Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers

Toxicology Letters

Volumn 173, Issue 2, 2007, Pages 101-106

  Feng, Shixia ^a   Kapur, Sunil ^a   Sarkar, Mohamadi ^a   Muhammad, Raheema ^a   Mendes, Paul ^a   Newland, Kirk ^b   Roethig, Hans J ^a  

^a Philip Morris USA   (United States)

^b MDS Inc   (Canada)

Author keywords

Nicotine; Nicotine equivalents; Respiratory retention; Smoking; Urinary excretion

Indexed keywords

3' HYDROXYCOTININE; 3' HYDROXYCOTININE O GLUCURONIDE; COTININE; COTININE N GLUCURONIDE; NICOTINE DERIVATIVE; NICOTINE N GLUCURONIDE; UNCLASSIFIED DRUG;

ADULT; ANALYTIC METHOD; ARTICLE; CIGARETTE SMOKING; COMPARATIVE STUDY; CONTROLLED STUDY; EXPOSURE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SMOKING; STEADY STATE; URINALYSIS; URINARY EXCRETION;

ADULT; BIOLOGICAL MARKERS; BIOTRANSFORMATION; BREATH TESTS; CHROMATOGRAPHY, LIQUID; COTININE; GLUCURONATES; HALF-LIFE; HUMANS; INHALATION; LUNG; MALE; MODELS, BIOLOGICAL; NICOTINE; NICOTINIC AGONISTS; SMOKING; TANDEM MASS SPECTROMETRY;

EID: 34548388783     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2007.06.016     Document Type: Article

References (20)

1. Armitage A.K., Dixon M., Frost B.E., Mariner D.C., and Sinclair N.M. The effect of inhalation volume and breath-hold duration on the retention of nicotine and solanesol in the human respiratory tract and on subsequent plasma nicotine concentrations during cigarette smoking. Beitr. Tabakforsch. Int. 21 (2004) 240-249
2. Armitage A.K., Dixon M., Frost B.E., Mariner D.C., and Sinclair N.M. The effect of tobacco blend additives on the retention of nicotine and solanesol in the human respiratory tract and on subsequent plasma nicotine concentrations during cigarette smoking. Chem. Res. Toxicol. 17 (2004) 537-544
3. Andersson G., Vala E.K., and Curvall M. The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers. J. Oral Pathol. Med. 26 (1997) 117-123
4. Baker R.R., and Dixon M. The retention of tobacco smoke constituents in the human respiratory tract. Inhal. Toxicol. 18 (2006) 255-294
5. Benowitz N.L., and Jacob III P. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clin. Pharmacol. Ther. 56 (1994) 483-493
6. Benowitz N.L., and Jacob III P. Trans-3′-hydroxycotinine: disposition kinetics, effects and plasma levels during cigarette smoking. Br. J. Clin. Pharmacol. 51 (2001) 53-59
7. Benowitz N.L., Jacob III P., Fong I., and Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J. Pharmacol. Exp. Ther. 268 (1994) 296-303
8. Boswell C., Curvall M., Elswick Jr. R.K., and Leyden D. Modeling nicotine intake in smokers and snuff users using biological fluid nicotine metabolites. Biomarkers 5 (2000) 341-354
9. Byrd G.D., Chang K.M., Greene J.M., and deBethizy J.D. Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3′-hydroxycotinine in smokers. Drug Metab. Dispos. 20 (1992) 192-197
10. Greenberg L.A., Lester D., and Haggard H.W. The absorption of nicotine in tobacco smoking. J. Pharmacol. Exp. Ther. 104 (1952) 162-167
11. Feng S., Plunkett S.E., Lam K., Kapur S., Muhammad R., Jin Y., Zimmermann M., Mendes P., Kinser R., Hans J., and Roethig H.J. A new method for estimating the retention of selected smoke constituents in the respiratory tract of smokers during cigarette smoking. Inhal. Toxicol. 19 (2007) 169-179
12. Hatsukami D.K., Benowitz N.L., Rennard S.I., Oncken C., and Hecht S.S. Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine Tob. Res. 8 (2006) 600-622
13. Heavner D.L., Richardson J.D., Morgan W.T., and Ogden M.W. Validation and application of a method for the determination of nicotine and five major metabolites in smokers' urine by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr. 19 (2005) 312-328
14. Hecht S.S. Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. Carcinogenesis 23 (2002) 907-922
15. Hecht S.S., Carmella S.G., and Murphy S.E. Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol. Biomarkers Prev. 8 (1999) 907-913
16. Lafontaine M., Champmartin C., Simon P., Delsaut P., and Funck-Brentano C. 3-Hydroxybenzo[a]pyrene in urine of smokers and non-smokers. Toxicol. Lett. 162 (2006) 181-185
17. Meger M., Meger-Kossien I., Schuler-Metz A., Janket D., and Scherer G. Simultaneous determination of nicotine and eight nicotine metabolites in urine of smokers using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 778 (2002) 251-261
18. Roethig H.J., Kinser R.D., Lau R.W., Walk R.A., and Wang N. Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking. J. Clin. Pharmacol. 45 (2005) 133-145
19. Scherer G. Smoking behaviour and compensation: a review of the literature. Psychopharmacology (Berl.) 145 (1999) 1-20
20. Tricker A.R. Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour. Toxicology 183 (2003) 151-173