Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling

International Journal of Environmental Research and Public Health

Volumn 7, Issue 9, 2010, Pages 3406-3421

  Yamazaki, Hiroshi ^a   Horiuchi, Kana ^a   Takano, Ryohji ^a,b   Nagano, Taku ^a   Shimizu, Makiko ^a   Kitajima, Masato ^b   Murayama, Norie ^a   Shono, Fumiaki ^c  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b Fujitsu Kyusyu Systems   (Japan)

^c Japan Chemical Industry Associations   (Japan)

Author keywords

Biomonitoring; Cytochrome P450; Human liver microsomes; No observed adverse effect level; Physiologically based biokinetic modeling; Simulation

Indexed keywords

COTININE; CYTOCHROME P450; NICOTINE;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; BLOOD LEVEL; CHEMICAL ANALYSIS; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSIMETRY; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; IN VIVO STUDY; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT; SMOKING; TOXICOKINETICS; VALIDATION PROCESS;

NICOTIANA TABACUM; RATTUS;

EID: 78649613713     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph7093406     Document Type: Article

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