A mutation changes ligand selectivity and transmembrane signaling preference of the neurokinin-1 receptor

Journal of Biological Chemistry

Volumn 272, Issue 12, 1997, Pages 7646-7655

  Riitano, Daniela ^a   Werge, Thomas M ^a,b   Costa, Tommaso ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MUTANT PROTEIN; NEUROKININ 1 RECEPTOR; NEUROKININ A; NEUROKININ B; PHOSPHATIDYLINOSITIDE; SUBSTANCE P DERIVATIVE; TACHYKININ;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; LIGAND BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; LIGANDS; MUTAGENESIS; PROTEIN BINDING; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TACHYKININS;

EID: 0030903883     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.12.7646     Document Type: Article

References (18)

1. Erspamer, V. (1981) Trends Neurosci. 4, 297-369
2. Nakanishi, S. (1987) Physiol. Rev. 67, 123-136
3. Schwyzer, R. (1977) Ann. N. Y. Acad. Sci. 297, 3-26
4. Yokota, Y., Akazawa, C., Ohkubo, H., and Nakanishi, S. (1992) EMBO J. 11, 3585-3591
5. Werge, T. M. (1994) J. Biol. Chem. 269, 22054-22058
6. Amati, V., Werge, T. M., Cattaneo, A., and Tramontane, A. (1995) Protein Eng. 8, 403-408
7. Fong, T. M., Yu, H., Cascieri, M. A., Underwood, D., Swain, C. J., and Strader, C. D. (1994) J. Biol. Chem. 269, 14957-14961
8. Cascieri, M. A., Shiao, L. L., Mills, S. G., Maccoss, M., Swain, C. J., Yu, H., Ber, E., Sadowski, S., Wu, M. T., Strader, C. D., and Fong, T. M. (1995) Mol. Pharmacol. 47, 660-665
9. Li, Y.-M., Marnerakis, M., Stimson, E. R., and Maggio, J. E. (1995) J. Biol. Chem. 270, 1213-1220
10. Boyd, N. D., Kage, R., Dumas, J. J., Krause, J. E., and Leeman, S. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 433-437
11. Girault, S., Sagan, S., Bolbach, G., Lavielle, S., and Chassaing, G. (1996) Eur. J. Biochem., 240, 215-222
12. Morimoto, H., Murai, M., Maeda, Y., Yamaoka, M., Nishikawa, M., Kiyotoh, S., and Fujii, T. J. (1992) Pharmacol. Exp. Ther. 262, 393-402
13. Fujii, T., Murai, M., Morimoto, H., Maeda, Y., Yamaoka, M., Hagiwara, D., Miyake, H., Ikari, N., and Matsuo, M. (1992) Br. J. Pharmacol. 107, 785-789
14. Edmonds-Alt, X., Doutremepuich, J. D., Heaulme, M., Neliat, G., Santucci, V., Steinberg, R., Vilain, P., Bichon, D., Ducoux, J. P., Proiotto, V., Van Broeck, D., Soubrie, P., Le Fur, G., and Breliere, J. C. (1993) Eur. J. Pharmacol. 230, 403-413
15. Sisto, A., Arcamone, F., Centini, F., Finchem, C. I., Lombardi, P., Monteagudo, E., Potier, E., Terracciano, R., Giolitti, A., and Croger, K. (1995) 14th American Peptide Symposium, Columbus, OH, p. 648
16. Snider, R. M., Constantine, J. W., Lowe, J. A., III, Longo, K. P., Lebel, W. S., Woody, H. A., Drozda, S. E., Desai, M. C., Vinick, F. J., Spencer, R. W., and Hess, H. J. (1991) Science 251, 435-437
17. McLean, S., Ganong, A., Seymour, P. A., Snider, R. M., Desai, M. C., Rosen, T., Bryce, D. K., Longo, K. P., Reynolds, L. S., Robinson, G., Schmidt, A. W., Soik, K., and Heym, J. (1993) Pharmacol. Exp. Ther. 267, 472-479
18. Garret, C., Carruette, A., Fardin, V., Moussaoui, S., Peyronel, J. F., Blanchard, J. C., and Laduron, P. M. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 10208-10212