4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition

Journal of Cell Science

Volumn 112, Issue 14, 1999, Pages 2409-2417

  Liu, Wei ^a   Akhand, Anwarul A ^a   Kato, Masashi ^a   Yokoyama, Itsuo ^a   Miyata, Toshio ^b   Kurokawa, Kiyoshi ^b   Uchida, Koji ^c   Nakashima, Izumi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

4 Hydroxynonenal; EGFR; Growth inhibition; MAPK; Receptor clustering

Indexed keywords

4 HYDROXYNONENAL; CASEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MEMBRANE LIPID;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CROSS LINKING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALDEHYDES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELL LINE; CROSS-LINKING REAGENTS; ENZYME ACTIVATION; GENISTEIN; HUMANS; LIPID PEROXIDATION; OXIDATIVE STRESS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TYROSINE; TYRPHOSTINS;

EID: 0032780007     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Barrera, G., Pizzimenti, S., Muraca, R., Barbiero, G., Bonelli, G., Baccino, F. M., Fazio, V. M. and Dianzani, M. U. (1996). Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells. Free Radical Bio. Med. 20, 455-462.
2. Bellomo, G., Maggi, E., Palladini, G., Seccia, M., Perani, G., Marchesi, E. and Finardi, G. (1996). Oxidized lipoproteins and atherogenesis. Cardiologia 41, 417-425.
3. Blenis, J. (1993). Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Nat. Acad. Sci. USA 90, 5889-5892.
4. Carini, R., Mazzanti, R., Biasi, F., Chiarpotto, E., Marmo, G., Moscarella, S., Gentilini, P., Dianzani, M. U. and Poli, G. (1988). Fluorescent aldehyde-protein adducts in the blood serum of healthy alcoholics. In Alcohol Toxicity and Free Padical Mechanisms (ed. R. Normann, C. Ribicre and H. Rouach). pp. 61-64. Pergamon Press, Oxford.
5. Carraway III, K. L. and Cerione, R. A. (1993). Inhibition of epidermal growth factor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain. J. Biol. Chem. 268, 23860-23867.
6. Cochet, C., Kashles, O., Chambhaz, E. M., Borrello, I., King, C. R. and Schlessinger, J. (1988). Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent. J. Biol. Chem. 263, 3290-3295.
7. Curzio, M., Esterbauer, H. and Dianzani, M. U. (1985). Chemotactic activity of hydroxyalkenals on rat neutrophils. Int. J. Tissue Reac. 7, 137-142.
8. Dabrowski, A., Groblewski, G. E., Schafer, C., Guan, K. L. and Williams, J. A. (1997). Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. Am. J. Phys, 273, 1472-1479.
9. Dent, P., Reardon, D. B., Morrison, D. K. and Sturgill, T. W. (1995). Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. mol. Cell. Biol. 15, 4125-4135.
10. Downward, J., Parker, P. and Waterfield, M. D. (1984). Autophosphorylation sites on the epidermal growth factor receptor. Nature 311, 483-485.
11. Downward, J., Waterfield, M. D. and Parker, P. J. (1985). Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. J. Biol. Chem. 260, 14538-14546.
12. Cip1/WAFq/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. J. Cell Biol 131, 235-242.
13. Fanger, G. R., Johnson, N. L. and Johnson, G. L. (1997). MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16, 4961-4972.
14. Ghosh, S., Strum, J. C., Sciorra, V. A., Daniel, L. and Bell, R. M. (1996). Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells. J. Biol Chem. 271, 8472-8480.
15. Goillot, E., Raingeaud, J., Ranger, A., Tepper, R. I., Davis, R. J., Harlow, E. and Sanchez, I. (1997). Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc. Nat. Acad. Sci. USA 94, 3302-3307.
16. Hamaguchi, M., Xiao, H., Uehara, Y., Onnishi, Y. and Nagai, Y. (1993). Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with phosphatidylinositol 3′ kinase. Oncogene 8, 559-564.
17. Hennig, B. and Chow, C. K. (1988). Lipid peroxidation and endothelial cell injury: implications in atherosclerosis. Free Radic. Biol. Med. 4, 99-106.
18. Huang, R. P. and Adamson, E. D. (1995). A biological role for Egr-1 in cell survival following ultra-violet irradiation. Oncogene 10, 467-475.
19. Huang, R. P., Wu, J. X., Fan, Y. and Adamson, E. D. (1996). UV activates growth factor receptor via reactive oxygen intermediates. J. Cell Biol. 133, 211-220.
20. Hubler, L., Leventhal, P. S. and Bertics, P. J. (1992). Alteration of the kinetic properties of the epidermal growth factor receptor tyrosine kinase by basic proteins. Biochem. J. 281, 107-114.
21. Jain, S. K., McVie, R., Duett, J. and Herbst, J. J. (1989). Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 38, 1539-1543.
22. Kaufmann, A. M., Lichtner, R. B., Schirrmacher, V. and Khazaie, K. (1996). Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis. Oncogene 13, 2349-2358.
23. Kawamoto, T., Sato, J. D., Le, A., Polikoff, J., Sato, G. H. and Mendelsohn, J. (1983). Growth stimulation of A431 cell by epidermal growth factor: Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc. Nat. Acad. Sci. USA 80, 1337-1341.
24. Kern, F. G., Mcleskey, S. W., Zhang, L., Kurebayashi, J., Liu, Y., Ding, I. Y., Kharbanda, S., Chen, D., Miller, D. and Cullen, K. (1994). Transfected MCF-7 cells as a model for breast-cancer progression. Breast Cancer Res. Treat. 31, 153-165.
25. King, I. C. and Sartorelli, A. C. (1986). The relationship between epidermal growth factor receptors and the terminal differentiation of A431 carcinoma cells. Biochem. Biophys. Res. Commun. 140, 837-843.
26. Kirichenko, A., Li, L., Morandi, M. T. and Holian, A. (1996) 4-Hydroxy-2-nonenal-protein adducts and apoptosis in murine lung cells after acute ozone exposure. Toxicol. Appl. Pharm. 141, 416-424.
27. Koland, J. G. and Cerione, R. A. (1988). Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism. J. Biol. Chem. 263, 2230-2237.
28. Kruman, I., Bruce-keller, A. J., Bredesen, D., Waeg, G. and Mattson, M. P. (1997). Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089-5100.
29. Krupp, M. N., Connolly, D. T. and Lane, M. D. (1982). Synthesis, turnover and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblasts. J. Biol. Chem. 257, 11489-11496.
30. Lemmon, M. A and Schlessinger, J. (1994). Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem. Sci. 19, 459-463.
31. Levitzki, A. and Gazit, A. (1995). Tyrosine kinase inhibition: an approach to drug development. Science 267, 1782-1788.
32. Li, L., Hamilton, R. F., Kirichenko, A. and Holian, A. (1996). 4-Hydroxynonenal induced cell death in murine alveolar macrophages. Toxicol. Appl. Pharmacol. 139, 135-143.
33. Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K. and Mattson, M. P. (1997). A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide. J. Neurochem. 68, 255-264.
34. Masui, H., Castro, L. and Mendelsohn, J. (1993). Consumption of EGF by A431 cells: evidence for receptor recycling. J. Cell Biol. 120, 85-93.
35. Mohammadi, M., Honegger, A., Sorokin, A., Ulltoch, A., Schlessinger, J. and Hurwitz, D. R. (1993). Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase. Biochemistry 32, 8742-8748.
36. Nakashima I., Zhang, Y. H., Rahman, S. M., Yoshida, T., Isobe, k., Ding, L. N., Iwamoto, T., Hamaguchi, M., Ikezawa, H. and Taguchi, R. (1991). Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death. J. Immunol. 147, 1153-1162.
37. Natarajan, V., Scribner, W. M. and Taher, N. M. (1993). 4-Hydroxynonenal, a metabolite of lipid peroxidation, activites phospholipase D in vascular endothelial cells. Free Radic. Biol. Med. 15, 365-375.
38. Ogata, A., Chauhan, D., Teoh, G., Treon, S. P., Urashima, M., Schlossman, R. L. and Anderson, K. C. (1997). IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade. J. Immunol. 159, 2212-2221.
39. Osherov, N. and Levitzki, A. (1994). Epidermal-growth-factor-dependent activation of the src-family kinases. Eur. J. Biochem, 225, 1047-1053.
40. ++-ATPase activity in rat liver plasma membranes following carbon tetrachloride intoxication. Chem. Biol. Interact. 73, 103-119.
41. 2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. J. Invest. Dermatol. 110, 966-971.
42. Poot, M., Verkerk, A., Koster, J. F., Esterbauer, H. and Jongkind, J. F. (1988). Reversible inhibition of DNA and protein synthesis by cumene hydroperoxide and 4-hydroxynonenal. Mech. Ageing Dev. 43, 1-9.
43. Rao, G. N. (1996). Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases. Oncogene 13, 713-719.
44. Rehemtulla, A., Hamilton, C., Chinnaiyan, A. M. and Dixit, V. M. (1997). Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J. Biol. Chem. 272, 25783-25786.
45. Schlessinger, J. (1986). Allosteric regulation of the epidermal growth factor receptor kinase. J. Cell Biol. 103, 2067-2072.
46. Schlessinger, J. (1988). Signal transaction by allosteric receptor oligomerization. Trends Biochem. Sci. 13, 443-447.
47. Schmidt-Ullrich, R. K., Mikkielsen, R. B., Dent, P., Todd, D. G., valerie, K., Kavanagh, B. D., Contessa, J. N., Rorrer, W. K. and Chen, P. B. (1997). Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15, 1191-1197.
48. Taccone-Gallucci, M., Giardini, O., Lubrano, R., Bandino, D., Mazzarella V., Mannarino, O., Melani, C., Morosetti, M., Elli, M., Tozzo, C et al. (1987). Red blood cell lipid peroxidation in predialysis chronic renal failure. Clin. Nephrol. 27, 238-241.
49. Uchida, K., Szweda, L. I., Chae H. Z. and Stadtraan, E. R. (1992). Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Proc. Nat. Acatl. Sci. USA 90, 8742-8746.
50. Ullrich, A. and Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212,
51. Warmuth, I., Harth, Y., Matsui M, S., Wang, N. and Deleo, V. A. (1994). Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor. Cancer Res. 54, 374-376.
52. Wedegaertner, P. B. and Gill, G. N. (1989). Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. J. Biol. Chem. 264, 11346-11353.
53. Williams, R. Sanghera, J., Wu, F., Carbonaro-Hall, D., Campbell, D, L., Warburton, D., Pelech, S. and Hall, F. (1993). Identification of a human epidermal growth factor receptor-associated protein kinase as a new member of the mitogen activated protein kinase/extracellular signal-regulated protein kinase family. J. Biol Chem. 268, 18213-18217.
54. Yarden, Y. and Schlessinger, J. (1987). Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry 26, 1434-1442.
55. Zarkovic, N., Ilic, Z., Jurin, M., Schaur, R, J., PuhL, H. and Esterbauer, H. (1993). Stimulation of HeIa cell growth by physiological concentrations of 4-hydroxynonenal. Cell Biochem. Funct. 11, 279-286.