OpenEye Scientific Software Inc.; 2005.
-
(2005)
ROCS
-
-
|