Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 3, 2010, Pages 799-806

  Goldstein, Carmit ^a   Schroeder, Jonathan C ^a   Fortin, Jean Philippe ^a   Goss, Jennifer M ^b,c   Schaus, Scott E ^b   Beinborn, Martin ^a   Kopin, Alan S ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Boston University   (United States)

^c CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; METHYL 3 [[3 [4 (3 ACETAMIDOPHENYL) PIPERIDIN 1 YL]PROPYL]CARBAMOYL] 4(3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; BODY WEIGHT; CELL STRAIN HEK293; CELL SURFACE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GENES, REPORTER; HEK293 CELLS; HUMANS; HYPOTHALAMIC HORMONES; MELANINS; MUTATION, MISSENSE; PIPERIDINES; PITUITARY HORMONES; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRIMIDINES; RECEPTORS, SOMATOSTATIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THINNESS; TRANSFECTION;

EID: 78649536986     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.174029     Document Type: Article

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