Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population

International Journal of Environmental Research and Public Health

Volumn 7, Issue 7, 2010, Pages 2953-2964

  Nagano, Taku ^a   Yamazaki, Hiroshi ^a   Shimizu, Makiko ^a   Kiyotani, Kazuma ^b   Kamataki, Tetsuya ^a,b   Takano, Ryohji ^a   Murayama, Norie ^a   Shono, Fumiaki ^c  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c Japan Chemical Industry Associations (JCIA)   (Japan)

Author keywords

3 hydroxycotinine; Biomarker; CYP2A6; Cytochrome P450; Genetic polymorphism; Smoking index

Indexed keywords

3' HYDROXYCOTININE; COTININE; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; NICOTINE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; BLOOD ANALYSIS; BLOOD CELL COUNT; CIGARETTE SMOKING; CONTROLLED STUDY; ENVIRONMENTAL MONITORING; GENETIC POLYMORPHISM; GENOTYPE; HISTOGRAM; HUMAN; HUMAN EXPERIMENT; JAPANESE; LINEAR REGRESSION ANALYSIS; MALE; SMOKING; SMOKING HABIT; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 78649592964     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph7072953     Document Type: Article

References (25)

1. Benowitz, N.L.; Hukkanen, J.; Jacob, P., III. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb. Exp. Pharmacol. 2009, 192, 29-60.
2. Benowitz, N.L. Pharmacology of nicotine: addiction and therapeutics. Annu. Rev. Pharmacol. Toxicol. 1996, 36, 597-613.
3. Kume, A.; Kume, T.; Masuda, K.; Shibuya, F.; Yamazaki, H. Dose-dependent effects of cigarette smoke on blood biomarkers in healthy Japanese volunteers: observations from smoking and non-smoking. J. Health Sci. 2009, 55, 259-264.
4. Rose, J.E.; Behm, F.M.; Westman, E.C.; Coleman, R.E. Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction. Drug Alcohol Depend. 1999, 56, 99-107.
5. Sontag, S.; Graham, D.Y.; Belsito, A.; Weiss, J.; Farley, A.; Grunt, R.; Cohen, N.; Kinnear, D.; Davis, W.; Archambault, A. Cimetidine, cigarette smoking, and recurrence of duodenal ulcer. N. Engl. J. Med. 1984, 311, 689-693.
6. Terry, P.D.; Rohan, T.E.; Franceschi, S.; Weiderpass, E. Cigarette smoking and the risk of endometrial cancer. Lancet Oncol. 2002, 3, 470-480.
7. Terry, P.D.; Rohan, T.E. Cigarette smoking and the risk of breast cancer in women: a review of the literature. Cancer Epidemiol. Biomarkers Prev. 2002, 11, 953-971.
8. Ishizaka, N.; Ishizaka, Y.; Toda, E.; Nagai, R.; Koike, K.; Hashimoto, H.; Yamakado, M. Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women. Diabetes Res Clin. Pract. 2007, 78, 72-76.
9. Hukkanen, J.; Jacob, P., III; Benowitz, N.L. Metabolism and disposition kinetics of nicotine. Pharmacol. Rev. 2005, 57, 79-115.
10. Kwon, J.T.; Nakajima, M.; Chai, S.; Yom, Y.K.; Kim, H.K.; Yamazaki, H.; Shon, D.R.; Yamamoto, T.; Kuroiwa, Y.; Yokoi, T. Nicotine metabolism and CYP2A6 allele frequencies in Koreans. Pharmacogenetics 2001, 11, 317-323.
11. Nakajima, M.; Kwon, J.T.; Tanaka, N.; Zenta, T.; Yamamoto, Y.; Yamamoto, H.; Yamazaki, H.; Yamamoto, T.; Kokoiwa, Y.; Yokoi, T. Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans. Clin. Pharmacol. Ther. 2001, 69, 72-78.
12. Ellis, J.A.; Gwynn, C.; Garg, R.K.; Philburn, R.; Aldous, K.M.; Perl, S.B.; Thorpe, L.; Frieden, T.R. Secondhand smoke exposure among nonsmokers nationally and in New York City. Nicotine Tob. Res. 2009, 11, 362-370.
13. Miyatake, N.; Wada, J.; Kawasaki, Y.; Nishii, K.; Makino, H.; Numata, T. Relationship between metabolic syndrome and cigarette smoking in the Japanese population. Intern. Med. 2006, 45, 1039-1043.
14. Neovius, M.; Sundstrom, J.; Rasmussen, F. Combined effects of overweight and smoking in late adolescence on subsequent mortality: nationwide cohort study. BMJ 2009, 338, b496.
15. Feng, S.; Kapur, S.; Sarkar, M.; Muhammad, R.; Mendes, P.; Newland, K.; Roethig, H.J. Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers. Toxicol. Lett. 2007, 173, 101-106.
16. Roethig, H.J.; Munjal, S.; Feng, S.; Liang, Q.; Sarkar, M.; Walk, R.A.; Mendes, P.E. Population estimates for biomarkers of exposure to cigarette smoke in adult U.S. cigarette smokers. Nicotine Tob. Res. 2009, 11, 1216-1225.
17. Johnstone, E.; Benowitz, N.; Cargill, A.; Jacob, R.; Hinks, L.; Day, I.; Murphy, M.; Walton, R. Determinants of the rate of nicotine metabolism and effects on smoking behavior. Clin. Pharmacol. Ther. 2006, 80, 319-330.
18. Ho, M.K.; Faseru, B.; Choi, W.S.; Nollen, N.L.; Mayo, M.S.; Thomas, J.L.; Okuyemi, K.S.; Ahluwalia, J.S.; Benowitz, N.L.; Tyndale, R.F. Utility and relationships of biomarkers of smoking in African-American light smokers. Cancer Epidemiol. Biomarkers Prev. 2009, 18, 3426-3434.
19. Yamanaka, H.; Nakajima, M.; Nishimura, K.; Yoshida, R.; Fukami, T.; Katoh, M.; Yokoi, T. Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted. Eur. J. Pharm. Sci. 2004, 22, 419-425.
20. Kiyotani, K.; Yamazaki, H.; Fujieda, M.; Iwano, S.; Matsumura, K.; Satarug, S.; Ujjin, P.; Shimada, T.; Guengerich, F.P.; Parkinson, A.; Nakagawa, K.; Honda, G.; Ishizaki, T.; Kamataki, T. Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). Pharmacogenetics 2003, 13, 689-695.
21. Fujieda, M.; Yamazaki, H.; Saito, T.; Kiyotani, K.; Gyamfi, M.A.; Sakurai, M.; Dosaka-Akita, H.; Sawamura, Y.; Yokota, J.; Kunitoh, H.; Kamataki, T. Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers. Carcinogenesis 2004, 25, 2451-2458.
22. Nakajima, M.; Yamagishi, S.; Yamamoto, H.; Yamamoto, T.; Kuroiwa, Y.; Yokoi, T. Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans. Clin. Pharmacol. Ther. 2000, 67, 57-69.
23. Yamazaki, H.; Inoue, K.; Hashimoto, M.; Shimada, T. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch. Toxicol. 1999, 73, 65-70.
24. Su, T.; Bao, Z.P.; Zhang, Q.Y.; Smith, T.J.; Hong, J.Y.; Ding, X.X. Human cytochrome P450 CYP2A13: Predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 2000, 60, 5074-5079.
25. Bao, Z.; He, X.Y.; Ding, X.; Prabhu, S.; Hong, J.Y. Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug Metab. Dispos. 2005, 33, 258-261.